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  1. Article ; Online: Robotic surgery: A pending subject in oral and maxillofacial surgery.

    Aragón Niño, Íñigo / Cebrián Carretero, José Luis

    Journal of dental sciences

    2024  Volume 19, Issue 2, Page(s) 1282–1284

    Language English
    Publishing date 2024-01-22
    Publishing country Netherlands
    Document type Journal Article ; Review
    ISSN 2213-8862
    ISSN (online) 2213-8862
    DOI 10.1016/j.jds.2024.01.006
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  2. Article: New Technologies for Personalized Medicine in Head and Neck Oncologic and Reconstructive Surgery.

    Cebrián Carretero, José Luis / Navarro Cuéllar, Carlos

    Journal of clinical medicine

    2022  Volume 11, Issue 15

    Abstract: The search for standardized protocols has been a constant concern in Head and Neck Reconstructive Surgery [ ... ]. ...

    Abstract The search for standardized protocols has been a constant concern in Head and Neck Reconstructive Surgery [...].
    Language English
    Publishing date 2022-07-22
    Publishing country Switzerland
    Document type Editorial
    ZDB-ID 2662592-1
    ISSN 2077-0383
    ISSN 2077-0383
    DOI 10.3390/jcm11154261
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  3. Article: Application of 3D technology for the design of a guidewire for deep cervicofacial collections percutaneous management.

    López-Martínez, Clara / Pampín-Martínez, Marta-María / García-López-Chicharro, Alba / Aragón-Niño, Íñigo / Cebrián-Carretero, José-Luis

    Journal of clinical and experimental dentistry

    2024  Volume 16, Issue 3, Page(s) e383–e386

    Abstract: Background: This study aims to present a case of deep cervicofacial abscesses and demonstrate the efficacy of CT-guided drainage with a custom-designed puncture guide in a challenging anatomical location. The use of this type of guide is an innovative ... ...

    Abstract Background: This study aims to present a case of deep cervicofacial abscesses and demonstrate the efficacy of CT-guided drainage with a custom-designed puncture guide in a challenging anatomical location. The use of this type of guide is an innovative technique since CAD-CAM technology has not been used for this type of application until now.
    Material and methods: A 76-year-old man with persistent facial swelling and trismus underwent surgical drainage initially, but symptoms persisted. A CT-guided transcutaneous approach was planned using a custom-designed positioning guide created with "in-house" 3D technology. The guide was fabricated using Surgical Guide resin, and the patient underwent successful CT-guided drainage.
    Results: The intervention facilitated precise drainage without damaging critical anatomical structures. The patient exhibited prompt clinical improvement, shortened hospitalization, and favorable aesthetic outcomes.
    Conclusions: CT-guided drainage, particularly when combined with a custom puncture guide, offers a less invasive alternative for challenging cervicofacial abscesses. This approach proves valuable in reducing procedure duration, minimizing soft tissue trauma, and enhancing preoperative planning, making it especially beneficial for patients with high anesthetic risk or complex anatomical considerations.
    Language English
    Publishing date 2024-03-01
    Publishing country Spain
    Document type Case Reports
    ZDB-ID 2586647-3
    ISSN 1989-5488
    ISSN 1989-5488
    DOI 10.4317/jced.61354
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  4. Article: Venous malformation differential diagnosis with an odontogenic abscess on a pediatric patient. Case report and review of the literature.

    Álvaro-Martinez, María / Cuesta-Urquía, Carolina / Ortiz-Peces, Luis / Noguera-Tomás, Jorge / González-Otero, Teresa / Cebrián-Carretero, José-Luis

    Journal of clinical and experimental dentistry

    2024  Volume 16, Issue 3, Page(s) e387–e390

    Abstract: Venous malformations (VMs) are aberrant venous vessel angiogenesis present at birth. However, they can become apparent later in life, debuting in early childhood. This poses a clinical quest for surgeons, dentists, and pediatricians, as they might appear ...

    Abstract Venous malformations (VMs) are aberrant venous vessel angiogenesis present at birth. However, they can become apparent later in life, debuting in early childhood. This poses a clinical quest for surgeons, dentists, and pediatricians, as they might appear as a compressible mass in the head and neck region, not uncommonly mistaking them for odontogenic abscesses or other soft tissue tumors. The differential diagnosis can be challenging and imaging techniques are often needed. Ultrasounds are extremely useful initially as other diagnostic tools can be potentially harmful in the context of a VM. MRI is key as it provides accurate extension and location information, and allows to plan invasive treatment alternatives if the patient requires it. In this article, we present the case of a 6-year-old girl who was treated by mistake for an infection upon the diagnosis of an incipient odontogenic abscess instead of a venous malformation, and a literature review on VMs.
    Language English
    Publishing date 2024-03-01
    Publishing country Spain
    Document type Case Reports
    ZDB-ID 2586647-3
    ISSN 1989-5488
    ISSN 1989-5488
    DOI 10.4317/jced.61416
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  5. Article: Commentary on "Clinicopathological features of programmed cell death-ligand 1 expression in patients with oral squamous cell carcinoma".

    Peña-Cardelles, Juan Francisco / Moro-Rodríguez, José Ernesto / Cebrián-Carretero, José Luís / Pozo-Kreilinger, José Juan

    Open medicine (Warsaw, Poland)

    2022  Volume 17, Issue 1, Page(s) 227–228

    Language English
    Publishing date 2022-02-01
    Publishing country Poland
    Document type Journal Article
    ZDB-ID 2829380-0
    ISSN 2391-5463
    ISSN 2391-5463
    DOI 10.1515/med-2022-0431
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  6. Article ; Online: Mechanisms of Cisplatin Resistance in HPV Negative Head and Neck Squamous Cell Carcinomas.

    Griso, Ana Belén / Acero-Riaguas, Lucía / Castelo, Beatriz / Cebrián-Carretero, José Luis / Sastre-Perona, Ana

    Cells

    2022  Volume 11, Issue 3

    Abstract: Head and neck squamous cell carcinomas (HNSCCs) are the eighth most common cancers worldwide. While promising new therapies are emerging, cisplatin-based chemotherapy remains the gold standard for advanced HNSCCs, although most of the patients relapse ... ...

    Abstract Head and neck squamous cell carcinomas (HNSCCs) are the eighth most common cancers worldwide. While promising new therapies are emerging, cisplatin-based chemotherapy remains the gold standard for advanced HNSCCs, although most of the patients relapse due to the development of resistance. This review aims to condense the different mechanisms involved in the development of cisplatin resistance in HNSCCs and highlight future perspectives intended to overcome its related complications. Classical resistance mechanisms include drug import and export, DNA repair and oxidative stress control. Emerging research identified the prevalence of these mechanisms in populations of cancer stem cells (CSC), which are the cells mainly contributing to cisplatin resistance. The use of old and new CSC markers has enabled the identification of the characteristics within HNSCC CSCs predisposing them to treatment resistance, such as cell quiescence, increased self-renewal capacity, low reactive oxygen species levels or the acquisition of epithelial to mesenchymal transcriptional programs. In the present review, we will discuss how cell intrinsic and extrinsic cues alter the phenotype of CSCs and how they influence resistance to cisplatin treatment. In addition, we will assess how the stromal composition and the tumor microenvironment affect drug resistance and the acquisition of CSCs' characteristics through a complex interplay between extracellular matrix content as well as immune and non-immune cell characteristics. Finally, we will describe how alterations in epigenetic modifiers or other signaling pathways can alter tumor behavior and cell plasticity to induce chemotherapy resistance. The data generated in recent years open up a wide range of promising strategies to optimize cisplatin therapy, with the potential to personalize HNSCC patient treatment strategies.
    MeSH term(s) Antineoplastic Agents/pharmacology ; Antineoplastic Agents/therapeutic use ; Cell Line, Tumor ; Cisplatin/pharmacology ; Cisplatin/therapeutic use ; Drug Resistance, Neoplasm ; Epithelial-Mesenchymal Transition ; Humans ; Papillomavirus Infections/drug therapy ; Squamous Cell Carcinoma of Head and Neck/drug therapy ; Tumor Microenvironment
    Chemical Substances Antineoplastic Agents ; Cisplatin (Q20Q21Q62J)
    Language English
    Publishing date 2022-02-05
    Publishing country Switzerland
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 2661518-6
    ISSN 2073-4409 ; 2073-4409
    ISSN (online) 2073-4409
    ISSN 2073-4409
    DOI 10.3390/cells11030561
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  7. Article: Peripheral odontogenic keratocyst. A Case report.

    Hornillos-de Villota, María / Pampin-Martínez, Marta Mª / Moran-Soto, Mª José / Cebrián-Carretero, José-Luis

    Journal of clinical and experimental dentistry

    2023  Volume 15, Issue 2, Page(s) e169–e172

    Abstract: Odontogenic keratocysts (OKCs) are benign cysts arising from the dental lamina and its remnants. They are most commonly located in the posterior body and the ramus of the mandible. The diagnosis of peripheral OKCs (other than intraosseous) are extremely ... ...

    Abstract Odontogenic keratocysts (OKCs) are benign cysts arising from the dental lamina and its remnants. They are most commonly located in the posterior body and the ramus of the mandible. The diagnosis of peripheral OKCs (other than intraosseous) are extremely rare and the current literature is limited. The most common location is the gingiva, but mucosal, epidermal, and even intramuscular sites have also been described. Currently 15 cases have been described. The origin and nature of peripheral OKC still remains controversial. The differential diagnosis includes gingival cyst, mucoceles and epidermoid cyst. Soft tissue OKCs have a lower rate of recurrences; 12,5% vs. 62% in intraosseus OKCs. We report a case of a 58-year-old woman with a peripheral OKC, located in the left masticatory space. We performed a review of the existing literature on peripheral odontogenic keratocysts.
    Language English
    Publishing date 2023-02-01
    Publishing country Spain
    Document type Case Reports
    ZDB-ID 2586647-3
    ISSN 1989-5488
    ISSN 1989-5488
    DOI 10.4317/jced.60033
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  8. Article: Buccal cheek mucosa solitary fibrous tumor. Case report.

    García-López-Chicharro, Alba / Pampín-Martínez, Marta-María / López-Martínez, Clara / Aragón-Niño, Íñigo / Cebrián-Carretero, José-Luis

    Journal of clinical and experimental dentistry

    2023  Volume 15, Issue 12, Page(s) e1064–e1067

    Abstract: Solitary fibrous tumor (STF) is a mesenchymal tumor that mainly appears in the pleura. Its presence in the oral cavity is very uncommon, being the buccal mucosa the most frequent location. Imaging cannot distinguish this entity between other types of ... ...

    Abstract Solitary fibrous tumor (STF) is a mesenchymal tumor that mainly appears in the pleura. Its presence in the oral cavity is very uncommon, being the buccal mucosa the most frequent location. Imaging cannot distinguish this entity between other types of tumors, being histological and immunohistochemical studies essential for its diagnosis. Immunohistochemical stains typically show positive results for CD34, Bcl2, and CD99. Surgical removal with wide margins is the gold standard treatment, requiring a close follow up due to recurrence risk. We present a case report of a solitary fibrous tumor located in the buccal cheek mucosa and the surgical approach.
    Language English
    Publishing date 2023-12-01
    Publishing country Spain
    Document type Case Reports
    ZDB-ID 2586647-3
    ISSN 1989-5488
    ISSN 1989-5488
    DOI 10.4317/jced.61157
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  9. Article ; Online: Genetic Profile of Arteriovenous Anomalies of the Head and Neck: Implications in Progression and Therapeutic Approaches.

    Pampín Martínez, Marta Maria / Rodríguez-Laguna, Lara / Gómez García, Elena / Cebrián Carretero, Jose Luis / González Otero, Teresa / López Gutiérrez, Juan Carlos

    Journal of pediatric surgery

    2023  Volume 58, Issue 10, Page(s) 2043–2049

    Abstract: Background: Arteriovenous Malformations (AVMs) are complex vascular anomalies that are usually sporadic and can have a variable clinical course. Treatment of AVMs can lead to severe sequeale and require thorough decision-making. There is a lack of ... ...

    Abstract Background: Arteriovenous Malformations (AVMs) are complex vascular anomalies that are usually sporadic and can have a variable clinical course. Treatment of AVMs can lead to severe sequeale and require thorough decision-making. There is a lack of standardized treatment protocols showing a growing need for pharmacological targeted therapies, specially in the most severe cases where surgery may not be feasible. Current knowledge in molecular pathways and genetic diagnosis have shed light in the pathophysiology of AVMs, opening possibilities for personalized treatment strategies.
    Methods: We performed a retrospective review of patients with head and neck AVMs treated in our department between 2003 and 2021 and performed a complete physical examination and imaging with ultrasound and angio-CT or MRI. Patients underwent genetic testing on AVMs' tissue samples and/or peripheral blood samples. Patients were grouped according to the genetic variant and a correlation between phenotype and genotype was studied.
    Results: 22 patients with head and neck AVMs were included. We found eight patients with varians in MAP2K1, four patients with pathogenic variants in KRAS, six patients with pathogenic variants in RASA1, one patient with a pathogenic variant in BRAF, one patient with a pathogenic variant in NF1, another patient with a pathogenic variant in CELSR1 and one patient with pathogenic variants in PIK3CA and GNA14. Patients with MAP2K1 variants were the biggest group, with a moderate clinical course. Patients with KRAS mutations showed the most aggressive clinical course and a high rate of recurrence and osteolysis. Patients with RASA1 variants showed a characteristic phenotype with an ipsilateral capillary malformation in the neck.
    Conclusion: We found a correlation between genotype and phenotype in this group of patients. The genetic diagnosis of AVMs is recommended in order to stablish a personalized treatment strategy. Targeted therapies are currently being investigated with promising results and may be recommended in addition to conventional surgical or embolization procedures, specially in the most complex cases.
    Level of evidence: Level IV.
    MeSH term(s) Humans ; Genetic Profile ; Proto-Oncogene Proteins p21(ras)/genetics ; Head ; Arteriovenous Malformations/genetics ; Arteriovenous Malformations/therapy ; Arteriovenous Malformations/diagnosis ; Embolization, Therapeutic/methods ; Disease Progression ; Treatment Outcome ; GTP-Binding Protein alpha Subunits, Gq-G11/genetics ; p120 GTPase Activating Protein/genetics
    Chemical Substances Proto-Oncogene Proteins p21(ras) (EC 3.6.5.2) ; GNA14 protein, human (EC 3.6.5.1) ; GTP-Binding Protein alpha Subunits, Gq-G11 (EC 3.6.5.1) ; RASA1 protein, human ; p120 GTPase Activating Protein
    Language English
    Publishing date 2023-02-07
    Publishing country United States
    Document type Journal Article
    ZDB-ID 80165-3
    ISSN 1531-5037 ; 0022-3468
    ISSN (online) 1531-5037
    ISSN 0022-3468
    DOI 10.1016/j.jpedsurg.2023.01.047
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  10. Article ; Online: Static retractor made from vessel loop.

    Cuesta Urquia, Carolina / González Martin-Moro, Javier / Aragón Niño, Íñigo / Hornillos de Villota, María / Cebrián Carretero, Jose Luis

    The British journal of oral & maxillofacial surgery

    2023  Volume 62, Issue 3, Page(s) 304–305

    MeSH term(s) Humans ; Equipment Design ; Surgical Instruments
    Language English
    Publishing date 2023-12-20
    Publishing country Scotland
    Document type Journal Article
    ZDB-ID 605685-4
    ISSN 1532-1940 ; 0266-4356
    ISSN (online) 1532-1940
    ISSN 0266-4356
    DOI 10.1016/j.bjoms.2023.12.011
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