Article ; Online: Epigallocatechin gallate is a potent inhibitor of cystathionine beta-synthase: Structure-activity relationship and mechanism of action.
Nitric oxide : biology and chemistry
2022 Volume 128, Page(s) 12–24
Abstract: Epigallocatechin gallate (EGCG) is the main bioactive component of green tea. Through screening of a small library of natural compounds, we discovered that EGCG inhibits cystathionine β-synthase (CBS), a major ... ...
| Abstract | Epigallocatechin gallate (EGCG) is the main bioactive component of green tea. Through screening of a small library of natural compounds, we discovered that EGCG inhibits cystathionine β-synthase (CBS), a major H |
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| MeSH term(s) | Catechin/analogs & derivatives ; Cystathionine beta-Synthase/metabolism ; Cystathionine gamma-Lyase/metabolism ; Humans ; Hydrogen Sulfide/metabolism ; Phosphates ; Pyridoxal ; Structure-Activity Relationship | |||||
| Chemical Substances | Phosphates ; Pyridoxal (3THM379K8A) ; Catechin (8R1V1STN48) ; epigallocatechin gallate (BQM438CTEL) ; Cystathionine beta-Synthase (EC 4.2.1.22) ; Cystathionine gamma-Lyase (EC 4.4.1.1) ; Hydrogen Sulfide (YY9FVM7NSN) | |||||
| Language | English | |||||
| Publishing date | 2022-08-13 | |||||
| Publishing country | United States | |||||
| Document type | Journal Article ; Research Support, Non-U.S. Gov't | |||||
| ZDB-ID | 1362794-6 | |||||
| ISSN | 1089-8611 ; 1089-8603 | |||||
| ISSN (online) | 1089-8611 | |||||
| ISSN | 1089-8603 | |||||
| DOI | 10.1016/j.niox.2022.07.007 | |||||
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| Database | MEDical Literature Analysis and Retrieval System OnLINE |
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