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  1. Article ; Online: Reply to Dr. Lacrosse et al.

    Cederholm, Tommy E

    Clinical nutrition (Edinburgh, Scotland)

    2016  Volume 36, Issue 1, Page(s) 309

    Language English
    Publishing date 2016-09-24
    Publishing country England
    Document type Letter ; Comment
    ZDB-ID 604812-2
    ISSN 1532-1983 ; 0261-5614
    ISSN (online) 1532-1983
    ISSN 0261-5614
    DOI 10.1016/j.clnu.2016.09.017
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    In stock of ZB MED Cologne/Königswinter

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  2. Article: A posteriori dietary patterns in 71-year-old Swedish men and the prevalence of sarcopenia 16 years later

    Karlsson, Mikael / Becker, Wulf / Cederholm, Tommy E. / Byberg, Liisa

    British journal of nutrition. 20222021 Sept. 14 29, Sept. 14 29, v. 128, no. 5

    2022  

    Abstract: The role of diet in sarcopenia is unclear, and results from studies using dietary patterns (DP) are inconsistent. We assessed how adherences to a posteriori DP are associated with the prevalence of sarcopenia and its components 16 years later. Four DP ... ...

    Abstract The role of diet in sarcopenia is unclear, and results from studies using dietary patterns (DP) are inconsistent. We assessed how adherences to a posteriori DP are associated with the prevalence of sarcopenia and its components 16 years later. Four DP were defined in the Uppsala Longitudinal Study of Adult Men at baseline (n 1133, average age 71 years). Among 257 men with information at follow-up, 19 % (n 50) had sarcopenia according to the European Working Group on sarcopenia in Older People 2 definition. Adherence to DP2 (mainly characterised by high intake of vegetables, green salad, fruit, poultry, rice and pasta) was non-linearly associated with sarcopenia; adjusted OR and 95 % CI for medium and high v. low adherence: 0·41 (0·17, 0·98) and 0·40 (0·17, 0·94). The OR per standard deviation (sd) higher adherence to DP2 was 0·70 (0·48, 1·03). Adjusted OR (95 % CI) for 1 sd higher adherence to DP1 (mainly characterised by high consumption of milk and cereals), DP3 (mainly characterised by high consumption of bread, cheese, marmalade, jam and sugar) and DP4 (mainly characterised by high consumption of potatoes, meat and egg and low consumption of fermented milk) were 1·04 (0·74, 1·46), 1·19 (0·71, 2·00) and 1·08 (0·77, 1·53), respectively. There were no clear associations between adherence to the DP and muscle strength, muscle mass, physical performance or sarcopenia using EWGSOP1 (sarcopenia n 54). Our results indicate that diet may be a potentially modifiable risk factor for sarcopenia in old Swedish men.
    Keywords breads ; cheeses ; diet ; eggs ; fermented milk ; fruits ; longitudinal studies ; meat ; milk ; muscle strength ; muscle tissues ; pasta ; physical activity ; poultry ; rice ; risk factors ; salads ; sarcopenia ; standard deviation ; sugars
    Language English
    Dates of publication 2022-0914
    Size p. 909-920.
    Publishing place Cambridge University Press
    Document type Article
    ZDB-ID 280396-3
    ISSN 1475-2662 ; 0007-1145
    ISSN (online) 1475-2662
    ISSN 0007-1145
    DOI 10.1017/S0007114521003901
    Database NAL-Catalogue (AGRICOLA)

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  3. Article ; Online: A posteriori dietary patterns in 71-year-old Swedish men and the prevalence of sarcopenia 16 years later.

    Karlsson, Mikael / Becker, Wulf / Cederholm, Tommy E / Byberg, Liisa

    The British journal of nutrition

    2021  , Page(s) 1–12

    Abstract: The role of diet in sarcopenia is unclear, and results from studies using dietary patterns (DP) are inconsistent. We assessed how adherences to a posteriori DP are associated with the prevalence of sarcopenia and its components 16 years later. Four DP ... ...

    Abstract The role of diet in sarcopenia is unclear, and results from studies using dietary patterns (DP) are inconsistent. We assessed how adherences to a posteriori DP are associated with the prevalence of sarcopenia and its components 16 years later. Four DP were defined in the Uppsala Longitudinal Study of Adult Men at baseline (n 1133, average age 71 years). Among 257 men with information at follow-up, 19 % (n 50) had sarcopenia according to the European Working Group on sarcopenia in Older People 2 definition. Adherence to DP2 (mainly characterised by high intake of vegetables, green salad, fruit, poultry, rice and pasta) was non-linearly associated with sarcopenia; adjusted OR and 95 % CI for medium and high v. low adherence: 0·41 (0·17, 0·98) and 0·40 (0·17, 0·94). The OR per standard deviation (sd) higher adherence to DP2 was 0·70 (0·48, 1·03). Adjusted OR (95 % CI) for 1 sd higher adherence to DP1 (mainly characterised by high consumption of milk and cereals), DP3 (mainly characterised by high consumption of bread, cheese, marmalade, jam and sugar) and DP4 (mainly characterised by high consumption of potatoes, meat and egg and low consumption of fermented milk) were 1·04 (0·74, 1·46), 1·19 (0·71, 2·00) and 1·08 (0·77, 1·53), respectively. There were no clear associations between adherence to the DP and muscle strength, muscle mass, physical performance or sarcopenia using EWGSOP1 (sarcopenia n 54). Our results indicate that diet may be a potentially modifiable risk factor for sarcopenia in old Swedish men.
    Language English
    Publishing date 2021-09-29
    Publishing country England
    Document type Journal Article
    ZDB-ID 280396-3
    ISSN 1475-2662 ; 0007-1145
    ISSN (online) 1475-2662
    ISSN 0007-1145
    DOI 10.1017/S0007114521003901
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    In stock of ZB MED Cologne/Königswinter

    Ue I Zs.184: Show issues Location:
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  4. Article ; Online: Response and Adherence of Nursing Home Residents to a Nutrition/Exercise Intervention.

    Karlsson, Emelie S / Grönstedt, Helena K / Faxén-Irving, Gerd / Franzén, Erika / Luiking, Yvette C / Seiger, Åke / Vikström, Sofia / Wimo, Anders / Cederholm, Tommy E / Boström, Anne-Marie

    Journal of the American Medical Directors Association

    2021  Volume 22, Issue 9, Page(s) 1939–1945.e3

    Abstract: Objectives: Interindividual response variability to nutrition and exercise interventions is extensive in older adults. A group of nursing home (NH) residents participated in a combined intervention. The objective of this post-hoc analysis was to ... ...

    Abstract Objectives: Interindividual response variability to nutrition and exercise interventions is extensive in older adults. A group of nursing home (NH) residents participated in a combined intervention. The objective of this post-hoc analysis was to identify factors associated with intervention response measured by change in physical function and body composition.
    Design: Post-hoc analyses in the Older Person's Exercise and Nutrition study, a 2-arm randomized trial. The primary outcomes were 30-second Chair Stand Test and composite scores combining physical function and fat-free mass. A secondary outcome was intervention adherence. A 12-week intervention of sit-to-stand exercises and protein-rich nutritional supplements did not improve chair-stand capacity vs control on intention-to-treat basis.
    Setting and participants: Residents ≥75 years of age from dementia and somatic units in eight NHs in Sweden.
    Methods: Logistic regressions were performed to define factors associated with response (maintenance/improvement) or nonresponse (deterioration) in 30-second Chair Stand Test, and with intervention adherence. Linear regressions were performed to explore factors associated with response in composite scores.
    Results: Mean age of participants (n = 52 intervention, n = 49 control) was 85.8 years. Sarcopenia was occurring in 74%. Sarcopenia at baseline (P = .005) and high adherence to nutritional supplements (P = .002) increased the odds of response. Higher independence in daily activities increased the odds of adherence to sit-to-stand exercises (P = .027) and the combined intervention (P = .020). Allocation to the intervention group and higher self-perceived health were associated with higher composite scores.
    Conclusions and implications: NH residents with baseline sarcopenia, better self-perceived health, and high adherence to nutritional supplements benefitted most from a combined nutrition and exercise intervention regarding chair-stand capacity and composite scores of function and fat-free mass. Adherence was related to higher grade of independence. Understanding factors associated with response and adherence to an intervention will help target susceptible residents in most need of support and to optimize the outcome.
    MeSH term(s) Aged ; Aged, 80 and over ; Exercise ; Exercise Therapy ; Humans ; Nursing Homes ; Nutritional Status ; Sarcopenia/prevention & control
    Language English
    Publishing date 2021-05-04
    Publishing country United States
    Document type Journal Article ; Randomized Controlled Trial ; Research Support, Non-U.S. Gov't
    ZDB-ID 2171030-2
    ISSN 1538-9375 ; 1525-8610
    ISSN (online) 1538-9375
    ISSN 1525-8610
    DOI 10.1016/j.jamda.2021.04.001
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 5971: Show issues Location:
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  5. Article ; Online: Toward a definition of sarcopenia.

    Cederholm, Tommy E / Bauer, Juergen M / Boirie, Yves / Schneider, Stephane M / Sieber, Cornel C / Rolland, Yves

    Clinics in geriatric medicine

    2011  Volume 27, Issue 3, Page(s) 341–353

    Abstract: The definition of sarcopenia has been thoroughly discussed by scientific stakeholders and industry representatives to increase the clinical applicability of the concept. The pooled consensus from 3 of 5 recent and parallel processes, of which 2 are ... ...

    Abstract The definition of sarcopenia has been thoroughly discussed by scientific stakeholders and industry representatives to increase the clinical applicability of the concept. The pooled consensus from 3 of 5 recent and parallel processes, of which 2 are pending, is that sarcopenia is mainly, but not only, an age-related condition defined by the combined presence of reduced muscle mass and muscle function. Contributing factors to sarcopenia are senescence, chronic disease, physical inactivity, and poor food intake. Cachexia may be considered as one etiologic pathway of an accelerated sarcopenia. The adjusted and extended definitions of sarcopenia promote the clinical use of the concept.
    MeSH term(s) Aged, 80 and over ; Aging ; Body Composition ; Frail Elderly ; Humans ; International Cooperation ; Muscle Strength ; Muscle, Skeletal ; Sarcopenia/etiology ; Terminology as Topic
    Language English
    Publishing date 2011-08
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1064151-8
    ISSN 1879-8853 ; 0749-0690
    ISSN (online) 1879-8853
    ISSN 0749-0690
    DOI 10.1016/j.cger.2011.04.001
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    Se 987: Show issues Location:
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  6. Article: Nutritional status using mini nutritional assessment and subjective global assessment predict mortality in geriatric patients.

    Persson, Margareta D / Brismar, Kerstin E / Katzarski, Krassimir S / Nordenström, Jörgen / Cederholm, Tommy E

    Journal of the American Geriatrics Society

    2002  Volume 50, Issue 12, Page(s) 1996–2002

    Abstract: Objectives: To evaluate the clinical assessment of nutritional status and mortality in geriatric patients.: Design: Prospective follow-up study.: Setting: Acute geriatric inpatient ward.: Participants: Eighty-three consecutive acute geriatric ... ...

    Abstract Objectives: To evaluate the clinical assessment of nutritional status and mortality in geriatric patients.
    Design: Prospective follow-up study.
    Setting: Acute geriatric inpatient ward.
    Participants: Eighty-three consecutive acute geriatric patients (mean age +/- standard deviation = 83 +/- 7; 68% women).
    Measurements: Patients were classified as (1) having protein-energy malnutrition (PEM), (2) having moderate PEM or being at risk for PEM, or (3) being well nourished according to Subjective Global Assessment (SGA) and Mini Nutritional Assessment (MNA). Body mass index ((BMI) kg/m2), arm anthropometry, and handgrip strength were determined. In a subgroup of patients (n = 39), body composition was analyzed using dual energy x-ray absorption and bioelectrical impedance. Three-year mortality data were obtained from the Swedish population records.
    Results: Twenty percent and 26% of the patients were classified as having PEM based on SGA and MNA, respectively, whereas 43% and 56%, respectively, were classified as having moderate PEM or being at risk for PEM. Objective measures, such as BMI, arm anthropometry, handgrip, and body fat were 20% to 50% lower in the malnourished group than in the well-nourished subjects (P <.05). Moreover, mortality was higher in those classified as being malnourished, ranging from 40% after 1 year to 80% after 3 years, compared with 20% after 1 year (P =.03-0.17) and 50% after 3 years (P <.01) in patients classified as being well nourished.
    Conclusion: Fewer than one-third of newly admitted geriatric patients had a normal nutritional status according to SGA and MNA. BMI, arm anthropometry, body fat mass, and handgrip strength were reduced, and 1-, 2-, and 3-year mortality was higher in patients classified as malnourished. The present data justify the use of SGA and MNA for the assessment of nutritional status in geriatric patients.
    MeSH term(s) Aged/physiology ; Aged, 80 and over ; Anthropometry ; Body Composition ; Body Mass Index ; Female ; Follow-Up Studies ; Growth Substances/blood ; Humans ; Intercellular Signaling Peptides and Proteins/blood ; Male ; Mortality ; Nutritional Status ; Prospective Studies ; Protein-Energy Malnutrition/diagnosis
    Chemical Substances Growth Substances ; Intercellular Signaling Peptides and Proteins ; myotrophin
    Language English
    Publishing date 2002-12
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 80363-7
    ISSN 1532-5415 ; 0002-8614
    ISSN (online) 1532-5415
    ISSN 0002-8614
    DOI 10.1046/j.1532-5415.2002.50611.x
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