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  1. Article: The Relationship Between Cancer Patients' Supportive Care Needs and Their Attitudes Toward Complementary and Alternative Medicine.

    Çelik, H / Aslan, H

    Nigerian journal of clinical practice

    2024  Volume 27, Issue 4, Page(s) 415–423

    Abstract: Background: Cancer patients have high supportive care needs related to the nature of the disease and treatment methods. To meet these needs or reduce symptoms, patients can be expected to resort to alternative treatment methods.: Aim: To examine the ... ...

    Abstract Background: Cancer patients have high supportive care needs related to the nature of the disease and treatment methods. To meet these needs or reduce symptoms, patients can be expected to resort to alternative treatment methods.
    Aim: To examine the relationship between the supportive care needs of cancer patients and their attitudes toward complementary and alternative medicine (CAM).
    Methods: This was a cross-sectional study involving 289 cancer patients at the Oncology Hospital in east of Turkey. Short-Form Supportive Care Needs Survey Questionnaire (SCNS-SF 29) and Holistic Complementary and Alternative Medicine Questionnaire (HCAMQ) were standard instruments used for data collection. The association between supportive care needs and attitude toward CAM was determined.
    Results: The mean age of the study participants was 56.7 ± 12.7 years. There were 180 females (62.3%) and 109 males (37.7%). The mean score of the SCNS-SF 29 of the study participant was 101.19 ± 33.97. It was found that the patients' psychological needs were the highest, followed by health services and information, daily life, and sexuality needs, respectively. The mean score of the HCAMQ was 27.16 ± 9.54. There was a weak, significant negative correlation between HCAM and psychological supportive care needs (r: -0.240, P: 0.003). However, there was no significant relationship between needs related to health services information, daily life sexuality, and attitudes toward CAM.
    Conclusions: Cancer patients have high supportive care requirements. Those with high psychological needs have a positive attitude toward HCAM. Incorporation of HCAM in the care of cancer patients may improve their quality of care.
    MeSH term(s) Humans ; Female ; Male ; Middle Aged ; Complementary Therapies/statistics & numerical data ; Complementary Therapies/psychology ; Neoplasms/therapy ; Neoplasms/psychology ; Cross-Sectional Studies ; Turkey ; Surveys and Questionnaires ; Aged ; Adult ; Social Support ; Health Services Needs and Demand ; Needs Assessment
    Language English
    Publishing date 2024-04-29
    Publishing country India
    Document type Journal Article
    ZDB-ID 1458330-6
    ISSN 1119-3077
    ISSN 1119-3077
    DOI 10.4103/njcp.njcp_377_22
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    Zs.A 4975: Show issues Location:
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  2. Book ; Audio / Video ; Thesis: Klinisch-retrospektive Studie über die Komplikationen bei Totalprothesen

    Celik, Hidir

    2011  

    Author's details vorgelegt von: Hidir Celik
    Language German
    Size 1 CD-ROM, 12 cm
    Publishing country Germany
    Document type Book ; Audio / Video ; Thesis
    Thesis / German Habilitation thesis Witten, Herdecke, Univ., Diss., 2011
    HBZ-ID HT017080234
    Database Catalogue ZB MED Medicine, Health

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    2011 MO 755 order for loan Magazin

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  3. Article ; Online: Comparing the effects of akimbo and bent-in-front arm positions on jump metrics: Validity and reliability of a modified 10/5 repeated jump test.

    Celik, Huseyin / Bulut, Suleyman

    Journal of biomechanics

    2024  Volume 163, Page(s) 111945

    Abstract: The purpose of this study was to compare the effects of two arm positions, akimbo and the newly introduced bent-in-front, on jump metrics in the ten-to-five repeated jump test (10/5 RJT) and to evaluate the reliability and validity of new modified bent- ... ...

    Abstract The purpose of this study was to compare the effects of two arm positions, akimbo and the newly introduced bent-in-front, on jump metrics in the ten-to-five repeated jump test (10/5 RJT) and to evaluate the reliability and validity of new modified bent-in-front variation. In contrast to akimbo, bent-in-front arm variation allows participants to use their arms freely by holding them with free hands, with parallel arms bent in front of chest and elbows pointing downward without swinging. This new arm position was designed to alleviate postural control difficulties and ensure smooth movement during repeated jumps on the force plate. However, the 10/5 RJT was designed to measure lower-body stretch-shortening cycle (SSC) performance, and it is unknown whether the bent-in-front arm variation would affect jump performance, such as arm swing. If the arms can be freed without interfering with jump performance, it would be possible to determine lower-body SSC performance without the contribution of the arms and have the advantage of postural control assistance. Fifty-five healthy sports science students who regularly participated in intercollegiate or recreational sports performed 10/5 RJT with arms akimbo and bent-in-front during two sessions. Four jump metrics, including the reactive strength index, and four reliability and validity statistics, including intraclass-correlation-coefficients, were estimated. The results indicated no significant differences in the jump metrics between two arm variations. Bent-in-front arm variation can be deemed as a valid and reliable test. Therefore, the newly introduced 10/5 RJT with arms bent-in-front can be used to evaluate SSC performance in this cohort.
    MeSH term(s) Humans ; Reproducibility of Results ; Sports ; Movement ; Students
    Language English
    Publishing date 2024-01-11
    Publishing country United States
    Document type Journal Article
    ZDB-ID 218076-5
    ISSN 1873-2380 ; 0021-9290
    ISSN (online) 1873-2380
    ISSN 0021-9290
    DOI 10.1016/j.jbiomech.2024.111945
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  4. Article ; Online: Enhanced Molecular Response in Myeloproliferative Neoplasms with Complete JAK2V617F Inhibition.

    Celik, Hamza / Challen, Grant A

    Cancer discovery

    2024  Volume 14, Issue 5, Page(s) 701–703

    Abstract: Summary: Dunbar, Bowman, and colleagues present here a novel genetic mouse model with inducible and reversible expression of the JAK2V617F mutation in the endogenous locus. Results from this study clearly demonstrate an absolute requirement for ... ...

    Abstract Summary: Dunbar, Bowman, and colleagues present here a novel genetic mouse model with inducible and reversible expression of the JAK2V617F mutation in the endogenous locus. Results from this study clearly demonstrate an absolute requirement for myeloproliferative neoplasm-initiating cells for this mutation in their survival and imply that more efficacious inhibitors could be curative for these patients even in the setting of additional cooperating mutations. See related article by Dunbar et al., p. 737 (8).
    MeSH term(s) Janus Kinase 2/genetics ; Janus Kinase 2/antagonists & inhibitors ; Animals ; Mice ; Myeloproliferative Disorders/genetics ; Myeloproliferative Disorders/drug therapy ; Humans ; Mutation ; Disease Models, Animal ; Protein Kinase Inhibitors/therapeutic use ; Protein Kinase Inhibitors/pharmacology
    Chemical Substances Janus Kinase 2 (EC 2.7.10.2) ; Protein Kinase Inhibitors
    Language English
    Publishing date 2024-03-19
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2625242-9
    ISSN 2159-8290 ; 2159-8274
    ISSN (online) 2159-8290
    ISSN 2159-8274
    DOI 10.1158/2159-8290.CD-23-1522
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  5. Article ; Online: The Importance of Lumbar Lordosis during Laparoscopic Trocar Entry.

    Bektaş, Onur / Çelik, Hüsnü

    Journal of minimally invasive gynecology

    2024  

    Abstract: Study objective: Investigating the effect of lumbar lordosis on the relationship between abdominal trocar entry points and major vascular structures.: Design: Retrospective cohort.: Setting: Tertiary referral center.: Patients: Distances ... ...

    Abstract Study objective: Investigating the effect of lumbar lordosis on the relationship between abdominal trocar entry points and major vascular structures.
    Design: Retrospective cohort.
    Setting: Tertiary referral center.
    Patients: Distances between the skin and the aorta and inferior vena cava at the trocar entry points, both at the umbilicus and 3 cm and 5 cm superior to the umbilicus, were measured at entry angles of 90 and 45 degrees in 101 abdominal computer tomography images.
    Interventions: The relationship of these values with lumbar lordosis was investigated concerning menopausal status, body mass index (BMI), and parity differences. To assess the isolated effect of lumbar lordosis, a simulated 30-degree increase in the lordosis angle was applied to the patients' computed tomography images. The impact of this increased lumbar lordosis angle on the distances between the skin and major vessels was then evaluated at both the umbilical and supraumbilical trocar entry sites.
    Measurements and main results: In the tomographic images of all patients, the distances from the skin to vascular structures were measured at a 90-degree entry angle, resulting in measurements of 8.97 cm ± 2.81 at the umbilicus, 10.89 cm ± 3.02 at 3 cm above the umbilicus, and 11.36 cm ± 2.88 at 5 cm above the umbilicus. These distances exhibited significant differences between patients with BMI <30 and BMI ≥30, as well as between premenopausal and postmenopausal patients. However, at a 45-degree entry angle, vascular structures were observed in only a few patients during trocar projection, and no measurable values were determined. In the simulation, it was found that a 1-degree increase in lumbar lordosis angle resulted in a decrease of 0.272 mm ± 0.018 in the distance between the skin and vascular structures at the umbilicus, 0.425 mm ± 0.024 at 3 cm above the umbilicus, and 0.428 mm ± 0.024 at 5 cm above the umbilicus.
    Conclusion: An increase in the degree of lumbar lordosis reduces the distance between trocar entry points and major vascular structures. Along with other factors during Veress and trocar entry, lumbar lordosis should be carefully considered.
    Language English
    Publishing date 2024-03-23
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2186934-0
    ISSN 1553-4669 ; 1553-4650
    ISSN (online) 1553-4669
    ISSN 1553-4650
    DOI 10.1016/j.jmig.2024.03.012
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  6. Article: Malar rash and hand tremor in early symptoms of cerebrotendinous xanthomatosis and the effect of chenodeoxycholic acid on them.

    Yılmaz, Banu Kadıoğlu / Çelik, Halil

    Journal of clinical lipidology

    2024  

    Abstract: Background: Cerebrotendinous xanthomatosis (CTX, OMIM #213700) is a rare but treatable lipid storage disease resulting from mutations in the CYP27A1 gene.: Purpose: The study aims to evaluate patients diagnosed with CTX and reveal new information, ... ...

    Abstract Background: Cerebrotendinous xanthomatosis (CTX, OMIM #213700) is a rare but treatable lipid storage disease resulting from mutations in the CYP27A1 gene.
    Purpose: The study aims to evaluate patients diagnosed with CTX and reveal new information, especially about the signs of CTX and patients' response to the treatment.
    Methods: The study was conducted retrospectively in 12 definitively diagnosed CTX patients. The patients' clinical, laboratory, imaging, genetic findings, and CDCA (chenodeoxycholic acid) treatment results were analyzed.
    Results: The median age at diagnosis for the patients was 16.5 years (minimum-maximum: 7-32). Juvenile cataracts, detected in more than 90% (11/12) of the patients, were the most common clinical finding. Malar rash, not previously reported in the literature for CTX, was present in 75% (9/12) of the patients. Hand tremors, the first neurological symptom, occurred in adolescence and were the initial symptom of the disease in five patients. Hand tremors were present in 83.3% (10/12) of the patients. Hand tremors (in 5 patients) and malar rash (in 2 patients) were clinical findings with full recovery due to the CDCA treatment.
    Conclusion: The study defines the malar rash finding, which has not been reported in the literature before, as a possible new clinical finding in CTX disease, attributed to its partial or full recovery with CDCA treatment. Additionally, as a novelty in the literature, our study highlights the full recovery of neurological findings, such as hand tremors, in CTX. Patients presenting with hand tremors and malar rash, especially in adolescence, should undergo CTX investigation for early diagnosis and treatment.
    Language English
    Publishing date 2024-02-28
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2365061-8
    ISSN 1876-4789 ; 1933-2874
    ISSN (online) 1876-4789
    ISSN 1933-2874
    DOI 10.1016/j.jacl.2024.02.009
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  7. Article ; Online: Evaluation of Sleep Habits and Their Relationship With Quality of Life in Children With Epilepsy.

    Özdemir, Fatih Mehmet Akif / Çelik, Halil

    Pediatric neurology

    2024  Volume 155, Page(s) 114–119

    Abstract: Background: The aim of this study was to investigate sleep habits, quality of life (QoL), and the relationship between them in children with epilepsy.: Methods: In this cross-sectional study, children aged two to 18 years being followed up for ... ...

    Abstract Background: The aim of this study was to investigate sleep habits, quality of life (QoL), and the relationship between them in children with epilepsy.
    Methods: In this cross-sectional study, children aged two to 18 years being followed up for epilepsy were assessed using the Children's Sleep Habits Questionnaire (CSHQ) and the Pediatric Quality of Life Inventory (PedsQL). Pearson or Spearman correlation analysis was performed to examine the relationship between normally distributed and non-normally distributed variables, respectively. Linear regression analysis was used to examine independent variables associated with PedsQL total scale score. Level of significance was accepted as P < 0.05.
    Results: The study included 112 children with a mean age of 10.5 ± 4.4 years (51.8% female). The frequency of poor sleep habits was 96.4%. There was a good level of agreement between children's and parents' PedsQL total, physical health, and psychosocial health scores (P < 0.001). Correlation analysis between QoL and sleep parameters revealed negative correlations between total sleep score and self-assessed PedsQL total scale, physical health, and psychosocial health scores (P < 0.05) and parent-assessed PedsQL total scale and psychosocial health scores (P < 0.05). The results of linear regression analysis indicated that the factors most significantly associated with lower QoL were high CSHQ total sleep score and exclusively daytime seizures (P < 0.001).
    Conclusions: It was found that children with epilepsy had poor sleep habits and low QoL and that poor sleep habits have a negative impact on QoL.
    MeSH term(s) Humans ; Quality of Life ; Female ; Male ; Child ; Cross-Sectional Studies ; Epilepsy/physiopathology ; Adolescent ; Child, Preschool ; Sleep Wake Disorders/etiology ; Sleep Wake Disorders/physiopathology ; Sleep/physiology ; Surveys and Questionnaires ; Habits
    Language English
    Publishing date 2024-03-06
    Publishing country United States
    Document type Journal Article
    ZDB-ID 639164-3
    ISSN 1873-5150 ; 0887-8994
    ISSN (online) 1873-5150
    ISSN 0887-8994
    DOI 10.1016/j.pediatrneurol.2024.03.002
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    Zs.A 2260: Show issues Location:
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  8. Article: Evaluation of stress distribution on an endodontically treated maxillary central tooth with lesion restored with different crown materials: A finite element analysis.

    Kirmali, Ömer / Icen, Gülsah / Kursat Celik, H / Rennie, Allan E W

    Heliyon

    2024  Volume 10, Issue 3, Page(s) e25829

    Abstract: Objectives: The biomechanical response of teeth with periapical lesions that have been restored using various substructure materials, as well as the stress mapping in the alveolar bone, has not been thoroughly described. In this context, the objective ... ...

    Abstract Objectives: The biomechanical response of teeth with periapical lesions that have been restored using various substructure materials, as well as the stress mapping in the alveolar bone, has not been thoroughly described. In this context, the objective of this study is to investigate the structural stress distributions on root canal-treated maxillary right central incisors with lesions restored using different crown materials under linear static loading conditions through finite element analysis (FEA).
    Methods: In the study, five FEA models were utilised to represent healthy teeth and teeth restored with different substructure materials: (A) a healthy tooth, (B) a lesioned, root canal-treated, composite-filled tooth, (C) a lesioned, fiber-posted, zirconia-based crown, (D) a tooth with lesions, a fiber post, and Ni-Cr infrastructure crown, (E) a tooth with a lesion, a fiber post, and an IPS E-max infrastructure crown. A force of 100 N was applied at an angle of 45° to the long axis of the tooth from 2 mm cervical to the incisal line on the palatal surface. Deformation behaviour and maximum equivalent stress distributions on the tooth sub-components, including the bony structure for each model, were simulated.
    Results: Differences were observed in the stress distributions of the models. The maximum stress values of the models representing the restorations with different infrastructures varied, and the highest value was obtained in the model of the E-max crown (Model E: 136.050 MPa). The minimum stress magnitudes were obtained from Model B the composite-filled tooth (80.39 MPa); however, it was observed that the equivalent stresses in all the models showed a similar distribution for all components with varying magnitudes. In periapical lesion areas, low stresses were observed. In all models, the cervicobuccal collar region of the teeth had dense equivalent stresses.
    Conclusion: Different restorative treatment methods applied to root canal-treated teeth with periapical lesions can impact the stress in the alveolar bone and the biomechanical response of the tooth. Relatively high stress values in the cortical bone at the cervical line of the tooth have been observed to decrease towards the apical region. This observation may suggest a potential healing effect by reducing pressure in the periapical lesion area.
    Clinical significance: Composite resin restorations can be considered the first-choice treatment option for the restoration of root canal-treated teeth with lesions. In crown restorations, it would be advantageous to prefer zirconia or metal-supported prostheses in terms of biomechanics.
    Language English
    Publishing date 2024-02-05
    Publishing country England
    Document type Journal Article
    ZDB-ID 2835763-2
    ISSN 2405-8440
    ISSN 2405-8440
    DOI 10.1016/j.heliyon.2024.e25829
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  9. Article ; Online: Nitrosative stress-based specific evaluation of creatine use in combination with aerobic running exercise at different speeds: a preclinical study in mice.

    Taskin, A / Celik, H / Taskin, S

    European review for medical and pharmacological sciences

    2023  Volume 27, Issue 14, Page(s) 6709–6717

    Abstract: Objective: In acute and chronic aerobic exercise, skeletal muscle and liver are the main organs that adapt and regulate metabolic activity. The levels of nitrosative stress caused by exercise in these organs are extremely important in the continuity of ... ...

    Abstract Objective: In acute and chronic aerobic exercise, skeletal muscle and liver are the main organs that adapt and regulate metabolic activity. The levels of nitrosative stress caused by exercise in these organs are extremely important in the continuity of exercise, its health-promoting benefits, and the evaluation of therapeutic efficacy. In this study, nitrosative stress levels were investigated in musculus quadriceps femoris tissue and liver tissue of mice that were given low and high-speed aerobic running exercise and also received Cr supplementation.
    Materials and methods: In this study, nitrosative stress levels were investigated in the muscle/liver tissue of 42 BALB/c mice that were given low and high-speed aerobic running exercise and creatine monohydrate (Cr) (40 mg/kg of diet daily) supplementation with exercise. The study included six groups with and without Cr supplementation, low-speed aerobic running, high-speed aerobic running, and no exercise. The mice in groups with low-speed and high-speed aerobic exercise with and without Cr supplementation were run on the treadmill for 8 weeks. Then, nitric oxide (NO·), nitric oxide synthase (NOS), and peroxynitrite (ONOO-) levels in muscle/liver tissue were measured by spectrophotometric method.
    Results: It was found that the nitrosative stress level in the groups that did low and high-speed aerobic running exercises increased compared to the group that did not exercise. It was found that NO· decreased NOS activity and ONOO- level increased in muscle tissues of low and high-speed aerobic exercise groups that received Cr supplementation compared to those that did not. However, NO· and ONOO- levels in liver tissue decreased while NOS activity did not change. The lowest level of nitrosative stress in both muscle and liver tissue was found in the low-speed exercise group receiving Cr supplementation.
    Conclusions: Although supplements in exercise are an important component, the simultaneously measured nitrosative stress level is critical in determining the optimal exercise.
    MeSH term(s) Mice ; Animals ; Creatine ; Nitrosative Stress ; Running/physiology ; Dietary Supplements ; Muscle, Skeletal/physiology
    Chemical Substances Creatine (MU72812GK0)
    Language English
    Publishing date 2023-08-21
    Publishing country Italy
    Document type Journal Article
    ZDB-ID 605550-3
    ISSN 2284-0729 ; 1128-3602 ; 0392-291X
    ISSN (online) 2284-0729
    ISSN 1128-3602 ; 0392-291X
    DOI 10.26355/eurrev_202307_33141
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  10. Article ; Online: DNA damage and changes in oxidized biomolecules in COVID-19 patients treated in intensive care units: a single center experience.

    Duran, E / Taşkın, S / Pehlivan, B / Çelik, H

    European review for medical and pharmacological sciences

    2023  Volume 27, Issue 13, Page(s) 6414–6421

    Abstract: Objective: COVID-19 is a deadly disease. Investigations are being conducted on the underlying mechanisms to predict prognosis and reduce mortality rates. In this study, the extent of DNA damage and serum levels of oxidized biomolecules were investigated. ...

    Abstract Objective: COVID-19 is a deadly disease. Investigations are being conducted on the underlying mechanisms to predict prognosis and reduce mortality rates. In this study, the extent of DNA damage and serum levels of oxidized biomolecules were investigated. We hypothesize that malondialdehyde (MDA) and protein carbonyl (PC) serum levels and DNA damage levels may be biomarkers that can be used in prognostic decision making and prediction of mortality in COVID-19 patients.
    Patients and methods: Patients included in the study were divided into two groups according to their survival. These groups were compared in terms of serum MDA, PC levels, DNA damage degrees and mortality on the 1st, 3rd, and 5th days of ICU admission.
    Results: In patients who died, MDA levels increased over time (p=0.023), PC levels peaked on the third day of admission to the intensive care units (ICU), and then decreased, while DNA damage increased gradually (p=0.013). In surviving patients, MDA levels decreased over time (p=0.018); PC levels were at their peak on the first day of admission to the ICU and then decreased (p=0.018); DNA damage decreased initially, and then increased minimally compared to Day 1.
    Conclusions: For COVID-19 ICU patients, serum levels of MDA and PC and degrees of DNA damage can strengthen prognostic decision-making and contribute to reducing mortality.
    MeSH term(s) Humans ; COVID-19 ; Biomarkers ; Prognosis ; Intensive Care Units ; Critical Care
    Chemical Substances Biomarkers
    Language English
    Publishing date 2023-07-17
    Publishing country Italy
    Document type Journal Article
    ZDB-ID 605550-3
    ISSN 2284-0729 ; 1128-3602 ; 0392-291X
    ISSN (online) 2284-0729
    ISSN 1128-3602 ; 0392-291X
    DOI 10.26355/eurrev_202307_33001
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