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  1. Article: Information Diana Celio. Rückblick SGC Kongress 2018. Wo liegt das gesunde Mass?

    Celio, Diana

    Swiss knife

    2018  Volume -, Issue 3, Page(s) 4

    Language German ; French ; English
    Document type Article
    ZDB-ID 2270030-4
    ISSN 1661-1381
    Database Current Contents Medicine

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    Zs.A 6429: Show issues Location:
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  2. Article: Metronidazole and Peripheral Neuropathy: A Report of Two Cases of (Unusual) Side Effects.

    Gussago, Stefano / Poroli Bastone, Cristiana / Celio, Diana / Arigoni, Michele / Quarenghi, Massimo C

    Cureus

    2022  Volume 14, Issue 10, Page(s) e30889

    Abstract: Metronidazole is an antibiotic commonly prescribed for anaerobic and protozoan infections. Despite its good safety profile, this drug frequently causes a series of well-known side effects (nausea and intestinal transit disorders, dysgeusia, headaches, ... ...

    Abstract Metronidazole is an antibiotic commonly prescribed for anaerobic and protozoan infections. Despite its good safety profile, this drug frequently causes a series of well-known side effects (nausea and intestinal transit disorders, dysgeusia, headaches, and alcohol intolerance). However, there are few data in the literature, mainly case reports and case series, about the onset of peripheral neuropathy with a generally self-limiting course after drug withdrawal. Thus, we herein describe two cases of peripheral neuropathy due to treatment with metronidazole. A 69-year-old woman treated with a total of 55 g of metronidazole for diverticular disease and a 52-year-old male patient on a long course of antibiotic therapy for hepatic abscesses (a cumulative dose of 168 g) developed peripheral neuropathy. The suspicion of metronidazole side effects was raised after the exclusion of other causes. After the suspension of the drug, different degrees of improvement were observed. Metronidazole is an effective antibiotic for treating infections caused by anaerobic or protozoan pathogens, and it has a good pharmacological and economic safety profile. However, in the existing literature, prolonged therapy regimens (>4 weeks of treatment and/or 42 g cumulative dose) may increase the risk of developing neurological complications, in particular peripheral polyneuropathy.
    Language English
    Publishing date 2022-10-31
    Publishing country United States
    Document type Case Reports
    ZDB-ID 2747273-5
    ISSN 2168-8184
    ISSN 2168-8184
    DOI 10.7759/cureus.30889
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Bowel function recovery after laparoscopic transverse colectomy within an ERAS program: a comparison to right and left colectomy.

    Roesel, Raffaello / Mongelli, Francesco / Ajani, Costanza / Iaquinandi, Fabiano / Celio, Diana / Christoforidis, Dimitri

    Langenbeck's archives of surgery

    2021  Volume 406, Issue 5, Page(s) 1563–1570

    Abstract: Background: It is known that functional recovery of the bowel is slower after right colectomy (RC) compared to left colectomy (LC), but very little has been reported on transverse colectomy (TC).: Objectives: The aim of this study was to compare the ... ...

    Abstract Background: It is known that functional recovery of the bowel is slower after right colectomy (RC) compared to left colectomy (LC), but very little has been reported on transverse colectomy (TC).
    Objectives: The aim of this study was to compare the clinical and early functional outcomes of TC, a more infrequent operation, to RC, and LC for colorectal cancer.
    Methods: Between December 2011 and December 2017, all patients undergoing elective colon resection in our institution were treated according to a standardized ERAS protocol and entered in a prospective database. We included in the study patients undergoing laparoscopic TC, RC, or LC for cancer with curative intent. The primary endpoint was prolonged postoperative ileus (PPOI), defined as need to insert a nasogastric tube, or refractory nausea VAS > 4 on or after the third postoperative day. Secondary endpoints were postoperative morbidity and length of hospital stay (LoS).
    Results: Out of 286 patients, 126 met the inclusion criteria: 20 underwent TC, 65 RC, and 41 LC. Patients in LC group were younger than in TC and RC groups; other baseline demographics were similar. PPOI was observed in 5 (25%), 26 (40%), and 10 (24%) patients in TC, RC, and LC groups, respectively (p = 0.417). In single group comparisons, the incidence of PPOI in the TC group was significantly lower in comparison to the RC group (OR for RC: 4.255, 95% CI 1.092-16.667, p = 0.037) and similar to the LC group. No significant differences in terms of postoperative complications or LoS stay were observed.
    Conclusion: The incidence of PPOI after segmental laparoscopic colectomy for cancer within an ERAS program appears as infrequent in TC as in LC and lower than after RC. It may be reasonable to consider a slower oral intake after RC, as it represents an independent predictor of PPOI.
    MeSH term(s) Colectomy ; Elective Surgical Procedures ; Humans ; Ileus/epidemiology ; Ileus/etiology ; Laparoscopy ; Length of Stay ; Postoperative Complications/epidemiology ; Recovery of Function
    Language English
    Publishing date 2021-01-17
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 1423681-3
    ISSN 1435-2451 ; 1435-2443
    ISSN (online) 1435-2451
    ISSN 1435-2443
    DOI 10.1007/s00423-021-02082-3
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Uk I Zs.10: Show issues Location:
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  4. Article ; Online: ERAS, length of stay and private insurance: a retrospective study.

    Celio, Diana A / Poggi, Roberto / Schmalzbauer, Mike / Rosso, Raffaele / Majno, Pietro / Christoforidis, Dimitri

    International journal of colorectal disease

    2019  Volume 34, Issue 11, Page(s) 1865–1870

    Abstract: Purpose: Hospital discharge after colorectal resection within an Enhanced Recovery After Surgery (ERAS) program occurs earlier compared to standard-care postoperative pathways but often later than what objective criteria of "readiness for discharge" ... ...

    Abstract Purpose: Hospital discharge after colorectal resection within an Enhanced Recovery After Surgery (ERAS) program occurs earlier compared to standard-care postoperative pathways but often later than what objective criteria of "readiness for discharge" could allow. The aim of this study was to analyse reasons and risk factors of such discharge delay.
    Methods: All elective patients admitted for colorectal resection at the regional Hospital of Lugano in 2014 and 2015 were included. The postoperative day on which patients fulfilled consensus agreed criteria (according to Fiore) for readiness for discharge (POD-F) and the effective day of discharge (POD-D) were determined. We analysed the reasons for discharge delay (POD-D>POD-F) and performed univariate and multivariate analysis to determine risk factors.
    Results: One hundred thirty-eight patients were included in the study. Median POD-F was 5 (2-48) days, POD-D was 6 (3-50) days. In 94 patients, POD-D occurred later than POD-F with a median delay of 1 (1-11) days. Reasons for discharge delay were insufficient social support in 13 (14%), patient's preference in 39 (41%) and medical team preference in 41 (44%). Private insurance (OR 2.61, 95%CI 1.08-6.34, p = 0.034) and patient discharged on a day other than Monday (OR 2.94, 95%CI 1.16-7.14, p = 0.023) were independent predictors for discharge delay.
    Conclusion: Even when objective criteria for readiness for discharge have been fulfilled, patients and/or doctors often do not feel comfortable with hospital discharge at this time point. Length of stay, even within an ERAS program, is still influenced by several non-medical factors and is therefore not a precise surrogate marker of outcomes.
    MeSH term(s) Adult ; Aged ; Aged, 80 and over ; Enhanced Recovery After Surgery ; Factor Analysis, Statistical ; Female ; Humans ; Insurance ; Length of Stay ; Male ; Middle Aged ; Patient Discharge ; Retrospective Studies ; Risk Factors ; Young Adult
    Language English
    Publishing date 2019-10-08
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 84975-3
    ISSN 1432-1262 ; 0179-1958
    ISSN (online) 1432-1262
    ISSN 0179-1958
    DOI 10.1007/s00384-019-03391-2
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 2121: Show issues Location:
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  5. Article ; Online: Combined surgical approach for retrorectal tumours with intra-operative CT guidance: sacral chordoma - a video vignette.

    Popeskou, Sotirios Georgios / Cristaudi, Alessandra / Garofalo, Fabio / Celio, Diana / Mongeli, Francesco / Scarone, Pietro / Majno-Hurst, Pietro / Christoforidis, Dimitri

    Colorectal disease : the official journal of the Association of Coloproctology of Great Britain and Ireland

    2020  Volume 23, Issue 3, Page(s) 759–760

    MeSH term(s) Chordoma/diagnostic imaging ; Chordoma/surgery ; Humans ; Sacrum/diagnostic imaging ; Sacrum/surgery ; Spinal Neoplasms/diagnostic imaging ; Spinal Neoplasms/surgery ; Tomography, X-Ray Computed
    Language English
    Publishing date 2020-12-18
    Publishing country England
    Document type Letter ; Video-Audio Media
    ZDB-ID 1440017-0
    ISSN 1463-1318 ; 1462-8910
    ISSN (online) 1463-1318
    ISSN 1462-8910
    DOI 10.1111/codi.15476
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 5799: Show issues Location:
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  6. Article ; Online: Handling of informed consent and patient inclusion in research with geriatric trauma patients - a matter of protection or disrespect?

    Jensen, Jana S / Reiter-Theil, Stella / Celio, Diana A / Jakob, Marcel / Vach, Werner / Saxer, Franziska J

    Clinical interventions in aging

    2019  Volume 14, Page(s) 321–334

    Abstract: Background: Despite the aging of numerous societies and future health care challenges, clinical research in the elderly is underrepresented. The aim of this review was to analyze the current practice exemplary in gerontotraumatology and to discuss ... ...

    Abstract Background: Despite the aging of numerous societies and future health care challenges, clinical research in the elderly is underrepresented. The aim of this review was to analyze the current practice exemplary in gerontotraumatology and to discuss potential improvements.
    Materials and methods: A literature review was performed in 2016 based on a PubMed search for gerontotraumatologic studies published between 2005 and 2015. Trials were evaluated for methodology and ethical and age-related aspects.
    Results: The search revealed 649 articles, 183 of which met the inclusion criteria. The age range for inclusion was heterogeneous; one-third of trials included patients <65 years and only 11% excluded very elderly. Seventy-four trials excluded patients with typical comorbidities, with 55% of these without stating scientific reasons. Frailty was assessed in 94 trials and defined as the exclusion criterion in 66 of them. Informed consent (IC) was reportedly obtained in 144 trials; descriptions of the IC process mostly remained vague. Substitute decision making was described in 19 trials; the consenting party remained unclear in 45 articles. Diagnosed dementia was a primary exclusion criterion in 31% of the trials. Seventeen trials assessed decisional capacity before inclusion, with six using specific assessments.
    Conclusion: Many trials in gerontotraumatology exclude relevant subgroups of patients, and thus risk presenting biased estimates of the relevant treatment effects. Exclusion based on age, cognitive impairment, or other exhaustive exclusion criteria impedes specific scientific progress in the treatment of elderly patients. Meaningful trials could profit from a staged, transparent approach that fosters shared decision making. Rethinking current policies is indispensable to improve treatment and care of elderly trauma patients and to protect study participants and researchers alike.
    MeSH term(s) Aged ; Aged, 80 and over ; Clinical Trials as Topic/methods ; Humans ; Informed Consent ; Mental Competency ; Middle Aged ; Patient Selection ; Proxy ; Wounds and Injuries/therapy
    Language English
    Publishing date 2019-02-13
    Publishing country New Zealand
    Document type Journal Article ; Review
    ZDB-ID 2364924-0
    ISSN 1178-1998 ; 1176-9092
    ISSN (online) 1178-1998
    ISSN 1176-9092
    DOI 10.2147/CIA.S191751
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 6742: Show issues Location:
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