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Article: Utility of the Algase Wandering Scale in an outpatient Alzheimer's disease sample.

Marcus, Jacqueline F / Cellar, Janet S / Ansari, Farzaneh Pour / Bliwise, Donald L

International journal of geriatric psychiatry

2007 Volume 22, Issue 8, Page(s) 801–805

Abstract: Background: Wandering represents a major problem in the management of patients with Alzheimer's disease (AD). In this study we examined the utility of the Algase Wandering Scale (AWS), a newly developed psychometric instrument that asks caregivers to ... ...

Abstract	Background: Wandering represents a major problem in the management of patients with Alzheimer's disease (AD). In this study we examined the utility of the Algase Wandering Scale (AWS), a newly developed psychometric instrument that asks caregivers to assess the likelihood of wandering behavior. Methods: The AWS was administered to the caregivers of 40 AD patients and total and subscale scores were examined in relation to measures of mental and functional status, depressive symptoms and medication usage. Results: AWS scores were comparable, though slightly lower, than those normative values previously published. Higher scores were associated with more severe dementia. The Negative Outcome subscale showed a significant increase in reported falls or injuries in association with anti-depressant use. Conclusions: These data provide some construct validation for the AWS as a potentially useful scale to assess wandering behaviors in AD.
MeSH term(s)	Accidental Falls/prevention & control ; Accidental Falls/statistics & numerical data ; Activities of Daily Living/psychology ; Aged ; Aged, 80 and over ; Alzheimer Disease/diagnosis ; Alzheimer Disease/epidemiology ; Alzheimer Disease/psychology ; Antidepressive Agents/adverse effects ; Antidepressive Agents/therapeutic use ; Caregivers/psychology ; Cross-Sectional Studies ; Depression/diagnosis ; Depression/epidemiology ; Depression/psychology ; Female ; Georgia ; Humans ; Male ; Mental Disorders/diagnosis ; Mental Disorders/epidemiology ; Mental Disorders/psychology ; Mental Status Schedule/statistics & numerical data ; Neuropsychological Tests/statistics & numerical data ; Orientation ; Psychometrics ; Risk Factors ; Wounds and Injuries/epidemiology ; Wounds and Injuries/prevention & control ; Wounds and Injuries/psychology
Chemical Substances	Antidepressive Agents
Language	English
Publishing date	2007-08
Publishing country	England
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
ZDB-ID	806736-3
ISSN	1099-1166 ; 0885-6230
ISSN (online)	1099-1166
ISSN	0885-6230
DOI	10.1002/gps.1745
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Article: Daytime sleepiness and functional impairment in Alzheimer disease.

Lee, Jung Hie / Bliwise, Donald L / Ansari, Farzaneh Pour / Goldstein, Felicia C / Cellar, Janet S / Lah, James J / Levey, Allan I

The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry

2007 Volume 15, Issue 7, Page(s) 620–626

Abstract: Objective: Daytime sleep has been noted to accompany dementing illness and is more pronounced as dementia severity increases. Although acknowledged by caregivers, sleepiness during the daytime is among the least troublesome of sleep behaviors described ... ...

Abstract	Objective: Daytime sleep has been noted to accompany dementing illness and is more pronounced as dementia severity increases. Although acknowledged by caregivers, sleepiness during the daytime is among the least troublesome of sleep behaviors described in Alzheimer Disease (AD) patients. The purpose of this study was to examine whether patient and spouse/caregiver reports of daytime sleepiness in AD were associated with lower functional status in those patients. Methods: The authors utilized the Epworth Sleepiness Scale to assess reported daytime sleepiness and a modification of the Lawton and Brody scale to assess functional status in a group of 137 AD patients. The authors also examined typical bedtimes and wakeup times via questionnaire. Results: Higher levels of daytime sleepiness were associated with greater impairments in functional status. These results were independent of level of cognitive impairment, as assessed with Mini-Mental State Exam, and they were also detectable when the authors limited analyses to data reported only by spouse/caregiver. Findings were not associated with medication use. AD patients also had earlier bedtimes and later wake-up times than a comparison group. Conclusion: Even apart from its association with impaired cognition, daytime sleepiness was associated with functional impairment in AD patients. Although daytime sleep may represent a welcome relief for caregivers, its presence may be associated with greater impairment in instrumental activities and may warrant intervention.
MeSH term(s)	Aged ; Alzheimer Disease/diagnosis ; Alzheimer Disease/epidemiology ; Alzheimer Disease/physiopathology ; Disorders of Excessive Somnolence/epidemiology ; Female ; Humans ; Male ; Neuropsychological Tests ; Prevalence ; Severity of Illness Index ; Sleep Disorders, Circadian Rhythm/epidemiology
Language	English
Publishing date	2007-07
Publishing country	England
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
ZDB-ID	1278145-9
ISSN	1545-7214 ; 1064-7481
ISSN (online)	1545-7214
ISSN	1064-7481
DOI	10.1097/JGP.0b013e3180381521
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Article: Feasibility of ambulatory overnight oximetry in consecutive patients in a dementia clinic.

Bliwise, Donald L / Lee, Jung-Hie / Wood-Siverio, Cathy / Cellar, Janet S / Lah, James J / Levey, Allan I

Journal of the American Geriatrics Society

2005 Volume 53, Issue 3, Page(s) 545–546

MeSH term(s)	Aged ; Cyclopentolate/adverse effects ; Delirium/chemically induced ; Humans ; Male ; Mydriatics/adverse effects ; Ophthalmic Solutions/adverse effects
Chemical Substances	Mydriatics ; Ophthalmic Solutions ; Cyclopentolate (I76F4SHP7J)
Language	English
Publishing date	2005-03
Publishing country	United States
Document type	Case Reports ; Letter
ZDB-ID	80363-7
ISSN	1532-5415 ; 0002-8614
ISSN (online)	1532-5415
ISSN	0002-8614
DOI	10.1111/j.1532-5415.2005.53178_2.x
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Article ; Online: Association of common genetic variants in GPCPD1 with scaling of visual cortical surface area in humans.

Bakken, Trygve E / Roddey, J Cooper / Djurovic, Srdjan / Akshoomoff, Natacha / Amaral, David G / Bloss, Cinnamon S / Casey, B J / Chang, Linda / Ernst, Thomas M / Gruen, Jeffrey R / Jernigan, Terry L / Kaufmann, Walter E / Kenet, Tal / Kennedy, David N / Kuperman, Joshua M / Murray, Sarah S / Sowell, Elizabeth R / Rimol, Lars M / Mattingsdal, Morten /

Melle, Ingrid / Agartz, Ingrid / Andreassen, Ole A / Schork, Nicholas J / Dale, Anders M / Weiner, Michael / Aisen, Paul / Petersen, Ronald / Jack, Clifford R / Jagust, William / Trojanowki, John Q / Toga, Arthur W / Beckett, Laurel / Green, Robert C / Saykin, Andrew J / Morris, John / Liu, Enchi / Montine, Tom / Gamst, Anthony / Thomas, Ronald G / Donohue, Michael / Walter, Sarah / Gessert, Devon / Sather, Tamie / Harvey, Danielle / Kornak, John / Dale, Anders / Bernstein, Matthew / Felmlee, Joel / Fox, Nick / Thompson, Paul / Schuff, Norbert / Alexander, Gene / DeCarli, Charles / Bandy, Dan / Koeppe, Robert A / Foster, Norm / Reiman, Eric M / Chen, Kewei / Mathis, Chet / Cairns, Nigel J / Taylor-Reinwald, Lisa / Trojanowki, J Q / Shaw, Les / Lee, Virginia M Y / Korecka, Magdalena / Crawford, Karen / Neu, Scott / Foroud, Tatiana M / Potkin, Steven / Shen, Li / Kachaturian, Zaven / Frank, Richard / Snyder, Peter J / Molchan, Susan / Kaye, Jeffrey / Quinn, Joseph / Lind, Betty / Dolen, Sara / Schneider, Lon S / Pawluczyk, Sonia / Spann, Bryan M / Brewer, James / Vanderswag, Helen / Heidebrink, Judith L / Lord, Joanne L / Johnson, Kris / Doody, Rachelle S / Villanueva-Meyer, Javier / Chowdhury, Munir / Stern, Yaakov / Honig, Lawrence S / Bell, Karen L / Morris, John C / Ances, Beau / Carroll, Maria / Leon, Sue / Mintun, Mark A / Schneider, Stacy / Marson, Daniel / Griffith, Randall / Clark, David / Grossman, Hillel / Mitsis, Effie / Romirowsky, Aliza / deToledo-Morrell, Leyla / Shah, Raj C / Duara, Ranjan / Varon, Daniel / Roberts, Peggy / Albert, Marilyn / Onyike, Chiadi / Kielb, Stephanie / Rusinek, Henry / de Leon, Mony J / Glodzik, Lidia / De Santi, Susan / Doraiswamy, P Murali / Petrella, Jeffrey R / Coleman, R Edward / Arnold, Steven E / Karlawish, Jason H / Wolk, David / Smith, Charles D / Jicha, Greg / Hardy, Peter / Lopez, Oscar L / Oakley, MaryAnn / Simpson, Donna M / Porsteinsson, Anton P / Goldstein, Bonnie S / Martin, Kim / Makino, Kelly M / Ismail, M Saleem / Brand, Connie / Mulnard, Ruth A / Thai, Gaby / Mc-Adams-Ortiz, Catherine / Womack, Kyle / Mathews, Dana / Quiceno, Mary / Diaz-Arrastia, Ramon / King, Richard / Weiner, Myron / Martin-Cook, Kristen / DeVous, Michael / Levey, Allan I / Lah, James J / Cellar, Janet S / Burns, Jeffrey M / Anderson, Heather S / Swerdlow, Russell H / Apostolova, Liana / Lu, Po H / Bartzokis, George / Silverman, Daniel H S / Graff-Radford, Neill R / Parfitt, Francine / Johnson, Heather / Farlow, Martin R / Hake, Ann Marie / Matthews, Brandy R / Herring, Scott / van Dyck, Christopher H / Carson, Richard E / MacAvoy, Martha G / Chertkow, Howard / Bergman, Howard / Hosein, Chris / Black, Sandra / Stefanovic, Bojana / Caldwell, Curtis / Ging-Yuek / Hsiung, Robin / Feldman, Howard / Mudge, Benita / Assaly, Michele / Kertesz, Andrew / Rogers, John / Trost, Dick / Bernick, Charles / Munic, Donna / Kerwin, Diana / Mesulam, Marek-Marsel / Lipowski, Kristina / Wu, Chuang-Kuo / Johnson, Nancy / Sadowsky, Carl / Martinez, Walter / Villena, Teresa / Turner, Raymond Scott / Johnson, Kathleen / Reynolds, Brigid / Sperling, Reisa A / Johnson, Keith A / Marshall, Gad / Frey, Meghan / Yesavage, Jerome / Taylor, Joy L / Lane, Barton / Rosen, Allyson / Tinklenberg, Jared / Sabbagh, Marwan / Belden, Christine / Jacobson, Sandra / Kowall, Neil / Killiany, Ronald / Budson, Andrew E / Norbash, Alexander / Johnson, Patricia Lynn / Obisesan, Thomas O / Wolday, Saba / Bwayo, Salome K / Lerner, Alan / Hudson, Leon / Ogrocki, Paula / Fletcher, Evan / Carmichael, Owen / Olichney, John / Kittur, Smita / Borrie, Michael / Lee, T-Y / Bartha, Rob / Johnson, Sterling / Asthana, Sanjay / Carlsson, Cynthia M / Potkin, Steven G / Preda, Adrian / Nguyen, Dana / Tariot, Pierre / Fleisher, Adam / Reeder, Stephanie / Bates, Vernice / Capote, Horacio / Rainka, Michelle / Scharre, Douglas W / Kataki, Maria / Zimmerman, Earl A / Celmins, Dzintra / Brown, Alice D / Pearlson, Godfrey D / Blank, Karen / Anderson, Karen / Santulli, Robert B / Schwartz, Eben S / Sink, Kaycee M / Williamson, Jeff D / Garg, Pradeep / Watkins, Franklin / Ott, Brian R / Querfurth, Henry / Tremont, Geoffrey / Salloway, Stephen / Malloy, Paul / Correia, Stephen / Rosen, Howard J / Miller, Bruce L / Mintzer, Jacobo / Longmire, Crystal Flynn / Spicer, Kenneth / Finger, Elizabether / Rachinsky, Irina / Drost, Dick / Jernigan, Terry / McCabe, Connor / Grant, Ellen / Ernst, Thomas / Kuperman, Josh / Chung, Yoon / Murray, Sarah / Bloss, Cinnamon / Darst, Burcu / Pritchett, Lexi / Saito, Ashley / Amaral, David / DiNino, Mishaela / Eyngorina, Bella / Sowell, Elizabeth / Houston, Suzanne / Soderberg, Lindsay / Kaufmann, Walter / van Zijl, Peter / Rizzo-Busack, Hilda / Javid, Mohsin / Mehta, Natasha / Ruberry, Erika / Powers, Alisa / Rosen, Bruce / Gebhard, Nitzah / Manigan, Holly / Frazier, Jean / Kennedy, David / Yakutis, Lauren / Hill, Michael / Gruen, Jeffrey / Bosson-Heenan, Joan / Carlson, Heatherly

Proceedings of the National Academy of Sciences of the United States of America

2012 Volume 109, Issue 10, Page(s) 3985–3990

Abstract: Visual cortical surface area varies two- to threefold between human individuals, is highly heritable, and has been correlated with visual acuity and visual perception. However, it is still largely unknown what specific genetic and environmental factors ... ...

Abstract	Visual cortical surface area varies two- to threefold between human individuals, is highly heritable, and has been correlated with visual acuity and visual perception. However, it is still largely unknown what specific genetic and environmental factors contribute to normal variation in the area of visual cortex. To identify SNPs associated with the proportional surface area of visual cortex, we performed a genome-wide association study followed by replication in two independent cohorts. We identified one SNP (rs6116869) that replicated in both cohorts and had genome-wide significant association (P(combined) = 3.2 × 10(-8)). Furthermore, a metaanalysis of imputed SNPs in this genomic region identified a more significantly associated SNP (rs238295; P = 6.5 × 10(-9)) that was in strong linkage disequilibrium with rs6116869. These SNPs are located within 4 kb of the 5' UTR of GPCPD1, glycerophosphocholine phosphodiesterase GDE1 homolog (Saccharomyces cerevisiae), which in humans, is more highly expressed in occipital cortex compared with the remainder of cortex than 99.9% of genes genome-wide. Based on these findings, we conclude that this common genetic variation contributes to the proportional area of human visual cortex. We suggest that identifying genes that contribute to normal cortical architecture provides a first step to understanding genetic mechanisms that underlie visual perception.
MeSH term(s)	Adolescent ; Adult ; Aged ; Brain/pathology ; Brain Mapping/methods ; Cohort Studies ; Diagnostic Imaging/methods ; Female ; Genetic Variation ; Genome-Wide Association Study ; Genomics ; Genotype ; Humans ; Male ; Middle Aged ; Models, Genetic ; Phosphoric Diester Hydrolases/genetics ; Polymorphism, Single Nucleotide ; Saccharomyces cerevisiae/metabolism ; Visual Cortex/anatomy & histology ; Visual Cortex/pathology
Chemical Substances	Phosphoric Diester Hydrolases (EC 3.1.4.-) ; glycerophosphocholine phosphodiesterase (EC 3.1.4.2) ; glycerophosphodiester phosphodiesterase (EC 3.1.4.46)
Language	English
Publishing date	2012-02-16
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Research Support, U.S. Gov't, P.H.S.
ZDB-ID	209104-5
ISSN	1091-6490 ; 0027-8424
ISSN (online)	1091-6490
ISSN	0027-8424
DOI	10.1073/pnas.1105829109
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Article: Subregional neuroanatomical change as a biomarker for Alzheimer's disease

Holland, Dominic / Brewer, James B / Hagler, Donald J / Fenema-Notestine, Christine / Dale, Anders M / Weiner, Michael / Thal, Leon / Petersen, Ronald / Jack, Clifford R. Jr / Jagust, William / Trojanowki, John / Toga, Arthur W / Beckett, Laurel / Green, Robert C / Gamst, Anthony / Potter, William Z / Montine, Tom / Anders, Dale / Bernstein, Matthew /

Felmlee, Joel / Fox, Nick / Thompson, Paul / Schuff, Norbert / Alexander, Gene / Bandy, Dan / Koeppe, Robert A / Foster, Norm / Reiman, Eric M / Chen, Kewei / Shaw, Les / Lee, Virginia M.-Y / Korecka, Magdalena / Crawford, Karen / Neu, Scott / Harvey, Danielle / Kornak, John / Kachaturian, Zaven / Frank, Richard / Snyder, Peter J / Molchan, Susan / Kaye, Jeffrey / Vorobik, Remi / Quinn, Joseph / Schneider, Lon / Pawluczyk, Sonia / Spann, Bryan / Fleisher, Adam S / Vanderswag, Helen / Heidebrink, Judith L / Lord, Joanne L / Johnson, Kris / Doody, Rachelle S / Villanueva-Meyer, Javier / Chowdhury, Munir / Stern, Yaakov / Honig, Lawrence S / Bell, Karen L / Morris, John C / Mintun, Mark A / Schneider, Stacy / Marson, Daniel / Griffith, Randall / Badger, Beverly / Grossman, Hillel / Tang, Cheuk / Stern, Jessica / deToledo-Morrell, Leyla / Shah, Raj C / Bach, Julie / Duara, Ranjan / Isaacson, Richard / Strauman, Silvia / Albert, Marilyn S / Pedroso, Julia / Toroney, Jaimie / Rusinek, Henry / de Leon, Mony J / De Santi, Susan M / Doraiswamy, P. Murali / Petrella, Jeffrey R / Aiello, Marilyn / Clark, Christopher M / Pham, Cassie / Nunez, Jessica / Smith, Charles D / Given, Curtis A. II / Hardy, Peter / DeKosky, Steven T / Oakley, MaryAnn / Simpson, Donna M / Ismail, M. Saleem / Porsteinsson, Anton / McCallum, Colleen / Cramer, Steven C / Mulnard, Ruth A / McAdams-Ortiz, Catherine / Diaz-Arrastia, Ramon / Martin-Cook, Kristen / DeVous, Michael / Levey, Allan I / Lah, James J / Cellar, Janet S / Burns, Jeffrey M / Anderson, Heather S / Laubinger, Mary M / Bartzokis, George / Silverman, Daniel H.S / Lu, Po H / Fletcher, Rita / Parfitt, Francine / Johnson, Heather / Farlow, Martin / Herring, Scott / Hake, Ann M / van Dyck, Christopher H / MacAvoy, Martha G / Bifano, Laurel A / Chertkow, Howard / Bergman, Howard / Hosein, Chris / Black, Sandra / Graham, Simon / Caldwell, Curtis / Feldman, Howard / Assaly, Michele / Hsiung, Ging-Yuek R / Kertesz, Andrew / Rogers, John / Trost, Dick / Bernick, Charles / Gitelman, Darren / Johnson, Nancy / Mesulam, Marsel / Sadowsky, Carl / Villena, Teresa / Mesner, Scott / Aisen, Paul S / Johnson, Kathleen B / Behan, Kelly E / Sperling, Reisa A / Rentz, Dorene M / Johnson, Keith A / Rosen, Allyson / Tinklenberg, Jared / Ashford, Wes / Sabbagh, Marwan / Connor, Donald / Obradov, Sanja / Killiany, Ron / Norbash, Alex / Obisesan, Thomas O / Jayam-Trouth, Annapurni / Wang, Paul / Auchus, Alexander P / Huang, Juebin / Friedland, Robert P / DeCarli, Charles / Fletcher, Evan / Carmichael, Owen / Kittur, Smita / Mirje, Seema / Johnson, Sterling C / Borrie, Michael / Lee, T.-Y / Asthana, Sanjay / Carlsson, Cynthia M / Potkin, Steven G / Highum, Diane / Preda, Adrian / Nguyen, Dana / Tariot, Pierre N / Hendin, Barry A / Scharre, Douglas W / Kataki, Maria / Beversdorf, David Q / Zimmerman, Earl A / Celmins, Dzintra / Brown, Alice D / Gandy, Sam / Marenberg, Marjorie E / Rovner, Barry W / Pearlson, Godfrey / Blank, Karen / Anderson, Karen / Saykin, Andrew J / Santulli, Robert B / Pare, Nadia / Williamson, Jeff D / Sink, Kaycee M / Potter, Huntington / Ashok Raj, B / Giordano, Amy / Ott, Brian R / Wu, Chuang-Kuo / Cohen, Ronald / Wilks, Kerri L / Safirstein, Beth E

Proceedings of the National Academy of Sciences of the United States of America. 2009 Dec. 8, v. 106, no. 49

2009

Abstract: Regions of the temporal and parietal lobes are particularly damaged in Alzheimer's disease (AD), and this leads to a predictable pattern of brain atrophy. In vivo quantification of subregional atrophy, such as changes in cortical thickness or structure ... ...

Abstract	Regions of the temporal and parietal lobes are particularly damaged in Alzheimer's disease (AD), and this leads to a predictable pattern of brain atrophy. In vivo quantification of subregional atrophy, such as changes in cortical thickness or structure volume, could lead to improved diagnosis and better assessment of the neuroprotective effects of a therapy. Toward this end, we have developed a fast and robust method for accurately quantifying cerebral structural changes in several cortical and subcortical regions using serial MRI scans. In 169 healthy controls, 299 subjects with mild cognitive impairment (MCI), and 129 subjects with AD, we measured rates of subregional cerebral volume change for each cohort and performed power calculations to identify regions that would provide the most sensitive outcome measures in clinical trials of disease-modifying agents. Consistent with regional specificity of AD, temporal-lobe cortical regions showed the greatest disease-related changes and significantly outperformed any of the clinical or cognitive measures examined for both AD and MCI. Global measures of change in brain structure, including whole-brain and ventricular volumes, were also elevated in AD and MCI, but were less salient when compared to changes in normal subjects. Therefore, these biomarkers are less powerful for quantifying disease-modifying effects of compounds that target AD pathology. The findings indicate that regional temporal lobe cortical changes would have great utility as outcome measures in clinical trials and may also have utility in clinical practice for aiding early diagnosis of neurodegenerative disease.
Keywords	Alzheimer disease ; atrophy ; biomarkers ; brain ; clinical trials ; cognition ; early diagnosis ; magnetic resonance imaging ; neurodegenerative diseases ; neuroprotective effect ; therapeutics
Language	English
Dates of publication	2009-1208
Size	p. 20954-20959.
Publishing place	National Academy of Sciences
Document type	Article
ZDB-ID	209104-5
ISSN	1091-6490 ; 0027-8424
ISSN (online)	1091-6490
ISSN	0027-8424
DOI	10.1073/pnas.0906053106
Database	NAL-Catalogue (AGRICOLA)

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Article: Utility of the Algase Wandering Scale in an outpatient Alzheimer's disease sample.

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Article: Daytime sleepiness and functional impairment in Alzheimer disease.

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Article: Feasibility of ambulatory overnight oximetry in consecutive patients in a dementia clinic.

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Article ; Online: Association of common genetic variants in GPCPD1 with scaling of visual cortical surface area in humans.

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Article: Subregional neuroanatomical change as a biomarker for Alzheimer's disease

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