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  1. Article ; Online: Correlation between corneal thickness, keratometry, age, and differential pressure difference in healthy eyes

    Ahmet Colakoglu / Iffet Emel Colakoglu / Cemile Banu Cosar

    Scientific Reports, Vol 11, Iss 1, Pp 1-

    2021  Volume 9

    Abstract: Abstract To determine the use of differential pressure difference (DPD), in air-puff differential tonometry, as a potential biomechanical measure of the cornea and elucidate its relationship with the intraocular pressure (IOP), central corneal thickness, ...

    Abstract Abstract To determine the use of differential pressure difference (DPD), in air-puff differential tonometry, as a potential biomechanical measure of the cornea and elucidate its relationship with the intraocular pressure (IOP), central corneal thickness, corneal curvature, and age. This study comprised 396 eyes from 198 patients and was conducted at Acibadem University, School of Medicine, Department of Ophthalmology, Istanbul, Turkey. The central corneal curvature and refraction of the eyes were measured using an Auto Kerato-Refractometer (KR-1; Topcon Corporation, Tokyo, Japan). IOP and central corneal thickness were measured using a tono-pachymeter (CT-1P; Topcon Corporation, Tokyo, Japan), wherein two separate readings of IOP were obtained using two different modes: 1–30 and 1–60. The difference between these two readings was recorded as the DPD. The factors affecting the DPD were determined by stepwise multiple linear regression analysis. DPD varied over a dynamic range of − 3.0 to + 5.0 mmHg and was weakly correlated with the central corneal thickness (r = 0.115, p < 0.05). DPD showed no significant correlation with IOP 1–30 (p > 0.05). A weak but statistically significant (p < 0.05) positive correlation of DPD was observed with age (r = 0.123), Kavg (r = 0.102), and the CCT (r = 0.115). There was a significant correlation between DPD and Kavg, CCT, and age. There was no significant correlation between DPD and IOP 1–30. Age-related changes in the corneal ultrastructure may be a plausible explanation for the weak positive association between age and DPD. The proposed method may prove a valid non-invasive tool for the evaluation of corneal biomechanics and introduce DPD in the decision-making of routine clinical practice.
    Keywords Medicine ; R ; Science ; Q
    Language English
    Publishing date 2021-02-01T00:00:00Z
    Publisher Nature Portfolio
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  2. Article ; Online: Intrauterine Cataract Diagnosis and Follow-up

    Sevinç Aksay / İbrahim Bildirici / Cemile Banu Coşar / Yasemin Alanay / Engin Ciğercioğulları

    Türk Oftalmoloji Dergisi, Vol 50, Iss 4, Pp 245-

    2020  Volume 247

    Abstract: In this article, we report a 21-gestational-week fetus diagnosed with congenital cataract by ultrasonography. The parents decided to terminate the pregnancy and asked for examination of the fetus. An amniocentesis was performed for fetal karyotyping. ... ...

    Abstract In this article, we report a 21-gestational-week fetus diagnosed with congenital cataract by ultrasonography. The parents decided to terminate the pregnancy and asked for examination of the fetus. An amniocentesis was performed for fetal karyotyping. After termination of the pregnancy, fetal autopsy was conducted. Whole exome sequencing (Trio-WES) analysis of the mother and father was done from peripheral blood samples. In the pathologic autopsy report, bilateral anterior and posterior subcapsular cataracts were confirmed. Whole exome sequencing analysis revealed a previously unreported class 3 variant of uncertain significance (c755A>G [P.Lys252Arg]) of the CRYBB1 gene, which is associated with congenital cataract, that was homozygous in the fetus and heterozygous in the parents. The obtained result is consistent with a genetic diagnosis of isolated autosomal recessive congenital cataract.
    Keywords class 3 variant of uncertain significance (c755a>g [p.lys252arg]) ; congenital cataract ; autosomal recessive inheritance ; Medicine ; R ; Ophthalmology ; RE1-994
    Subject code 610
    Language English
    Publishing date 2020-08-01T00:00:00Z
    Publisher Galenos Yayinevi
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  3. Article ; Online: Comparison of visual acuity, refractive results and complications of femtosecond laser with mechanical microkeratome in LASIK

    Murat Moray / Tansu Gonen / Cemile Banu Cosar / Asim Bozkurt Sener

    International Journal of Ophthalmology, Vol 6, Iss 3, Pp 350-

    2013  Volume 355

    Abstract: AIM: To compare the outcomes of laser in situ keratomileusis (LASIK) performed with a femtosecond laser (Femtec, Technolas Perfect Vision GmbH, Germany) versus a mechanical microkeratome (Hansatome, Bausch and Lomb, USA) for the correction of myopia and ... ...

    Abstract AIM: To compare the outcomes of laser in situ keratomileusis (LASIK) performed with a femtosecond laser (Femtec, Technolas Perfect Vision GmbH, Germany) versus a mechanical microkeratome (Hansatome, Bausch and Lomb, USA) for the correction of myopia and astigmatism.METHODS: In this retrospective study, patients who had undergone LASIK using the 80-kHz Femtec femtosecond laser were compared to age- and refraction-matched patients in whom the Hansatome microkeratome was used. Refractive and visual results 1 month and 3 months postoperatively, and complication rates were compared between the two groups.RESULTS: A total of 280 eyes were analyzed (140 in each group). At 3 months postoperatively in the Femtec vs Hansatome group, spherical equivalent refraction was within ±1.00D of emmetropia in 140 vs 138 eyes (P=0.498), the cylinder was within ±0.50D in 137 vs 139 eyes (P=0.622), and the UDVA was 20/20 or better in 136 vs 137 eyes (P=0.724), respectively. There was no statistically significant difference in the complication rates between the two groups (P=0.099). CONCLUSION: LASIK performed both with Femtec femtosecond laser and Hansatome microkeratome achieved satisfactory refractive and visual results at 3 months postoperatively, without significant differences in efficacy, safety, and complication rates between the two procedures.
    Keywords laser in situ keratomileusis ; femtosecond laser ; Femtec ; microkeratome ; Hansatome ; Ophthalmology ; RE1-994 ; Medicine ; R ; DOAJ:Ophthalmology ; DOAJ:Medicine (General) ; DOAJ:Health Sciences
    Language English
    Publishing date 2013-06-01T00:00:00Z
    Publisher IJO Press
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  4. Article ; Online: Long-term follow-up results of corneal collagen cross-linking in keratoconus

    Ayşe Ebru Kılavuzoğlu / Ali Rıza Cenk Çelebi / Cemile Banu Coşar / Asım Bozkurt Şener

    Journal of Clinical and Experimental Investigations, Vol 6, Iss 4, Pp 343-

    2015  Volume 350

    Abstract: Objective: To evaluate the changes in corneal parameters (keratometry, corneal thickness, topography indices) after corneal collagen cross-linking in keratoconus. Methods: The medical records of 6 patients who underwent corneal collagen cross-linking ... ...

    Abstract Objective: To evaluate the changes in corneal parameters (keratometry, corneal thickness, topography indices) after corneal collagen cross-linking in keratoconus. Methods: The medical records of 6 patients who underwent corneal collagen cross-linking treatment for keratoconus and have been followed-up for a minimum of 24 months were recruited. Best corrected visual acuity (BCVA), maximum keratometry (Kmax), central corneal thickness (CCT) values and corneal topography indices: index of surface variance (ISV), index of vertical asymmetry (IVA), keratoconus index (KI), central keratoconus index (CKI), minimum radius of curvature (Rmin), index of height asymmetry (IHA), and index of height decentralisation (IHD) were recorded. Results: The mean preoperative Kmax value was 46.67±4.15 (43.30-57.10) D and the mean Kmax value at the final postoperative visit was 45.41±2.95 (43.00-53.20) D. Mean preoperative CCT was 494.70±33.69 (438-537) µm and final postoperative mean CCT was 495.60±34.99 (433-539) µm. The deterioration in corneal topography indices stopped during the follow-up period of each case. Conclusion: Stopping the deterioration of corneal parameters in keratoconus is the desired outcome after cross-linking treatment. Our results found an improvement or at least stabilization in all topography indices in keratoconus patients. J Clin Exp Invest 2015; 6 (4): 343-350
    Keywords Keratoconus ; corneal collagen cross-linking ; Medicine ; R
    Subject code 001
    Language English
    Publishing date 2015-12-01T00:00:00Z
    Publisher Modestum Publishing LTD
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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