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Article: GINA 2019 - astımda basamak 1 ve 2 tedavisi: Değişiklikler ve nedenleri.

Cengiz, Ali / Bavbek, Sevim

2021 Volume 69, Issue 2, Page(s) 261–268

Abstract: Asthma is a heterogeneous lung disease characterized by chronic airway inflammation. It was suggested that patients with mild asthma symptoms could be managed with as-needed short-acting β2-agonists (SABA) in previous years. In 2019, GINA made a radical ... ...

Title translation	GINA 2019 - step 1 and 2 treatment in asthma: Updates with reasons behind.
Abstract	Asthma is a heterogeneous lung disease characterized by chronic airway inflammation. It was suggested that patients with mild asthma symptoms could be managed with as-needed short-acting β2-agonists (SABA) in previous years. In 2019, GINA made a radical change and recommended that SABA should not be used as monotherapy in patients with mild asthma, but instead as-needed low-dose inhaled corticosteroid (ICS)-formoterol or "additional low-dose ICS taken whenever SABA is taken" treatments should be commenced to relieve and control symptoms. The approach emerged in the light of the studies that indicate the increased risk of severe exacerbation and asthma-related death due to overuse of SABA. The present article aimed to enlighten the updates in GINA 2019 step 1 and 2 treatment, the grounds for these updates with the supportive studies.
MeSH term(s)	Adrenergic beta-Antagonists/administration & dosage ; Adrenergic beta-Antagonists/adverse effects ; Adrenergic beta-Antagonists/therapeutic use ; Anti-Asthmatic Agents/administration & dosage ; Anti-Asthmatic Agents/adverse effects ; Anti-Asthmatic Agents/therapeutic use ; Asthma/drug therapy ; Humans ; Prescription Drug Overuse
Chemical Substances	Adrenergic beta-Antagonists ; Anti-Asthmatic Agents
Language	Turkish
Publishing date	2021-07-10
Publishing country	Turkey
Document type	Journal Article
ZDB-ID	2468802-2
ISSN	0494-1373
ISSN	0494-1373
DOI	10.5578/tt.20219817
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Article ; Online: Gram-negative bacteremia, the risk factors, and outcome in children.

Gumus, Dilan Demir / Demir, Osman Oguz / Aykac, Kubra / Hazirolan, Gulsen / Avci, Hanife / Ceyhan, Mehmet / Cengiz, Ali Bulent / Ozsurekci, Yasemin

Diagnostic microbiology and infectious disease

2024 Volume 109, Issue 3, Page(s) 116324

Abstract: We aimed to determine the epidemiology and resistance patterns of Gram-negative bacteria, the risk factors and outcome of bloodstream infection (BSI). In all, 412 episodes in children who were hospitalized with the diagnosis of bacteremia were analyzed. ... ...

Abstract	We aimed to determine the epidemiology and resistance patterns of Gram-negative bacteria, the risk factors and outcome of bloodstream infection (BSI). In all, 412 episodes in children who were hospitalized with the diagnosis of bacteremia were analyzed. The most common microorganisms were Klebsiella spp. (43.9%), Escherichia coli (13.5 %) and Acinetobacter spp. (10.6 %). Among isolates, 41.2 % were multidrug-resistant, 13.5 % were extensively drug-resistant and 0.4 % were pan-drug-resistant. Carbapenem resistance was revealed in 27.6 % of isolates. Carbapenem and colistin resistance increased over the years. The most common risk factors were the presence of a central-venous catheter and pediatric intensive care unit admission. Clinical response and infection-related mortality were significantly different in cases infected with carbapenem-resistant gram-negative (CRGN) vs carbapenem-susceptible gram-negative bacteria. The increase in multi-resistant Klebsiella spp. seems to be the biggest obstacles in fight against nosocomial infections. The increasing number of CRGN infections over the years affects both the clinical response and mortality rate of BSI.
Language	English
Publishing date	2024-04-23
Publishing country	United States
Document type	Journal Article
ZDB-ID	604920-5
ISSN	1879-0070 ; 0732-8893
ISSN (online)	1879-0070
ISSN	0732-8893
DOI	10.1016/j.diagmicrobio.2024.116324
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Zs.A 1845: Show issues

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Article ; Online: Nutrient recovery from municipal solid waste leachate in the scope of circular economy: Recent developments and future perspectives.

Ersahin, Mustafa Evren / Cicekalan, Busra / Cengiz, Ali Izzet / Zhang, Xuedong / Ozgun, Hale

Journal of environmental management

2023 Volume 335, Page(s) 117518

Abstract: Holistically considering the current situation of the commercial synthetic fertilizer (CSF) market, recent global developments, and future projection studies, dependency on CSFs in agricultural production born significant risks, especially to the food ... ...

Abstract	Holistically considering the current situation of the commercial synthetic fertilizer (CSF) market, recent global developments, and future projection studies, dependency on CSFs in agricultural production born significant risks, especially to the food security of foreign-dependent countries. The foreign dependency of countries in terms of CSFs can be reduced by the concepts such as the circular economy and resource recovery. Recently, waste streams are considered as a source in order to produce recovery-based fertilizers (RBF). RBFs produced from different waste streams can be substituted with CSFs as input for agricultural applications. Municipal solid waste leachate (MSWL) is one of the waste streams that have a high potential for RBF production. Distribution of the published papers over the years shows that this potential was noticed by more researchers in the millennium. MSWL contains a remarkable amount of nitrogen and phosphorus which are the main nutrients required for agricultural production. These nutrients can be recovered with many different methods such as microalgae cultivation, chemical precipitation, ammonia stripping, membrane separation, etc. MSWL can be generated within the different phases of municipal solid waste (MSW) management. Although it is mainly composed of landfill leachate (LL), composting plant leachate (CPL), incineration plant leachate (IPL), and transfer station leachate (TSL) should be considered as potential sources to produce RBF. This study compiles studies conducted on MSWL from the perspective of nitrogen and phosphorus recovery. Moreover, recent developments and limitations of the subject were extensively discussed and future perspectives were introduced by considering the entire MSW management. Investigated studies in this review showed that the potential of MSWL to produce RBF is significant. The outcomes of this paper will serve the countries for ensuring their food security by implementing the resource recovery concept to produce RBF. Thus, the risks born with the recent global developments could be overcome in this way besides the positive environmental outcomes of resource recovery.
MeSH term(s)	Solid Waste/analysis ; Waste Management/methods ; Incineration ; Nitrogen ; Phosphorus ; Water Pollutants, Chemical/analysis ; Fertilizers ; Waste Disposal Facilities ; Refuse Disposal/methods
Chemical Substances	Solid Waste ; Nitrogen (N762921K75) ; Phosphorus (27YLU75U4W) ; Water Pollutants, Chemical ; Fertilizers
Language	English
Publishing date	2023-02-24
Publishing country	England
Document type	Journal Article ; Review
ZDB-ID	184882-3
ISSN	1095-8630 ; 0301-4797
ISSN (online)	1095-8630
ISSN	0301-4797
DOI	10.1016/j.jenvman.2023.117518
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Article ; Online: Catheter-related bloodstream infections in children receiving parenteral nutrition: Experience of a single center with 178 patients

Ozturk, Zeynelabidin / Demir, Hulya / Karhan, Asuman Nur / Cengiz, Ali Bulent / Özen, Hasan / Saltik Temizel, Inci Nur / Yuce, Aysel

Société francophone nutrition clinique et métabolisme (SFNCM) Nutrition clinique et métabolisme. 2023 Feb., v. 37, no. 1 p.39-44

2023

Abstract: Catheter-related bloodstream infections are common in children who require parenteral nutrition and can have serious consequences, including mortality. This study aims to evaluate the frequency and nature of catheter-related bloodstream infections in ... ...

Abstract	Catheter-related bloodstream infections are common in children who require parenteral nutrition and can have serious consequences, including mortality. This study aims to evaluate the frequency and nature of catheter-related bloodstream infections in children receiving parenteral nutrition. Patients between one month and 18 years of age who received parenteral nutrition within two years were evaluated for indications and complications by focusing on catheter-related bloodstream infections. Twenty-nine different catheter-related bloodstream infections were detected in 24 of 147 episodes in which parenteral nutrition was delivered via a catheter. The frequency of catheter-related bloodstream infections was 7.7 infections per 1000 catheter days. Coagulase-negative staphylococci, Gram-negative enteric bacilli, enterococci, and Candida species were the most common causative microorganisms. Five patients died. Infection frequency increased with increasing PN duration and receiving PN via a non-tunneled internal jugular catheter. Gender, age, and the number of catheter lumens were not associated with infection frequency. Catheter-related bloodstream infection is a common complication in children receiving parenteral nutrition. Appropriate management is essential. Because parenteral nutrition duration is a risk for catheter-related bloodstream infections, the transition to enteral feeding should be considered as soon as possible.
Keywords	Candida ; Enterococcus ; blood flow ; catheters ; enteral feeding ; gender ; mortality ; parenteral feeding ; risk ; Catheter related infection ; Central venous catheter ; Children ; Parenteral nutrition ; Bactériémie liée au cathéter ; Cathéter veineux central ; Enfants ; Nutrition parentérale ; CI ; CVC ; CRBSI ; IQR ; OR ; PN
Language	English
Dates of publication	2023-02
Size	p. 39-44.
Publishing place	Elsevier Masson SAS
Document type	Article ; Online
ZDB-ID	1131758-9
ISSN	0985-0562
ISSN	0985-0562
DOI	10.1016/j.nupar.2022.10.005
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: Methylprednisolone use in children with severe pneumonia caused by severe acute respiratory syndrome coronavirus 2.

Ozsurekci, Yasemin / Aykac, Kubra / Demir, Osman Oguz / Ilbay, Sare / Kesici, Selman / Karakaya, Jale / Cengiz, Ali Bulent

Pediatrics international : official journal of the Japan Pediatric Society

2023 Volume 65, Issue 1, Page(s) e15603

Abstract: Background: This study aimed to evaluate the effectiveness and optimal use of corticosteroids in children with severe coronavirus disease 2019 (COVID-19) pneumonia, for which effective treatment is still lacking with respect to this population.: ... ...

Abstract	Background: This study aimed to evaluate the effectiveness and optimal use of corticosteroids in children with severe coronavirus disease 2019 (COVID-19) pneumonia, for which effective treatment is still lacking with respect to this population. Methods: We conducted a retrospective study and included patients (aged < 18 years) with severe COVID-19 pneumonia and/or acute respiratory distress syndrome (ARDS) who received standard doses (2-4 mg/kg/day) and high doses (>250 mg/day) of methylprednisolone (MPZ). We adjusted for patients on steroid treatments with a propensity score and compared the side effects of different MPZ doses and patient survival. Results: Fifty-nine patients were included: 61% were male, the median age was 8, interquartile range (IQR) 2-15) years. The overall survival was 84.4% in patients treated with standard-dose MPZ (n = 45, 76.3%) and 92.2% in patients treated with high-dose MPZ (n = 14, 23.7%; p = 0.67). The demographic, clinical, and laboratory data did not differ significantly after propensity score matching, apart from bradycardia, which was a prominent feature of the high-dose group. The clinical and radiological response rates on day 7 were higher and the need for invasive mechanical ventilation (IMV) was lower in the high-dose group. Conclusion: The patients with high-dose MPZ had better clinical and radiological responses than those with standard-dose MPZ, although the mortality rate did not differ between standard and high-dose regimens of MPZ.
MeSH term(s)	Humans ; Male ; Child ; Child, Preschool ; Adolescent ; Female ; SARS-CoV-2 ; COVID-19 ; Methylprednisolone/therapeutic use ; Retrospective Studies ; Respiratory Distress Syndrome/drug therapy ; Respiration, Artificial
Chemical Substances	Methylprednisolone (X4W7ZR7023)
Language	English
Publishing date	2023-08-29
Publishing country	Australia
Document type	Journal Article
ZDB-ID	1470376-2
ISSN	1442-200X ; 1328-8067
ISSN (online)	1442-200X
ISSN	1328-8067
DOI	10.1111/ped.15603
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Zs.A 848: Show issues

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Article ; Online: The Relation between Pregnancy-Associated Plasma Protein A and Obstructive Sleep Apnea Syndrome.

Cengiz, Ali / Konuk, Suat / Tuğ, Tuncer

Canadian respiratory journal

2018 Volume 2018, Page(s) 3297810

Abstract: Aim: We aimed to investigate the relationship between serum pregnancy-associated plasma protein A (PAPP-A) levels and obstructive sleep apnea syndrome (OSAS).: Materials and method: 44 patients with OSAS and 44 healthy adults were included in this ... ...

Abstract	Aim: We aimed to investigate the relationship between serum pregnancy-associated plasma protein A (PAPP-A) levels and obstructive sleep apnea syndrome (OSAS). Materials and method: 44 patients with OSAS and 44 healthy adults were included in this study. The participants having rheumatic or systemic inflammatory disease, advanced liver or kidney failure, diabetes, heart failure, hypertension, pregnancy, prerenal azotemia, known history of coronary artery disease, any pulmonary disease, rhinitis, or atopy, history of major trauma or surgery within the last six 6 months, and inhaled nasal or systemic corticosteroid use or other anti-inflammatory medications and those with <18 years of age were excluded. Serum PAPP-A levels were determined by the Elisa method with the immune sandwich measuring method. Statistical analysis of the study was performed with SPSS 17.0 statistical analysis package program, and Results: Serum PAPP-A levels of patients with OSAS (2.350 ng/ml (0.641-4.796)) were significantly higher ( Conclusion: Higher PAPP-A levels in OSAS patients that were found in this study show inflammatory component in OSAS.
MeSH term(s)	Adult ; Case-Control Studies ; Female ; Humans ; Male ; Middle Aged ; Pregnancy-Associated Plasma Protein-A/metabolism ; Respiratory Function Tests ; Sleep Apnea, Obstructive/blood
Chemical Substances	Pregnancy-Associated Plasma Protein-A (EC 3.4.24.-) ; PAPPA protein, human (EC 3.4.24.79)
Language	English
Publishing date	2018-06-03
Publishing country	Egypt
Document type	Journal Article
ZDB-ID	1213103-9
ISSN	1916-7245 ; 1198-2241
ISSN (online)	1916-7245
ISSN	1198-2241
DOI	10.1155/2018/3297810
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Article ; Online: Neurologic manifestations in children with COVID-19.

Gürlevik, Sibel Laçinel / Günbey, Ceren / Ozsurekci, Yasemin / Kesici, Selman / Gocmen, Rahsan / Temucin, Çağrı / Özen, Seza / Cengiz, Ali Bulent / Yalnızoglu, Dilek

European journal of paediatric neurology : EJPN : official journal of the European Paediatric Neurology Society

2022 Volume 39, Page(s) 118–119

MeSH term(s)	COVID-19/complications ; Child ; Humans ; Nervous System Diseases/etiology
Language	English
Publishing date	2022-06-13
Publishing country	England
Document type	Letter ; Comment
ZDB-ID	1397146-3
ISSN	1532-2130 ; 1090-3798
ISSN (online)	1532-2130
ISSN	1090-3798
DOI	10.1016/j.ejpn.2022.06.004
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Zs.A 4867: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (2.OG) ab Jg. 2022: Lesesaal (EG)
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Article ; Online: Age and C-reactive protein as modifiers of Kocher criteria in pediatric septic knee monoarthritis.

Hanalioglu, Damla / Turker, Erdinc / Kamaci, Saygın / Ozsurekci, Yasemin / Cengiz, Ali Bulent / Ceyhan, Mehmet / Teksam, Ozlem

The American journal of emergency medicine

2022 Volume 60, Page(s) 145–151

Abstract: Introduction: Although Kocher criteria can distinguish a septic hip from an aseptic cause, they may not apply to a septic knee. We aimed to identify predictors to discriminate septic and aseptic causes of acute knee monoarthritis in children who ... ...

Abstract	Introduction: Although Kocher criteria can distinguish a septic hip from an aseptic cause, they may not apply to a septic knee. We aimed to identify predictors to discriminate septic and aseptic causes of acute knee monoarthritis in children who underwent arthrocentesis. Methods: We conducted a retrospective cohort study among children who underwent arthrocentesis for suspected septic arthritis of the knee. Collected data included demographic, clinical and laboratory characteristics. We performed univariate and multivariable analyses to identify predictors of the septic knee. We further investigated accuracy of different predictive models. Results: A total of 60 patients who underwent arthrocentesis for suspected knee septic arthritis were included in this study. Septic arthritis of the knee was confirmed in 32 (53%) patients. Age ≤ 5 years (OR 4.237, [95% CI 1.270-14.127], p = 0.019), WBC > 12,000 cells/mm Conclusion: Based on these findings, we propose an algorithm to identify low, intermediate and high-risk patients for knee septic arthritis. Our proposed two-step algorithm incorporating major (age, WBC, CRP) and minor (fever, ESR, non-weight bearing) criteria can serve as a simple decision-support tool to justify arthrocentesis in children with suspected knee septic arthritis.
MeSH term(s)	Arthritis, Infectious/complications ; Arthritis, Infectious/diagnosis ; Arthrocentesis/adverse effects ; C-Reactive Protein/metabolism ; Child ; Child, Preschool ; Fever/etiology ; Humans ; Knee Joint ; Retrospective Studies
Chemical Substances	C-Reactive Protein (9007-41-4)
Language	English
Publishing date	2022-08-06
Publishing country	United States
Document type	Journal Article
ZDB-ID	605890-5
ISSN	1532-8171 ; 0735-6757
ISSN (online)	1532-8171
ISSN	0735-6757
DOI	10.1016/j.ajem.2022.08.002
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Article: The Effect of Biologics in the Treatment of Multisystem Inflammatory Syndrome in Children (Mis-C): A Single-Center Propensity-Score-Matched Study.

Basaran, Ozge / Batu, Ezgi Deniz / Kaya Akca, Ummusen / Atalay, Erdal / Kasap Cuceoglu, Muserref / Sener, Seher / Balık, Zeynep / Karabulut, Erdem / Kesici, Selman / Karagoz, Tevfik / Ozsurekci, Yasemin / Bilginer, Yelda / Cengiz, Ali Bulent / Ozen, Seza

Children (Basel, Switzerland)

2023 Volume 10, Issue 6

Abstract: Multisystem inflammatory syndrome in children (MIS-C) is a serious condition characterized by excessive inflammation that can arise as a complication of SARS-CoV-2 infection in children. While our understanding of COVID-19 and MIS-C has been advancing, ... ...

Abstract	Multisystem inflammatory syndrome in children (MIS-C) is a serious condition characterized by excessive inflammation that can arise as a complication of SARS-CoV-2 infection in children. While our understanding of COVID-19 and MIS-C has been advancing, there is still uncertainty regarding the optimal treatment for MIS-C. In this study, we aimed to compare the clinical and laboratory outcomes of MIS-C patients treated with IVIG plus corticosteroids (CS) to those treated with IVIG plus CS and an additional biologic drug. We used the propensity score (PS)-matching method to assess the relationships between initial treatment and outcomes. The primary outcome was a left ventricular ejection fraction of less than 55% on day 2 or beyond and/or the requirement of inotrope support on day 2 or beyond. We included 79 MIS-C patients (median age 8.51 years, 33 boys) followed in our center. Among them, 50 children (25 in each group) were allocated to the PS-matched cohort sample. The primary outcome was observed in none of the patients in the IVIG and CS group, while it occurred in eight patients in the IVIG plus CS and biologic group (
Language	English
Publishing date	2023-06-11
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2732685-8
ISSN	2227-9067
ISSN	2227-9067
DOI	10.3390/children10061045
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Article ; Online: Stenotrophomonas maltophilia bacteremia in children - A 10-year analysis.

Büyükcam, Ayşe / Bıçakcıgil, Asiye / Cengiz, Ali B / Sancak, Banu / Ceyhan, Mehmet / Kara, Ateş

Archivos argentinos de pediatria

2020 Volume 118, Issue 3, Page(s) e317–e323

Abstract: Stenotrophomonas maltophilia is a multidrug-resistant, Gramnegative, and biofilm-forming pathogen. Information is limited concerning S. maltophilia bacteremia in children. Clinical data and microbiological test results collected in a tertiary children's ... ...

Title translation	Bacteriemia por Stenotrophomonas maltophilia en niños: análisis de 10 años.
Abstract	Stenotrophomonas maltophilia is a multidrug-resistant, Gramnegative, and biofilm-forming pathogen. Information is limited concerning S. maltophilia bacteremia in children. Clinical data and microbiological test results collected in a tertiary children's hospital over a ten-year period were reviewed. Children 0-18 years old who had positive clinical specimen, blood and/or catheter cultures were included. We identified 20 S. maltophilia isolates from 12 pediatric patients with confirmed infections. The median age was 28 months (range: 3.1-187.3). The rate of previous use of antimicrobial therapy was 83 %. The median antibiotic number was 3 (range: 0-7) within 30 days prior to onset of S. maltophilia bacteremia. Catheter related infection was the main infectious source (66.6 %). The mortality rate was 33.3 %. The death of two non-survivors was associated with pneumonia. S. maltophilia should be considered a breakthrough agent for bacteremia in children with underlying disease exposed to broad-spectrum antibiotics during long-term hospitalization.
MeSH term(s)	Adolescent ; Anti-Bacterial Agents/adverse effects ; Bacteremia/diagnosis ; Bacteremia/etiology ; Bacteremia/microbiology ; Bacteremia/mortality ; Catheter-Related Infections/diagnosis ; Catheter-Related Infections/etiology ; Catheter-Related Infections/microbiology ; Catheter-Related Infections/mortality ; Child ; Child, Preschool ; Cross Infection/diagnosis ; Cross Infection/etiology ; Cross Infection/microbiology ; Cross Infection/mortality ; Female ; Gram-Negative Bacterial Infections/diagnosis ; Gram-Negative Bacterial Infections/etiology ; Gram-Negative Bacterial Infections/microbiology ; Gram-Negative Bacterial Infections/mortality ; Hospitalization ; Humans ; Infant ; Infant, Newborn ; Male ; Retrospective Studies ; Risk Factors ; Stenotrophomonas maltophilia/immunology
Chemical Substances	Anti-Bacterial Agents
Language	Spanish
Publishing date	2020-06-12
Publishing country	Argentina
Document type	Journal Article ; Observational Study
ZDB-ID	424449-7
ISSN	1668-3501 ; 0325-0075 ; 0004-0487
ISSN (online)	1668-3501
ISSN	0325-0075 ; 0004-0487
DOI	10.5546/aap.2020.eng.e317
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