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  1. Article ; Online: Catheter-related bloodstream infections in children receiving parenteral nutrition: Experience of a single center with 178 patients

    Ozturk, Zeynelabidin / Demir, Hulya / Karhan, Asuman Nur / Cengiz, Ali Bulent / Özen, Hasan / Saltik Temizel, Inci Nur / Yuce, Aysel

    Société francophone nutrition clinique et métabolisme (SFNCM) Nutrition clinique et métabolisme. 2023 Feb., v. 37, no. 1 p.39-44

    2023  

    Abstract: Catheter-related bloodstream infections are common in children who require parenteral nutrition and can have serious consequences, including mortality. This study aims to evaluate the frequency and nature of catheter-related bloodstream infections in ... ...

    Abstract Catheter-related bloodstream infections are common in children who require parenteral nutrition and can have serious consequences, including mortality. This study aims to evaluate the frequency and nature of catheter-related bloodstream infections in children receiving parenteral nutrition. Patients between one month and 18 years of age who received parenteral nutrition within two years were evaluated for indications and complications by focusing on catheter-related bloodstream infections. Twenty-nine different catheter-related bloodstream infections were detected in 24 of 147 episodes in which parenteral nutrition was delivered via a catheter. The frequency of catheter-related bloodstream infections was 7.7 infections per 1000 catheter days. Coagulase-negative staphylococci, Gram-negative enteric bacilli, enterococci, and Candida species were the most common causative microorganisms. Five patients died. Infection frequency increased with increasing PN duration and receiving PN via a non-tunneled internal jugular catheter. Gender, age, and the number of catheter lumens were not associated with infection frequency. Catheter-related bloodstream infection is a common complication in children receiving parenteral nutrition. Appropriate management is essential. Because parenteral nutrition duration is a risk for catheter-related bloodstream infections, the transition to enteral feeding should be considered as soon as possible.
    Keywords Candida ; Enterococcus ; blood flow ; catheters ; enteral feeding ; gender ; mortality ; parenteral feeding ; risk ; Catheter related infection ; Central venous catheter ; Children ; Parenteral nutrition ; Bactériémie liée au cathéter ; Cathéter veineux central ; Enfants ; Nutrition parentérale ; CI ; CVC ; CRBSI ; IQR ; OR ; PN
    Language English
    Dates of publication 2023-02
    Size p. 39-44.
    Publishing place Elsevier Masson SAS
    Document type Article ; Online
    ZDB-ID 1131758-9
    ISSN 0985-0562
    ISSN 0985-0562
    DOI 10.1016/j.nupar.2022.10.005
    Database NAL-Catalogue (AGRICOLA)

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  2. Article ; Online: Methylprednisolone use in children with severe pneumonia caused by severe acute respiratory syndrome coronavirus 2.

    Ozsurekci, Yasemin / Aykac, Kubra / Demir, Osman Oguz / Ilbay, Sare / Kesici, Selman / Karakaya, Jale / Cengiz, Ali Bulent

    Pediatrics international : official journal of the Japan Pediatric Society

    2023  Volume 65, Issue 1, Page(s) e15603

    Abstract: Background: This study aimed to evaluate the effectiveness and optimal use of corticosteroids in children with severe coronavirus disease 2019 (COVID-19) pneumonia, for which effective treatment is still lacking with respect to this population.: ... ...

    Abstract Background: This study aimed to evaluate the effectiveness and optimal use of corticosteroids in children with severe coronavirus disease 2019 (COVID-19) pneumonia, for which effective treatment is still lacking with respect to this population.
    Methods: We conducted a retrospective study and included patients (aged < 18 years) with severe COVID-19 pneumonia and/or acute respiratory distress syndrome (ARDS) who received standard doses (2-4 mg/kg/day) and high doses (>250 mg/day) of methylprednisolone (MPZ). We adjusted for patients on steroid treatments with a propensity score and compared the side effects of different MPZ doses and patient survival.
    Results: Fifty-nine patients were included: 61% were male, the median age was 8, interquartile range (IQR) 2-15) years. The overall survival was 84.4% in patients treated with standard-dose MPZ (n = 45, 76.3%) and 92.2% in patients treated with high-dose MPZ (n = 14, 23.7%; p = 0.67). The demographic, clinical, and laboratory data did not differ significantly after propensity score matching, apart from bradycardia, which was a prominent feature of the high-dose group. The clinical and radiological response rates on day 7 were higher and the need for invasive mechanical ventilation (IMV) was lower in the high-dose group.
    Conclusion: The patients with high-dose MPZ had better clinical and radiological responses than those with standard-dose MPZ, although the mortality rate did not differ between standard and high-dose regimens of MPZ.
    MeSH term(s) Humans ; Male ; Child ; Child, Preschool ; Adolescent ; Female ; SARS-CoV-2 ; COVID-19 ; Methylprednisolone/therapeutic use ; Retrospective Studies ; Respiratory Distress Syndrome/drug therapy ; Respiration, Artificial
    Chemical Substances Methylprednisolone (X4W7ZR7023)
    Language English
    Publishing date 2023-08-29
    Publishing country Australia
    Document type Journal Article
    ZDB-ID 1470376-2
    ISSN 1442-200X ; 1328-8067
    ISSN (online) 1442-200X
    ISSN 1328-8067
    DOI 10.1111/ped.15603
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Age and C-reactive protein as modifiers of Kocher criteria in pediatric septic knee monoarthritis.

    Hanalioglu, Damla / Turker, Erdinc / Kamaci, Saygın / Ozsurekci, Yasemin / Cengiz, Ali Bulent / Ceyhan, Mehmet / Teksam, Ozlem

    The American journal of emergency medicine

    2022  Volume 60, Page(s) 145–151

    Abstract: Introduction: Although Kocher criteria can distinguish a septic hip from an aseptic cause, they may not apply to a septic knee. We aimed to identify predictors to discriminate septic and aseptic causes of acute knee monoarthritis in children who ... ...

    Abstract Introduction: Although Kocher criteria can distinguish a septic hip from an aseptic cause, they may not apply to a septic knee. We aimed to identify predictors to discriminate septic and aseptic causes of acute knee monoarthritis in children who underwent arthrocentesis.
    Methods: We conducted a retrospective cohort study among children who underwent arthrocentesis for suspected septic arthritis of the knee. Collected data included demographic, clinical and laboratory characteristics. We performed univariate and multivariable analyses to identify predictors of the septic knee. We further investigated accuracy of different predictive models.
    Results: A total of 60 patients who underwent arthrocentesis for suspected knee septic arthritis were included in this study. Septic arthritis of the knee was confirmed in 32 (53%) patients. Age ≤ 5 years (OR 4.237, [95% CI 1.270-14.127], p = 0.019), WBC > 12,000 cells/mm
    Conclusion: Based on these findings, we propose an algorithm to identify low, intermediate and high-risk patients for knee septic arthritis. Our proposed two-step algorithm incorporating major (age, WBC, CRP) and minor (fever, ESR, non-weight bearing) criteria can serve as a simple decision-support tool to justify arthrocentesis in children with suspected knee septic arthritis.
    MeSH term(s) Arthritis, Infectious/complications ; Arthritis, Infectious/diagnosis ; Arthrocentesis/adverse effects ; C-Reactive Protein/metabolism ; Child ; Child, Preschool ; Fever/etiology ; Humans ; Knee Joint ; Retrospective Studies
    Chemical Substances C-Reactive Protein (9007-41-4)
    Language English
    Publishing date 2022-08-06
    Publishing country United States
    Document type Journal Article
    ZDB-ID 605890-5
    ISSN 1532-8171 ; 0735-6757
    ISSN (online) 1532-8171
    ISSN 0735-6757
    DOI 10.1016/j.ajem.2022.08.002
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Neurologic manifestations in children with COVID-19.

    Gürlevik, Sibel Laçinel / Günbey, Ceren / Ozsurekci, Yasemin / Kesici, Selman / Gocmen, Rahsan / Temucin, Çağrı / Özen, Seza / Cengiz, Ali Bulent / Yalnızoglu, Dilek

    European journal of paediatric neurology : EJPN : official journal of the European Paediatric Neurology Society

    2022  Volume 39, Page(s) 118–119

    MeSH term(s) COVID-19/complications ; Child ; Humans ; Nervous System Diseases/etiology
    Language English
    Publishing date 2022-06-13
    Publishing country England
    Document type Letter ; Comment
    ZDB-ID 1397146-3
    ISSN 1532-2130 ; 1090-3798
    ISSN (online) 1532-2130
    ISSN 1090-3798
    DOI 10.1016/j.ejpn.2022.06.004
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article: The Effect of Biologics in the Treatment of Multisystem Inflammatory Syndrome in Children (Mis-C): A Single-Center Propensity-Score-Matched Study.

    Basaran, Ozge / Batu, Ezgi Deniz / Kaya Akca, Ummusen / Atalay, Erdal / Kasap Cuceoglu, Muserref / Sener, Seher / Balık, Zeynep / Karabulut, Erdem / Kesici, Selman / Karagoz, Tevfik / Ozsurekci, Yasemin / Bilginer, Yelda / Cengiz, Ali Bulent / Ozen, Seza

    Children (Basel, Switzerland)

    2023  Volume 10, Issue 6

    Abstract: Multisystem inflammatory syndrome in children (MIS-C) is a serious condition characterized by excessive inflammation that can arise as a complication of SARS-CoV-2 infection in children. While our understanding of COVID-19 and MIS-C has been advancing, ... ...

    Abstract Multisystem inflammatory syndrome in children (MIS-C) is a serious condition characterized by excessive inflammation that can arise as a complication of SARS-CoV-2 infection in children. While our understanding of COVID-19 and MIS-C has been advancing, there is still uncertainty regarding the optimal treatment for MIS-C. In this study, we aimed to compare the clinical and laboratory outcomes of MIS-C patients treated with IVIG plus corticosteroids (CS) to those treated with IVIG plus CS and an additional biologic drug. We used the propensity score (PS)-matching method to assess the relationships between initial treatment and outcomes. The primary outcome was a left ventricular ejection fraction of less than 55% on day 2 or beyond and/or the requirement of inotrope support on day 2 or beyond. We included 79 MIS-C patients (median age 8.51 years, 33 boys) followed in our center. Among them, 50 children (25 in each group) were allocated to the PS-matched cohort sample. The primary outcome was observed in none of the patients in the IVIG and CS group, while it occurred in eight patients in the IVIG plus CS and biologic group (
    Language English
    Publishing date 2023-06-11
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2732685-8
    ISSN 2227-9067
    ISSN 2227-9067
    DOI 10.3390/children10061045
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Changing Disease Course of Crimean-Congo Hemorrhagic Fever in Children, Turkey.

    Oygar, Pembe Derin / Gürlevik, Sibel Laçinel / Sağ, Erdal / İlbay, Sare / Aksu, Tekin / Demir, Osman Oğuz / Coşgun, Yasemin / Eyüpoğlu, Selin Aytaç / Karakaya, Jale / Cangül, Şule Ünal / Cengiz, Ali Bülent / Özsürekci, Yasemin

    Emerging infectious diseases

    2023  Volume 29, Issue 2, Page(s) 268–277

    Abstract: Crimean-Congo hemorrhagic fever (CCHF), endemic in certain regions of the world, is listed as a priority disease with pandemic potential. Since CCHF was first identified in Turkey, children have been known to experience milder disease than adults. ... ...

    Abstract Crimean-Congo hemorrhagic fever (CCHF), endemic in certain regions of the world, is listed as a priority disease with pandemic potential. Since CCHF was first identified in Turkey, children have been known to experience milder disease than adults. However, during the COVID-19 pandemic, we observed an unusually severe disease course, including hemophagocytic lymphohistiocytosis (HLH). We examined cytokine/chemokine profiles of 9/12 case-patients compared with healthy controls at 3 time intervals. Interferon pathway-related cytokines/chemokines, including interleukin (IL) 18, macrophage inflammatory protein 3α, and IL-33, were elevated, but tumor necrosis factor-α, IL-6, CXCL8 (formerly IL-8), and cytokines acting through C-C chemokine receptor 2 and CCR5 were lower among case-patients than controls. Interferon pathway activation and cytokines/chemokines acting through CCR2 and CCR5 improved health results among children with severe CCHF. Children can experience severe CCHF, including HLH, and HLH secondary to CCHF can be successfully treated with intravenous immunoglobulin and steroid therapy.
    MeSH term(s) Adult ; Humans ; Child ; Hemorrhagic Fever, Crimean/drug therapy ; Hemorrhagic Fever, Crimean/epidemiology ; Hemorrhagic Fever, Crimean/pathology ; Hemorrhagic Fever Virus, Crimean-Congo ; Turkey/epidemiology ; Pandemics ; COVID-19/epidemiology ; Cytokines ; Disease Progression ; Chemokines ; Interferons ; Lymphohistiocytosis, Hemophagocytic/epidemiology
    Chemical Substances Cytokines ; Chemokines ; Interferons (9008-11-1)
    Language English
    Publishing date 2023-01-24
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 1380686-5
    ISSN 1080-6059 ; 1080-6040
    ISSN (online) 1080-6059
    ISSN 1080-6040
    DOI 10.3201/eid2902.220976
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Usage of Plasma Presepsin, C-Reactive Protein, Procalcitonin and Proadrenomedullin to Predict Bacteremia in Febril Neutropenia of Pediatric Hematological Malignancy Patients.

    Arıkan, Kamile / Karadag-Oncel, Eda / Aytac, Selin / Cetin, Mualla / Cengiz, Ali Bülent / Gümrük, Fatma / Kara, Ates / Ceyhan, Mehmet

    Laboratory medicine

    2021  Volume 52, Issue 5, Page(s) 477–484

    Abstract: Objective: To investigate the value of presepsin and proadrenomedullin (proADM) as new markers for febrile neutropenia, by comparing them with conventional markers.: Methods: Plasma specimens for presepsin, proADM, C-reactive protein (CRP), and ... ...

    Abstract Objective: To investigate the value of presepsin and proadrenomedullin (proADM) as new markers for febrile neutropenia, by comparing them with conventional markers.
    Methods: Plasma specimens for presepsin, proADM, C-reactive protein (CRP), and procalcitonin (PCT) were collected every 3 days during each episode of febrile neutropenia.
    Results: A total of 39 patients experiencing a collective 47 episodes of febrile neutropenia with hematological malignant neoplasms, as well as 40 healthy control patients without infectious disease, were enrolled in this study. Levels of the studied analytes in the presepsin 1 group (with baseline values taken at admission), presepsin 2 group (values recorded on the 3rd day of febrile neutropenia), and presepsin 3 group (values recorded on the 6th day of hospitalization) were all higher in the subgroups with bacteremia. C-reactive protein 1 (baseline value taken at admission), procalcitonin 1 (as recorded at admission), and procalcitonin 2 (recorded on the 3rd day of febrile neutropenia) were higher in the subroups with bacteremia (P =.03, P = .04, and P = .04, respectively). In multivariate logistic regression analysis, presepsin 1 and/or PCT 1/CRP 1 combined analysis was superior in predicting bacteremia.
    Conclusion: Presepsin could be used in combination with other biomarkers to detect bacteremia.
    MeSH term(s) Adrenomedullin ; Bacteremia/diagnosis ; Biomarkers ; C-Reactive Protein ; Child ; Febrile Neutropenia ; Hematologic Neoplasms/complications ; Humans ; Lipopolysaccharide Receptors ; Neoplasms ; Peptide Fragments ; Procalcitonin ; Protein Precursors
    Chemical Substances Biomarkers ; Lipopolysaccharide Receptors ; Peptide Fragments ; Procalcitonin ; Protein Precursors ; presepsin protein, human ; proadrenomedullin ; Adrenomedullin (148498-78-6) ; C-Reactive Protein (9007-41-4)
    Language English
    Publishing date 2021-04-07
    Publishing country England
    Document type Journal Article
    ZDB-ID 391758-7
    ISSN 1943-7730 ; 0007-5027
    ISSN (online) 1943-7730
    ISSN 0007-5027
    DOI 10.1093/labmed/lmab002
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Outcome predictors of influenza for hospitalization and mortality in children.

    Ozsurekci, Yasemin / Aykac, Kubra / Bal, Fatma / Bayhan, Cihangul / Basaranoglu, Sevgen T / Alp, Alpaslan / Cengiz, Ali Bulent / Kara, Ates / Ceyhan, Mehmet

    Journal of medical virology

    2021  Volume 93, Issue 11, Page(s) 6148–6154

    Abstract: Severity of disease caused by influenza virus and the influencing factors that may be different. Moreover, the disease course actually may not be determined specifically in children because of lower seroprotection rates of children. Herein, the results ... ...

    Abstract Severity of disease caused by influenza virus and the influencing factors that may be different. Moreover, the disease course actually may not be determined specifically in children because of lower seroprotection rates of children. Herein, the results clinic and outcome data of children with influenza from Turkey were reported. We present here the results from 2013 to 2017. Nasopharyngeal swab samples of the children with influenza were investigated via multiplex polymerase chain reaction. A total of 348 children were diagnosed with influenza; 143 (41.1%) were influenza A, 85 (24.4%) were influenza B, and 120 (34.5%) were mixt infection with other respiratory viruses. Fifty-four percent of children admitted to intensive care unit (ICU) were under 2 years of age (p = .001). Having an underlying disease was detected as the main predictor for both hospitalization and ICU stay according to multiple logistic regression analysis (odds ratio [OR], 11.784: 95% confidence interval [CI], 5.212-26.643; p = .001 and OR, 4.972: 95% CI, 2.331-10.605; p = .001, respectively). Neurological symptoms most frequently seen in cases who died (44.4%; p = .02). Lymphopenia was relatively higher (55.6%) and thrombocytopenia was most frequently seen in cases who died (77.8%) with a significant ratio (p = .001). Underlying diseases was found a risk factor for influenza being hospitalized and being admitted to ICU. Children under 2 years of age and with underlying diseases should be vaccinated particularly in countries where the influenza vaccination is still not routinely implemented in the immunization schedule. Highlights Underlying diseases is a risk factor for influenza to be hospitalized and admitted to ICU. Influenza vaccination is of great importance to prevent life-threatening complications of influenza, particularly in children require ICU admission. The possibility to reduce the outpatient visit number by vaccination has a great impact on disease burden in addition to the underestimated crucial social benefits, as well.
    MeSH term(s) Adolescent ; Child ; Child, Preschool ; Female ; Hospitalization/statistics & numerical data ; Humans ; Infant ; Infant, Newborn ; Influenza A virus/isolation & purification ; Influenza B virus/isolation & purification ; Influenza Vaccines/administration & dosage ; Influenza, Human/mortality ; Influenza, Human/prevention & control ; Intensive Care Units/statistics & numerical data ; Logistic Models ; Male ; Retrospective Studies ; Risk Factors ; Turkey/epidemiology
    Chemical Substances Influenza Vaccines
    Language English
    Publishing date 2021-02-09
    Publishing country United States
    Document type Journal Article
    ZDB-ID 752392-0
    ISSN 1096-9071 ; 0146-6615
    ISSN (online) 1096-9071
    ISSN 0146-6615
    DOI 10.1002/jmv.26833
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: The use of serum endothelial adhesion molecules in pediatric patients with leukemia with febrile neutropenia to predict bacteremia.

    Arıkan, Kamile / Karadağ-Oncel, Eda / Aytac, Selin / Cengiz, Ali Bülent / Duygu Cetinkaya, Fahriye / Kara, Ates / Ceyhan, Mehmet

    Cytokine

    2021  Volume 148, Page(s) 155692

    Abstract: Objective: Febrile neutropenia (FN) represents a life-threatening complication in hematological malignancies. We aimed to analyze the utility of soluble vascular cell adhesion molecule 1 (sVCAM-1), intercellular adhesion molecule 1 (sICAM-1), vascular ... ...

    Abstract Objective: Febrile neutropenia (FN) represents a life-threatening complication in hematological malignancies. We aimed to analyze the utility of soluble vascular cell adhesion molecule 1 (sVCAM-1), intercellular adhesion molecule 1 (sICAM-1), vascular endothelial growth factor (VEGF) levels compared with C-reactive protein (CRP) and procalcitonin (PCT) during febrile neutropenia episodes of pediatric patients with leukemia.
    Methods: Two plasma samples, on day 0 (initial of episode) and day 3 (48-72 h after episode), for VCAM-1, ICAM-1 and VEGF, CRP and PCT were prospectively collected concomitantly during each febrile neutropenic episode between December 2016 and December 2017. The primary outcome was bacteremia and the secondary outcome was intensive care unit (ICU) admission.
    Results: Twenty-two (28.6%) acute lymphoblastic lymphoma (ALL), seventeen (22.1%) acute myeloblastic lymphoma (AML) patients and thirty-eight (49.3%) control patients with no known underlying disease or fever were included in this study. Of the 39 patients; 16 (41%) had bacteremia. Mean serum sVCAM1 and sICAM1 levels were significantly higher in control group, compared to FN patients (p < 0.001). Mean serum sVCAM2 level was significantly higher in FN patients with bacteremia compared to FN patients without bacteremia (144.97 ± 70.35 pg/mL vs 85.45 ± 53.76 pg/mL, p = 0.022). Mean sVCAM1 and 2 levels were higher in FN patients with ICU admission. In this study, we found that sVCAM-1 and VEGF, when combined to CRP and PCT, could predict gram-negative bacteremia in FN episodes of pediatric hematological malignancy.
    Conclusion: Serum endothelial adhesion molecules, excluding sVCAM-1, cannot predict bacteremia and ICU admission alone in FN patients; but may be associated with clinical outcome when used with PCT and CRP.
    MeSH term(s) Bacteremia/blood ; Bacteremia/complications ; Cell Adhesion Molecules/blood ; Child ; Child, Preschool ; Endothelial Cells/metabolism ; Febrile Neutropenia/blood ; Febrile Neutropenia/complications ; Febrile Neutropenia/microbiology ; Humans ; Infant ; Intensive Care Units ; Leukemia/blood ; Leukemia/complications ; Leukemia/microbiology ; Logistic Models ; Multivariate Analysis ; ROC Curve ; Treatment Outcome ; Vascular Endothelial Growth Factor A/blood
    Chemical Substances Cell Adhesion Molecules ; Vascular Endothelial Growth Factor A
    Language English
    Publishing date 2021-09-06
    Publishing country England
    Document type Journal Article ; Observational Study
    ZDB-ID 1018055-2
    ISSN 1096-0023 ; 1043-4666
    ISSN (online) 1096-0023
    ISSN 1043-4666
    DOI 10.1016/j.cyto.2021.155692
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article: Is it possible to attenuate amphotericin B-induced electrolyte imbalances in children with N-acetylcysteine?

    Arikan, Kamile / Karadag-Oncel, Eda / Cengiz, Ali Bülent / Ceyhan, Mehmet / Kara, Ates

    Trace elements and electrolytes

    2021  Volume 38, Issue 4, Page(s) 193

    Language German
    Document type Article
    ZDB-ID 1181166-3
    ISSN 0946-2104
    Database Current Contents Medicine

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