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  1. Article: Congenital Optic Disc Anomalies: Insights from Multimodal Imaging.

    Cennamo, Gilda / Rinaldi, Michele / Concilio, Marina / Costagliola, Ciro

    Journal of clinical medicine

    2024  Volume 13, Issue 5

    Abstract: In this comprehensive review, we delve into the significance of multimodal imaging in diagnosing and managing complications of congenital optic disc anomalies. While the fundus examination is the gold standard tool in the diagnosis of these pathologies, ... ...

    Abstract In this comprehensive review, we delve into the significance of multimodal imaging in diagnosing and managing complications of congenital optic disc anomalies. While the fundus examination is the gold standard tool in the diagnosis of these pathologies, spectral domain (SD) optical coherence tomography (OCT) and optical coherence tomography angiography (OCTA) could shed light on the pathogenesis and treatment. Moreover, this review seeks to offer a comprehensive insight into the multimodal approach of these rare congenital pathologies. In conclusion, congenital anomalies of the optic nerve represent a major challenge for ophthalmologists. Further research could be useful to clarify the pathophysiology of these diseases and define a correct and more specific treatment approach.
    Language English
    Publishing date 2024-03-06
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2662592-1
    ISSN 2077-0383
    ISSN 2077-0383
    DOI 10.3390/jcm13051509
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Choroidal Thickness and brolucizumab intravitreal injection: Cause or effect of intraocular inflammation?

    Cennamo, Gilda / Rinaldi, Michele / Malvone, Emanuele / Costagliola, Ciro

    Photodiagnosis and photodynamic therapy

    2024  Volume 47, Page(s) 104072

    Abstract: Purpose: to analyze the structural changes of choroidal thickness in patients with brolucizumab-related exudative vitritis after intravitreal injection, using EDI-OCT.: Methods: One hundred eyes of one hundred patients, affected by exudative age ... ...

    Abstract Purpose: to analyze the structural changes of choroidal thickness in patients with brolucizumab-related exudative vitritis after intravitreal injection, using EDI-OCT.
    Methods: One hundred eyes of one hundred patients, affected by exudative age related-macular degeneration treated with brolucizumab intravitreal injection between January 2022 and august 2023 at Eye clinic of University of Federico II Naples, were enrolled. All eyes underwent macular examination using Enhanced Deep Imaging-OCT (Spectralis, Heidelberg Engineering inc.) preoperatively and at each postoperative check (1, 3, 6, 12 months). Anterior segment evaluation at slit lamp before and after injection was performed.
    Results: Of the 100 treated eyes, 4 showed inflammatory signs related to exudative vitreitis, with inflammation signs at slit lamp examination and confirmed by OCT and B scan ecography. EDI-OCT revealed, in all of these 4 patients, a significant increase of choroidal thickness compared to baseline.
    Conclusion: choroidal thickness could be correlated in the inflammatory response generated in patients undergoing treatment with brolucizumab.
    Language English
    Publishing date 2024-03-30
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 2149918-4
    ISSN 1873-1597 ; 1572-1000
    ISSN (online) 1873-1597
    ISSN 1572-1000
    DOI 10.1016/j.pdpdt.2024.104072
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  3. Article: Exploring the Impact of Glycemic Control on Diabetic Retinopathy: Emerging Models and Prognostic Implications.

    Tecce, Nicola / Cennamo, Gilda / Rinaldi, Michele / Costagliola, Ciro / Colao, Annamaria

    Journal of clinical medicine

    2024  Volume 13, Issue 3

    Abstract: This review addresses the complexities of type 1 diabetes (T1D) and its associated complications, with a particular focus on diabetic retinopathy (DR). This review outlines the progression from non-proliferative to proliferative diabetic retinopathy and ... ...

    Abstract This review addresses the complexities of type 1 diabetes (T1D) and its associated complications, with a particular focus on diabetic retinopathy (DR). This review outlines the progression from non-proliferative to proliferative diabetic retinopathy and diabetic macular edema, highlighting the role of dysglycemia in the pathogenesis of these conditions. A significant portion of this review is devoted to technological advances in diabetes management, particularly the use of hybrid closed-loop systems (HCLSs) and to the potential of open-source HCLSs, which could be easily adapted to different patients' needs using big data analytics and machine learning. Personalized HCLS algorithms that integrate factors such as patient lifestyle, dietary habits, and hormonal variations are highlighted as critical to reducing the incidence of diabetes-related complications and improving patient outcomes.
    Language English
    Publishing date 2024-01-31
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2662592-1
    ISSN 2077-0383
    ISSN 2077-0383
    DOI 10.3390/jcm13030831
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article: Editorial: Ocular ultrasonography and optical coherence tomography in the optic nerve disease.

    Rosa, Nicola / Cennamo, Gilda / De Bernardo, Maddalena

    Frontiers in medicine

    2023  Volume 10, Page(s) 1161123

    Language English
    Publishing date 2023-02-28
    Publishing country Switzerland
    Document type Editorial
    ZDB-ID 2775999-4
    ISSN 2296-858X
    ISSN 2296-858X
    DOI 10.3389/fmed.2023.1161123
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Reply to comment on: Morphovascular changes after Anti-VEGF intravitreal injection for a choroidal neovascularization secondary to COVID-19 infection in a pediatric patient.

    Cennamo, Gilda / Massa, Luigi / Montanaro, Lucia / Magli, Adriano / Costagliola, Ciro

    Photodiagnosis and photodynamic therapy

    2023  Volume 43, Page(s) 103675

    MeSH term(s) Humans ; Child ; Intravitreal Injections ; Photosensitizing Agents/therapeutic use ; Photochemotherapy/methods ; COVID-19 ; Ranibizumab/therapeutic use ; Choroidal Neovascularization/drug therapy
    Chemical Substances Photosensitizing Agents ; Ranibizumab (ZL1R02VT79)
    Language English
    Publishing date 2023-06-25
    Publishing country Netherlands
    Document type Letter
    ZDB-ID 2149918-4
    ISSN 1873-1597 ; 1572-1000
    ISSN (online) 1873-1597
    ISSN 1572-1000
    DOI 10.1016/j.pdpdt.2023.103675
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  6. Article ; Online: Morphovascular changes after anti-VEGF intravitreal injection for a choroidal neovascularization secondary to COVID-19 infection in a pediatric patient.

    Cennamo, Gilda / Massa, Luigi / Montanaro, Lucia / Magli, Adriano / Costagliola, Ciro

    Photodiagnosis and photodynamic therapy

    2023  Volume 42, Page(s) 103577

    Abstract: Choroidal neovascularization (CNV) is a common pathologic lesion that occurs in various chorioretinopathy. Although the incidence of CNV is quite rare in children and adolescents, these lesions have a severe impact on visual acuity and quality of life ... ...

    Abstract Choroidal neovascularization (CNV) is a common pathologic lesion that occurs in various chorioretinopathy. Although the incidence of CNV is quite rare in children and adolescents, these lesions have a severe impact on visual acuity and quality of life over patients' lifetime. The management of CNV in pediatric patients is challenging, clear guidelines are limited due to a lack of randomized clinical trials. However, the more promising option is the use of vascular endothelial growth factor (VEGF) inhibitors. We reported a case of recurrent idiopathic choroidal neovascularization in a healthy pediatric patient after COVID 19 infection. Optical coherence tomography angiofraphy (OCTA) showed, in a non invasive way, a choroidal neovascularization at the posterior pole including macula and superior temporal arcade in the right eye, while the left eye was unaffected. In order to inactivate the neovascularization, intravitreal injections of anti-VEGF (Lucentis-Ranibizumab 0.3 mL) were performed in the right eye. Six months after the injections BCVA of the right eye was improved from 0.7 logMAR to 0.2 logMAR. OCT-A examination did not detect any signs of attivation of the preexistent neovascularization. It is reasonable to assert that Anti-VEGF could be the main treatment in case of choroidal neovascularization in young patients after COVID 19 infection due to the high chorioretinal level of VEGF-A described in these diseases.
    MeSH term(s) Adolescent ; Humans ; Child ; Vascular Endothelial Growth Factor A ; Angiogenesis Inhibitors/therapeutic use ; Intravitreal Injections ; Quality of Life ; Photosensitizing Agents/therapeutic use ; Photochemotherapy/methods ; COVID-19/complications ; COVID-19/pathology ; Ranibizumab/therapeutic use ; Choroidal Neovascularization/drug therapy ; Macula Lutea ; Tomography, Optical Coherence ; Fluorescein Angiography ; Retrospective Studies
    Chemical Substances Vascular Endothelial Growth Factor A ; Angiogenesis Inhibitors ; Photosensitizing Agents ; Ranibizumab (ZL1R02VT79)
    Language English
    Publishing date 2023-04-19
    Publishing country Netherlands
    Document type Case Reports
    ZDB-ID 2149918-4
    ISSN 1873-1597 ; 1572-1000
    ISSN (online) 1873-1597
    ISSN 1572-1000
    DOI 10.1016/j.pdpdt.2023.103577
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  7. Article ; Online: Evaluation of changes in epivascular glia before and after intravitreal dexamethasone implant: An OCT pilot study.

    Cennamo, Gilda / Montanaro, Lucia / Massa, Luigi / Malvone, Emanuele / Costagliola, Ciro

    Photodiagnosis and photodynamic therapy

    2023  Volume 43, Page(s) 103688

    Abstract: Purpose: To detect changes in epivascular glia (EVG) in diabetic retinopathy after intravitreal dexamethasone implant using en face optical coherence tomography (enface OCT) and OCT angiography (OCTA) and to correlate improvements in functional and ... ...

    Abstract Purpose: To detect changes in epivascular glia (EVG) in diabetic retinopathy after intravitreal dexamethasone implant using en face optical coherence tomography (enface OCT) and OCT angiography (OCTA) and to correlate improvements in functional and structural features.
    Methods: A total of 38 eyes of 38 patients were enroled in this prospective study. They were divided into two different study groups: the first group including 20 eyes with diabetic retinopathy type 1 complicated by macular oedema and the control group including 18 eyes from 18 healthy age-matched patients. The main outcome measures were: (i) differences at baseline in the foveal avascuar zone (FAZ) area in the study group versus control; (ii) the presence of epivascular glia in the study group versus control, (iii) differences at baseline between foveal macular thickness versus control; (iv) changes in foveal macular thickness, FAZ and epivascular glia in the study group before and after intravitreal dexamethasone implant.
    Results: At baseline FAZ area detected at OCTA was larger in the study group than in the control group, and epivascular glia was only detected in the study group. Three months after intravitreal injection of dexamethasone implant in the study group the best corrected visual acuity (BCVA) improved and central macular tickness reduced (P<0.0001). No significant differences were found in FAZ area while epivascular glia disappeared in 80% of the patients after treatment.
    Conclusions: Glia activation due to retinal inflammation in diabetic retinopathy (DR) can be detected on en face-OCT as epivascular glia. Intravitreal dexamethasone (DEX) implant improves both the anatomical and functional condition in the presence of these signs.
    MeSH term(s) Humans ; Dexamethasone/therapeutic use ; Glucocorticoids ; Diabetic Retinopathy/drug therapy ; Pilot Projects ; Prospective Studies ; Photochemotherapy/methods ; Photosensitizing Agents/therapeutic use ; Macula Lutea ; Tomography, Optical Coherence/methods ; Intravitreal Injections ; Retrospective Studies ; Treatment Outcome
    Chemical Substances Dexamethasone (7S5I7G3JQL) ; Glucocorticoids ; Photosensitizing Agents
    Language English
    Publishing date 2023-07-01
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 2149918-4
    ISSN 1873-1597 ; 1572-1000
    ISSN (online) 1873-1597
    ISSN 1572-1000
    DOI 10.1016/j.pdpdt.2023.103688
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  8. Article ; Online: Changes in macular pigment optical density after full-thickness macular hole closure using inverted flap technique.

    Rinaldi, Michele / Cennamo, Gilda / Passaro, Maria Laura / Costagliola, Ciro

    Photodiagnosis and photodynamic therapy

    2023  Volume 45, Page(s) 103950

    Abstract: Full-thickness macular hole (FTMH) is a debilitating retinal disorder, particularly in its advanced forms, necessitating surgical intervention for vision restoration. This case report details the successful closure of a large FTMH using the inverted flap ...

    Abstract Full-thickness macular hole (FTMH) is a debilitating retinal disorder, particularly in its advanced forms, necessitating surgical intervention for vision restoration. This case report details the successful closure of a large FTMH using the inverted flap technique, highlighting the essential role of multimodal imaging, and particularly macular pigment optical density (MPOD) assessment, in preoperative and postoperative evaluation. A 55-year-old patient presented with severe vision loss in one eye due to a large FTMH. Surgery was performed by an expert vitreoretinal surgeon, resulting in significant postoperative improvements in visual acuity and retinal architecture. Multimodal imaging, including MPOD assessment, played a pivotal role in preoperative evaluation and postoperative monitoring. The notable increase in MPOD following successful surgery suggests its potential role as a valuable adjunctive biomarker associated with a good visual prognosis following this type of macular hole surgical interventions.
    MeSH term(s) Humans ; Middle Aged ; Retinal Perforations/surgery ; Macular Pigment ; Photochemotherapy/methods ; Photosensitizing Agents ; Retinal Diseases
    Chemical Substances Macular Pigment ; Photosensitizing Agents
    Language English
    Publishing date 2023-12-23
    Publishing country Netherlands
    Document type Case Reports
    ZDB-ID 2149918-4
    ISSN 1873-1597 ; 1572-1000
    ISSN (online) 1873-1597
    ISSN 1572-1000
    DOI 10.1016/j.pdpdt.2023.103950
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  9. Article ; Online: Structural and vascular features in cavitary congenital optic disc anomaly associated with metaphyseal acroscyphodysplasia.

    Fossataro, Federica / D'Andrea, Luca / Cennamo, Gilda

    European journal of ophthalmology

    2021  Volume 32, Issue 4, Page(s) NP34–NP37

    Abstract: Purpose: To evaluate the radial peripapillary vascular plexus of a cavitary congenital optic disc anomaly in a young patient with recessive autosomal metaphyseal acroscyphodysplasia using optical coherence tomography angiography (OCTA).: Methods: ... ...

    Abstract Purpose: To evaluate the radial peripapillary vascular plexus of a cavitary congenital optic disc anomaly in a young patient with recessive autosomal metaphyseal acroscyphodysplasia using optical coherence tomography angiography (OCTA).
    Methods: Observational case report.
    Results: A 17-year-old man, with diagnosis of metaphyseal acroscyphodysplasia was referred to Eye Clinic for fundus examination and multimodal imaging for retinal epithelium hypertrophy in the right eye. Clinical examination showed cup-shaped metaphyses, short stature, hyperthelorism, and telecanthus. An optic disc coloboma was detected in the right eye on fundus examination. Wide field en-face Optical Coherence Tomography (OCT) showed a hyporeflective area corresponding to the right optic disc coloboma. At OCTA examination, the whole papillary region revealed a rarefaction of the vascular network, while the ganglion cell complex's and retinal fiber layers' parameters were normal in both eyes.
    Conclusion: The presence of coloboma disc congenital defect linked to embryological abnormalities during the development process could pave the way for a wider understanding of the pathogenesis of metaphyseal acroscyphodysplasia by increasingly framing it as a systemic disease.
    MeSH term(s) Adolescent ; Coloboma/diagnosis ; Epiphyses/abnormalities ; Exostoses, Multiple Hereditary ; Eye Abnormalities/pathology ; Fluorescein Angiography/methods ; Hand Deformities, Congenital ; Humans ; Knee/abnormalities ; Male ; Optic Disk/pathology ; Optic Nerve/abnormalities ; Tomography, Optical Coherence/methods
    Language English
    Publishing date 2021-02-14
    Publishing country United States
    Document type Case Reports ; Journal Article ; Observational Study
    ZDB-ID 1089461-5
    ISSN 1724-6016 ; 1120-6721
    ISSN (online) 1724-6016
    ISSN 1120-6721
    DOI 10.1177/1120672121995745
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 3342: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  10. Article ; Online: Multimodal imaging in differential diagnosis between papilledema and choroidal neovascularization associated with morning glory syndrome.

    Cennamo, Gilda / Montorio, Daniela / Brescia Morra, Vincenzo / Costagliola, Ciro

    European journal of ophthalmology

    2022  Volume 33, Issue 6, Page(s) NP100–NP102

    Abstract: Purpose: To describe the role of optical coherence tomography angiography (OCTA) to help in differential diagnosis between papilledema and a rare case of choroidal neovascularization (CNV) associated with Morning Glory Syndrome (MGS).: Methods: ... ...

    Abstract Purpose: To describe the role of optical coherence tomography angiography (OCTA) to help in differential diagnosis between papilledema and a rare case of choroidal neovascularization (CNV) associated with Morning Glory Syndrome (MGS).
    Methods: Observational case report.
    Results: A 22-year old man was referred to Eye clinic from Neurological unit with a diagnosis of papilledema in right eye. OCTA scans on the optic disc revealed a dense radial peripapillary vascular network while two polypoidal choroidal vasculopathy (PCV) were present in peripapillary region at the edge of staphyloma in corrispondence of choriocapillary layer. Therefore, the patient underwent three-monthly intravitreal injections of anti-vascular endothelial growth factor. One and six months after loading phase, the PCVs showed no clinical activity at structural spectral domain-OCT and OCTA.
    Conclusion: This case revealed the crucial role of OCTA as an efficace diagnostic technique in discriminating papilledema from MGS complicated by CNV, allowing to make differential diagnosis, useful in ophthalmological and neurological clinical practice.
    Language English
    Publishing date 2022-12-04
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1089461-5
    ISSN 1724-6016 ; 1120-6721
    ISSN (online) 1724-6016
    ISSN 1120-6721
    DOI 10.1177/11206721221143606
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 3342: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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