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Article ; Online: Idiopathic Granulomatous Mastitis: The Importance of Summarizing the Heterogenous Evidence of the Current Literature.

Barra, Fabio / Centurioni, Maria Grazia / Gustavino, Claudio / Alessandri, Franco / Ferrero, Simone

Journal of investigative surgery : the official journal of the Academy of Surgical Research

2021 Volume 35, Issue 3, Page(s) 721–722

MeSH term(s)	Diagnosis, Differential ; Female ; Granulomatous Mastitis/diagnosis ; Granulomatous Mastitis/surgery ; Humans
Language	English
Publishing date	2021-03-27
Publishing country	United States
Document type	Journal Article
ZDB-ID	639444-9
ISSN	1521-0553 ; 0894-1939
ISSN (online)	1521-0553
ISSN	0894-1939
DOI	10.1080/08941939.2021.1901162
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Article ; Online: Fishbone double-layer barbed suture in cesarean section: a help in preventing long-term obstetric sequelae?

Alessandri, Franco / Evangelisti, Giulio / Centurioni, Maria Grazia / Gustavino, Claudio / Ferrero, Simone / Barra, Fabio

Archives of gynecology and obstetrics

2021 Volume 304, Issue 3, Page(s) 573–576

Abstract: Due to the high number of cesarean sections over the last two decades, there has been a growing awareness of the post-surgical obstetric long-term sequelae (i.e., uterine scar defects and abnormal placentation) following this surgical procedure. Knotless ...

Abstract	Due to the high number of cesarean sections over the last two decades, there has been a growing awareness of the post-surgical obstetric long-term sequelae (i.e., uterine scar defects and abnormal placentation) following this surgical procedure. Knotless barbed suture is an absorbable bidirectional and unidirectional monofilament, characterized by the presence of "barbs" along its length. After being introduced in gynecology, the favorable features of the knotless barbed suture, such as the uniform distribution of tensile force, provide the rationale for studying its benefits in obstetric surgery. Recently, our research group has investigated a double-layer barbed suture ("fishbone" suture) for closing the uterine wall during cesarean section by a case-control study, reporting a low incidence of uterine scar defects and a reduced size of defects in women who had developed them (NCT04825821). In the near future, large prospective studies are strongly awaited to investigate reproductive outcomes and long-term sequelae after cesarean section performed with knotless barbed suture.
MeSH term(s)	Case-Control Studies ; Cesarean Section/adverse effects ; Female ; Humans ; Pregnancy ; Suture Techniques ; Sutures/adverse effects
Language	English
Publishing date	2021-06-19
Publishing country	Germany
Document type	News
ZDB-ID	896455-5
ISSN	1432-0711 ; 0932-0067
ISSN (online)	1432-0711
ISSN	0932-0067
DOI	10.1007/s00404-021-06121-8
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Article: Histopathological and Immunohistochemical Prognostic Factors in High-Grade Non-Endometrioid Carcinomas of the Endometrium (HG-NECs): Is It Possible to Identify Subgroups at Increased Risk?

Paudice, Michele / Biatta, Chiara Maria / Scaglione, Giulia / Parodi, Alessia / Mammoliti, Serafina / Moioli, Melita / Centurioni, Maria Grazia / Barra, Fabio / Ferrero, Simone / De Cian, Franco / Mazzocco, Katia / Vellone, Valerio Gaetano

Diagnostics (Basel, Switzerland)

2023 Volume 13, Issue 13

Abstract: Endometrial cancer is an emerging disease with an increase in prevalence of aggressive histotypes in recent years.: Background: In the present study, potential histopathological and immunohistochemical prognostic markers were investigated. Consecutive ...

Abstract	Endometrial cancer is an emerging disease with an increase in prevalence of aggressive histotypes in recent years. Background: In the present study, potential histopathological and immunohistochemical prognostic markers were investigated. Consecutive cases of high-grade non-endometrioid carcinoma (HG-NEC) of the endometrium were considered. Methods: Each surgical specimen was routinely processed; the most significant block was selected for immunohistochemistry and tested for ER, PR, ki67, p53, E-cadherin, β-catenin, Bcl-2 and cyclin D1. For each immunomarker, the percentage of positive tumor cells was evaluated (%) and dichotomized as low and high according to the distribution in the study population. Follow-up was collected for disease-free survival (DFS) and overall survival (OS). Thirty-three cases were eligible: 19 resulted in FIGO I-II; 14 resulted in FIGO III-IV. Twelve patients suffered a recurrent disease (mean follow-up 24.6 months); 8 patients died of the disease (mean follow-up 26.6 months). Results: Women with recurrent disease demonstrated a significantly higher Bcl2% (35.84 ± 30.96% vs. 8.09 ± 11.56%; Conclusions: HG-NEC represents a heterogeneous group of endometrial aggressive neoplasms with a worrisome prognosis, often at an advanced stage at presentation. Bcl-2 and PR may represent promising markers to identify a subgroup of patients having an even worse prognosis requiring a careful and close follow-up.
Language	English
Publishing date	2023-06-26
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2662336-5
ISSN	2075-4418
ISSN	2075-4418
DOI	10.3390/diagnostics13132171
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Article ; Online: Vaginal Natural Orifice Transluminal Endoscopic Surgery (NOTES) for Treating Benign Adnexal Diseases: Past Results and Future Developments.

Evangelisti, Giulio / Barra, Fabio / Centurioni, Maria Grazia / D'Alessandro, Gloria / Alessandri, Franco / Ferrero, Simone

Journal of investigative surgery : the official journal of the Academy of Surgical Research

2020 Volume 35, Issue 2, Page(s) 409–410

MeSH term(s)	Adnexal Diseases/surgery ; Female ; Humans ; Laparoscopy ; Natural Orifice Endoscopic Surgery ; Vagina/surgery
Language	English
Publishing date	2020-12-08
Publishing country	United States
Document type	Letter
ZDB-ID	639444-9
ISSN	1521-0553 ; 0894-1939
ISSN (online)	1521-0553
ISSN	0894-1939
DOI	10.1080/08941939.2020.1843205
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Article ; Online: Serum Albumin in Patients Affected by Gynecological Cancers: Can It Have a Future Role in Prognostic Index or Nomogram?

Barra, Fabio / Alessandri, Franco / Evangelisti, Giulio / Centurioni, Maria Grazia / Ferrero, Simone

Journal of investigative surgery : the official journal of the Academy of Surgical Research

2020 Volume 35, Issue 2, Page(s) 432–433

MeSH term(s)	Humans ; Neoplasms ; Nomograms ; Prognosis ; Serum Albumin
Chemical Substances	Serum Albumin
Language	English
Publishing date	2020-12-02
Publishing country	United States
Document type	Journal Article ; Comment
ZDB-ID	639444-9
ISSN	1521-0553 ; 0894-1939
ISSN (online)	1521-0553
ISSN	0894-1939
DOI	10.1080/08941939.2020.1845881
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Article ; Online: Incidence and ultrasonographic characteristics of cesarean scar niches after uterine closure by double-layer barbed suture: A prospective comparative study.

Alessandri, Franco / Centurioni, Maria Grazia / Perrone, Umberto / Evangelisti, Giulio / Urso, Claudia / Paratore, Marco / Guida, Elisabetta / Nappini, Alice / Gustavino, Claudio / Ferrero, Simone / Barra, Fabio

International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics

2023 Volume 162, Issue 3, Page(s) 895–905

Abstract: Objective: To compare the ultrasonographic features of uterine scars and clinical symptoms after cesarean delivery (CD) using barbed and conventional smooth sutures.: Methods: This case-control study enrolled women who underwent primary CD at 37 ... ...

Abstract	Objective: To compare the ultrasonographic features of uterine scars and clinical symptoms after cesarean delivery (CD) using barbed and conventional smooth sutures. Methods: This case-control study enrolled women who underwent primary CD at 37 weeks of pregnancy or later. The uterus was closed using either double-layer unidirectional barbed suture or conventional double-layer smooth suture. Ultrasound scans of the uterine scar and evaluations of menstrual patterns were performed at 6, 12, and 24 months after surgery. Results: In all, 102 patients underwent uterine closure with barbed suture, while 135 patients underwent smooth suture. At 6 months, patients in the barbed group had a lower incidence of uterine niches (20.2% vs 32.6%) that were also shallower in depth (P < 0.001). Lower incidence of niches was also observed in the barbed group at 12 and 24 months (P = 0.043 and 0.048, respectively). At these two follow-up times, the smooth group had a higher number of patients reporting postmenstrual spotting (P < 0.05) and more postmenstrual spotting days per month (P < 0.050). Conclusion: The use of double-layer barbed suture during CD was associated with a lower incidence of scar niches and a more favorable menstrual pattern compared with the use of smooth suture.
MeSH term(s)	Pregnancy ; Humans ; Female ; Cicatrix/diagnostic imaging ; Cicatrix/epidemiology ; Cicatrix/etiology ; Case-Control Studies ; Incidence ; Prospective Studies ; Uterus/diagnostic imaging ; Uterus/surgery ; Sutures
Language	English
Publishing date	2023-03-15
Publishing country	United States
Document type	Journal Article
ZDB-ID	80149-5
ISSN	1879-3479 ; 0020-7292
ISSN (online)	1879-3479
ISSN	0020-7292
DOI	10.1002/ijgo.14744
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Article ; Online: BRCA mutation carriers' perception about benefits and risks associated with combined hormonal contraceptives use.

Grandi, Giovanni / Monari, Francesca / Boggio Sola, Valentina / Cortesi, Laura / Toss, Angela / Del Savio, Maria Chiara / Melotti, Chiara / Centurioni, Maria Grazia / Gustavino, Claudio / Varesco, Liliana / Facchinetti, Fabio / Barra, Fabio

The European journal of contraception & reproductive health care : the official journal of the European Society of Contraception

2022 Volume 27, Issue 6, Page(s) 439–444

Abstract: Objective: To evaluate the actual perceptions about combined hormonal contraceptives (CHCs) use in BRCA mutation carriers in comparison to women from the general population.: Methods: This was a cross-sectional, observational study involving two ... ...

Abstract	Objective: To evaluate the actual perceptions about combined hormonal contraceptives (CHCs) use in BRCA mutation carriers in comparison to women from the general population. Methods: This was a cross-sectional, observational study involving two Italian referral centres for hereditary cancers. An identical questionnaire investigating how CHC use could affect the risk of developing some types of cancer, specific diseases, and symptoms was administered to 85 BRCA mutation carriers and 85 healthy women without this genetic mutation (control group). Women's perceptions were evaluated using specific questions and Likert scales (-5 to +5). Results: Perceptions about the effects of CHC use on developing specific diseases and symptoms did not differ between BRCA mutation carriers and controls. Conversely, the protective effects of CHC use on colorectal ( Conclusions: Investing time and effort in transmitting the correct key messages about oncological risk related to CHC use could potentially increase their use in BRCA mutation carriers.
MeSH term(s)	Female ; Humans ; Contraceptive Agents ; Cross-Sectional Studies ; Mutation ; Perception ; Risk Assessment ; Heterozygote ; Genes, BRCA1 ; Genes, BRCA2 ; Health Knowledge, Attitudes, Practice
Chemical Substances	Contraceptive Agents
Language	English
Publishing date	2022-08-10
Publishing country	England
Document type	Observational Study ; Journal Article
ZDB-ID	1397560-2
ISSN	1473-0782 ; 1362-5187
ISSN (online)	1473-0782
ISSN	1362-5187
DOI	10.1080/13625187.2022.2107199
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Article ; Online: Natural Orifice Transluminal Endoscopic Surgery (NOTES): Landscape of Current Experimental Applications in Gynecological Surgery.

Barra, Fabio / Alessandri, Franco / Evangelisti, Giulio / Altieri, Michele / Soriero, Domenico / Gustavino, Claudio / Centurioni, Maria Grazia / Ferrero, Simone

Journal of investigative surgery : the official journal of the Academy of Surgical Research

2020 Volume 34, Issue 8, Page(s) 922–923

MeSH term(s)	Female ; Gynecologic Surgical Procedures ; Humans ; Natural Orifice Endoscopic Surgery
Language	English
Publishing date	2020-01-21
Publishing country	United States
Document type	Journal Article ; Comment
ZDB-ID	639444-9
ISSN	1521-0553 ; 0894-1939
ISSN (online)	1521-0553
ISSN	0894-1939
DOI	10.1080/08941939.2020.1713935
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Article ; Online: Pelvic Sentinel Lymph Node Detection: An Increasing Role in Surgical Approaches for Early-Stage Gynecological Malignant Diseases.

Barra, Fabio / Gallo, Gaetano / Evangelisti, Giulio / Gustavino, Claudio / Centurioni, Maria Grazia / Alessandri, Franco / Ferrero, Simone

Journal of investigative surgery : the official journal of the Academy of Surgical Research

2020 Volume 34, Issue 10, Page(s) 1119–1120

MeSH term(s)	Lymph Node Excision ; Lymph Nodes/surgery ; Pelvis/surgery ; Sentinel Lymph Node/surgery
Language	English
Publishing date	2020-04-30
Publishing country	United States
Document type	Journal Article ; Comment
ZDB-ID	639444-9
ISSN	1521-0553 ; 0894-1939
ISSN (online)	1521-0553
ISSN	0894-1939
DOI	10.1080/08941939.2020.1761489
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Article ; Online: Current and experimental drug therapy for the treatment of polycystic ovarian syndrome.

Della Corte, Luigi / Foreste, Virginia / Barra, Fabio / Gustavino, Claudio / Alessandri, Franco / Centurioni, Maria Grazia / Ferrero, Simone / Bifulco, Giuseppe / Giampaolino, Pierluigi

Expert opinion on investigational drugs

2020 Volume 29, Issue 8, Page(s) 819–830

Abstract: Introduction: Polycystic ovary syndrome (PCOS) is an endocrine disorder that affects 8-13% of reproductive-age women. Irregular periods, hirsutism, or infertility are the most common clinical presentations of patients affected by PCOS. This syndrome is ... ...

Abstract	Introduction: Polycystic ovary syndrome (PCOS) is an endocrine disorder that affects 8-13% of reproductive-age women. Irregular periods, hirsutism, or infertility are the most common clinical presentations of patients affected by PCOS. This syndrome is also linked to metabolic abnormalities such as type 2 diabetes, insulin resistance and obesity. The optimal therapeutic approach is still unknown. Areas covered: This narrative review offers an overview of the literature on current and experimental pharmacological options for treating PCOS and highlights ongoing clinical trials. Several electronic databases were searched and current research registers were analyzed to the present year. The papers selected for this review were critically analyzed, and all data available were summarized, organized, and explored to derive key information. Expert opinion: The main goal of PCOS treatment is to obtain a metabolic and hormonal balance. Optimal PCOS therapy should be direct to the reproductive abnormalities and the entire spectrum of endocrine and metabolic complications that appear to have a long-term negative impact on PCOS patient health, as in post-menopausal period. The discovery of new mechanisms in PCOS pathogenesis will offer the possibility of testing new drug classes.
MeSH term(s)	Animals ; Diabetes Mellitus, Type 2/etiology ; Drug Development ; Female ; Hirsutism/etiology ; Humans ; Insulin Resistance ; Obesity/etiology ; Polycystic Ovary Syndrome/complications ; Polycystic Ovary Syndrome/drug therapy ; Polycystic Ovary Syndrome/physiopathology
Language	English
Publishing date	2020-06-27
Publishing country	England
Document type	Journal Article ; Review
ZDB-ID	1182884-5
ISSN	1744-7658 ; 0967-8298 ; 1354-3784
ISSN (online)	1744-7658
ISSN	0967-8298 ; 1354-3784
DOI	10.1080/13543784.2020.1781815
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