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Article ; Online: Commentary on "A Misguided Venture: Presidential Fitness and the Duty to Warn".

Cepeda, Manuel

2018 Volume 111, Issue 12, Page(s) 770–771

MeSH term(s)	Duty to Warn
Language	English
Publishing date	2018-10-21
Publishing country	United States
Document type	Journal Article ; Comment
ZDB-ID	185329-6
ISSN	1541-8243 ; 0038-4348
ISSN (online)	1541-8243
ISSN	0038-4348
DOI	10.14423/SMJ.0000000000000895
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Article ; Online: The Burden of Cardiovascular Disease in the Post-COVID Era.

Liu, Justin / Cepeda, Maria / Frangaj, Brulinda / Shimbo, Daichi

Primary care

2023 Volume 51, Issue 1, Page(s) 1–11

Abstract: In 2019, before the COVID-19 pandemic, cardiovascular disease (CVD) was the leading cause of death. Since 2020, the pandemic has had far-reaching effects on the landscape of health care including CVD prevention and management. Recent decreases in life ... ...

Abstract	In 2019, before the COVID-19 pandemic, cardiovascular disease (CVD) was the leading cause of death. Since 2020, the pandemic has had far-reaching effects on the landscape of health care including CVD prevention and management. Recent decreases in life expectancy in the United States could potentially be explained by issues related to disruptions in CVD prevention and control of CVD risk factors from the COVID-19 pandemic. This article reviews the effects of the SARS-CoV-2 virus and the accompanying pandemic on CVD risk factor prevention and management in the United States. Potential solutions are also proposed for these patients.
MeSH term(s)	Humans ; United States/epidemiology ; Cardiovascular Diseases/epidemiology ; Cardiovascular Diseases/prevention & control ; Cardiovascular Diseases/etiology ; COVID-19 ; SARS-CoV-2 ; Pandemics ; Risk Factors
Language	English
Publishing date	2023-09-01
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	604005-6
ISSN	1558-299X ; 0095-4543
ISSN (online)	1558-299X
ISSN	0095-4543
DOI	10.1016/j.pop.2023.08.001
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Article ; Online: Status of ambulatory blood pressure monitoring and home blood pressure monitoring for the diagnosis and management of hypertension in the US: an up-to-date review.

Cepeda, Maria / Pham, Patrick / Shimbo, Daichi

Hypertension research : official journal of the Japanese Society of Hypertension

2023 Volume 46, Issue 3, Page(s) 620–629

Abstract: The diagnosis and management of hypertension has been based on the measurement of blood pressure (BP) in the office setting. However, data have demonstrated that BP may substantially differ when measured in the office than when measured outside the ... ...

Abstract	The diagnosis and management of hypertension has been based on the measurement of blood pressure (BP) in the office setting. However, data have demonstrated that BP may substantially differ when measured in the office than when measured outside the office setting. Higher out-of-office BP is associated with increased cardiovascular risk independent of office BP. Ambulatory BP monitoring (ABPM) and home BP monitoring (HBPM) are validated approaches for out-of-office BP measurement. In the 2015 and 2021 United States Preventive Services Task Force (USPSTF) reports on screening for hypertension, ABPM was recommended as the reference standard for out-of-office BP monitoring and for confirming an initial diagnosis of hypertension. This recommendation was based on data from more published studies of ABPM vs. HBPM on the predictive value of out-of-office BP independent of office BP. Therefore, HBPM was recommended as an alternative approach when ABPM was not available or well tolerated. The 2017 American College of Cardiology (ACC)/American Heart Association (AHA) BP guideline recommended ABPM as the preferred initial approach for detecting white-coat hypertension and masked hypertension among adults not taking antihypertensive medication. In contrast, HBPM was recommended as the preferred initial approach for detecting the white-coat effect and masked uncontrolled hypertension among adults taking antihypertensive medication. The current review provides an overview of ABPM and HBPM in the US, including best practices, BP thresholds that should be used for the diagnosis and treatment of hypertension, barriers to widespread use of such monitoring, US guideline recommendations for ABPM and HBPM, and data supporting HBPM over ABPM.
MeSH term(s)	Adult ; Humans ; United States ; Blood Pressure Monitoring, Ambulatory ; Antihypertensive Agents/therapeutic use ; Hypertension/drug therapy ; Blood Pressure Determination ; Blood Pressure
Chemical Substances	Antihypertensive Agents
Language	English
Publishing date	2023-01-05
Publishing country	England
Document type	Journal Article ; Review
ZDB-ID	1175297-x
ISSN	1348-4214 ; 0916-9636
ISSN (online)	1348-4214
ISSN	0916-9636
DOI	10.1038/s41440-022-01137-2
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Article: Assessing cross-border integration of capacity mechanisms in coupled electricity markets

Cepeda, Mauricio

Energy policy. 2018 Aug., v. 119

2018

Abstract: There is momentum in a number of European electricity markets towards the implementation of national generation capacity mechanisms. This renewed interest in capacity mechanisms raises the question of the cohabitation of both relatively well-integrated ... ...

Abstract	There is momentum in a number of European electricity markets towards the implementation of national generation capacity mechanisms. This renewed interest in capacity mechanisms raises the question of the cohabitation of both relatively well-integrated short-term energy markets and national generation capacity mechanisms. This paper examines a key issue of generation adequacy policies in a multi-market environment: the effect of foreign generators’ and interconnectors’ inclusion in national capacity mechanisms. The results show that the absence of cross-border participation could lead to significant social welfare losses associated with over and under-capacity procuring risk. This implies a vicious circle: as capacity mechanisms over or under-procure capacity, cross-border trade of electricity becomes more distorted, which in turn undermines the effectiveness of capacity mechanisms themselves. The findings also show that the inclusion of interconnectors in national capacity mechanisms could induce investments in merchant interconnections by compensating for network externalities and adjusting profit levels on the basis of the interconnection costs. However, despite the participation of interconnectors in capacity mechanisms, the exclusion of foreign generation of this market-based scheme undermines efficiency. In the absence of a wider EU single capacity mechanism, the inclusion of foreign generators and interconnectors in national capacity mechanisms should ensure the most efficient cohabitation of the EU Single Market and national capacity mechanisms.
Keywords	European Union ; electricity ; energy ; issues and policy ; markets ; momentum ; risk ; social welfare ; trade
Language	English
Dates of publication	2018-08
Size	p. 28-40.
Publishing place	Elsevier Ltd
Document type	Article
ISSN	0301-4215
DOI	10.1016/j.enpol.2018.04.016
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: Treatment patterns and comorbid burden of patients newly diagnosed with multiple sclerosis in the United States.

Kern, David M / Cepeda, M Soledad

BMC neurology

2020 Volume 20, Issue 1, Page(s) 296

Abstract: Background: The treatment landscape for multiple sclerosis (MS) is quickly evolving. Understanding real-world treatment patterns of patients is necessary to identifying potential gaps in care.: Methods: Patients with incident MS were identified from ... ...

Abstract	Background: The treatment landscape for multiple sclerosis (MS) is quickly evolving. Understanding real-world treatment patterns of patients is necessary to identifying potential gaps in care. Methods: Patients with incident MS were identified from a large national claims database during 1/1/2014-6/30/2019. Patients had ≥2 diagnoses for MS or an inpatient hospitalization with a primary diagnosis of MS. Patients were required to have enrollment in the database ≥1 year prior to and ≥ 1 year following their first MS diagnosis. Treatment sequences were captured for all available disease modifying therapies (DMTs) during all available follow-up. Presence of comorbid conditions were captured during the one year prior to and following (and including) the index date; absolute change in prevalence from the pre- to post-index periods was calculated. Results: We identified 5691 patients with incident MS. Common comorbidities included physical symptoms (e.g., pain, weakness, fatigue), mental health conditions (anxiety, depression), and cardiovascular/metabolic conditions (hypertension, hyperlipidemia, diabetes, obesity). Just 1994 (35.0%) of patients received a DMT at any time during follow-up. Of those receiving a DMT, 28.2% went on to receive a second line of therapy, 5.8% received a third, and just 0.9% went on to a fourth line. Use of more than one DMT concomitantly occurred in just 1.8% of all treated patients. Glatiramer and dimethyl fumarate were by far the most common first-line treatments received accounting for nearly 62% of patients receiving a DMT. Conclusion: Approximately two-thirds of patients newly diagnosed with MS did not receive a DMT and the disease is accompanied by a significant comorbid burden.
MeSH term(s)	Cardiovascular Diseases/epidemiology ; Comorbidity ; Databases, Factual ; Dimethyl Fumarate/therapeutic use ; Drug Utilization/statistics & numerical data ; Female ; Glatiramer Acetate/therapeutic use ; Humans ; Male ; Mental Disorders/epidemiology ; Middle Aged ; Multiple Sclerosis/diagnosis ; Multiple Sclerosis/drug therapy ; Multiple Sclerosis/epidemiology ; Retrospective Studies ; United States
Chemical Substances	Glatiramer Acetate (5M691HL4BO) ; Dimethyl Fumarate (FO2303MNI2)
Language	English
Publishing date	2020-08-11
Publishing country	England
Document type	Journal Article
ISSN	1471-2377
ISSN (online)	1471-2377
DOI	10.1186/s12883-020-01882-2
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Article ; Online: Differences between men and women in response to antiseizure medication use and the likelihood of developing treatment resistant epilepsy.

Cepeda, M Soledad / Teneralli, Rachel E / Kern, David M / Novak, Gerald

Epilepsia open

2022 Volume 7, Issue 4, Page(s) 598–607

Abstract: Objective: The prevalence of epilepsy is slightly higher in women than in men and sensitivity to seizure stimuli differs between sexes. Some evidence suggests sex differences in response to antiseizure medications exist mainly due to inconsistent ... ...

Abstract	Objective: The prevalence of epilepsy is slightly higher in women than in men and sensitivity to seizure stimuli differs between sexes. Some evidence suggests sex differences in response to antiseizure medications exist mainly due to inconsistent pharmacokinetic differences; however, there is a lack of real-world evidence examining differences in response to antiseizure medications between men and women. Methods: This was a retrospective population-based cohort study in five large US healthcare databases. The population included adult patients with epilepsy, newly exposed to levetiracetam, and naive to antiseizure medication. The first exposure to levetiracetam was the index date. The requirement that all patients received the same medication was done to avoid potential confounding due to differences in index treatment. The outcome was the development of treatment resistant epilepsy (TRE), defined as having at least three distinct antiseizure medications in 1 year. The proportion of patients who developed TRE within 1 year following the index date was calculated. To compare the risk of developing TRE between sexes, relative risks (RR) and 95% confidence intervals (CI) were calculated, and estimates were pooled using meta-analytic techniques stratified by gender and age. Results: A total of 147 334 subjects were included in the databases, 50.8% were women, and 4.27% developed TRE. The comorbid profile differed greatly between men and women; however, the types of epilepsy syndromes observed during baseline were similar between the two groups. Across all databases, women were more likely to develop TRE than men (pooled RR 1.27, 95% CI 1.17-1.38). Results remained similar when stratified by age. Significance: This study assessed sex differences in response to antiseizure medications using the development of TRE as a proxy for effectiveness. Women newly exposed to levetiracetam were 27% more likely to develop TRE than men, independent of age.
MeSH term(s)	Adult ; Female ; Humans ; Male ; Levetiracetam/therapeutic use ; Anticonvulsants/therapeutic use ; Retrospective Studies ; Cohort Studies ; Epilepsy/drug therapy
Chemical Substances	Levetiracetam (44YRR34555) ; Anticonvulsants
Language	English
Publishing date	2022-08-08
Publishing country	United States
Document type	Journal Article
ISSN	2470-9239
ISSN (online)	2470-9239
DOI	10.1002/epi4.12632
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Article ; Online: Treatment patterns of patients diagnosed with major depressive disorder and suicidal ideation or attempt: a U.S. population-based study utilizing real-world data.

Kern, David M / Cepeda, M Soledad / Wiegand, Frank

BMC psychiatry

2021 Volume 21, Issue 1, Page(s) 608

Abstract: Background: There is a knowledge gap regarding the treatment patterns of patients with major depressive disorder (MDD) who experience suicidal ideation or a suicide attempt (SI/SA).: Methods: Patients with SI/SA were identified from a large US-based ... ...

Abstract	Background: There is a knowledge gap regarding the treatment patterns of patients with major depressive disorder (MDD) who experience suicidal ideation or a suicide attempt (SI/SA). Methods: Patients with SI/SA were identified from a large US-based claims database covering 84 million lives, during 1/1/2014-3/31/2020. Patients with MDD were indexed at their first diagnosis for SI/SA and followed up to 365 days. Treatment patterns were captured at the class level and included procedures of electroconvulsive therapy and transcranial magnetic stimulation, and pharmacotherapy including selective serotonin reuptake inhibitors (SSRIs), serotonin and norepinephrine reuptake inhibitors, tricyclic antidepressants, other antidepressants, anxiolytics, hypnotics/sedatives, antipsychotics, psychostimulants, and lithium. Results: There were 42,204 MDD + SI/SA patients identified. In the year prior to the index event > 40% of individuals received an SSRI and more than one-third received an anxiolytic. Within 1 year following, 84.4% received ≥1 of the treatments of interest. Of those, 70.2% went on to a subsequent class-based regimen, 46.3% received a third, and 28.1% received ≥4. More than three-quarters of patients received multiple treatment classes simultaneously. SSRIs were the most common treatments during follow-up (61.9%), followed by other antidepressants (51.3%), anxiolytics (50.8%) and anticonvulsants (43.6%). Conclusions: There was a large amount of variability and polypharmacy in the treatments received by MDD patients with SI/SA, and is much more complex than what has been previously observed in the general MDD population. Within one-year, many patients received four or more unique class-based regimens and most patients received treatments from multiple classes simultaneously, indicating the high unmet medical need and therapy refractoriness of this patient population.
MeSH term(s)	Antidepressive Agents/therapeutic use ; Antidepressive Agents, Tricyclic/therapeutic use ; Depressive Disorder, Major/drug therapy ; Humans ; Serotonin Uptake Inhibitors/therapeutic use ; Suicidal Ideation
Chemical Substances	Antidepressive Agents ; Antidepressive Agents, Tricyclic ; Serotonin Uptake Inhibitors
Language	English
Publishing date	2021-12-06
Publishing country	England
Document type	Journal Article
ZDB-ID	2050438-X
ISSN	1471-244X ; 1471-244X
ISSN (online)	1471-244X
ISSN	1471-244X
DOI	10.1186/s12888-021-03616-1
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Article: Sociocultural factors during COVID-19 pandemic: Information consumption on Twitter.

Perez-Cepeda, Maximiliano / Arias-Bolzmann, Leopoldo G

Journal of business research

2021 Volume 140, Page(s) 384–393

Abstract: The purpose of the research is to describe the sociocultural factors that emerged during the COVID-19 pandemic. Twitter is used as an instrument for data collection. The study is qualitative and uses the netnographic method. To analyze the flow of ... ...

Abstract	The purpose of the research is to describe the sociocultural factors that emerged during the COVID-19 pandemic. Twitter is used as an instrument for data collection. The study is qualitative and uses the netnographic method. To analyze the flow of messages posted on Twitter, the model proposed by Perez-Cepeda and Arias-Bolzmann (2020), which describes sociocultural factors, is taken as a basis. The semantics that people use are a type of functional knowledge that reveals sociocultural factors. Sentiments were analyzed through lexicon-based methods, which are the most suitable. The categorization and classification of the data are performed based on the information that users post on Twitter. The tweets related to COVID-19 describe the sociocultural issues and the level of sentiment around the pandemic. The discussion centers on the COVID-19 pandemic, information consumption, lexicon, sociocultural factors and sentiment analysis. The study was limited to the social media Twitter; another limitation was not to consider the social group of the users who interact with @pandemic_Covid-19, official account of the World Health Organization (WHO). This research contributes to the social sciences, focusing on sociocultural interaction through the use of the social network Twitter. It describes the link between sociocultural factors and the level of sentiment on issues related to the COVID-19 pandemic.
Language	English
Publishing date	2021-11-11
Publishing country	United States
Document type	Journal Article
ISSN	0148-2963
ISSN	0148-2963
DOI	10.1016/j.jbusres.2021.11.008
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Article: Somatic Embryogenesis and

Barrera, Marion / Olmedo, Blanca / Zúñiga, Carolina / Cepeda, Mario / Olivares, Felipe / Vergara, Ricardo / Cordero-Lara, Karla / Prieto, Humberto

Plants (Basel, Switzerland)

2024 Volume 13, Issue 3

Abstract: Rice ( ...

Abstract	Rice (
Language	English
Publishing date	2024-01-31
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2704341-1
ISSN	2223-7747
ISSN	2223-7747
DOI	10.3390/plants13030416
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Article ; Online: Treatment with TNF-α inhibitors versus methotrexate and the association with dementia and Alzheimer's disease.

Kern, David M / Lovestone, Simon / Cepeda, M Soledad

Alzheimer's & dementia (New York, N. Y.)

2021 Volume 7, Issue 1, Page(s) e12163

Abstract: Introduction: Peripheral inhibition of tumor necrosis factor (TNF)-α, outside of the central nervous system, may result in clinical improvement of Alzheimer's disease (AD) outcomes. TNF-α inhibitors (TNFIs) are effective treatments for various ... ...

Abstract	Introduction: Peripheral inhibition of tumor necrosis factor (TNF)-α, outside of the central nervous system, may result in clinical improvement of Alzheimer's disease (AD) outcomes. TNF-α inhibitors (TNFIs) are effective treatments for various autoimmune conditions and may be effective for preventing and/or treating AD. The objective of this study was to compare the risk of dementia and AD in patients initiating methotrexate versus those initiating TNFIs. Methods: Insurance claims data from databases of commercially insured and Medicare-eligible patients were used to estimate the risk of dementia and AD within patients with rheumatoid arthritis (RA) initiating a TNFI versus initiation of methotrexate. A sensitivity analysis included all patients without the RA diagnosis requirement. The at-risk period spanned from the index date until a diagnosis of the outcome, loss-to-follow-up, or receipt of the comparator drug. Patients were matched 1-to-1 using propensity scores. A Cox proportional hazards model was used to estimate the hazard ratio (HR). Negative controls were used to calibrate the results. Results: A total of 11,092 new TNFI patients and 44,023 new methotrexate patients were identified, and 8925 from each group were matched. The outcome of dementia occurred in 1.4% of patients in both groups. The calibrated results from the Cox regression found no difference between the two groups (commercially insured database: calibrated HR = 0.69, 95% confidence interval = 0.45 to 1.05; Medicare-only database: 1.14, 0.66 to 1.96). Results were similar in all sensitivity analyses: outcome of AD and including patients without RA. Discussion: No significant difference for the risk of dementia or AD was seen between patients initiating a TNFI versus methotrexate. Although this study cannot conclude whether use of TNFIs is protective against dementia and AD compared with receiving no treatment, there was no evidence that it is more protective than the active comparator methotrexate.
Language	English
Publishing date	2021-09-20
Publishing country	United States
Document type	Journal Article
ZDB-ID	2832891-7
ISSN	2352-8737 ; 2352-8737
ISSN (online)	2352-8737
ISSN	2352-8737
DOI	10.1002/trc2.12163
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