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Article ; Online: Direct-Acting Antiviral Use for Genotype 1b Hepatitis C Patients with Associated Hematological Disorders from Romania.

Marincu, Iosif / Bratosin, Felix / Curescu, Manuela / Suciu, Oana / Turaiche, Mirela / Cerbu, Bianca / Vidican, Iulia

2021 Volume 57, Issue 9

Abstract: Background and ... ...

Abstract	Background and objectives
MeSH term(s)	Antiviral Agents/therapeutic use ; Drug Therapy, Combination ; Genotype ; Hepatitis C ; Hepatitis C, Chronic/complications ; Hepatitis C, Chronic/drug therapy ; Humans ; Romania ; Treatment Outcome
Chemical Substances	Antiviral Agents
Language	English
Publishing date	2021-09-18
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2188113-3
ISSN	1648-9144 ; 1010-660X
ISSN (online)	1648-9144
ISSN	1010-660X
DOI	10.3390/medicina57090986
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Article ; Online: Assessing Pretransplant and Posttransplant Therapy Response in Multiple Myeloma Patients.

Potre, Cristina / Borsi, Ema / Potre, Ovidiu / Samfireag, Miruna / Costachescu, Dan / Cerbu, Bianca / Bratosin, Felix / Secosan, Cristina / Negrean, Rodica Anamaria

Current oncology (Toronto, Ont.)

2022 Volume 29, Issue 11, Page(s) 8501–8512

Abstract: Multiple myeloma (MM) is a hematologic cancer defined by an abnormal development of clonal plasma cells in the bone marrow, releasing vast quantities of immunoglobulins and different proteins. In the majority of patients, MM remains incurable despite ... ...

Abstract	Multiple myeloma (MM) is a hematologic cancer defined by an abnormal development of clonal plasma cells in the bone marrow, releasing vast quantities of immunoglobulins and different proteins. In the majority of patients, MM remains incurable despite decades of medical improvement and a number of treatment breakthroughs. Frontline standard-of-care has little long-term success, with the majority of patients eventually relapsing, although the overall progression-free survival (PFS) has improved significantly in the last ten years. Patients who are eligible for a transplant have the highest PFS rate at 5 years, depending on medication response and other various factors that are yet to be discovered. Therefore, the current study aimed to evaluate the response to VCD (bortezomib, cyclophosphamide, dexamethasone) and VTD (bortezomib, thalidomide, dexamethasone) used as pretransplant regimens, as well as to compare responses between thalidomide and lenalidomide used as maintenance therapy posttransplant. This retrospective study was performed on a group of 105 hospitalized patients in the Hematology Department of the Timisoara Municipal Emergency Clinical Hospital between January 2016 and December 2021. Data was collected from the paper records of patients with MM who were under-followed. The treatment regimens used as induction therapy were either VCD or VTD if cyclophosphamide was contraindicated. Of the 105 patients, 27 became eligible for bone marrow transplantation. Furthermore, they received maintenance therapy which was based on either lenalidomide with dexamethasone or thalidomide with dexamethasone. Of the 62 patients treated with VTD, 17.7% were in complete remission before stem cell transplantation. Of the 43 patients treated with VCD, 37.2% were in complete remission. The 5-year mean progression-free survival (PFS) in the entire cohort was better in the group treated with the VTD regimen (31.6 vs. 27.2 months). However, in the 27 patients undergoing maintenance after ASCT, the PFS with thalidomide was 35.5 months (95% CI = 27-42), while the PFS rate in those receiving maintenance treatment with lenalidomide was 46.1 months (95% CI = 20-73). VCD proved to be superior to VTD in inducing complete pretransplant responses. Regarding maintenance therapy, patients from the lenalidomide group had superior responses compared with those under thalidomide.
MeSH term(s)	Humans ; Multiple Myeloma/drug therapy ; Bortezomib/therapeutic use ; Bortezomib/pharmacology ; Thalidomide/therapeutic use ; Thalidomide/adverse effects ; Lenalidomide/therapeutic use ; Retrospective Studies ; Antineoplastic Combined Chemotherapy Protocols ; Neoplasm Recurrence, Local/drug therapy ; Dexamethasone/therapeutic use ; Dexamethasone/pharmacology ; Cyclophosphamide/therapeutic use
Chemical Substances	Bortezomib (69G8BD63PP) ; Thalidomide (4Z8R6ORS6L) ; Lenalidomide (F0P408N6V4) ; Dexamethasone (7S5I7G3JQL) ; Cyclophosphamide (8N3DW7272P)
Language	English
Publishing date	2022-11-08
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	1236972-x
ISSN	1718-7729 ; 1198-0052
ISSN (online)	1718-7729
ISSN	1198-0052
DOI	10.3390/curroncol29110670
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Article ; Online: Predictive Factors for the First Recurrence of

Marincu, Iosif / Bratosin, Felix / Vidican, Iulia / Cerbu, Bianca / Turaiche, Mirela / Tirnea, Livius / Timircan, Madalina

Medicina (Kaunas, Lithuania)

2020 Volume 56, Issue 9

Abstract: Background and objectives: ...

Abstract	Background and objectives:
MeSH term(s)	Aged ; Anti-Bacterial Agents/therapeutic use ; Clostridium Infections/complications ; Clostridium Infections/diagnosis ; Clostridium Infections/drug therapy ; Cross Infection/complications ; Cross Infection/diagnosis ; Cross Infection/drug therapy ; Cross Infection/microbiology ; Enterocolitis/complications ; Enterocolitis/diagnosis ; Enterocolitis/drug therapy ; Enterocolitis/microbiology ; Female ; Fever/microbiology ; Gastrointestinal Diseases/complications ; Humans ; Immunocompromised Host ; Male ; Reinfection ; Retrospective Studies ; Risk Factors ; Romania
Chemical Substances	Anti-Bacterial Agents
Language	English
Publishing date	2020-08-29
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2188113-3
ISSN	1648-9144 ; 1010-660X
ISSN (online)	1648-9144
ISSN	1010-660X
DOI	10.3390/medicina56090439
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Article: Predictive Value of Comorbid Conditions for COVID-19 Mortality.

Marincu, Iosif / Bratosin, Felix / Vidican, Iulia / Bostanaru, Andra-Cristina / Frent, Stefan / Cerbu, Bianca / Turaiche, Mirela / Tirnea, Livius / Timircan, Madalina

Journal of clinical medicine

2021 Volume 10, Issue 12

Abstract: In this paper, we aim at understanding the broad spectrum of factors influencing the survival of infected patients and the correlations between these factors to create a predictive probabilistic score for surviving the COVID-19 disease. Initially, 510 ... ...

Abstract	In this paper, we aim at understanding the broad spectrum of factors influencing the survival of infected patients and the correlations between these factors to create a predictive probabilistic score for surviving the COVID-19 disease. Initially, 510 hospital admissions were counted in the study, out of which 310 patients did not survive. A prediction model was developed based on this data by using a Bayesian approach. Following the data collection process for the development study, the second cohort of patients totaling 541 was built to validate the risk matrix previously created. The final model has an area under the curve of 0.773 and predicts the mortality risk of SARS-CoV-2 infection based on nine disease groups while considering the gender and age of the patient as distinct risk groups. To ease medical workers' assessment of patients, we created a visual risk matrix based on a probabilistic model, ranging from a score of 1 (very low mortality risk) to 5 (very high mortality risk). Each score comprises a correlation between existing comorbid conditions, the number of comorbid conditions, gender, and age group category. This clinical model can be generalized in a hospital context and can be used to identify patients at high risk for whom immediate intervention might be required.
Language	English
Publishing date	2021-06-16
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2662592-1
ISSN	2077-0383
ISSN	2077-0383
DOI	10.3390/jcm10122652
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Article: Foodborne Botulism in Western Romania: Ten Years' Experience at a Tertiary Infectious Disease Hospital.

Marincu, Iosif / Bratosin, Felix / Vidican, Iulia / Cerbu, Bianca / Suciu, Oana / Turaiche, Mirela / Tirnea, Livius / Timircan, Madalina

Healthcare (Basel, Switzerland)

2021 Volume 9, Issue 9

Abstract: Objectives: The purpose of this study was to analyze epidemiological data concerning foodborne botulism in Western Romania over the last decade. Botulism, the toxin formed by the bacterium : Methods: Medical records were retrospectively analyzed from ...

Abstract	Objectives: The purpose of this study was to analyze epidemiological data concerning foodborne botulism in Western Romania over the last decade. Botulism, the toxin formed by the bacterium Methods: Medical records were retrospectively analyzed from 2010 to 2020 for all food botulism cases. A seroneutralization test was performed with type A, B and E anti-botulinum sera to establish the kind of toxin involved. Results: Overall, 18 cases of foodborne botulism were admitted to the hospital during this period and confirmed by laboratory analysis. Most of the participants in our study were men (61.1%), and 77.8% of the total lived in rural areas. All the participants showed classic symptoms of botulism, and dysphagia was present in all cases. The trivalent ABE antitoxin was administered by the hospital, and toxin type B was isolated in all patients. The main sources of the toxin were pork, ham and canned pork meat. Conclusions: Stronger efforts are needed to foster community awareness of foodborne botulism, particularly in home-preserved food.
Language	English
Publishing date	2021-09-02
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2721009-1
ISSN	2227-9032
ISSN	2227-9032
DOI	10.3390/healthcare9091149
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Liver Impairment and Hematological Changes in Patients with Chronic Hepatitis C and COVID-19: A Retrospective Study after One Year of Pandemic.

Cerbu, Bianca / Pantea, Stelian / Bratosin, Felix / Vidican, Iulia / Turaiche, Mirela / Frent, Stefan / Borsi, Ema / Marincu, Iosif

Medicina (Kaunas, Lithuania)

2021 Volume 57, Issue 6

Abstract: Background and ... ...

Abstract	Background and Objectives
MeSH term(s)	COVID-19 ; Hepatitis C, Chronic/complications ; Hepatitis C, Chronic/drug therapy ; Hepatitis C, Chronic/epidemiology ; Humans ; Pandemics ; Retrospective Studies ; SARS-CoV-2
Language	English
Publishing date	2021-06-10
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2188113-3
ISSN	1648-9144 ; 1010-660X
ISSN (online)	1648-9144
ISSN	1010-660X
DOI	10.3390/medicina57060597
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Article ; Online: The Efficacy of Convalescent Plasma Use in Critically Ill COVID-19 Patients.

Tirnea, Livius / Bratosin, Felix / Vidican, Iulia / Cerbu, Bianca / Turaiche, Mirela / Timircan, Madalina / Margan, Madalin-Marius / Marincu, Iosif

Medicina (Kaunas, Lithuania)

2021 Volume 57, Issue 3

Abstract: Background and Objectives: ...

Abstract	Background and Objectives:
MeSH term(s)	Adult ; Anti-Bacterial Agents/therapeutic use ; Anticoagulants/therapeutic use ; Antiviral Agents/therapeutic use ; C-Reactive Protein/metabolism ; COVID-19/blood ; COVID-19/physiopathology ; COVID-19/therapy ; Critical Illness ; Glucocorticoids/therapeutic use ; Humans ; Immunization, Passive/methods ; Interleukin-6/blood ; Leukocyte Count ; Male ; Middle Aged ; Pilot Projects ; Romania ; SARS-CoV-2 ; Treatment Outcome
Chemical Substances	Anti-Bacterial Agents ; Anticoagulants ; Antiviral Agents ; Glucocorticoids ; Interleukin-6 ; C-Reactive Protein (9007-41-4)
Language	English
Publishing date	2021-03-11
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2188113-3
ISSN	1648-9144 ; 1010-660X
ISSN (online)	1648-9144
ISSN	1010-660X
DOI	10.3390/medicina57030257
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Article: Biological Profile and Clinical Features as Determinants for Prolonged Hospitalization in Adult Patients with Measles: A Monocentric Study in Western Romania

Turaiche, Mirela / Feciche, Bogdan / Gluhovschi, Adrian / Bratosin, Felix / Bogdan, Iulia / Bota, Adrian Vasile / Grigoras, Mirela Loredana / Gurban, Camelia Vidita / Cerbu, Bianca / Toma, Ana-Olivia / Gurumurthy, Srivathsava / Wulandari, Prima Hapsari / Marincu, Iosif

Pathogens. 2022 Sept. 07, v. 11, no. 9

2022

Abstract: Measles is a highly infectious and sometimes deadly illness that is preventable with vaccination. The present research aims to analyze the most recent measles epidemic from Romania that occurred in a population with a falling desire to receive ... ...

Abstract	Measles is a highly infectious and sometimes deadly illness that is preventable with vaccination. The present research aims to analyze the most recent measles epidemic from Romania that occurred in a population with a falling desire to receive immunizations, by detailing the clinical picture and biological profile of hospitalized patients. A secondary goal of the present research is to identify characteristics that increase the likelihood of a longer hospitalization and the development of measles-related pneumonia. A retrospective cohort study was conducted to follow the course and effects of measles virus infection in adult hospitalized patients who were divided into two groups based on whether they had been in the hospital for more than 6 days or fewer than 6 days. A total of 114 adult patients with measles were eligible to participate in the trial if they had a positive measles-specific IgM antibody test resulting from the study. The average age in the short hospital stay group was 28.1 years, while the average age in the long hospital stay group was 31.9 years. There was a statistically significant difference in the number of Roma persons in the research groups, with 17.4 percent of them having a lengthy hospital stay compared to 5.9 percent in the group with a short hospital stay, according to the findings. It was observed that many patients had a long hospitalization associated with chronic lung disease (OR = 1.07), liver damage (OR = 1.66), Roma ethnicity (OR = 1.79), a long duration elapsed from the last MMR dose (OR = 2.02), elevated c-reactive protein (OR = 2.17), the presence of bilateral pulmonary condensations on X-ray (OR = 3.13), and elevated procalcitonin (OR = 3.49). The same significant independent risk factors were also associated with the development of pneumonia. It is of imperative need to address these risk factors in a patient with measles, moreover in association with an unknown status of vaccination. Vaccination awareness against measles must be pushed in Romania to determine a higher than 95% coverage. Significant efforts are still needed to ensure improved protection against measles epidemics within a specific region or population and, more importantly, in patients with significant risk factors for complications, as described in this study.
Keywords	C-reactive protein ; Measles morbillivirus ; X-radiation ; adults ; antibodies ; cohort studies ; hospitals ; liver ; measles ; nationalities and ethnic groups ; patients ; pneumonia ; risk ; vaccination ; Romania
Language	English
Dates of publication	2022-0907
Publishing place	Multidisciplinary Digital Publishing Institute
Document type	Article
ZDB-ID	2695572-6
ISSN	2076-0817
ISSN	2076-0817
DOI	10.3390/pathogens11091018
Database	NAL-Catalogue (AGRICOLA)

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Article: Biological Profile and Clinical Features as Determinants for Prolonged Hospitalization in Adult Patients with Measles: A Monocentric Study in Western Romania.

Pathogens (Basel, Switzerland)

2022 Volume 11, Issue 9

Abstract	Measles is a highly infectious and sometimes deadly illness that is preventable with vaccination. The present research aims to analyze the most recent measles epidemic from Romania that occurred in a population with a falling desire to receive immunizations, by detailing the clinical picture and biological profile of hospitalized patients. A secondary goal of the present research is to identify characteristics that increase the likelihood of a longer hospitalization and the development of measles-related pneumonia. A retrospective cohort study was conducted to follow the course and effects of measles virus infection in adult hospitalized patients who were divided into two groups based on whether they had been in the hospital for more than 6 days or fewer than 6 days. A total of 114 adult patients with measles were eligible to participate in the trial if they had a positive measles-specific IgM antibody test resulting from the study. The average age in the short hospital stay group was 28.1 years, while the average age in the long hospital stay group was 31.9 years. There was a statistically significant difference in the number of Roma persons in the research groups, with 17.4 percent of them having a lengthy hospital stay compared to 5.9 percent in the group with a short hospital stay, according to the findings. It was observed that many patients had a long hospitalization associated with chronic lung disease (OR = 1.07), liver damage (OR = 1.66), Roma ethnicity (OR = 1.79), a long duration elapsed from the last MMR dose (OR = 2.02), elevated c-reactive protein (OR = 2.17), the presence of bilateral pulmonary condensations on X-ray (OR = 3.13), and elevated procalcitonin (OR = 3.49). The same significant independent risk factors were also associated with the development of pneumonia. It is of imperative need to address these risk factors in a patient with measles, moreover in association with an unknown status of vaccination. Vaccination awareness against measles must be pushed in Romania to determine a higher than 95% coverage. Significant efforts are still needed to ensure improved protection against measles epidemics within a specific region or population and, more importantly, in patients with significant risk factors for complications, as described in this study.
Language	English
Publishing date	2022-09-07
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2695572-6
ISSN	2076-0817
ISSN	2076-0817
DOI	10.3390/pathogens11091018
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Laboratory Profile of COVID-19 Patients with Hepatitis C-Related Liver Cirrhosis.

Cerbu, Bianca / Grigoras, Mirela Loredana / Bratosin, Felix / Bogdan, Iulia / Citu, Cosmin / Bota, Adrian Vasile / Timircan, Madalina / Bratu, Melania Lavinia / Levai, Mihaela Codrina / Marincu, Iosif

Journal of clinical medicine

2022 Volume 11, Issue 3

Abstract: Patients with cirrhosis are known to have multiple comorbidities and impaired organ system functioning due to alterations caused by chronic liver failure. In the past two years, since the COVID-19 pandemic started, several studies have described the ... ...

Abstract	Patients with cirrhosis are known to have multiple comorbidities and impaired organ system functioning due to alterations caused by chronic liver failure. In the past two years, since the COVID-19 pandemic started, several studies have described the affinity of SARS-CoV-2 with the liver and biliary cells. Considering hepatitis C as a significant independent factor for cirrhosis in Romania, this research was built on the premises that this certain group of patients is susceptible to alterations of their serum parameters that are yet to be described, which might be useful in the management of COVID-19 in these individuals. A retrospective cohort study was developed at a tertiary hospital for infectious disease in Romania, which included a total of 242 patients with hepatitis C cirrhosis across two years, out of which 46 patients were infected with SARS-CoV-2. Stratification by patient weight and COVID-19 status identified several important laboratory serum tests as predictors for acute-on-chronic liver failure and risk for intensive care unit admission. Thus, white blood cell count, lymphocyte count, ferritin, hypoglycemia, prothrombin time, and HCV viral load were independent risk factors for ACLF in patients with COVID-19. High PT, creatinine, BUN, and HCV viral load were the strongest predictors for ICU admission. Inflammatory markers and parameters of gas exchange were also observed as risk factors for ACLF and ICU admission, including procalcitonin, CRP, IL-6, and D-dimers. Our study questions and confirms the health impact of COVID-19 on patients with cirrhosis and whether their laboratory profile significantly changes due to SARS-CoV-2 infection.
Language	English
Publishing date	2022-01-27
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2662592-1
ISSN	2077-0383
ISSN	2077-0383
DOI	10.3390/jcm11030652
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