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Article ; Online: Evaluation and Management of Lower-Extremity Ulcers.

Cereda, Emanuele

2018 Volume 378, Issue 3, Page(s) 301–302

MeSH term(s)	Diabetic Foot ; Humans ; Leg Ulcer ; Ulcer
Language	English
Publishing date	2018-01-18
Publishing country	United States
Document type	Letter ; Comment
ZDB-ID	207154-x
ISSN	1533-4406 ; 0028-4793
ISSN (online)	1533-4406
ISSN	0028-4793
DOI	10.1056/NEJMc1715237
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Article ; Online: Nutritional therapy in chronic wound management for older adults.

Cereda, Emanuele / Veronese, Nicola / Caccialanza, Riccardo

Current opinion in clinical nutrition and metabolic care

2023 Volume 27, Issue 1, Page(s) 3–8

Abstract: Purpose of review: We provided an updated overview of recent data on the value of nutritional therapy in the management of chronic wounds in older adults.: Recent findings: In the last years, advances in this area were limited, but new data suggest ... ...

Abstract	Purpose of review: We provided an updated overview of recent data on the value of nutritional therapy in the management of chronic wounds in older adults. Recent findings: In the last years, advances in this area were limited, but new data suggest considering nutritional care (screening and assessment of malnutrition and nutritional interventions) also in patients with chronic wounds other than pressure ulcers, namely venous leg and diabetic foot ulcers, as in these patients, nutritional derangements can be present despite overweight/obesity and their management is beneficial. Summary: Chronic wounds are wounds in which the process of repair does not progress normally due to a disruption in one or more of the healing phases. Nutritional therapy is aimed at recovering the process of repair. General principles of nutritional care in geriatrics apply to these patients but disease-specific recommendations are available, particularly for pressure ulcers. Interventions should address nutritional status, comorbidities, hydration and should provide key nutrients playing an active role in the healing process (arginine, zinc, and antioxidants) but always within the context of an individual care plan addressing patients requirements, particularly protein needs. Further evidence of efficacy in vascular and diabetic foot ulcers is warranted.
MeSH term(s)	Humans ; Aged ; Diabetic Foot/therapy ; Pressure Ulcer/therapy ; Wound Healing ; Nutritional Support ; Malnutrition/therapy
Language	English
Publishing date	2023-11-02
Publishing country	England
Document type	Review ; Journal Article
ZDB-ID	1460178-3
ISSN	1473-6519 ; 1363-1950
ISSN (online)	1473-6519
ISSN	1363-1950
DOI	10.1097/MCO.0000000000000990
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Article ; Online: The Impact of Malnutrition on Skin Integrity and Wound Healing.

Demarest-Litchford, Mary / Munoz, Nancy / Strange, Nancy / Casirati, Amanda / Cereda, Emanuele

Advances in skin & wound care

2024 Volume 37, Issue 3, Page(s) 126–135

Abstract: General purpose: To recognize valuable resources from the Malnutrition Quality Improvement Initiative for acute care patients and malnutrition quality improvement measures for postacute care residents.: Target audience: This continuing education ... ...

Abstract	General purpose: To recognize valuable resources from the Malnutrition Quality Improvement Initiative for acute care patients and malnutrition quality improvement measures for postacute care residents. Target audience: This continuing education activity is intended for physicians, physician assistants, nurse practitioners, and registered nurses with an interest in skin and wound care. Learning objectives/outcomes: After participating in this educational activity, the participant will:1. Distinguish the prevalence of malnutrition among acute care patients.2. Explain the assessment guidelines for identifying malnutrition.3. Identify the resources available for measuring malnutrition quality improvement.
MeSH term(s)	Humans ; Skin ; Wound Healing ; Malnutrition/diagnosis ; Physicians ; Nurse Practitioners
Language	English
Publishing date	2024-02-23
Publishing country	United States
Document type	Journal Article
ZDB-ID	2012792-3
ISSN	1538-8654 ; 1527-7941
ISSN (online)	1538-8654
ISSN	1527-7941
DOI	10.1097/ASW.0000000000000107
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Article ; Online: Metformin use is associated with reduced mortality risk in diabetic patients with Parkinson's disease.

Pezzoli, Gianni / Cereda, Emanuele / Calandrella, Daniela / Barichella, Michela / Bonvegna, Salvatore / Isaias, Ioannis U

Clinical nutrition ESPEN

2024 Volume 60, Page(s) 309–312

Abstract: Introduction: Parkinson's disease (PD) and type-2 diabetes (T2D) arguably share pathophysiologic mechanisms, resulting in a more severe phenotype and progression and diabetes is currently considered a risk factor of PD. Besides, research suggests ... ...

Abstract	Introduction: Parkinson's disease (PD) and type-2 diabetes (T2D) arguably share pathophysiologic mechanisms, resulting in a more severe phenotype and progression and diabetes is currently considered a risk factor of PD. Besides, research suggests antidiabetic therapies as potential disease-modifying strategies. The main aim was to assess the impact of a metformin-inclusive antidiabetic treatment on patient all-cause mortality. Methods: A nested case-control prospective study including newly diagnosed PD patients reporting the onset of T2D within ±2 years from the onset of PD (n = 159) and matched (1:5; gender, year of PD onset and age at PD onset) non-diabetic cases (n = 795) followed until death or censoring. Patients on a metformin-inclusive treatment regimen were compared to those receiving other oral anti-diabetics (OADs). Results: Among patients with T2D, 123 were treated with a drug regimen containing metformin (alone [65.0%] or in combination with other drugs [35.0%]) and 36 were prescribed other OADs. During a median PD duration of 96 months [IQR, 60-144], 171 patients died. Diabetes was not associated with reduced survival: fully-adjusted HR = 1.19 [95%CI, 0.81-1.76] (P = 0.37). After stratifying for T2D treatment, a metformin-inclusive regimen was not associated with increased risk of death (HR = 1.06 [95%CI, 0.61-1.84]; P = 0.83), while patients receiving other OADs had reduced survival (HR = 1.83 [95%CI, 1.01-3.32]; P = 0.034). Conclusions: Metformin use was not associated with increased risk of death in diabetic patients with PD reporting concomitant onset of the two diseases. Metformin appears to be a promising disease-modifying therapy given also the preclinical background, low cost and satisfactory safety and tolerability. Further studies are warranted to investigate its impact on disease progression.
MeSH term(s)	Humans ; Metformin/therapeutic use ; Prospective Studies ; Parkinson Disease/complications ; Parkinson Disease/drug therapy ; Hypoglycemic Agents/therapeutic use ; Diabetes Mellitus, Type 2/complications ; Diabetes Mellitus, Type 2/drug therapy
Chemical Substances	Metformin (9100L32L2N) ; Hypoglycemic Agents
Language	English
Publishing date	2024-02-21
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ISSN	2405-4577
ISSN (online)	2405-4577
DOI	10.1016/j.clnesp.2024.02.018
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Article ; Online: The use of phase angle in patients with digestive and liver diseases.

Casirati, Amanda / Crotti, Silvia / Raffaele, Alessandro / Caccialanza, Riccardo / Cereda, Emanuele

Reviews in endocrine & metabolic disorders

2023 Volume 24, Issue 3, Page(s) 503–524

Abstract: Diseases of the liver and the digestive system can lead to malnutrition through an action of reduced food intake or nutrient use, inflammation and impaired metabolism, which result in substantial changes in body composition. Frequently, malnutrition ... ...

Abstract	Diseases of the liver and the digestive system can lead to malnutrition through an action of reduced food intake or nutrient use, inflammation and impaired metabolism, which result in substantial changes in body composition. Frequently, malnutrition manifests itself with weight loss and reduced muscle mass. However, weight loss and body mass index lack sensitivity to detect the loss of muscle mass and are not informative in distinguishing body water compartments and in characterizing their distribution. This issue is particularly relevant to these two disease models, which are frequently associated with fluid volume imbalances. Phase angle is a useful indicator for cell membrane integrity, water distribution between the intracellular and extracellular spaces and prediction of body cell mass as it is described by measured components of electrical impedance. Malnutrition, inflammation and oxidative stress impair electric tissue properties leading to lower values of PhA. In patients with inflammatory bowel and liver diseases, PhA was consistently found to be related to nutritional status and body composition, particularly the depletion of lean body mass and sarcopenia. It has been associated with prognosis, disease stage and severity and found to be helpful in monitoring fluid shifts and response to interventions.
MeSH term(s)	Humans ; Nutrition Assessment ; Nutritional Status ; Malnutrition/complications ; Liver Diseases ; Weight Loss ; Inflammation/complications
Language	English
Publishing date	2023-02-06
Publishing country	Germany
Document type	Journal Article ; Review
ZDB-ID	2185718-0
ISSN	1573-2606 ; 1389-9155
ISSN (online)	1573-2606
ISSN	1389-9155
DOI	10.1007/s11154-023-09785-6
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Zs.A 6069: Show issues

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Article ; Online: Whey Protein, Leucine- and Vitamin-D-Enriched Oral Nutritional Supplementation for the Treatment of Sarcopenia.

Cereda, Emanuele / Pisati, Roberto / Rondanelli, Mariangela / Caccialanza, Riccardo

Nutrients

2022 Volume 14, Issue 7

Abstract: Sarcopenia has been recognized as a muscle disease, with adverse consequences on health. Updated recommendations, aimed at increasing awareness of sarcopenia and its accompanying risks, have been produced to urge the early detection and treatment of this ...

Abstract	Sarcopenia has been recognized as a muscle disease, with adverse consequences on health. Updated recommendations, aimed at increasing awareness of sarcopenia and its accompanying risks, have been produced to urge the early detection and treatment of this disease. Recommended treatment is based on an individually tailored resistance exercise training program, the optimization of protein intake using high-quality protein sources (i.e., whey protein) in order to provide a high amount of essential amino acids-particularly leucine-and addressing vitamin D deficiency/insufficiency. The purpose of this review is to collate and describe all of the relevant efficacy studies carried out with a muscle-targeted oral nutritional supplementation (MT-ONS)-namely a whey-protein-based, leucine- and vitamin D-enriched formula aimed at optimizing their intake and satisfying their requirements-in different patient populations and clinical settings in order to determine if there is enough evidence to recommend prescription for the treatment of sarcopenia or its prevention in high-risk patient populations. Trials using a MT-ONS with or without a concomitant physical exercise program were systematically searched (up to June 2021), and those addressing relevant endpoints (muscle mass, physical performance and function) were critically reviewed. In total, 10 articles providing efficacy data from eight trials were identified and narratively reviewed. As far as older patients with sarcopenia are concerned, MT-ONS has been pertinently tested in six clinical trials (duration 4-52 weeks), mostly using a high-quality randomized controlled trial design and demonstrating efficacy in increasing the muscle mass and strength, as well as the physical performance versus iso-caloric placebo or standard practice. Consistent results have been observed in various clinical settings (community, rehabilitation centers, care homes), with or without adjunctive physical exercise programs. A positive effect on markers of inflammation has also been shown. A muscle-protein-sparing effect, with benefits on physical performance and function, has also been demonstrated in patients at risk of losing skeletal muscle mass (three trials), such as older patients undergoing weight loss or intensive rehabilitation programs associated with neurological disability (Parkinson's disease). MT-ONS has demonstrated not only a significant efficacy in clinical variables, but also a positive impact on healthcare resource consumption in the rehabilitation setting (length of stay and duration of rehabilitation). In summary, MT-ONS, alone or in association with an appropriate exercise program, is an effective therapy for older patients with sarcopenia and should be offered as a first-line treatment, not only to improve clinical outcomes but also to reduce healthcare resource consumption, particularly in patients admitted to a rehabilitation center.
MeSH term(s)	Dietary Supplements ; Humans ; Leucine ; Muscle Strength ; Muscle, Skeletal ; Randomized Controlled Trials as Topic ; Sarcopenia/complications ; Sarcopenia/drug therapy ; Vitamins/pharmacology ; Vitamins/therapeutic use ; Whey Proteins
Chemical Substances	Vitamins ; Whey Proteins ; Leucine (GMW67QNF9C)
Language	English
Publishing date	2022-04-06
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2518386-2
ISSN	2072-6643 ; 2072-6643
ISSN (online)	2072-6643
ISSN	2072-6643
DOI	10.3390/nu14071524
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Article ; Online: Nutrition and Wound Care.

Munoz, Nancy / Litchford, Mary / Cereda, Emanuele

Physical medicine and rehabilitation clinics of North America

2022 Volume 33, Issue 4, Page(s) 811–822

Abstract: Nutrition is an important component of health and well-being. A compromised nutritional status has been linked to increased risk for wound development, difficulty managing, and decreased wound healing rate. Malnutrition contributes to an ... ...

Abstract	Nutrition is an important component of health and well-being. A compromised nutritional status has been linked to increased risk for wound development, difficulty managing, and decreased wound healing rate. Malnutrition contributes to an immunocompromised system, reduced collagen synthesis, and diminished tensile strength during the wound healing process. This is why assessment and optimization of nutritional status should be incorporated as part of a comprehensive treatment plan for individuals with wounds. The nutrition care plan must include individualized interventions designed to address the individual's nutrition diagnosis. This article reviews the role of nutrition in wound prevention, management, and treatment.
MeSH term(s)	Collagen ; Humans ; Malnutrition/diagnosis ; Malnutrition/prevention & control ; Nutrition Assessment ; Nutrition Therapy ; Nutritional Status ; Wound Healing
Chemical Substances	Collagen (9007-34-5)
Language	English
Publishing date	2022-09-28
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	1196791-2
ISSN	1558-1381 ; 1047-9651
ISSN (online)	1558-1381
ISSN	1047-9651
DOI	10.1016/j.pmr.2022.06.007
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Article ; Online: Treatment of Pressure Ulcers.

Cereda, Emanuele

Annals of internal medicine

2015 Volume 163, Issue 8, Page(s) 646–647

MeSH term(s)	Humans ; Pressure Ulcer/therapy
Language	English
Publishing date	2015-10-20
Publishing country	United States
Document type	Comment ; Letter
ZDB-ID	336-0
ISSN	1539-3704 ; 0003-4819
ISSN (online)	1539-3704
ISSN	0003-4819
DOI	10.7326/L15-5148
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Article ; Online: Role of muscle-targeted nutritional therapy: new data.

Cereda, Emanuele / Veronese, Nicola / Caccialanza, Riccardo

Current opinion in clinical nutrition and metabolic care

2022 Volume 25, Issue 3, Page(s) 142–153

Abstract: Purpose of review: To provide an updated overview of recent efficacy data on the use of muscle-targeted nutritional therapy, which should consider the optimization of protein and essential amino acids intakes, possibly in combination with ... ...

Abstract	Purpose of review: To provide an updated overview of recent efficacy data on the use of muscle-targeted nutritional therapy, which should consider the optimization of protein and essential amino acids intakes, possibly in combination with supplementation with vitamin D (correction of deficiency/insufficiency status) and v-3 fatty acids. Recent findings: Intervention studies conducted in the last years in different healthcare settings and heterogeneous patient populations support the use of muscle-targeted oral nutritional supplementation to improve muscle mass, function and physical performance in patients with sarcopenia. Higher efficacy is likely to be achieved in combination with individually tailored resistance exercise training programs and when nutritional therapy and the provision of specific nutrients result in an adequate protein-calorie balance. However, not only a reactive but also a pro-active application of this therapy could be proposed as evidence exists on the maintenance of or improvement in the same outcome variables in patients at risk of losing skeletal muscle mass. Summary: Based on available efficacy data, both a reactive and pro-active use of muscle-targeted nutritional therapy are promising and should be proposed. However, future research should be directed toward the management of patient populations characterized by substantial muscle wasting, as these have been frequently excluded from previous trials, perhaps to avoid confounding.
MeSH term(s)	Dietary Supplements ; Humans ; Muscle Strength/physiology ; Muscle, Skeletal/metabolism ; Muscular Diseases/metabolism ; Nutrition Therapy ; Sarcopenia ; Vitamin D/metabolism ; Vitamin D/therapeutic use
Chemical Substances	Vitamin D (1406-16-2)
Language	English
Publishing date	2022-02-18
Publishing country	England
Document type	Journal Article ; Review ; Research Support, Non-U.S. Gov't
ZDB-ID	1460178-3
ISSN	1473-6519 ; 1363-1950
ISSN (online)	1473-6519
ISSN	1363-1950
DOI	10.1097/MCO.0000000000000822
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Zs.A 5586: Show issues

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Article ; Online: Dietary supplement use in ambulatory cancer patients: a survey on prevalence, motivation and attitudes.

Tank, Maja / Franz, Kristina / Cereda, Emanuele / Norman, Kristina

Journal of cancer research and clinical oncology

2021 Volume 147, Issue 7, Page(s) 1917–1925

Abstract: Purpose: Patients with cancer often believe dietary supplements (DS) such as micronutrients and botanical products to be health supporting and non-toxic despite growing concerns regarding potential pharmacological interactions. Studies on the prevalence ...

Abstract	Purpose: Patients with cancer often believe dietary supplements (DS) such as micronutrients and botanical products to be health supporting and non-toxic despite growing concerns regarding potential pharmacological interactions. Studies on the prevalence of DS use among patients with cancer are heterogeneous and mainly conducted at university-based cancer centers. This survey focused on a particular cancer patient group treated in an ambulatory setting without regular access to professional nutritional counselling. Methods: Patients with a history of cancer or hematological malignancy were included in this survey. A self-reported questionnaire was used to evaluate the different aspects of DS use, changes in dietary habits and patients' demographic characteristics. Results: Almost every second patient reported using DS (47.2%). Women (56.3%), patients with an academic degree (56.0%) and non-smokers (84.8%) were more inclined to use DS. Along with magnesium (16.6%), calcium (14.3%), multivitamins (12.0%) and vitamin C (9.4%), use of herbal supplements (12.6%) was common. Women (84.8% vs. 74.9% of men, p = < 0.001) and patients younger than 65 years (84.4% vs. 77.2% of patients > 65 y, p = 0.002) sought dietary advice more often. Support of the immune system was the main reason for DS use (26.4%) and a relevant number of patients (49.6%) reported to have changed their dietary habits following cancer diagnosis. Conclusion: DS use is common among patients with cancer treated in an ambulatory setting. This finding should encourage oncologists to implement detailed questioning about DS use and dietary habits to prevent potential interactions and offer substantial advice.
MeSH term(s)	Aged ; Ambulatory Care Facilities/statistics & numerical data ; Attitude ; Cancer Care Facilities/statistics & numerical data ; Cross-Sectional Studies ; Dietary Supplements ; Drug Interactions ; Feeding Behavior ; Female ; Follow-Up Studies ; Hematologic Neoplasms/diet therapy ; Hematologic Neoplasms/psychology ; Humans ; Male ; Motivation ; Prevalence ; Prognosis ; Surveys and Questionnaires
Language	English
Publishing date	2021-04-06
Publishing country	Germany
Document type	Journal Article
ZDB-ID	134792-5
ISSN	1432-1335 ; 0171-5216 ; 0084-5353 ; 0943-9382
ISSN (online)	1432-1335
ISSN	0171-5216 ; 0084-5353 ; 0943-9382
DOI	10.1007/s00432-021-03594-7
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