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  1. Book ; Online ; E-Book: Statistics and research methods for acute care and general surgeons

    Ceresoli, Marco / Abu-Zidan, Fikri M. / Staudenmayer, Kristan L. / Catena, F. / Coccolini, Federico

    (Hot topics in acute care surgery and trauma,)

    2022  

    Abstract: The main aim of this book is to offer an easy tool to read a scientific article with greater awareness, to understand and evaluate it more thoroughly, and to better plan research. Today, in the era of evidence-based medicine, both research and daily ... ...

    Author's details Marco Ceresoli, Fikri M. Abu-Zidan, Kristan L. Staudenmayer, Fausto Catena, Federico Coccolini, editors
    Series title Hot topics in acute care surgery and trauma,
    Abstract The main aim of this book is to offer an easy tool to read a scientific article with greater awareness, to understand and evaluate it more thoroughly, and to better plan research. Today, in the era of evidence-based medicine, both research and daily patient-focused clinical practice are no longer possible without a thorough knowledge of the literature and its continuous updates. Written by surgeons for surgeons, this practical book makes the basic concept of statistics and research methodology easy to understand and apply for young surgeons and researchers, students and residents.
    MeSH term(s) Evidence-Based Medicine ; Meta-Analysis as Topic. ; Research Design ; Research Design/statistics & numerical data ; Research Design/standards
    Keywords Surgical emergencies/Research/Methodology ; Surgical emergencies/Statistical methods ; Medical literature
    Subject code 617.0072
    Language English
    Dates of publication 2022-2022
    Size 1 online resource (177 pages) :, illustrations
    Publisher Springer International Publishing ; Imprint: Springer
    Publishing place Cham
    Document type Book ; Online ; E-Book
    Remark Zugriff für angemeldete ZB MED-Nutzerinnen und -Nutzer
    ISBN 3-031-13818-X ; 9783031138171 ; 978-3-031-13818-8 ; 3031138171
    DOI 10.1007/978-3-031-13818-8
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  2. Article ; Online: 1522-2022: Considerations on the First Description of the Caecal Appendix by Berengario da Carpi in its 500th Anniversary.

    Riva, Michele A / Ceresoli, Marco

    World journal of surgery

    2022  Volume 46, Issue 11, Page(s) 2554–2558

    MeSH term(s) Anniversaries and Special Events ; Appendix/surgery ; History, 16th Century ; Humans
    Language English
    Publishing date 2022-08-08
    Publishing country United States
    Document type Historical Article ; Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 224043-9
    ISSN 1432-2323 ; 0364-2313
    ISSN (online) 1432-2323
    ISSN 0364-2313
    DOI 10.1007/s00268-022-06688-6
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Reply to: Early non compliance to enhanced recovery pathway might be an alert for underlying complications following colon surgery.

    Ceresoli, Marco / Braga, Marco

    European journal of surgical oncology : the journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology

    2022  Volume 49, Issue 2, Page(s) 526

    MeSH term(s) Humans ; Digestive System Surgical Procedures/adverse effects ; Intestines ; Colon/surgery ; Postoperative Complications/epidemiology ; Postoperative Complications/etiology ; Length of Stay
    Language English
    Publishing date 2022-10-21
    Publishing country England
    Document type Letter ; Comment
    ZDB-ID 632519-1
    ISSN 1532-2157 ; 0748-7983
    ISSN (online) 1532-2157
    ISSN 0748-7983
    DOI 10.1016/j.ejso.2022.10.010
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Early non compliance to enhanced recovery pathway might be an alert for underlying complications following colon surgery.

    Ceresoli, Marco / Pedrazzani, Corrado / Pellegrino, Luca / Ficari, Ferdinando / Braga, Marco

    European journal of surgical oncology : the journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology

    2022  Volume 50, Issue 5, Page(s) 106650

    Abstract: Purpose: Early non compliance to postoperative ERAS pathway has been reported in 20-30% of patients who underwent elective colon surgery. The aim of the present study is to investigate the possible relationship between early non compliance and ... ...

    Abstract Purpose: Early non compliance to postoperative ERAS pathway has been reported in 20-30% of patients who underwent elective colon surgery. The aim of the present study is to investigate the possible relationship between early non compliance and postoperative complications.
    Methods: We reviewed a prospective database including 1391 consecutively collected patients undergoing elective colon surgery in 22 Italian hospitals between January 2017 and June 2020. Early compliance to ERAS protocol was assessed on postoperative day (POD) 2. Failure of oral feeding, urinary catheter removal, intravenous fluids stop, and adequate mobilization were indicators of non compliance. Postoperative follow-up was carried out for 30 days after hospital discharge. The association among early postoperative ERAS compliance and the occurrence of complications was assessed with uni- and multivariate analysis.
    Results: A total of 1089 (78.3%) patients had malignancy and minimally invasive surgery was successfully performed in 1174 (84.3%) patients. Postoperative morbidity occurred in 403 (29.0%) patients. At multivariate analysis, male gender, open surgery, and each of the four non compliance indicators on POD 2 were significantly associated to postoperative complications. Morbidity progressively increased from 16.8% in patients with full compliance to ERAS protocol to 47.2% in patients with two non compliance indicators and 69.2% in patients with all four indicators (p < 0.001).
    Conclusions: Early non compliance to ERAS protocol was significantly associated with postoperative morbidity.
    MeSH term(s) Humans ; Male ; Female ; Aged ; Enhanced Recovery After Surgery ; Postoperative Complications/epidemiology ; Middle Aged ; Guideline Adherence ; Colonic Neoplasms/surgery ; Italy ; Elective Surgical Procedures ; Colectomy/adverse effects ; Prospective Studies ; Minimally Invasive Surgical Procedures
    Language English
    Publishing date 2022-07-01
    Publishing country England
    Document type Journal Article
    ZDB-ID 632519-1
    ISSN 1532-2157 ; 0748-7983
    ISSN (online) 1532-2157
    ISSN 0748-7983
    DOI 10.1016/j.ejso.2022.06.033
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Effect of in-hospital delay on acute appendicitis severity: does time really matter?

    Agnesi, Stefano / Mauro Di Lucca, Gabriele / Benedetti, Fabio / Fattori, Luca / Degrate, Luca / Roccamatisi, Linda / Braga, Marco / Ceresoli, Marco

    Updates in surgery

    2024  

    Abstract: Appendicitis is one of the most common abdominal emergencies. Evidence is controversial in determining if the in-hospital time delay to surgery can worsen the clinical presentation of appendicitis. This study aimed to clarify if in-hospital surgical ... ...

    Abstract Appendicitis is one of the most common abdominal emergencies. Evidence is controversial in determining if the in-hospital time delay to surgery can worsen the clinical presentation of appendicitis. This study aimed to clarify if in-hospital surgical delay significantly affected the proportion of complicated appendicitis in a large prospective cohort of patients treated with appendectomy for acute appendicitis. Patients were grouped into low, medium, and high preoperative risk for acute appendicitis based on the Alvarado scoring system. Appendicitis was defined as complicated in cases of perforation, abscess, or diffuse peritonitis. The primary outcome was correlation of in-hospital delay with the proportion of complicated appendicitis. The study includes 804 patients: 278 (30.4%) had complicated appendicitis and median time delay to surgery in low-, medium-, and high-risk group was 23.15 h (13.51-31.48), 18.47 h (10.44-29.42), and 13.04 (8.13-24.10) h, respectively. In-hospital delay was not associated with the severity of appendicitis or with the presence of postoperative complications. It appears reasonably safe to delay appendicectomy for acute appendicitis up to 24 h from hospital admission. Duration of symptoms was a predictor of complicated appendicitis and morbidity. Timing for appendicectomy in acute appendicitis should be calculated from symptoms onset rather than hospital presentation.
    Language English
    Publishing date 2024-04-02
    Publishing country Italy
    Document type Journal Article
    ZDB-ID 2572692-4
    ISSN 2038-3312 ; 2038-131X
    ISSN (online) 2038-3312
    ISSN 2038-131X
    DOI 10.1007/s13304-024-01823-5
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article: Evaluating the Natural History of Groin Hernia from an "Unplanned" Watchful Waiting Strategy.

    Ceresoli, Marco / Adjei Antwi, Stella Konadu / Mehmeti, Megi / Marmaggi, Serena / Braga, Marco / Nespoli, Luca

    Journal of clinical medicine

    2023  Volume 12, Issue 12

    Abstract: Groin hernia is one of the most common surgical diagnoses worldwide. The indication for surgery in asymptomatic or mildly symptomatic patients is discussed. Some trials have demonstrated the safety of a watchful waiting strategy. During the pandemic, ... ...

    Abstract Groin hernia is one of the most common surgical diagnoses worldwide. The indication for surgery in asymptomatic or mildly symptomatic patients is discussed. Some trials have demonstrated the safety of a watchful waiting strategy. During the pandemic, waiting lists for hernia surgery dramatically increased the opportunity to evaluate the natural history of groin hernias. The present study aimed to evaluate the incidence of emergency hernia surgery in a large cohort of patients that were selected and were waiting for elective surgery. This is a retrospective cross-sectional cohort study including all patients evaluated and selected for elective groin hernia surgery at San Gerardo Hospital between 2017 and 2020. Elective and emergency hernia surgeries were recorded for all patients. The incidence of adverse events was also evaluated. Overall, 1423 patients were evaluated, and 964 selected patients (80.3%) underwent elective hernia surgery, while 17 patients (1.4%) required an emergency operation while waiting for an elective operation. A total of 220 (18.3%) patients were still awaiting surgery in March 2022. The overall cumulative risk levels for emergency hernia surgeries were 1%, 2%, 3.2%, and 5% at 12, 24, 36, and 48 months, respectively. There was no association between longer waiting periods and an increased need for emergency surgery. Our study indicates that up to 5% of patients with groin hernia require emergency surgery at 48 months from the evaluation; the increased waiting time for surgery for elective groin hernia repair was not associated with an increased incidence of adverse events.
    Language English
    Publishing date 2023-06-19
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2662592-1
    ISSN 2077-0383
    ISSN 2077-0383
    DOI 10.3390/jcm12124127
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Surgery or antibiotics for acute appendicitis? Take care about study's design and methodology!

    Ceresoli, Marco / Catena, Fausto / Ansaloni, Luca

    Updates in surgery

    2018  Volume 70, Issue 4, Page(s) 563–564

    Language English
    Publishing date 2018-03-27
    Publishing country Italy
    Document type Letter ; Comment
    ZDB-ID 2572692-4
    ISSN 2038-3312 ; 2038-131X
    ISSN (online) 2038-3312
    ISSN 2038-131X
    DOI 10.1007/s13304-018-0528-2
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Hyperthermic Intraperitoneal Chemotherapy in Ovarian Cancer.

    Ceresoli, Marco / Frigerio, Luigi / Ansaloni, Luca

    The New England journal of medicine

    2018  Volume 378, Issue 14, Page(s) 1363

    MeSH term(s) Female ; Humans ; Hyperthermia, Induced ; Ovarian Neoplasms
    Language English
    Publishing date 2018--05
    Publishing country United States
    Document type Letter ; Comment
    ZDB-ID 207154-x
    ISSN 1533-4406 ; 0028-4793
    ISSN (online) 1533-4406
    ISSN 0028-4793
    DOI 10.1056/NEJMc1802033
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Are endoscopic loop ties safe even in complicated acute appendicitis? A systematic review and meta-analysis.

    Ceresoli, Marco / Tamini, Nicolò / Gianotti, Luca / Braga, Marco / Nespoli, Luca

    International journal of surgery (London, England)

    2019  Volume 68, Page(s) 40–47

    Abstract: Background: Appendectomy is amongst the most common general surgical procedures and the laparoscopic approach is recognized and recommended by international guidelines as a valid option. The different closure techniques of the appendicular stump ... ...

    Abstract Background: Appendectomy is amongst the most common general surgical procedures and the laparoscopic approach is recognized and recommended by international guidelines as a valid option. The different closure techniques of the appendicular stump constitute a matter of debate since their possible implication in determining postoperative infectious complications. The aim of the present meta-analysis is to compare endostapler versus endoscopic loop ties for stump closure during laparoscopic appendectomy.
    Methods: This is a systematic review with meta-analysis of randomized trials and cohort studies comparing endostapler with endoscopic loop ties for the closure of appendicular sump in laparoscopy appendectomy. Subgroup analysis of pediatric patients and patients with complicated appendicitis were performed when data were available. Complicated acute appendicitis was defined as in case of gangrenous/necrotic appendix or perforated appendix. Main outcomes were wound infection rate, intra-abdominal infection rate, length of stay, readmission and reoperation rates.
    Results: a total of 5934 patients from 14 studies were included in the analysis. Endostapler was associated with a similar intra-abdominal abscess rate (RR 0.88, 95%C.I. 0.54-1.43) but a lower incidence of wound infection (RR 0.54, 95%C.I. 0.22-0.97) Length of stay, readmission and reoperation rates were similar. In subgroups analysis endostapler reduces significantly the wound infection rate in pediatric patients; no differences in main outcomes were observed in patients with complicated acute appendicitis.
    Conclusion: In complicated acute appendicitis the stump closure technique did not affect outcomes; the use of endostapler seems to be associated to a reduction of wound infection rate in pediatric patients with non-complicated acute appendicitis.
    MeSH term(s) Abdominal Abscess/etiology ; Adult ; Appendectomy/instrumentation ; Appendectomy/methods ; Appendicitis/pathology ; Appendicitis/surgery ; Child ; Female ; Humans ; Intraabdominal Infections/etiology ; Length of Stay ; Male ; Postoperative Complications/etiology ; Reoperation/statistics & numerical data ; Sutures/adverse effects ; Treatment Outcome ; Wound Closure Techniques/adverse effects ; Wound Closure Techniques/instrumentation ; Wound Infection/etiology
    Language English
    Publishing date 2019-06-18
    Publishing country England
    Document type Journal Article ; Meta-Analysis ; Systematic Review
    ZDB-ID 2212038-5
    ISSN 1743-9159 ; 1743-9191
    ISSN (online) 1743-9159
    ISSN 1743-9191
    DOI 10.1016/j.ijsu.2019.06.011
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Outpatient Non-operative Management of Uncomplicated Acute Appendicitis: A Non-inferiority Study.

    Ceresoli, Marco / Fumagalli, Chiara / Fugazzola, Paola / Zanini, Nicola / Magnone, Stefano / Ravasi, Michela / Bonalumi, Jacopo / Morezzi, Daniele / Bova, Raffaele / Sargenti, Benedetta / Schiavone, Luca / Lucianetti, Alessandro / Catena, Fausto / Ansaloni, Luca / Braga, Marco

    World journal of surgery

    2023  Volume 47, Issue 10, Page(s) 2378–2385

    Abstract: Introduction: Non-operative management (NOM) of uncomplicated acute appendicitis is a well-established alternative to upfront surgery. The administration of intravenous broad-spectrum antibiotics is usually performed in hospital, and only one study ... ...

    Abstract Introduction: Non-operative management (NOM) of uncomplicated acute appendicitis is a well-established alternative to upfront surgery. The administration of intravenous broad-spectrum antibiotics is usually performed in hospital, and only one study described outpatient NOM. The aim of this multicentre retrospective non-inferiority study was to evaluate both safety and non-inferiority of outpatient compared to inpatient NOM in uncomplicated acute appendicitis.
    Methods: The study included 668 consecutive patients with uncomplicated acute appendicitis. Patients were treated according to the surgeon's preference: 364 upfront appendectomy, 157 inpatient NOM (inNOM), and 147 outpatient NOM (outNOM). The primary endpoint was the 30-day appendectomy rate, with a non-inferiority limit of 5%. Secondary endpoints were negative appendectomy rate, 30-day unplanned emergency department (ED) visits, and length of stay.
    Results: 30-day appendectomies were 16 (10.9%) in the outNOM group and 23 (14.6%) in the inNOM group (p = 0.327). OutNOM was non-inferior to inNOM with a risk difference of-3.80% 97.5% CI (- 12.57; 4.97). No difference was found between inNOM and outNOM groups for the number of complicated appendicitis (3 vs. 5) and negative appendectomy (1 vs. 0). Twenty-six (17.7%) outNOM patients required an unplanned ED visit after a median of 1 (1-4) days. In the outNOM group, the mean cumulative in-hospital stay was 0.89 (1.94) days compared with 3.94 (2.17) days in the inNOM group (p < 0.001).
    Conclusions: Outpatient NOM was non-inferior to inpatient NOM with regard to the 30-day appendectomy rate, while a shorter hospital stay was found in the outNOM group. Further, studies are required to confirm these findings.
    MeSH term(s) Humans ; Appendicitis/surgery ; Appendicitis/drug therapy ; Outpatients ; Retrospective Studies ; Treatment Outcome ; Anti-Bacterial Agents/therapeutic use ; Acute Disease
    Chemical Substances Anti-Bacterial Agents
    Language English
    Publishing date 2023-05-20
    Publishing country United States
    Document type Multicenter Study ; Journal Article
    ZDB-ID 224043-9
    ISSN 1432-2323 ; 0364-2313
    ISSN (online) 1432-2323
    ISSN 0364-2313
    DOI 10.1007/s00268-023-07065-7
    Database MEDical Literature Analysis and Retrieval System OnLINE

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