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  1. Article ; Online: Implementation and Evaluation of a Novel Media Education Curriculum for Pediatric Residents.

    Kabra, Rashi / Steiner, Shara / Cerise, Jane / Saldanha, Nadia

    MedEdPORTAL : the journal of teaching and learning resources

    2023  Volume 19, Page(s) 11372

    Abstract: Introduction: Despite increasing awareness of media exposure to children and adolescents and the known value of media education for physicians, residency programs lack formal media education.: Methods: We designed an interactive curriculum for ... ...

    Abstract Introduction: Despite increasing awareness of media exposure to children and adolescents and the known value of media education for physicians, residency programs lack formal media education.
    Methods: We designed an interactive curriculum for pediatric residents to teach health effects of media as well as screening and counseling strategies. Instructional methods were based on constructivism, experiential learning, and situated learning theories. Participants independently reflected on a media viewing, then participated in two facilitator-led 1-hour workshops of two to three residents. Facilitators received speaker notes based on American Academy of Pediatrics media guidelines. Changes in knowledge, reported skills, and attitudes were assessed by pre- and posttests.
    Results: Twenty-one residents completed the curriculum from September 2021 through April 2022. Knowledge improved after the curriculum as the median score increased from 3 to 5 out of 6, although 4 months later it was insignificant. Reported skills in screening did not significantly change. Residents strongly agreed that media use was an important health issue, with medians of 9 or 10 out of 10 on all tests. Attitudes regarding residency preparedness and confidence in screening and counseling significantly improved from pretest medians of 6 and 6 out of 10, respectively, to posttest medians of 8 and 9 to 4-month posttest medians of 6 and 8.
    Discussion: A media curriculum for pediatric residents resulted in improved knowledge and attitudes. Enhanced attitudes demonstrated sustainability. All participants found the curriculum relevant and engaging and felt it should be continued.
    MeSH term(s) Adolescent ; Humans ; Child ; Curriculum ; Internship and Residency ; Problem-Based Learning ; Knowledge ; Physicians
    Language English
    Publishing date 2023-12-22
    Publishing country United States
    Document type Journal Article
    ISSN 2374-8265
    ISSN (online) 2374-8265
    DOI 10.15766/mep_2374-8265.11372
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Fetal echocardiographic features associated with bicuspid aortic valve.

    Burns, Joseph / Ganigara, Madhusudan / Cerise, Jane E / Hayes, Denise A

    Cardiology in the young

    2023  Volume 34, Issue 1, Page(s) 50–55

    Abstract: Background: Prenatal diagnosis of bicuspid aortic valve is challenging. Bicuspid aortic valve is often associated with aortic dilation.: Methods: Fetuses with postnatally confirmed bicuspid aortic valve were gestational age-matched with normal ... ...

    Abstract Background: Prenatal diagnosis of bicuspid aortic valve is challenging. Bicuspid aortic valve is often associated with aortic dilation.
    Methods: Fetuses with postnatally confirmed bicuspid aortic valve were gestational age-matched with normal controls. Complex lesions were excluded. Aortic valve and arch measurements by two blinded investigators were compared.
    Results: We identified 27 cases and 27 controls. Estimated fetal weight percentile was lower in cases than controls. Seven cases had one or more significant lesions including perimembranous ventricular septal defects (n = 2), isolated annular hypoplasia (n = 2), and/or arch hypoplasia/coarctation (n = 4). Fetuses with bicuspid aortic valves had significantly smaller median z-scores of the aortic annulus (-1.60 versus -0.53, p < 0.001) and root (-1.10 versus -0.53, p = 0.040), and larger ratios of root to annulus (1.32 versus 1.21, p < 0.001), sinotubular junction to annulus (1.07 versus 0.99, p < 0.001), ascending aorta to annulus (1.29 versus 1.18, p < 0.001), and transverse aorta to annulus (1.04 versus 0.96, p = 0.023). Leaflets were "doming" in 11 cases (41%) and 0 controls (p = 0.010), "thickened" in 10 cases (37%) and 0 controls (p = 0.002). We noted similar findings in the subgroup without significant additional cardiac defects.
    Conclusions: The appearance of doming or thickened aortic valve leaflets on fetal echocardiogram is associated with bicuspid aortic valve. Compared to controls, fetuses with bicuspid aortic valve had smaller aortic annulus sizes (possibly related to smaller fetal size) without proportionally smaller aortic measurements, resulting in larger aortic dimension to annulus ratios. Despite inherent challenges of diagnosing bicuspid aortic valve prenatally, these findings may increase suspicion and prompt appropriate postnatal follow-up.
    MeSH term(s) Pregnancy ; Female ; Humans ; Bicuspid Aortic Valve Disease ; Aortic Valve/abnormalities ; Aorta/diagnostic imaging ; Aortic Coarctation ; Echocardiography ; Retrospective Studies
    Language English
    Publishing date 2023-05-12
    Publishing country England
    Document type Journal Article
    ZDB-ID 1078466-4
    ISSN 1467-1107 ; 1047-9511
    ISSN (online) 1467-1107
    ISSN 1047-9511
    DOI 10.1017/S1047951123000744
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Barriers to Receiving Follow-up Care Among Childhood Cancer Survivors.

    Bossert, Sharon / Borenzweig, William / Benedict, Catherine / Cerise, Jane E / Siembida, Elizabeth J / Fish, Jonathan D

    Journal of pediatric hematology/oncology

    2023  Volume 45, Issue 7, Page(s) e827–e832

    Abstract: Little is known on why adherence to follow-up care in childhood cancer survivors (CCS) is lacking. This study characterized barriers to adherence to follow-up care among CCS, identified sociodemographic correlates of barriers, and examined whether ... ...

    Abstract Little is known on why adherence to follow-up care in childhood cancer survivors (CCS) is lacking. This study characterized barriers to adherence to follow-up care among CCS, identified sociodemographic correlates of barriers, and examined whether barriers to follow-up care relate to health-related quality of life. Adult CCS (N=84) were anonymously surveyed via REDCap using the Barriers to Care Questionnaire (BCQ) and the Quality of Life Scale-Cancer Survivor (QOL-CS). Both descriptive and correlation analyses were conducted. The median BCQ total score was 88.5 (interquartile ranges:78.4 to 95.7), with the greatest barriers reported in the Skills (eg, ease of navigating the healthcare system) and Pragmatism subscales (eg, cost). There was a statistically significant correlation between the BCQ total score and the QOL-CS total score (rs=0.47, P <0.0001) and the physical, psychological, and social QOL-CS subscales (all P 's<0.05). The results found that barriers to follow-up care for CCS are mostly related to cost and appointment logistics, and that more barriers to care is associated with lower health-related quality of life among CCS. Identifying barriers to follow-up care is the first step in improving adherence, which would allow for earlier detection of late effects of cancer therapy and thereby result in reductions in morbidity and mortality.
    MeSH term(s) Adult ; Humans ; Child ; Cancer Survivors ; Quality of Life ; Aftercare ; Neoplasms/therapy ; Neoplasms/psychology ; Surveys and Questionnaires
    Language English
    Publishing date 2023-07-20
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1231152-2
    ISSN 1536-3678 ; 1077-4114 ; 0192-8562
    ISSN (online) 1536-3678
    ISSN 1077-4114 ; 0192-8562
    DOI 10.1097/MPH.0000000000002714
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Lung ultrasound assessment of pulmonary edema in neonates with chronic lung disease before and after diuretic therapy.

    Kasniya, Gangajal / Weinberger, Barry / Cerise, Jane / Pulju, Margaret / Boyar, Vitaliya / Frunza, Florin / Kurepa, Dalibor

    Pediatric pulmonology

    2022  Volume 57, Issue 12, Page(s) 3145–3150

    Abstract: Introduction: Bronchopulmonary dysplasia (BPD) is characterized by lung injury with varying degrees of disrupted alveolarization, vascular remodeling, inflammatory cell proliferation, and pulmonary edema. Diuretics are often used to ameliorate the ... ...

    Abstract Introduction: Bronchopulmonary dysplasia (BPD) is characterized by lung injury with varying degrees of disrupted alveolarization, vascular remodeling, inflammatory cell proliferation, and pulmonary edema. Diuretics are often used to ameliorate the symptoms or progression of BPD. Our primary objective was to use lung ultrasound (LUS) to determine if diuretics decrease pulmonary edema in infants with BPD. The secondary objective was to assess changes in respiratory support during the first week after initiation of diuretics.
    Methods: Premature infants requiring noninvasive respiratory support and starting diuretic therapy for evolving BPD were compared with a similar group of infants not receiving diuretics (control). For the diuretic group, LUS exams were performed before and on Days 1, 3, and 6 after initiation of treatment. For the control group, LUS was performed at equivalent time points. A composite pulmonary edema severity (PES) score of 0-5 was calculated based on the total number of B-lines in six scanned areas. Respiratory support parameters (FiO
    Results: Infants in the diuretic (n = 28) and control (n = 23) groups were recruited at median corrected gestational ages of 34.2 (33.3-35.9) and 34.0 (33.4-36.3) weeks, respectively (p = 0.82). PES scores, FiO
    Conclusion: Diuretic use is associated with decreased pulmonary edema and improved oxygenation in infants with BPD during the first week of treatment.
    MeSH term(s) Infant, Newborn ; Infant ; Humans ; Pulmonary Edema/diagnostic imaging ; Pulmonary Edema/drug therapy ; Pulmonary Edema/etiology ; Chronic Disease ; Risk ; Diuretics/therapeutic use ; Bronchopulmonary Dysplasia/complications ; Bronchopulmonary Dysplasia/diagnostic imaging ; Bronchopulmonary Dysplasia/drug therapy ; Lung/diagnostic imaging
    Chemical Substances Diuretics
    Language English
    Publishing date 2022-10-11
    Publishing country United States
    Document type Journal Article
    ZDB-ID 632784-9
    ISSN 1099-0496 ; 8755-6863
    ISSN (online) 1099-0496
    ISSN 8755-6863
    DOI 10.1002/ppul.26150
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article: Utility of Methicillin-Resistant

    Sands, Ashley / Mulvey, Nicole / Iacono, Denise / Cerise, Jane / Hagmann, Stefan H F

    Antibiotics (Basel, Switzerland)

    2021  Volume 10, Issue 12

    Abstract: Studies in adults support the use of a negative methicillin- ... ...

    Abstract Studies in adults support the use of a negative methicillin-resistant
    Language English
    Publishing date 2021-11-23
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2681345-2
    ISSN 2079-6382
    ISSN 2079-6382
    DOI 10.3390/antibiotics10121434
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Continuous and intermittent administration of intravenous sildenafil in critically ill infants with pulmonary hypertension.

    Sharma, Chetan / Burns, Joseph / Kulkarni, Aparna / Cerise, Jane E / Molina Berganza, Fernando / Hayes, Denise A

    Pediatric pulmonology

    2021  Volume 56, Issue 9, Page(s) 2973–2978

    Abstract: Intravenous (IV) sildenafil may be administered as a continuous infusion or intermittent bolus dosing in infants with pulmonary hypertension (PH). We aimed to compare these delivery methods.: Methods: We retrospectively evaluated subjects less than 12 ...

    Abstract Intravenous (IV) sildenafil may be administered as a continuous infusion or intermittent bolus dosing in infants with pulmonary hypertension (PH). We aimed to compare these delivery methods.
    Methods: We retrospectively evaluated subjects less than 12 months old treated with IV sildenafil for PH. Vital signs, oxygen requirement, vasoactive-inotropic score (VIS), and echocardiogram results before and after sildenafil initiation, and the need for discontinuation due to side effects, were noted.
    Results: Forty-three subjects were identified (23 continuous, 20 intermittent). There were clinically significant differences in PH classifications between groups. The continuous group was significantly younger (p = 0.010) with higher baseline severity of illness suggested by higher inspired oxygen (FiO
    Conclusion: In this small cohort of infants treated with continuous or intermittent IV sildenafil, in the setting of different baseline characteristics between groups, there were no significant differences in changes in vital signs, VIS, FiO
    MeSH term(s) Critical Illness ; Humans ; Hypertension, Pulmonary/drug therapy ; Infant ; Infusions, Intravenous ; Prospective Studies ; Retrospective Studies ; Sildenafil Citrate/therapeutic use
    Chemical Substances Sildenafil Citrate (BW9B0ZE037)
    Language English
    Publishing date 2021-06-24
    Publishing country United States
    Document type Journal Article
    ZDB-ID 632784-9
    ISSN 1099-0496 ; 8755-6863
    ISSN (online) 1099-0496
    ISSN 8755-6863
    DOI 10.1002/ppul.25539
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Allergen Immunotherapy Extract Shortages and Their Effects on Clinical Care: A Work Group Report of the AAAAI Immunotherapy, Allergen Standardization, and Allergy Diagnostics Committee.

    Ezhuthachan, Idil Daloglu / Banks, Taylor A / Cerise, Jane E / Wong, Stephen C / Ponda, Punita

    The journal of allergy and clinical immunology. In practice

    2021  Volume 10, Issue 2, Page(s) 444–452

    Abstract: Allergen immunotherapy (AIT) is the only disease-modifying therapy indicated for treatment of allergic asthma, rhinitis, conjunctivitis, and Hymenoptera hypersensitivity. Manufacturing of the extracts used in AIT involve multistep complex processes as ... ...

    Abstract Allergen immunotherapy (AIT) is the only disease-modifying therapy indicated for treatment of allergic asthma, rhinitis, conjunctivitis, and Hymenoptera hypersensitivity. Manufacturing of the extracts used in AIT involve multistep complex processes as well as regulatory oversight. Furthermore, some source materials are vulnerable to unexpected events of nature. Given these circumstances, allergen extract supply can be disrupted with a potential to adversely impact patient care. A group of members from the American Academy of Allergy, Asthma, and Immunology (AAAAI) Immunotherapy, Allergy Standardization and Allergy Diagnostic Committee formed a workgroup to assess the frequency and effects of allergen extract shortages and associated factors. This workgroup developed a survey that was distributed to a random 20% of the AAAAI membership. In addition, the group also performed a review of the scientific literature on allergen extract supply and shortage. Based on the findings of the survey study and literature review, the workgroup reports frequency and extent of shortages, potential ways to improve communication with suppliers, and need for further guidance in patient care during times of shortage.
    MeSH term(s) Allergens ; Desensitization, Immunologic ; Humans ; Hypersensitivity/diagnosis ; Hypersensitivity/therapy ; Plant Extracts ; Reference Standards
    Chemical Substances Allergens ; Plant Extracts
    Language English
    Publishing date 2021-11-26
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 2843237-X
    ISSN 2213-2201 ; 2213-2198
    ISSN (online) 2213-2201
    ISSN 2213-2198
    DOI 10.1016/j.jaip.2021.10.057
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Ultrasound Assessment of Gastric Emptying in Premature Infants Treated With Non-Invasive Ventilatory Support.

    Hlaing, Arkar Ye / Weinberger, Barry / Schanler, Richard / Cerise, Jane / Kurepa, Dalibor

    Journal of pediatric gastroenterology and nutrition

    2021  Volume 73, Issue 2, Page(s) 197–202

    Abstract: Background: Nasal continuous positive airway pressure (CPAP) introduces positive pressure of air into both the trachea and stomach, which may affect gastric emptying. The rate of gastric emptying can be estimated by ultrasound (US) in neonates by two ... ...

    Abstract Background: Nasal continuous positive airway pressure (CPAP) introduces positive pressure of air into both the trachea and stomach, which may affect gastric emptying. The rate of gastric emptying can be estimated by ultrasound (US) in neonates by two validated techniques: "antral cross-sectional area" (ACSA, two-dimensional estimate of the surface area at the gastric antrum), and "spheroid gastric volume" (spheroid, three-dimensional estimate of the stomach volume).
    Objective: To compare gastric emptying rates in neonates on machine-derived nasal CPAP (MD-nCPAP, Avea and RAM cannula) with those on bubble CPAP (bCPAP, Fisher Paykel and Babi.Plus nasal prongs).
    Methods: Ultrasound measurements of the amount of the milk in the stomach were performed before feeding and at 1, 2, and 3 hours after the start of feeding, using both the ACSA and spheroid methods. Rates of gastric emptying were calculated during the "early" (1-2 hours) and "late" (2-3 hours) phases after feeding.
    Results: We recruited 32 infants (25-34 weeks gestational age, full enteral tube feedings, on nasal CPAP). Seventeen infants were treated with MD-nCPAP (median birth weight 1015 g [interquartile range (IQR): 870-1300], gestational age 28 weeks [IQR: 27-29], postnatal age 20 days [IQR: 14-28]), whereas 15 infants were treated with bCPAP (median birth weight 960 g [IQR: 855-1070], gestational age 27 weeks [IQR: 26-28], postnatal age 17 days [IQR: 15-25]). Gastric emptying rates (% emptied/min) were significantly faster in the "early" compared to the "late" phase for all infants. There were no significant differences in the rates of gastric emptying (either "early" or "late") or volumes of gastric residuals between infants receiving MD-nCPAP or bCPAP, measured by either method. Although no feeding intolerance was seen in either group, the volumes of residual gastric contents measured by both methods were higher than the volumes traditionally considered abnormal when obtained by gastric tube aspiration.
    Conclusions: Gastric emptying is faster during the "early" compared to the "late" phase. Gastric emptying rates are not different in infants receiving MD-nCPAP versus bCPAP. The presence of large residual gastric contents in infants who are tolerating feedings challenges the value of traditional gastric aspiration for the assessment of feeding tolerance in infants.
    MeSH term(s) Adolescent ; Adult ; Continuous Positive Airway Pressure ; Enteral Nutrition ; Gastric Emptying ; Gestational Age ; Humans ; Infant ; Infant, Newborn ; Infant, Premature ; Ultrasonography ; Young Adult
    Language English
    Publishing date 2021-04-10
    Publishing country United States
    Document type Journal Article
    ZDB-ID 603201-1
    ISSN 1536-4801 ; 0277-2116
    ISSN (online) 1536-4801
    ISSN 0277-2116
    DOI 10.1097/MPG.0000000000003157
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Breast Milk Production Variability Among Mothers of Preterm Infants.

    Gomez-Juge, Christina / Scarpelli, Victoria / Yellayi, Disha / Cerise, Jane / Weinberger, Barry / Brewer, Mariana / Maffei, Diana

    Breastfeeding medicine : the official journal of the Academy of Breastfeeding Medicine

    2022  Volume 18, Issue 8, Page(s) 571–578

    Abstract: Introduction: ...

    Abstract Introduction:
    MeSH term(s) Infant, Newborn ; Infant ; Female ; Humans ; Mothers ; Milk, Human ; Infant, Premature ; Breast Feeding ; Breast
    Language English
    Publishing date 2022-12-07
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2234680-6
    ISSN 1556-8342 ; 1556-8253
    ISSN (online) 1556-8342
    ISSN 1556-8253
    DOI 10.1089/bfm.2023.0018
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Association of race/ethnicity with mortality in patients hospitalized with COVID-19.

    Richardson, Safiya / Martinez, Johanna / Hirsch, Jamie S / Cerise, Jane / Lesser, Martin / Roswell, Robert O / Davidson, Karina W

    PloS one

    2022  Volume 17, Issue 8, Page(s) e0267505

    Abstract: Objective: To evaluate racial and ethnic differences in mortality among patients hospitalized with coronavirus disease 2019 (COVID-19) after adjusting for baseline characteristics and comorbidities.: Methods: This retrospective cohort study at 13 ... ...

    Abstract Objective: To evaluate racial and ethnic differences in mortality among patients hospitalized with coronavirus disease 2019 (COVID-19) after adjusting for baseline characteristics and comorbidities.
    Methods: This retrospective cohort study at 13 acute care facilities in the New York City metropolitan area included sequentially hospitalized patients between March 1, 2020, and April 27, 2020. Last day of follow up was July 31, 2020. Patient demographic information, including race/ethnicity and comorbidities, were collected. The primary outcome was in-hospital mortality.
    Results: A total of 10 869 patients were included in the study (median age, 65 years [interquartile range (IQR) 54-77; range, 18-107 years]; 40.5% female). In adjusted time-to-event analysis, increased age, male sex, insurance type (Medicare and Self-Pay), unknown smoking status, and a higher score on the Charlson Comorbidity Index were significantly associated with higher in-hospital mortality. Adjusted risk of hospital mortality for Black, Asian, Hispanic, multiracial/other, and unknown race/ethnicity patients were similar to risk for White patients.
    Conclusions: In a large diverse cohort of patients hospitalized with COVID-19, patients from racial/ethnic minorities experienced similar mortality risk as White patients.
    MeSH term(s) Aged ; COVID-19 ; Ethnicity ; Female ; Hospital Mortality/ethnology ; Hospitalization ; Humans ; Male ; Medicare ; Middle Aged ; Racial Groups ; Retrospective Studies ; SARS-CoV-2 ; United States ; White People
    Language English
    Publishing date 2022-08-04
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural
    ZDB-ID 2267670-3
    ISSN 1932-6203 ; 1932-6203
    ISSN (online) 1932-6203
    ISSN 1932-6203
    DOI 10.1371/journal.pone.0267505
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