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Article ; Online: Defective Interferon-Gamma Production Is Common in Chronic Pulmonary Aspergillosis.

Colombo, Stefano A P / Hashad, Rola / Denning, David W / Kumararatne, Dinakantha S / Ceron-Gutierrez, Lourdes / Barcenas-Morales, Gabriela / MacDonald, Andrew S / Harris, Chris / Doffinger, Rainer / Kosmidis, Chris

The Journal of infectious diseases

2021 Volume 225, Issue 10, Page(s) 1822–1831

Abstract: Background: Immune defects in chronic pulmonary aspergillosis (CPA) are poorly characterized. We compared peripheral blood cytokine profiles in patients with CPA versus healthy controls and explored the relationship with disease severity.: Methods: ... ...

Abstract	Background: Immune defects in chronic pulmonary aspergillosis (CPA) are poorly characterized. We compared peripheral blood cytokine profiles in patients with CPA versus healthy controls and explored the relationship with disease severity. Methods: Interferon-gamma (IFNγ), interleukin (IL)-17, tumor necrosis factor-α, IL-6, IL-12, and IL-10 were measured after in vitro stimulation of whole blood with lipopolysaccharide (LPS), phytohemagglutinin, β-glucan, zymosan (ZYM), IL-12 or IL-18, and combinations. Clinical parameters and mortality were correlated with cytokine production. Results: Cytokine profiles were evaluated in 133 patients (57.1% male, mean age 61 years). In comparison to controls, patients with CPA had significantly reduced production of IFNγ in response to stimulation with β-glucan + IL-12 (312 vs 988 pg/mL), LPS + IL-12 (252 vs 1033 pg/mL), ZYM + IL-12 (996 vs 2347 pg/mL), and IL-18 + IL-12 (7193 vs 12 330 pg/mL). Age >60 (hazard ratio [HR], 1.71; 95% confidence interval [CI], 1.00-2.91; P = .05) and chronic obstructive pulmonary disease (HR, 1.69; 95% CI, 1.03-2.78; P = .039) were associated with worse survival, whereas high IFNγ production in response to beta-glucan + IL-12 stimulation (HR, 0.48; 95% CI, .25-0.92; P = .026) was associated with reduced mortality. Conclusions: Patients with CPA show impaired IFNγ production in peripheral blood in response to stimuli. Defective IFNγ production ability correlates with worse outcomes. Immunotherapy with IFNγ could be beneficial for patients showing impaired IFNγ production in CPA.
MeSH term(s)	Cytokines ; Female ; Humans ; Interferon-gamma ; Interleukin-12 ; Interleukin-18 ; Lipopolysaccharides ; Male ; Middle Aged ; Pulmonary Aspergillosis ; Tumor Necrosis Factor-alpha ; beta-Glucans
Chemical Substances	Cytokines ; Interleukin-18 ; Lipopolysaccharides ; Tumor Necrosis Factor-alpha ; beta-Glucans ; Interleukin-12 (187348-17-0) ; Interferon-gamma (82115-62-6)
Language	English
Publishing date	2021-11-30
Publishing country	United States
Document type	Journal Article
ZDB-ID	3019-3
ISSN	1537-6613 ; 0022-1899
ISSN (online)	1537-6613
ISSN	0022-1899
DOI	10.1093/infdis/jiab583
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Article ; Online: Inherited salt-losing tubulopathies are associated with immunodeficiency due to impaired IL-17 responses.

Evans, Rhys D R / Antonelou, Marilina / Sathiananthamoorthy, Sanchutha / Rega, Marilena / Henderson, Scott / Ceron-Gutierrez, Lourdes / Barcenas-Morales, Gabriela / Müller, Christoph A / Doffinger, Rainer / Walsh, Stephen B / Salama, Alan D

Nature communications

2020 Volume 11, Issue 1, Page(s) 4368

Abstract: Increased extracellular sodium activates Th17 cells, which provide protection from bacterial and fungal infections. Whilst high salt diets have been shown to worsen autoimmune disease, the immunological consequences of clinical salt depletion are unknown. ...

Abstract	Increased extracellular sodium activates Th17 cells, which provide protection from bacterial and fungal infections. Whilst high salt diets have been shown to worsen autoimmune disease, the immunological consequences of clinical salt depletion are unknown. Here, we investigate immunity in patients with inherited salt-losing tubulopathies (SLT). Forty-seven genotyped SLT patients (with Bartter, Gitelman or EAST Syndromes) are recruited. Clinical features of dysregulated immunity are recorded with a standardised questionnaire and immunological investigations of IL-17 responsiveness undertaken. The effects of altering extracellular ionic concentrations on immune responses are then assessed. Patients are hypokalaemic and hypomagnesaemic, with reduced interstitial sodium stores determined by
MeSH term(s)	Adolescent ; Adult ; Aged, 80 and over ; Animals ; Child, Preschool ; Chronic Disease ; Cohort Studies ; Female ; Genetic Diseases, Inborn ; Humans ; Immunologic Deficiency Syndromes/etiology ; Interleukin-17/metabolism ; Kidney Tubules, Distal/pathology ; Magnesium/metabolism ; Male ; Middle Aged ; Potassium/metabolism ; Salts/metabolism ; Salts/therapeutic use ; Sodium/metabolism ; Sodium Chloride/metabolism ; Sodium Chloride, Dietary/therapeutic use ; Th17 Cells/metabolism ; Th2 Cells/metabolism ; Young Adult
Chemical Substances	Interleukin-17 ; Salts ; Sodium Chloride, Dietary ; Sodium Chloride (451W47IQ8X) ; Sodium (9NEZ333N27) ; Magnesium (I38ZP9992A) ; Potassium (RWP5GA015D)
Language	English
Publishing date	2020-08-31
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2553671-0
ISSN	2041-1723 ; 2041-1723
ISSN (online)	2041-1723
ISSN	2041-1723
DOI	10.1038/s41467-020-18184-3
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Article ; Online: SARS-CoV-2 Spike Protein Stabilized in the Closed State Induces Potent Neutralizing Responses.

Carnell, George W / Ciazynska, Katarzyna A / Wells, David A / Xiong, Xiaoli / Aguinam, Ernest T / McLaughlin, Stephen H / Mallery, Donna / Ebrahimi, Soraya / Ceron-Gutierrez, Lourdes / Asbach, Benedikt / Einhauser, Sebastian / Wagner, Ralf / James, Leo C / Doffinger, Rainer / Heeney, Jonathan L / Briggs, John A G

Journal of virology

2021 Volume 95, Issue 15, Page(s) e0020321

Abstract: The majority of SARS-CoV-2 vaccines in use or advanced development are based on the viral spike protein (S) as their immunogen. S is present on virions as prefusion trimers in which the receptor binding domain (RBD) is stochastically open or closed. ... ...

Abstract	The majority of SARS-CoV-2 vaccines in use or advanced development are based on the viral spike protein (S) as their immunogen. S is present on virions as prefusion trimers in which the receptor binding domain (RBD) is stochastically open or closed. Neutralizing antibodies have been described against both open and closed conformations. The long-term success of vaccination strategies depends upon inducing antibodies that provide long-lasting broad immunity against evolving SARS-CoV-2 strains. Here, we have assessed the results of immunization in a mouse model using an S protein trimer stabilized in the closed state to prevent full exposure of the receptor binding site and therefore interaction with the receptor. We compared this with other modified S protein constructs, including representatives used in current vaccines. We found that all trimeric S proteins induced a T cell response and long-lived, strongly neutralizing antibody responses against 2019 SARS-CoV-2 and variants of concern P.1 and B.1.351. Notably, the protein binding properties of sera induced by the closed spike differed from those induced by standard S protein constructs. Closed S proteins induced more potent neutralizing responses than expected based on the degree to which they inhibit interactions between the RBD and ACE2. These observations suggest that closed spikes recruit different, but equally potent, immune responses than open spikes and that this is likely to include neutralizing antibodies against conformational epitopes present in the closed conformation. We suggest that closed spikes, together with their improved stability and storage properties, may be a valuable component of refined, next-generation vaccines.
MeSH term(s)	Angiotensin-Converting Enzyme 2/chemistry ; Angiotensin-Converting Enzyme 2/immunology ; Animals ; Antibodies, Neutralizing/chemistry ; Antibodies, Neutralizing/immunology ; Antibodies, Viral/chemistry ; Antibodies, Viral/immunology ; COVID-19 Vaccines/chemistry ; COVID-19 Vaccines/immunology ; Epitopes/chemistry ; Epitopes/immunology ; HEK293 Cells ; Humans ; Mice ; Protein Stability ; SARS-CoV-2/chemistry ; SARS-CoV-2/immunology ; Spike Glycoprotein, Coronavirus/chemistry ; Spike Glycoprotein, Coronavirus/immunology
Chemical Substances	Antibodies, Neutralizing ; Antibodies, Viral ; COVID-19 Vaccines ; Epitopes ; Spike Glycoprotein, Coronavirus ; spike protein, SARS-CoV-2 ; ACE2 protein, human (EC 3.4.17.23) ; Angiotensin-Converting Enzyme 2 (EC 3.4.17.23)
Language	English
Publishing date	2021-07-12
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	80174-4
ISSN	1098-5514 ; 0022-538X
ISSN (online)	1098-5514
ISSN	0022-538X
DOI	10.1128/JVI.00203-21
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Article ; Online: Protein microarrays identify disease-specific anti-cytokine autoantibody profiles in the landscape of immunodeficiency.

Rosenberg, Jacob M / Price, Jordan V / Barcenas-Morales, Gabriela / Ceron-Gutierrez, Lourdes / Davies, Sophie / Kumararatne, Dinakantha S / Döffinger, Rainer / Utz, Paul J

The Journal of allergy and clinical immunology

2016 Volume 137, Issue 1, Page(s) 204–213.e3

Abstract: Background: Anti-cytokine autoantibodies (ACAAs) are pathogenic in a handful of rare immunodeficiencies. However, the prevalence and significance of other ACAAs across immunodeficiencies have not yet been described.: Objective: We profiled ACAAs in a ...

Abstract	Background: Anti-cytokine autoantibodies (ACAAs) are pathogenic in a handful of rare immunodeficiencies. However, the prevalence and significance of other ACAAs across immunodeficiencies have not yet been described. Objective: We profiled ACAAs in a diverse cohort of serum samples from patients with immunodeficiency and assessed the sensitivity and specificity of protein microarrays for ACAA identification and discovery. Methods: Highly multiplexed protein microarrays were designed and fabricated. Blinded serum samples from a cohort of 58 immunodeficiency patients and healthy control subjects were used to probe microarrays. Unsupervised hierarchical clustering was used to identify clusters of reactivity, and after unblinding, significance analysis of microarrays was used to identify disease-specific autoantibodies. A bead-based assay was used to validate protein microarray results. Blocking activity of serum containing ACAAs was measured in vitro. Results: Protein microarrays were highly sensitive and specific for the detection of ACAAs in patients with autoimmune polyendocrine syndrome type I and pulmonary alveolar proteinosis, detecting ACAA levels consistent with those reported in the published literature. Protein microarray results were validated by using an independent bead-based assay. To confirm the functional significance of these ACAAs, we tested and confirmed the blocking activity of select ACAAs in vitro. Conclusion: Protein microarrays are a powerful tool for ACAA detection and discovery, and they hold promise as a diagnostic for the evaluation and monitoring of clinical immunodeficiency.
MeSH term(s)	Autoantibodies/blood ; Cytokines/immunology ; Humans ; Immunologic Deficiency Syndromes/blood ; Immunologic Deficiency Syndromes/immunology ; Protein Array Analysis
Chemical Substances	Autoantibodies ; Cytokines
Language	English
Publishing date	2016-01
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
ZDB-ID	121011-7
ISSN	1097-6825 ; 1085-8725 ; 0091-6749
ISSN (online)	1097-6825 ; 1085-8725
ISSN	0091-6749
DOI	10.1016/j.jaci.2015.07.032
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Article: Critical Care Workers Have Lower Seroprevalence of SARS-CoV-2 IgG Compared with Non-patient Facing Staff in First Wave of COVID19.

Journal of critical care medicine (Universitatea de Medicina si Farmacie din Targu-Mures)

2021 Volume 7, Issue 3, Page(s) 199–210

Abstract: Introduction: In early 2020, at first surge of the coronavirus disease 2019 (COVID-19) pandemic, many health care workers (HCW) were re-deployed to critical care environments to support intensive care teams looking after patients with severe COVID-19. ... ...

Abstract	Introduction: In early 2020, at first surge of the coronavirus disease 2019 (COVID-19) pandemic, many health care workers (HCW) were re-deployed to critical care environments to support intensive care teams looking after patients with severe COVID-19. There was considerable anxiety of increased risk of COVID-19 for these staff. To determine whether critical care HCW were at increased risk of hospital acquired infection, we explored the relationship between workplace, patient facing role and evidence of immune exposure to the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) within a quaternary hospital providing a regional critical care response. Routine viral surveillance was not available at this time. Methods: We screened over 500 HCW (25% of the total workforce) for history of clinical symptoms of possible COVID19, assigning a symptom severity score, and quantified SARS-CoV-2 serum antibodies as evidence of immune exposure to the virus. Results: Whilst 45% of the cohort reported symptoms that they consider may have represented COVID-19, 14% had evidence of immune exposure. Staffs in patient facing critical care roles were least likely to be seropositive (9%) and staff working in non-patient facing roles most likely to be seropositive (22%). Anosmia and fever were the most discriminating symptoms for seropositive status. Older males presented with more severe symptoms. Of the 12 staff screened positive by nasal swab (10 symptomatic), 3 showed no evidence of seroconversion in convalescence. Conclusions: Patient facing staff working in critical care do not appear to be at increased risk of hospital acquired infection however the risk of nosocomial infection from non-patient facing staff may be more significant than previous recognised. Most symptoms ascribed to possible COVID-19 were found to have no evidence of immune exposure however seroprevalence may underrepresent infection frequency. Older male staff were at the greatest risk of more severe symptoms.
Language	English
Publishing date	2021-08-05
Publishing country	Poland
Document type	Journal Article
ISSN	2393-1809
ISSN	2393-1809
DOI	10.2478/jccm-2021-0018
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Article ; Online: SARS-CoV-2 spike protein arrested in the closed state induces potent neutralizing responses

Carnell, George W / Ciazynska, Katarzyna A / Wells, David A / Xiong, Xiaoli / Aguinam, Ernest T / McLaughlin, Stephen H / Mallery, Donna / Ebrahimi, Soraya / Ceron-Gutierrez, Lourdes / James, Leo C / Doffinger, Rainer / Heeney, Jonathan Luke / Briggs, John A. G.

bioRxiv

Abstract: The majority of SARS-CoV-2 vaccines in use or in advanced clinical development are based on the viral spike protein (S) as their immunogen. S is present on virions as pre-fusion trimers in which the receptor binding domain (RBD) is stochastically open or ...

Abstract	The majority of SARS-CoV-2 vaccines in use or in advanced clinical development are based on the viral spike protein (S) as their immunogen. S is present on virions as pre-fusion trimers in which the receptor binding domain (RBD) is stochastically open or closed. Neutralizing antibodies have been described that act against both open and closed conformations. The long-term success of vaccination strategies will depend upon inducing antibodies that provide long-lasting broad immunity against evolving, circulating SARS-CoV-2 strains, while avoiding the risk of antibody dependent enhancement as observed with other Coronavirus vaccines. Here we have assessed the results of immunization in a mouse model using an S protein trimer that is arrested in the closed state to prevent exposure of the receptor binding site and therefore interaction with the receptor. We compared this with a range of other modified S protein constructs, including representatives used in current vaccines. We found that all trimeric S proteins induce a long-lived, strongly neutralizing antibody response as well as T-cell responses. Notably, the protein binding properties of sera induced by the closed spike differed from those induced by standard S protein constructs. Closed S proteins induced more potent neutralising responses than expected based on the degree to which they inhibit interactions between the RBD and ACE2. These observations suggest that closed spikes recruit different, but equally potent, virus-inhibiting immune responses than open spikes, and that this is likely to include neutralizing antibodies against conformational epitopes present in the closed conformation. Together with their improved stability and storage properties we suggest that closed spikes may be a valuable component of refined, next-generation vaccines.
Keywords	covid19
Language	English
Publishing date	2021-01-14
Publisher	Cold Spring Harbor Laboratory
Document type	Article ; Online
DOI	10.1101/2021.01.14.426695
Database	COVID19

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Article ; Online: Accelerated waning of the humoral response to COVID-19 vaccines in obesity.

van der Klaauw, Agatha A / Horner, Emily C / Pereyra-Gerber, Pehuén / Agrawal, Utkarsh / Foster, William S / Spencer, Sarah / Vergese, Bensi / Smith, Miriam / Henning, Elana / Ramsay, Isobel D / Smith, Jack A / Guillaume, Stephane M / Sharpe, Hayley J / Hay, Iain M / Thompson, Sam / Innocentin, Silvia / Booth, Lucy H / Robertson, Chris / McCowan, Colin /

Kerr, Steven / Mulroney, Thomas E / O'Reilly, Martin J / Gurugama, Thevinya P / Gurugama, Lihinya P / Rust, Maria A / Ferreira, Alex / Ebrahimi, Soraya / Ceron-Gutierrez, Lourdes / Scotucci, Jacopo / Kronsteiner, Barbara / Dunachie, Susanna J / Klenerman, Paul / Park, Adrian J / Rubino, Francesco / Lamikanra, Abigail A / Stark, Hannah / Kingston, Nathalie / Estcourt, Lise / Harvala, Heli / Roberts, David J / Doffinger, Rainer / Linterman, Michelle A / Matheson, Nicholas J / Sheikh, Aziz / Farooqi, I Sadaf / Thaventhiran, James E D

Nature medicine

2023 Volume 29, Issue 5, Page(s) 1146–1154

Abstract: Obesity is associated with an increased risk of severe Coronavirus Disease 2019 (COVID-19) infection and mortality. COVID-19 vaccines reduce the risk of serious COVID-19 outcomes; however, their effectiveness in people with obesity is incompletely ... ...

Abstract	Obesity is associated with an increased risk of severe Coronavirus Disease 2019 (COVID-19) infection and mortality. COVID-19 vaccines reduce the risk of serious COVID-19 outcomes; however, their effectiveness in people with obesity is incompletely understood. We studied the relationship among body mass index (BMI), hospitalization and mortality due to COVID-19 among 3.6 million people in Scotland using the Early Pandemic Evaluation and Enhanced Surveillance of COVID-19 (EAVE II) surveillance platform. We found that vaccinated individuals with severe obesity (BMI > 40 kg/m
MeSH term(s)	Humans ; COVID-19 Vaccines ; Obesity, Morbid ; Longitudinal Studies ; Prospective Studies ; COVID-19/epidemiology ; COVID-19/prevention & control ; SARS-CoV-2 ; Obesity/epidemiology ; Antibodies, Neutralizing ; Antibodies, Viral ; Vaccination
Chemical Substances	COVID-19 Vaccines ; Antibodies, Neutralizing ; Antibodies, Viral
Language	English
Publishing date	2023-05-11
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, N.I.H., Extramural
ZDB-ID	1220066-9
ISSN	1546-170X ; 1078-8956
ISSN (online)	1546-170X
ISSN	1078-8956
DOI	10.1038/s41591-023-02343-2
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Article ; Online: Age-associated B cells predict impaired humoral immunity after COVID-19 vaccination in patients receiving immune checkpoint blockade.

Yam-Puc, Juan Carlos / Hosseini, Zhaleh / Horner, Emily C / Gerber, Pehuén Pereyra / Beristain-Covarrubias, Nonantzin / Hughes, Robert / Lulla, Aleksei / Rust, Maria / Boston, Rebecca / Ali, Magda / Fischer, Katrin / Simmons-Rosello, Edward / O'Reilly, Martin / Robson, Harry / Booth, Lucy H / Kahanawita, Lakmini / Correa-Noguera, Andrea / Favara, David / Ceron-Gutierrez, Lourdes /

Keller, Baerbel / Craxton, Andrew / Anderson, Georgina S F / Sun, Xiao-Ming / Elmer, Anne / Saunders, Caroline / Bermperi, Areti / Jose, Sherly / Kingston, Nathalie / Mulroney, Thomas E / Piñon, Lucia P G / Chapman, Michael A / Grigoriadou, Sofia / MacFarlane, Marion / Willis, Anne E / Patil, Kiran R / Spencer, Sarah / Staples, Emily / Warnatz, Klaus / Buckland, Matthew S / Hollfelder, Florian / Hyvönen, Marko / Döffinger, Rainer / Parkinson, Christine / Lear, Sara / Matheson, Nicholas J / Thaventhiran, James E D

Nature communications

2023 Volume 14, Issue 1, Page(s) 3292

Abstract: Age-associated B cells (ABC) accumulate with age and in individuals with different immunological disorders, including cancer patients treated with immune checkpoint blockade and those with inborn errors of immunity. Here, we investigate whether ABCs from ...

Abstract	Age-associated B cells (ABC) accumulate with age and in individuals with different immunological disorders, including cancer patients treated with immune checkpoint blockade and those with inborn errors of immunity. Here, we investigate whether ABCs from different conditions are similar and how they impact the longitudinal level of the COVID-19 vaccine response. Single-cell RNA sequencing indicates that ABCs with distinct aetiologies have common transcriptional profiles and can be categorised according to their expression of immune genes, such as the autoimmune regulator (AIRE). Furthermore, higher baseline ABC frequency correlates with decreased levels of antigen-specific memory B cells and reduced neutralising capacity against SARS-CoV-2. ABCs express high levels of the inhibitory FcγRIIB receptor and are distinctive in their ability to bind immune complexes, which could contribute to diminish vaccine responses either directly, or indirectly via enhanced clearance of immune complexed-antigen. Expansion of ABCs may, therefore, serve as a biomarker identifying individuals at risk of suboptimal responses to vaccination.
MeSH term(s)	Humans ; Immunity, Humoral ; Immune Checkpoint Inhibitors ; COVID-19 Vaccines ; COVID-19/prevention & control ; SARS-CoV-2 ; Vaccination ; Antigen-Antibody Complex ; Antibodies, Viral
Chemical Substances	Immune Checkpoint Inhibitors ; COVID-19 Vaccines ; Antigen-Antibody Complex ; Antibodies, Viral
Language	English
Publishing date	2023-06-27
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2553671-0
ISSN	2041-1723 ; 2041-1723
ISSN (online)	2041-1723
ISSN	2041-1723
DOI	10.1038/s41467-023-38810-0
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Article ; Online: Atypical B cells and impaired SARS-CoV-2 neutralization following heterologous vaccination in the elderly.

Ferreira, Isabella A T M / Lee, Colin Y C / Foster, William S / Abdullahi, Adam / Dratva, Lisa M / Tuong, Zewen Kelvin / Stewart, Benjamin J / Ferdinand, John R / Guillaume, Stephane M / Potts, Martin O P / Perera, Marianne / Krishna, Benjamin A / Peñalver, Ana / Cabantous, Mia / Kemp, Steven A / Ceron-Gutierrez, Lourdes / Ebrahimi, Soraya / Lyons, Paul / Smith, Kenneth G C /

Bradley, John / Collier, Dami A / McCoy, Laura E / van der Klaauw, Agatha / Thaventhiran, James E D / Farooqi, I Sadaf / Teichmann, Sarah A / MacAry, Paul A / Doffinger, Rainer / Wills, Mark R / Linterman, Michelle A / Clatworthy, Menna R / Gupta, Ravindra K

Cell reports

2023 Volume 42, Issue 8, Page(s) 112991

Abstract: Suboptimal responses to a primary vaccination course have been reported in the elderly, but there is little information regarding the impact of age on responses to booster third doses. Here, we show that individuals 70 years or older (median age 73, ... ...

Abstract	Suboptimal responses to a primary vaccination course have been reported in the elderly, but there is little information regarding the impact of age on responses to booster third doses. Here, we show that individuals 70 years or older (median age 73, range 70-75) who received a primary two-dose schedule with AZD1222 and booster third dose with mRNA vaccine achieve significantly lower neutralizing antibody responses against SARS-CoV-2 spike pseudotyped virus compared with those younger than 70 (median age 66, range 54-69) at 1 month post booster. Impaired neutralization potency and breadth post third dose in the elderly is associated with circulating "atypical" spike-specific B cells expressing CD11c and FCRL5. However, when considering individuals who received three doses of mRNA vaccine, we did not observe differences in neutralization or enrichment in atypical B cells. This work highlights the finding that AdV and mRNA COVID-19 vaccine formats differentially instruct the memory B cell response.
MeSH term(s)	Aged ; Humans ; COVID-19/prevention & control ; COVID-19 Vaccines ; ChAdOx1 nCoV-19 ; SARS-CoV-2 ; Vaccination
Chemical Substances	COVID-19 Vaccines ; ChAdOx1 nCoV-19 (B5S3K2V0G8)
Language	English
Publishing date	2023-08-16
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2649101-1
ISSN	2211-1247 ; 2211-1247
ISSN (online)	2211-1247
ISSN	2211-1247
DOI	10.1016/j.celrep.2023.112991
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Article ; Online: Age-related immune response heterogeneity to SARS-CoV-2 vaccine BNT162b2.

Collier, Dami A / Ferreira, Isabella A T M / Kotagiri, Prasanti / Datir, Rawlings P / Lim, Eleanor Y / Touizer, Emma / Meng, Bo / Abdullahi, Adam / Elmer, Anne / Kingston, Nathalie / Graves, Barbara / Le Gresley, Emma / Caputo, Daniela / Bergamaschi, Laura / Smith, Kenneth G C / Bradley, John R / Ceron-Gutierrez, Lourdes / Cortes-Acevedo, Paulina / Barcenas-Morales, Gabriela /

Linterman, Michelle A / McCoy, Laura E / Davis, Chris / Thomson, Emma / Lyons, Paul A / McKinney, Eoin / Doffinger, Rainer / Wills, Mark / Gupta, Ravindra K

Nature

2021 Volume 596, Issue 7872, Page(s) 417–422

Abstract: Although two-dose mRNA vaccination provides excellent protection against SARS-CoV-2, there is little information about vaccine efficacy against variants of concern (VOC) in individuals above eighty years of ... ...

Abstract	Although two-dose mRNA vaccination provides excellent protection against SARS-CoV-2, there is little information about vaccine efficacy against variants of concern (VOC) in individuals above eighty years of age
MeSH term(s)	Adult ; Aged ; Aged, 80 and over ; Aging/blood ; Aging/immunology ; Antibodies, Neutralizing/blood ; Antibodies, Neutralizing/immunology ; Antibodies, Viral/blood ; Antibodies, Viral/immunology ; Autoantibodies/immunology ; B-Lymphocytes/cytology ; B-Lymphocytes/immunology ; B-Lymphocytes/metabolism ; BNT162 Vaccine ; COVID-19 Vaccines/administration & dosage ; COVID-19 Vaccines/immunology ; Female ; Health Personnel ; Humans ; Immunity/genetics ; Immunization, Secondary ; Immunoglobulin A/immunology ; Immunoglobulin Class Switching ; Immunoglobulin G/genetics ; Immunoglobulin G/immunology ; Immunologic Memory/immunology ; Inflammation/blood ; Inflammation/immunology ; Interferon-gamma/immunology ; Interleukin-2/immunology ; Male ; Middle Aged ; SARS-CoV-2/immunology ; Somatic Hypermutation, Immunoglobulin ; Spike Glycoprotein, Coronavirus/immunology ; T-Lymphocytes/immunology ; Vaccination ; Vaccines, Synthetic/administration & dosage ; Vaccines, Synthetic/immunology ; mRNA Vaccines
Chemical Substances	Antibodies, Neutralizing ; Antibodies, Viral ; Autoantibodies ; COVID-19 Vaccines ; Immunoglobulin A ; Immunoglobulin G ; Interleukin-2 ; Spike Glycoprotein, Coronavirus ; Vaccines, Synthetic ; spike protein, SARS-CoV-2 ; Interferon-gamma (82115-62-6) ; BNT162 Vaccine (N38TVC63NU)
Language	English
Publishing date	2021-06-30
Publishing country	England
Document type	Comparative Study ; Journal Article ; Observational Study ; Research Support, Non-U.S. Gov't
ZDB-ID	120714-3
ISSN	1476-4687 ; 0028-0836
ISSN (online)	1476-4687
ISSN	0028-0836
DOI	10.1038/s41586-021-03739-1
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Zs.A 26: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (1.OG) ab Jg. 2022: Lesesaal (EG)
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