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Article ; Online: Identification of the novel HLA-DPA1*01:149 allele by next-generation sequencing.

Galluccio, Tiziana / Cerretti, Raffaella / Guagnano, Annalisa / Bianculli, Antonio Giuseppe / Andreani, Marco

2023 Volume 102, Issue 6, Page(s) 774–775

Abstract: The novel HLA-DPA1*01:149 allele differs from HLA-DPA1*01:03:01:05 by one nucleotide substitution in exon 2. ...

Abstract	The novel HLA-DPA101:149 allele differs from HLA-DPA101:03:01:05 by one nucleotide substitution in exon 2.
MeSH term(s)	Humans ; Alleles ; Histocompatibility Testing ; HLA-DP alpha-Chains/genetics ; High-Throughput Nucleotide Sequencing
Chemical Substances	HLA-DPA1 antigen ; HLA-DP alpha-Chains
Language	English
Publishing date	2023-09-28
Publishing country	England
Document type	Journal Article
ZDB-ID	2845111-9
ISSN	2059-2310 ; 2059-2302
ISSN (online)	2059-2310
ISSN	2059-2302
DOI	10.1111/tan.15231
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Article ; Online: Fatal acute graft-versus-host disease in Sézary Syndrome treated with Mogamulizumab and hematopoietic cell transplantation.

Trotta, Gentiana Elena / Ciangola, Giulia / Cerroni, Ilaria / Mezzanotte, Valeria / Nunzi, Andrea / Anemona, Lucia / Savino, Luca / De Angelis, Gottardo / Mariotti, Benedetta / Bonanni, Fabrizio / Meddi, Elisa / Zizzari, Annagiulia / Rapisarda, Vito Mario / Mangione, Ilaria / Bruno, Antonio / Cantonetti, Maria / Venditti, Adriano / Cerretti, Raffaella

Current research in translational medicine

2024 Volume 72, Issue 3, Page(s) 103452

Abstract: Sézary syndrome (SS) is a rare and aggressive T-cell lymphoma with a poor prognosis in advanced stages. Allogeneic hematopoietic cell transplantation (allo-HCT) offers a potential cure, but complications such as graft-versus-host disease (GvHD) remain a ... ...

Abstract	Sézary syndrome (SS) is a rare and aggressive T-cell lymphoma with a poor prognosis in advanced stages. Allogeneic hematopoietic cell transplantation (allo-HCT) offers a potential cure, but complications such as graft-versus-host disease (GvHD) remain a clinical challenge. Mogamulizumab, a humanized anti-CC chemokine receptor 4 (CCR4) antibody, is sometimes used as a bridge to transplantation, but its potential interactions with allo-HCT are unclear. This report describes the case of a 37-year-old man with advanced SS who received mogamulizumab therapy followed by allo-HCT from an HLA-identical sibling donor. The patient developed severe gastrointestinal acute GvHD, which was treated with steroids and infliximab. However, the condition rapidly progressed to severe intestinal symptoms and life-threatening haemorrhagic shock, ultimately resulting in the patient's death. This case highlights a potential link between mogamulizumab and severe acute GvHD promoted by drug-induced suppression of regulatory T cells. Further research is required to fully understand the interaction between mogamulizumab and allo-HCT and to determine whether it is an optimal approach as a bridge to transplant therapy. This paradigmatic case suggests the need of personalizing transplant strategies by selecting appropriate conditioning therapy and GvHD prophylaxis to minimize potential toxicity.
Language	English
Publishing date	2024-04-24
Publishing country	France
Document type	Letter
ISSN	2452-3186
ISSN (online)	2452-3186
DOI	10.1016/j.retram.2024.103452
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Article ; Online: Outcome prediction in myelodysplastic neoplasm undergoing hematopoietic cell transplant in the molecular era of IPSS-M.

Gurnari, Carmelo / Gagelmann, Nico / Badbaran, Anita / Awada, Hussein / Dima, Danai / Pagliuca, Simona / D'Aveni-Piney, Maud / Attardi, Enrico / Voso, Maria Teresa / Cerretti, Raffaella / Wolschke, Christine / Rubio, Marie Thérèse / Maciejewski, Jaroslaw P / Kröger, Nicolaus

Leukemia

2023 Volume 37, Issue 3, Page(s) 717–719

MeSH term(s)	Humans ; Hematopoietic Stem Cell Transplantation ; Myelodysplastic Syndromes/diagnosis ; Myelodysplastic Syndromes/genetics ; Myelodysplastic Syndromes/therapy ; Neoplasms/diagnosis ; Neoplasms/genetics ; Neoplasms/therapy ; Prognosis ; Retrospective Studies ; Treatment Outcome
Language	English
Publishing date	2023-01-28
Publishing country	England
Document type	Letter ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
ZDB-ID	807030-1
ISSN	1476-5551 ; 0887-6924
ISSN (online)	1476-5551
ISSN	0887-6924
DOI	10.1038/s41375-023-01820-4
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Zs.A 2295: Show issues

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Article: Cerebellar Neurocysticercosis as Long-Term Complication of Allogeneic Haematopoietic Stem Cell Transplantation from Haploidentical Donor.

Meconi, Federico / Ciangola, Giulia / Mariotti, Benedetta / Cerretti, Raffaella / Cudillo, Laura / Arcese, William / Picardi, Alessandra

Case reports in infectious diseases

2019 Volume 2019, Page(s) 4603130

Abstract: Neurocysticercosis, an infection of the central nervous system with the larval stage of the ... ...

Abstract	Neurocysticercosis, an infection of the central nervous system with the larval stage of the cestode
Language	English
Publishing date	2019-09-19
Publishing country	Egypt
Document type	Case Reports
ZDB-ID	2627642-2
ISSN	2090-6633 ; 2090-6625
ISSN (online)	2090-6633
ISSN	2090-6625
DOI	10.1155/2019/4603130
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Article ; Online: Impairment of FOXM1 expression in mesenchymal cells from patients with myeloid neoplasms, de novo and therapy-related, may compromise their ability to support hematopoiesis.

Falconi, Giulia / Galossi, Elisa / Fabiani, Emiliano / Pieraccioli, Marco / Travaglini, Serena / Hajrullaj, Hajro / Cerretti, Raffaella / Palmieri, Raffaele / Latagliata, Roberto / Maurillo, Luca / Voso, Maria Teresa

Scientific reports

2022 Volume 12, Issue 1, Page(s) 21231

Abstract: Bone marrow mesenchymal stem cells (BM-MSCs) exhibit multiple abnormalities in myelodysplastic syndromes (MDS) and acute myeloid leukemias (AML), including reduced proliferative and clonogenic capacity, altered morphology, impaired immunoregulatory ... ...

Abstract	Bone marrow mesenchymal stem cells (BM-MSCs) exhibit multiple abnormalities in myelodysplastic syndromes (MDS) and acute myeloid leukemias (AML), including reduced proliferative and clonogenic capacity, altered morphology, impaired immunoregulatory properties and capacity to support hematopoiesis. Here, we investigated expression of the FOXM1 gene, a transcription factor driving G2/M gene expression, in BM-MSCs isolated from patients with MDS and AML, de novo and therapy-related, compared to BM-MSCs isolated from healthy donors (HD). We observed a statistically significant downregulation of FOXM1 expression in BM-MSCs isolated from MDS and AML patients, as compared to controls. In parallel, expression of FOXM1 mitotic targets (CCNB1, CDC20, PLK1 and NDC80) was suppressed in patients' BM-MSCs, as compared to HD. No differences in the expression of FOXM1 and its mitotic targets were observed in BM-mononuclear cells from the different sources. From a functional standpoint, silencing of FOXM1 mRNA in healthy MSC induced a significant decrease in the expression of its targets. In this line, healthy MSC silenced for FOXM1 showed an impaired ability to support hematopoiesis in vitro. These findings suggest that deregulation of FOXM1 may be involved in the senescent phenotype observed in MSC derived from myeloid neoplasms.
MeSH term(s)	Humans ; Neoplasms ; Health Status ; Mesenchymal Stem Cells ; Forkhead Box Protein M1/genetics
Chemical Substances	FOXM1 protein, human ; Forkhead Box Protein M1
Language	English
Publishing date	2022-12-08
Publishing country	England
Document type	Journal Article
ZDB-ID	2615211-3
ISSN	2045-2322 ; 2045-2322
ISSN (online)	2045-2322
ISSN	2045-2322
DOI	10.1038/s41598-022-24644-1
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Article ; Online: Latent Tuberculosis Infection in Haematopoietic Stem Cell Transplant Recipients: A Retrospective Italian Cohort Study in Tor Vergata University Hospital, Rome.

Compagno, Mirko / Navarra, Assunta / Campogiani, Laura / Coppola, Luigi / Rossi, Benedetta / Iannetta, Marco / Malagnino, Vincenzo / Parisi, Saverio G / Mariotti, Benedetta / Cerretti, Raffaella / Arcese, William / Goletti, Delia / Andreoni, Massimo / Sarmati, Loredana

International journal of environmental research and public health

2022 Volume 19, Issue 17

Abstract: The results of tuberculosis (TB) screening and reactivation in a cohort of 323 adult patients undergoing haematopoietic stem cell transplantation (HSCT) from 2015 to 2019 at the University Hospital of Tor Vergata, Rome, Italy, were reported. A total of ... ...

Abstract	The results of tuberculosis (TB) screening and reactivation in a cohort of 323 adult patients undergoing haematopoietic stem cell transplantation (HSCT) from 2015 to 2019 at the University Hospital of Tor Vergata, Rome, Italy, were reported. A total of 260 patients, 59 (18.3%) autologous and 264 (81.7%) allogeneic transplants, underwent Interferon Release (IFN)-γ (IGRA) test screening: 228 (87.7%) were negative, 11 (4.2%) indeterminate and 21 (8.1%) positive. Most of the IGRA-positive patients were of Italian origin (95.2%) and significantly older than the IGRA-negative (
MeSH term(s)	Adult ; Cohort Studies ; Hematopoietic Stem Cell Transplantation/adverse effects ; Hospitals ; Humans ; Interferon-gamma Release Tests/methods ; Latent Tuberculosis/diagnosis ; Latent Tuberculosis/epidemiology ; Retrospective Studies ; Rome/epidemiology ; Tuberculin Test/methods ; Tuberculosis/diagnosis ; Tuberculosis/epidemiology
Language	English
Publishing date	2022-08-27
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2175195-X
ISSN	1660-4601 ; 1661-7827
ISSN (online)	1660-4601
ISSN	1661-7827
DOI	10.3390/ijerph191710693
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Article ; Online: Impact of Pretransplant Salvage Therapies on Outcome of Hodgkin Lymphoma Patients Performing Allogeneic Transplant.

Fanelli, Fulvia / Hohaus, Stefan / Cantonetti, Maria / Cimino, Giuseppe / Pennese, Elsa / Battistini, Roberta / Galli, Eugenio / Cerretti, Raffaella / Proia, Anna / Fatone, Federica / Provenzano, Ida / Abruzzese, Elisabetta / Finolezzi, Erica / Pulsoni, Alessandro / Rigacci, Luigi

Chemotherapy

2022 Volume 68, Issue 3, Page(s) 131–137

Abstract: Background: Allogeneic transplant is an effective salvage therapy in patients with Hodgkin lymphoma (HL) relapsed or refractory (R/R) to previous treatments. In recent years, immunotherapies (conjugated antibody and checkpoint inhibitors [CPI]) showed ... ...

Abstract	Background: Allogeneic transplant is an effective salvage therapy in patients with Hodgkin lymphoma (HL) relapsed or refractory (R/R) to previous treatments. In recent years, immunotherapies (conjugated antibody and checkpoint inhibitors [CPI]) showed interesting results and were used as bridge therapies to allotransplant. Aim: The aim of this retrospective study in Lazio region was to evaluate the impact of these new therapies on outcome after allogeneic hematopoietic stem cell transplantation (allo-SCT) in comparison with standard chemotherapies used in the past. Methods: We selected all consecutive patients with diagnosis of HL transplanted in four hematology transplant units, and we collected data obtained from patients' records concerning all the treatments before allo-SCT. Results: A total of 56 patients were enrolled in this study. All patients underwent allo-SCT for R/R HL. Seventeen patients (30%) received chemotherapy prior to allo-SCT (group B); they were treated between 2008 and 2015; and 39 patients (70%) received brentuximab vedotin (BV), CPI, or both before allo-SCT as a bridge to transplant (group A); they were treated between 2012 and 2020. Twenty-five patients were treated with BV alone, 2 with CPI alone, and 12 first with BV and then with CPI. No patient received concomitant BV and CPI. At 5 years from allo-SCT, overall survival (OS) was 59% and progression-free survival (PFS) was 65%. No statistical differences in OS or PFS were observed between patients in groups A and B. Relapse was significantly associated with a lower survival. The only factor associated with a reduced risk of relapse was development of any grade acute graft versus host disease (GVHD) (p > 0.02). Conclusions: This regional real-world experience shows the changes that have taken place in the last 10 years in R/R HL using new drugs to render a patient eligible for allo-SCT. This strategy appears to guarantee an impressive disease control with an increased risk of complications, for example, aGVHD, that appear to nullify this advantage at least in part.
MeSH term(s)	Humans ; Hodgkin Disease/drug therapy ; Salvage Therapy/methods ; Retrospective Studies ; Transplantation, Homologous/adverse effects ; Neoplasm Recurrence, Local ; Brentuximab Vedotin/therapeutic use ; Hematopoietic Stem Cell Transplantation/adverse effects
Chemical Substances	Brentuximab Vedotin (7XL5ISS668)
Language	English
Publishing date	2022-12-22
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	6708-8
ISSN	1421-9794 ; 0009-3157
ISSN (online)	1421-9794
ISSN	0009-3157
DOI	10.1159/000525819
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Article: A case of metachronous peripheral T-Cell non-Hodgkin lymphoma following chemotherapy for Hodgkin disease successfully treated with brentuximab vedotin.

Meconi, Federico / Provenzano, Ida / Nasso, Daniela / Mariotti, Benedetta / Pupo, Livio / Secchi, Roberto / Cerretti, Raffaella / Lucia, Anemona / Arcese, William / Cantonetti, Maria

Clinical case reports

2020 Volume 8, Issue 8, Page(s) 1353–1356

Abstract: Occasionally, non-Hodgkin lymphomas (NHL) occur simultaneously or subsequently to Hodgkin disease. We report on a case of a woman with Hodgkin lymphoma treated with ABVD, who developed 4 years later T-cell NHL with both nodal and extranodal involvement. ... ...

Abstract	Occasionally, non-Hodgkin lymphomas (NHL) occur simultaneously or subsequently to Hodgkin disease. We report on a case of a woman with Hodgkin lymphoma treated with ABVD, who developed 4 years later T-cell NHL with both nodal and extranodal involvement. Brentuximab vedotin could be an effective choice in treating metachronous T-cell NHL.
Language	English
Publishing date	2020-05-05
Publishing country	England
Document type	Case Reports
ZDB-ID	2740234-4
ISSN	2050-0904
ISSN	2050-0904
DOI	10.1002/ccr3.2898
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Article ; Online: Overlapping features of hepatic complications after hematopoietic cell transplantation in a rare T-cell lymphoma: A clinical challenge.

Current research in translational medicine

2023 Volume 72, Issue 2, Page(s) 103436

Abstract: We present the case of a young adult, who developed several hepatic post-HCT complications, which made differential diagnosis extremely difficult. ...

Abstract	We present the case of a young adult, who developed several hepatic post-HCT complications, which made differential diagnosis extremely difficult.
Language	English
Publishing date	2023-12-20
Publishing country	France
Document type	Letter
ISSN	2452-3186
ISSN (online)	2452-3186
DOI	10.1016/j.retram.2023.103436
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Article ; Online: Granulocyte-mobilized bone marrow.

Arcese, William / De Angelis, Gottardo / Cerretti, Raffaella

Current opinion in hematology

2012 Volume 19, Issue 6, Page(s) 448–453

Abstract: Purpose of review: In the last few years, mobilized peripheral blood has overcome bone marrow as a graft source, but, despite the evidence of a more rapid engraftment, the incidence of chronic graft-versus-host disease is significantly higher with, ... ...

Abstract	Purpose of review: In the last few years, mobilized peripheral blood has overcome bone marrow as a graft source, but, despite the evidence of a more rapid engraftment, the incidence of chronic graft-versus-host disease is significantly higher with, consequently, more transplant-related mortality on the long follow-up. Overall, the posttransplant outcome of mobilized peripheral blood recipients is similar to that of patients who are bone marrow grafted. More recently, the use of bone marrow after granulocyte colony-stimulating factor (G-CSF) donor priming has been introduced in the transplant practice. Herein, we review biological acquisitions and clinical results on the use of G-CSF-primed bone marrow as a source of hematopoietic stem cells (HSC) for allogeneic stem cell transplantation. Recent findings: G-CSF the increases the HSC compartment and exerts an intense immunoregulatory effect on marrow T-cells resulting in the shift from Th1 to Th2 phenotype with higher production of anti-inflammatory cytokines. The potential advantages of these biological effects have been translated in the clinical practice by using G-CSF primed unmanipulated bone marrow in the setting of transplant from human leukocyte antigen (HLA)-haploidentical donor with highly encouraging results. Summary: For patients lacking an HLA-identical sibling, the transplant of G-CSF primed unmanipulated bone marrow from a haploidentical donor combined with an intense in-vivo immunosuppression is a valid alternative achieving results that are well comparable with those reported for umbilical cord blood, HLA-matched unrelated peripheral blood/bone marrow or T-cell-depleted haploidentical transplant.
MeSH term(s)	Bone Marrow Transplantation/immunology ; Bone Marrow Transplantation/methods ; Graft vs Host Disease/immunology ; Graft vs Host Disease/prevention & control ; Granulocyte Colony-Stimulating Factor/pharmacology ; Granulocytes/cytology ; Granulocytes/immunology ; Hematopoietic Stem Cell Mobilization/methods ; Hematopoietic Stem Cell Transplantation/methods ; Humans ; T-Lymphocytes/immunology ; Transplantation, Homologous
Chemical Substances	Granulocyte Colony-Stimulating Factor (143011-72-7)
Language	English
Publishing date	2012-11
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Review
ZDB-ID	1153887-9
ISSN	1531-7048 ; 1065-6251
ISSN (online)	1531-7048
ISSN	1065-6251
DOI	10.1097/MOH.0b013e32835903ab
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