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  1. Article ; Online: Effects of repeated alcohol abstinence on within-subject prefrontal cortical gene expression in rhesus macaques.

    Hitzemann, Robert / Gao, Lina / Fei, Suzanne S / Ray, Karina / Vigh-Conrad, Katinka A / Phillips, Tamara J / Searles, Robert / Cervera-Juanes, Rita P / Khadka, Rupak / Carlson, Timothy L / Gonzales, Steven W / Newman, Natali / Grant, Kathleen A

    Advances in drug and alcohol research

    2024  Volume 4, Page(s) 12528

    Abstract: Male rhesus monkeys ( ...

    Abstract Male rhesus monkeys (
    Language English
    Publishing date 2024-04-26
    Publishing country Switzerland
    Document type Journal Article
    ISSN 2674-0001
    ISSN (online) 2674-0001
    DOI 10.3389/adar.2024.12528
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Neurobeachin, a promising target for use in the treatment of alcohol use disorder.

    Cuzon Carlson, Verginia C / Aylwin, Carlos F / Carlson, Timothy L / Ford, Matthew / Mesnaoui, Houda / Lomniczi, Alejandro / Ferguson, Betsy / Cervera-Juanes, Rita P

    Addiction biology

    2021  Volume 27, Issue 1, Page(s) e13107

    Abstract: Hazardous, heavy drinking increases risk for developing alcohol use disorder (AUD), which affects ~7% of adult Americans. Thus, understanding the molecular mechanisms promoting risk for heavy drinking is essential to developing more effective AUD ... ...

    Abstract Hazardous, heavy drinking increases risk for developing alcohol use disorder (AUD), which affects ~7% of adult Americans. Thus, understanding the molecular mechanisms promoting risk for heavy drinking is essential to developing more effective AUD pharmacotherapies than those currently approved by the FDA. Using genome-wide bisulfate sequencing, we identified DNA methylation (DNAm) signals within the nucleus accumbens core (NAcC) that differentiate nonheavy and heavy ethanol-drinking rhesus macaques. One differentially DNAm region (D-DMR) located within the gene neurobeachin (NBEA), which promotes synaptic membrane protein trafficking, was hypermethylated in heavy drinking macaques. A parallel study identified a similar NBEA D-DMR in human NAcC that distinguished alcoholic and nonalcoholic individuals. To investigate the role of NBEA in heavy ethanol drinking, we engineered a viral vector carrying a short hairpin RNA (shRNA) to reduce the expression of NBEA. Using two murine models of ethanol consumption: 4 days of drinking-in-the-dark and 4 weeks of chronic intermittent access, the knockdown of NBEA expression did not alter average ethanol consumption in either model. However, it did lead to a significant increase in the ethanol preference ratio. Following withdrawal, whole-cell patch clamp electrophysiological experiments revealed that Nbea knockdown led to an increase in spontaneous excitatory postsynaptic current amplitude with no alteration in spontaneous inhibitory postsynaptic currents, suggesting a specific role of NBEA in trafficking of glutamatergic receptors. Together, our findings suggest that NBEA could be targeted to modulate the preference for alcohol use.
    MeSH term(s) Adult ; Aged ; Alcohol Drinking/genetics ; Alcoholism/genetics ; Animals ; Carrier Proteins/genetics ; DNA Methylation/drug effects ; Humans ; Macaca mulatta ; Male ; Mice ; Mice, Inbred C57BL ; Middle Aged ; Nerve Tissue Proteins/genetics ; Nucleus Accumbens/drug effects
    Chemical Substances Carrier Proteins ; NBEA protein, human ; Nerve Tissue Proteins
    Language English
    Publishing date 2021-10-26
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural
    ZDB-ID 1324314-7
    ISSN 1369-1600 ; 1355-6215
    ISSN (online) 1369-1600
    ISSN 1355-6215
    DOI 10.1111/adb.13107
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 4586: Show issues Location:
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    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
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  3. Article ; Online: Modulation of Gpr39, a G-protein coupled receptor associated with alcohol use in non-human primates, curbs ethanol intake in mice.

    Cuzon Carlson, Verginia C / Ford, Matthew M / Carlson, Timothy L / Lomniczi, Alejandro / Grant, Kathleen A / Ferguson, Betsy / Cervera-Juanes, Rita P

    Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology

    2019  Volume 44, Issue 6, Page(s) 1103–1113

    Abstract: Alcohol use disorder (AUD) is a chronic condition with devastating health and socioeconomic effects. Still, pharmacotherapies to treat AUD are scarce. In a prior study aimed at identifying novel AUD therapeutic targets, we investigated the DNA methylome ... ...

    Abstract Alcohol use disorder (AUD) is a chronic condition with devastating health and socioeconomic effects. Still, pharmacotherapies to treat AUD are scarce. In a prior study aimed at identifying novel AUD therapeutic targets, we investigated the DNA methylome of the nucleus accumbens core (NAcc) of rhesus macaques after chronic alcohol use. The G-protein coupled receptor 39 (GPR39) gene was hypermethylated and its expression downregulated in heavy alcohol drinking macaques. GPR39 encodes a Zn
    MeSH term(s) Alcohol Drinking ; Alcoholism/drug therapy ; Alcoholism/prevention & control ; Animals ; Behavior, Animal/drug effects ; Disease Models, Animal ; Dose-Response Relationship, Drug ; Drinking Behavior/drug effects ; Macaca mulatta ; Mice ; Mice, Inbred C57BL ; Nucleus Accumbens/metabolism ; Pyrimidines/administration & dosage ; Pyrimidines/pharmacology ; Receptors, G-Protein-Coupled/agonists ; Sulfonamides/administration & dosage ; Sulfonamides/pharmacology
    Chemical Substances GPR39 protein, mouse ; GPR39-C3 ; Pyrimidines ; Receptors, G-Protein-Coupled ; Sulfonamides
    Language English
    Publishing date 2019-01-05
    Publishing country England
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 639471-1
    ISSN 1740-634X ; 0893-133X
    ISSN (online) 1740-634X
    ISSN 0893-133X
    DOI 10.1038/s41386-018-0308-1
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 2379: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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