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Article ; Online: Meningitis por Streptococcus salivarus tras anestesia subaracnoidea.

Cervero, Miguel

Enfermedades infecciosas y microbiologia clinica

2009 Volume 27, Issue 6, Page(s) 371–372

Title translation	Streptococcus salivarus meningitis following subarachnoid anesthesia.
MeSH term(s)	Anesthesia, Spinal/adverse effects ; Gloves, Protective ; Humans ; Iatrogenic Disease ; Infectious Disease Transmission, Professional-to-Patient/prevention & control ; Masks ; Meningitis, Bacterial/etiology ; Meningitis, Bacterial/microbiology ; Meningitis, Bacterial/prevention & control ; Streptococcal Infections/etiology ; Streptococcal Infections/prevention & control ; Subarachnoid Space ; Viridans Streptococci/isolation & purification ; Viridans Streptococci/pathogenicity ; Virulence ; Wound Infection/microbiology ; Wound Infection/prevention & control
Language	Spanish
Publishing date	2009-06
Publishing country	Spain
Document type	Letter
ZDB-ID	1070941-1
ISSN	1578-1852 ; 0213-005X
ISSN (online)	1578-1852
ISSN	0213-005X
DOI	10.1016/j.eimc.2008.11.003
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Article ; Online: Amikacin pharmacokinetics in elderly patients with severe infections.

Medellín-Garibay, Susanna E / Romano-Aguilar, Melissa / Parada, Alejandro / Suárez, David / Romano-Moreno, Silvia / Barcia, Emilia / Cervero, Miguel / García, Benito

European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences

2022 Volume 175, Page(s) 106219

Abstract: Objective: The aim of this study was to characterize the population pharmacokinetics of amikacin in elderly patients by means of nonlinear mixed effects modelling and to propose initial dosing schemes to optimize therapy based on PK/PD targets.: ... ...

Abstract	Objective: The aim of this study was to characterize the population pharmacokinetics of amikacin in elderly patients by means of nonlinear mixed effects modelling and to propose initial dosing schemes to optimize therapy based on PK/PD targets. Method: A total of 137 elderly patients from 65 to 94 years receiving intravenous amikacin and routine therapeutic drug monitoring at Hospital Universitario Severo Ochoa were included. Concentration-time data and clinical information were retrospectively collected; initial doses of amikacin ranged from 5.7 to 22.5 mg/kg/day and each patient provided between 1 and 10 samples. Results: Amikacin pharmacokinetics were best described by a two-compartment open model; creatinine clearance (CrCL) was related to drug clearance (2.75 L/h/80 mL/min) and it was augmented 28% when non-steroidal anti-inflammatory drugs were concomitantly administered. Body mass index (BMI) influenced the central volume of distribution (17.4 L/25 kg/m Conclusion: Initial dosing approach for amikacin was designed for elderly patients based on nonlinear mixed effects modeling to maximize the probability to attain efficacy and safety targets considering individual BMI and CrCL.
MeSH term(s)	Administration, Intravenous ; Aged ; Amikacin ; Anti-Bacterial Agents ; Humans ; Metabolic Clearance Rate ; Retrospective Studies
Chemical Substances	Anti-Bacterial Agents ; Amikacin (84319SGC3C)
Language	English
Publishing date	2022-05-23
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	1154366-8
ISSN	1879-0720 ; 0928-0987
ISSN (online)	1879-0720
ISSN	0928-0987
DOI	10.1016/j.ejps.2022.106219
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Article ; Online: HIV medical care interruption among people living with HIV in Spain, 2004-2020.

Izquierdo, Rebeca / Rava, Marta / Moreno-García, Estela / Blanco, José Ramón / Asensi, Víctor / Cervero, Miguel / Curran, Adrian / Rubio, Rafael / Iribarren, José Antonio / Jarrín, Inmaculada

AIDS (London, England)

2023 Volume 37, Issue 8, Page(s) 1277–1284

Abstract: Objective: We estimated the incidence rate of HIV medical care interruption (MCI) and its evolution over a 16-year-period, and identified associated risk factors among HIV-positive individuals from the Cohort of the Spanish AIDS Research Network in 2004- ...

Abstract	Objective: We estimated the incidence rate of HIV medical care interruption (MCI) and its evolution over a 16-year-period, and identified associated risk factors among HIV-positive individuals from the Cohort of the Spanish AIDS Research Network in 2004-2020. Design: We included antiretroviral-naive individuals aged at least 18 years at enrolment, recruited between January 1, 2004, and August 30, 2019, and followed-up until November 30, 2020. Methods: Individuals with any time interval of at least 15 months between two visits were defined as having a MCI. We calculated the incidence rate (IR) of having at least one MCI and used multivariable Poisson regression models to identify associated risk factors. Results: Of 15 274 individuals, 5481 (35.9%) had at least one MCI. Of those, 2536 (46.3%) returned to HIV care after MCI and 3753 (68.5%) were lost to follow-up at the end of the study period. The incidence rate (IR) of MCI was 7.2/100 person-years (py) [95% confidence interval (CI): 7.0-7.4]. The annual IR gradually decreased from 20.5/100 py (95% CI: 16.4-25.6) in 2004 to 4.9/100 py (95% CI: 4.4-5.5) in 2014, a slight increase was observed between 2015 and 2018, reaching 9.3/100 py (95% CI: 8.6-10.2) in 2019. Risk factors for MCI included younger age, lower educational level, having contracted HIV infection through injecting drug use or heterosexual intercourse, having been born outside of Spain, and CD4 + cell count >200 cell/μl, viral load <100 000 and co-infection with hepatitis C virus at enrolment. Conclusions: Around a third of individuals had at least one MCI during the follow-up. Identified predictors of MCI can help health workers to target and support most vulnerable individuals.
MeSH term(s)	Humans ; Adolescent ; Adult ; HIV Infections/drug therapy ; Spain/epidemiology ; Risk Factors ; Anti-Retroviral Agents/therapeutic use ; Hepatitis C/drug therapy ; CD4 Lymphocyte Count ; Incidence
Chemical Substances	Anti-Retroviral Agents
Language	English
Publishing date	2023-03-21
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	639076-6
ISSN	1473-5571 ; 0269-9370 ; 1350-2840
ISSN (online)	1473-5571
ISSN	0269-9370 ; 1350-2840
DOI	10.1097/QAD.0000000000003552
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Article: Beneficial Effect of Short-Term Supplementation of High Dose of Vitamin D

Cervero, Miguel / López-Wolf, Daniel / Casado, Guiomar / Novella-Mena, Maria / Ryan-Murua, Pablo / Taboada-Martínez, María Luisa / Rodríguez-Mora, Sara / Vigón, Lorena / Coiras, Mayte / Torres, Montserrat

Frontiers in pharmacology

2022 Volume 13, Page(s) 863587

Abstract: There is now sufficient evidence to support that vitamin D deficiency may predispose to SARS-CoV-2 infection and increase COVID-19 severity and mortality. It has been suggested that vitamin ... ...

Abstract	There is now sufficient evidence to support that vitamin D deficiency may predispose to SARS-CoV-2 infection and increase COVID-19 severity and mortality. It has been suggested that vitamin D
Language	English
Publishing date	2022-07-04
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2587355-6
ISSN	1663-9812
ISSN	1663-9812
DOI	10.3389/fphar.2022.863587
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Article ; Online: Predictors of low-level HIV viraemia and virological failure in the era of integrase inhibitors: A Spanish nationwide cohort.

Álvarez, Hortensia / Rava, Marta / Martínez, Cristina / Portilla, Joaquín / Peraire, Joaquim / Rivero, Antonio / Cervero, Miguel / Mariño, Ana / Poveda, Eva / Llibre, Josep M

HIV medicine

2022 Volume 23, Issue 8, Page(s) 825–836

Abstract: Objectives: To pinpoint factors associated with low-level viraemia (LLV) and virological failure (VF) in people living with HIV in the era of high-efficacy antiretroviral treatment (ART) and widespread use of integrase strand transfer inhibitor (INSTIs)- ...

Abstract	Objectives: To pinpoint factors associated with low-level viraemia (LLV) and virological failure (VF) in people living with HIV in the era of high-efficacy antiretroviral treatment (ART) and widespread use of integrase strand transfer inhibitor (INSTIs)-based ART. Methods: We included adults aged > 18 years starting their first ART between 2015 and 2018 in the Spanish HIV/AIDS Research Network National Cohort (CoRIS). Low-level viraemia was defined as plasma viral load (pVL) of 50-199 copies/mL at weeks 48 and 72 and VF was defined as pVL ≥ 50 copies/mL at week 48 and pVL ≥ 200 copies/mL at week 72. Multivariable logistic regression models assessed the impact on LLV and VF of baseline CD4 T-cell count, CD4/CD8 T-cell ratio and pVL, initial ART classes, age at ART initiation, time between HIV diagnosis and ART initiation, gender and transmission route. Results: Out of 4186 participants, 3120 (76.0%) started INSTIs, 455 (11.1%) started boosted protease inhibitors (bPIs) and 443 (10.8%) started nonnucleoside reverse transcriptase inhibitors (NNRTIs), either of them with two nucleos(t)ide reverse transcriptase inhibitors (NRTIs). Low-level viraemia was met in 2.5% of participants and VF in 4.3%. There were no significant differences throughout the years for both virological outcomes. Baseline HIV-1 RNA > 5 log Conclusions: The rates of LLV and VF were low but remained steady throughout the years. Baseline HIV-1 RNA > 5 log
MeSH term(s)	Adult ; Anti-HIV Agents/therapeutic use ; Anti-Retroviral Agents/therapeutic use ; Antiretroviral Therapy, Highly Active ; HIV Infections/drug therapy ; HIV Integrase Inhibitors/therapeutic use ; HIV-1 ; Humans ; Integrase Inhibitors/therapeutic use ; RNA/therapeutic use ; Reverse Transcriptase Inhibitors/therapeutic use ; Viral Load ; Viremia/drug therapy
Chemical Substances	Anti-HIV Agents ; Anti-Retroviral Agents ; HIV Integrase Inhibitors ; Integrase Inhibitors ; Reverse Transcriptase Inhibitors ; RNA (63231-63-0)
Language	English
Publishing date	2022-03-01
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2001932-4
ISSN	1468-1293 ; 1464-2662
ISSN (online)	1468-1293
ISSN	1464-2662
DOI	10.1111/hiv.13265
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Article ; Online: Hepatitis aguda no colestásica como primera manifestación de sífilis secundaria.

Rinascente, Chiara / Candela, Giancarlo / Cervero, Miguel / Lobato, Alejandro / Carbonell, Alejandro

Revista de gastroenterología del Perú : órgano oficial de la Sociedad de Gastroenterología del Perú

2015 Volume 35, Issue 3, Page(s) 247–249

Abstract: We present a 34 year old male who enter the Digestive Department of the University Hospital Severo Ochoa in Madrid, Spain with jaundice with a great elevation of transaminases in relationship with an infectious syndrome that was correctly diagnosed and ... ...

Title translation	Acute non cholestatic hepatitis as the first manifestation of secondary syphilis.
Abstract	We present a 34 year old male who enter the Digestive Department of the University Hospital Severo Ochoa in Madrid, Spain with jaundice with a great elevation of transaminases in relationship with an infectious syndrome that was correctly diagnosed and treated with a very good outcome.
Language	Spanish
Publishing date	2015-07
Publishing country	Peru
Document type	English Abstract ; Journal Article
ISSN	1609-722X
ISSN (online)	1609-722X
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Article ; Online: Changes in the immune response against SARS-CoV-2 in individuals with severe COVID-19 treated with high dose of vitamin D.

Torres, Montserrat / Casado, Guiomar / Vigón, Lorena / Rodríguez-Mora, Sara / Mateos, Elena / Ramos-Martín, Fernando / López-Wolf, Daniel / Sanz-Moreno, José / Ryan-Murua, Pablo / Taboada-Martínez, María Luisa / López-Huertas, María Rosa / Cervero, Miguel / Coiras, Mayte

Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie

2022 Volume 150, Page(s) 112965

Abstract: Main cause of severe illness and death in COVID-19 patients appears to be an excessive but ineffectual inflammatory immune response that may cause severe acute respiratory distress syndrome (ARDS). Vitamin D may favour an anti-inflammatory environment ... ...

Abstract	Main cause of severe illness and death in COVID-19 patients appears to be an excessive but ineffectual inflammatory immune response that may cause severe acute respiratory distress syndrome (ARDS). Vitamin D may favour an anti-inflammatory environment and improve cytotoxic response against some infectious diseases. A multicenter, single-blind, prospective, randomized clinical trial was approved in patients with COVID-19 pneumonia and levels of 25-hydroxyvitamin D (25(OH)D) of 14.8 ng/ml (SD: 6.18) to test antiviral efficacy, tolerance and safety of 10,000 IU/day of cholecalciferol (vitamin D
MeSH term(s)	Cholecalciferol/adverse effects ; Dietary Supplements ; Humans ; Immunity ; Prospective Studies ; Respiratory Distress Syndrome/drug therapy ; SARS-CoV-2 ; Single-Blind Method ; Vitamin D ; Vitamins/therapeutic use ; COVID-19 Drug Treatment
Chemical Substances	Vitamins ; Vitamin D (1406-16-2) ; Cholecalciferol (1C6V77QF41)
Language	English
Publishing date	2022-04-14
Publishing country	France
Document type	Journal Article ; Multicenter Study ; Randomized Controlled Trial
ZDB-ID	392415-4
ISSN	1950-6007 ; 0753-3322 ; 0300-0893
ISSN (online)	1950-6007
ISSN	0753-3322 ; 0300-0893
DOI	10.1016/j.biopha.2022.112965
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Article ; Online: Late HIV diagnosis among immigrants in Spain vs. native-born Spaniards, 2010-15.

Gogishvili, Megi / Huang, Terry T-K / Costa, Sergio A / Florez, Karen / Mateu-Gelabert, Pedro / Valls, Maria R A / Rivero, María / Saumoy, Maria / Samperiz, Gloria / Cervero, Miguel / Pulido, Federico / Pérez, José A

European journal of public health

2021 Volume 31, Issue 6, Page(s) 1123–1128

Abstract: Background: In 2012, the central government of Spain enacted Royal Decree-Law (RDL) 16/2012 and Royal Decree (RD) 1192/2012, which abolished universal healthcare coverage, thus limiting access to care for undocumented immigrants. Free health care was ... ...

Abstract	Background: In 2012, the central government of Spain enacted Royal Decree-Law (RDL) 16/2012 and Royal Decree (RD) 1192/2012, which abolished universal healthcare coverage, thus limiting access to care for undocumented immigrants. Free health care was also no longer granted to anyone who has never been employed. In this context, this study investigated the prevalence of late HIV diagnoses (LHDs) among immigrants living in Spain vs. native-born Spaniards. Methods: Data (n = 5943) from the 2010 to 2015 Cohort of the Spanish AIDs Research Network were used, including HIV-positive and antiretroviral therapy (ART)-naïve patients throughout Spain. Multivariate logistic models were fitted to compare the prevalence of LHD among the groups, adjusting for covariates. Results: The prevalence of LHD in the total sample was 39.5%. Compared with native-born Spaniards (n = 4445), immigrants (n = 1488) were more likely to have LHD (37.4% vs. 45.7%, respectively; P < 0.001). Multivariate analysis showed that the prevalence ratio of LHD among immigrants vs. native-born Spaniards was 1.15 [95% confidence interval (CI), 1.02-1.28], after adjusting for covariates. This disparity widened from 2010 to 2011 (APR = 1.14, 95% CI, 1.02-1.29) to 2012-15 (APR = 1.28, 95% CI, 1.17-1.39), although the change was not statistically significant. Conclusions: Immigrants in Spain had a higher risk of LHD compared with native-born counterparts. LHD is an important healthcare marker due to the positive benefits of early HIV diagnosis, including prevention, improvements in health outcomes and decreases in overall cost of treatment. More research is needed on the causes of the disparity and potential social and policy interventions to reduce the prevalence of LHD among immigrants.
MeSH term(s)	Emigrants and Immigrants ; HIV Infections/diagnosis ; HIV Infections/epidemiology ; Humans ; Indigenous Peoples ; Spain/epidemiology ; Undocumented Immigrants
Language	English
Publishing date	2021-08-17
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	1129243-x
ISSN	1464-360X ; 1101-1262
ISSN (online)	1464-360X
ISSN	1101-1262
DOI	10.1093/eurpub/ckab089
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Article ; Online: Envejecimiento e influencia de la inversión del cociente CD4/CD8 en la incidencia de las comorbilidades y mortalidad de una cohorte de pacientes infectados por el virus de inmunodeficiencia humana.

Cervero, Miguel / Torres, Rafael / Agud, Jose Luis / Pastor, Susana / Jusdado, Juan José

Medicina clinica

2016 Volume 146, Issue 5, Page(s) 189–193

Abstract: Background and objective: It has been postulated that the inversion of the CD4:CD8 ratio as a hallmark of immunosenescence can be an independent factor that can herald the risk of co-morbidities. We studied the influence of aging and inversion of the ... ...

Title translation	Aging and influence of inversion of the CD4:CD8 ratio in the incidence of co-morbidities and mortality in a cohort of patients infected with human immunodeficiency virus.
Abstract	Background and objective: It has been postulated that the inversion of the CD4:CD8 ratio as a hallmark of immunosenescence can be an independent factor that can herald the risk of co-morbidities. We studied the influence of aging and inversion of the CD4:CD8 ratio in the incidence of comorbidities and mortality in the cohort of Hosptital Severo Ochoa. Methods: We analyzed the differences in the incidence rates of age-adjusted morbidities and evaluated the inversion of the CD4:CD8 ratio as predictor of mortality and development of comorbidities. Results: Age was associated with an increased incidence rate of diabetes mellitus, fractures, COPD and non-AIDS malignancies. We found an increased incidence rate of non-AIDS clinical events (OR 2.25; 95% CI 1.025-4.94) and AIDS events (OR 3.48; 95% CI 1.58-7.64) in individuals with CD4:CD8 ratio<0.7. Moreover, patients with a CD4:CD8 ratio<0.7 ratio had a higher risk of mortality (OR 5.96; 95% CI 0.73 to 48.40). Conclusion: It is important to detect and prevent non-AIDS comorbidities in the presence of a CD4:CD8 ratio<0.7.
MeSH term(s)	Adolescent ; Adult ; Aged ; Aging/immunology ; CD4-CD8 Ratio ; Comorbidity ; Female ; Follow-Up Studies ; HIV Infections/epidemiology ; HIV Infections/immunology ; Humans ; Incidence ; Male ; Middle Aged ; Prospective Studies ; Spain/epidemiology ; Young Adult
Language	Spanish
Publishing date	2016-03-04
Publishing country	Spain
Document type	Journal Article
ZDB-ID	411607-0
ISSN	1578-8989 ; 0025-7753
ISSN (online)	1578-8989
ISSN	0025-7753
DOI	10.1016/j.medcli.2015.10.014
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Article ; Online: Factores predictivos de las interacciones farmacológicas clínicamente significativas en los pacientes tratados con regímenes basados en inhibidores de proteasa, inhibidores de transcriptasa inversa no nucleósidos y raltegravir.

Cervero, Miguel / Torres, Rafael / Jusdado, Juan José / Pastor, Susana / Agud, Jose Luis

Medicina clinica

2016 Volume 146, Issue 8, Page(s) 339–345

Title translation	Predictive factors of clinically significant drug-drug interactions among regimens based on protease inhibitors, non-nucleoside reverse transcriptase inhibitors and raltegravir.
MeSH term(s)	Adolescent ; Adult ; Aged ; Aged, 80 and over ; Anti-HIV Agents/adverse effects ; Anti-HIV Agents/therapeutic use ; Drug Interactions ; Drug Therapy, Combination ; Female ; Follow-Up Studies ; HIV Infections/drug therapy ; HIV Protease Inhibitors/adverse effects ; HIV Protease Inhibitors/therapeutic use ; Humans ; Logistic Models ; Male ; Middle Aged ; Multivariate Analysis ; Raltegravir Potassium/adverse effects ; Raltegravir Potassium/therapeutic use ; Retrospective Studies ; Reverse Transcriptase Inhibitors/adverse effects ; Reverse Transcriptase Inhibitors/therapeutic use ; Risk Factors ; Young Adult
Chemical Substances	Anti-HIV Agents ; HIV Protease Inhibitors ; Reverse Transcriptase Inhibitors ; Raltegravir Potassium (43Y000U234)
Language	Spanish
Publishing date	2016-04-15
Publishing country	Spain
Document type	Journal Article
ZDB-ID	411607-0
ISSN	1578-8989 ; 0025-7753
ISSN (online)	1578-8989
ISSN	0025-7753
DOI	10.1016/j.medcli.2016.01.016
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