Article ; Online: A role for Th17 cells in the immunopathogenesis of atopic dermatitis?
The Journal of investigative dermatology
2008 Volume 128, Issue 11, Page(s) 2569–2571
Abstract: Atopic dermatitis (AD) is a common inflammatory skin disease. Both epidermal barrier dysfunction and immunodysregulation are suggested to influence the pathogenesis of AD. AD has been considered a paradigmatic T helper cell (Th) 2-mediated disease, with ... ...
| Abstract | Atopic dermatitis (AD) is a common inflammatory skin disease. Both epidermal barrier dysfunction and immunodysregulation are suggested to influence the pathogenesis of AD. AD has been considered a paradigmatic T helper cell (Th) 2-mediated disease, with a switch to a Th1 cell environment during the chronic phase of the disease. Previously unreported findings now suggest a possible role for Th17 cells as well. |
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| MeSH term(s) | CD4-Positive T-Lymphocytes/immunology ; Dermatitis, Atopic/etiology ; Dermatitis, Atopic/immunology ; Disease Progression ; Humans ; Interleukin-17/metabolism ; Severity of Illness Index ; T-Lymphocytes, Helper-Inducer/metabolism ; Th1 Cells/metabolism ; Th2 Cells/metabolism | |||||
| Chemical Substances | Interleukin-17 | |||||
| Language | English | |||||
| Publishing date | 2008-10-09 | |||||
| Publishing country | United States | |||||
| Document type | Comment ; Journal Article | |||||
| ZDB-ID | 80136-7 | |||||
| ISSN | 1523-1747 ; 0022-202X | |||||
| ISSN (online) | 1523-1747 | |||||
| ISSN | 0022-202X | |||||
| DOI | 10.1038/jid.2008.283 | |||||
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| Database | MEDical Literature Analysis and Retrieval System OnLINE |
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