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Article: Replication of Genome-Wide Association Signals in UK Samples Reveals Risk Loci for Type 2 Diabetes

Zeggini, Eleftheria / Ahmad, Tariq / Ardern-Jones, A / Attwood, Antony P / Ball, Stephen G / Balmforth, Anthony J / Ban, Maria / Barbour, Jamie / Barrett, Jeffrey C / Barrett, Jennifer H / Barton, Anne / Bentley, David / Berg, J / Bishop, D. Timothy / Boorman, James P / Bradbury, Linda A / Bradshaw, N / Brady, A / Braga Marcano, Carolina A /
Braund, Peter S / Bredin, Francesca / Breen, Gerome / Brewer, C / Brice, G / Brown, Matthew A / Brown, Morris J / Bruce, Ian N / Bullman, B / Bumpstead, Suzannah J / Burke, Beverley / Burton, Paul R / Caesar, Sian / Campbell, J / Cant, Barbara / Cardin, Niall J / Cardon, Lon R / Castle, B / Caulfield, Mark / Cetnarsryj, R / Chaney, Amy / Chapman, C / Chu, C / Clayton, David G / Coates, N / Cole, T / Collier, David A / Compston, Alastair / Compston, Alistair / Connell, John / Conway, David / Craddock, Nick / Cummings, Fraser R / Davidson, R / Davison, Dan / Deloukas, Panos / Dixon, Richard J / Dobson, Richard / Dominiczak, Anna / Donaldson, A / Doney, Alex S.F / Donnelly, Peter / Donovan, Hannah / Dorkins, H / Douglas, F / Downes, Kate / Drummond, Hazel / Duncanson, Audrey / Dunger, David B / Easton, Doug / Eccles, D / Eeles, R / Elkin, Amanda / Ellard, Sian / Elliott, Katherine S / Elmslie, F / Evans, D.G / Evans, David / Everson, Ursula / Eyre, Steve / Farmer, Anne / Farrall, Martin / Farrar, Claire / Ferreira, Teresa / Ferrier, I. Nicol / Fisher, Sheila A / Forbes, Alastair / Franklyn, Jayne A / Fraser, Christine / Frayling, Timothy M / Freathy, Rachel M / Ghori, Mohammed J.R / Gilbert, Paul D / Goff, S / Goodman, S / Gordon-Smith, Katherine / Goris, An / Goudie, D / Gough, Stephen C.L / Gray, J / Green, Elaine K / Greenhalgh, L / Gregory, H / Groves, Christopher J / Grozeva, Detelina / Gungadoo, Johannie / Gwilliam, Rhian / Hall, Alistair S / Hallgrimsdóttir, Ingeleif B / Hamshere, Marian L / Harries, Lorna W / Hattersley, Andrew T / Heward, Joanne M / Hider, Samantha L / Hill, Adrian V.S / Hinks, Anne M / Hitman, Graham A / Hodgson, S.V / Holmans, Peter A / Homfray, T / Houlston, R.S / Howie, Bryan N / Hunt, Sarah E / Hussey, Judith M / Iles, Mark M / Inouye, Michael / Isaacs, John D / Izatt, L / Jackson, L / Jallow, Muminatou / Jeffers, L / Jewell, Derek P / John, Sally L / Johnson-Roffey, V / Jolley, Jennifer D / Jones, Ian R / Jones, Lisa / Jones, Richard W / Kavalier, F / Keniry, Andrew / King, Emma / Kirk, C / Kirov, George / Knight, Alexandra S / Knight, Beatrice / Koch, Kerstin / Kwiatkowski, Dominic P / Lalloo, F / Langman, C / Lango, Hana / Lathrop, G. Mark / Lee, Kate L / Lees, Charles W / Leung, Hin-Tak / Lewis, Cathryn M / Lindgren, Cecilia M / Locke, I / Longmuir, M / Lyons, Emily / Mackay, J / Magee, A / Mangino, Massimo / Mansfield, John C / Mansour, S / Maqbool, Azhar / Marchini, Jonathan L / Mathew, Christopher G / McArdle, Wendy L / McCarthy, Mark I / McGinnis, Ralph / McGuffin, Peter / Meech, Elizabeth / Miedzybrodzka, Z / Miller, J / Mohiuddin, M. Khalid / Morgan, Ann W / Morris, Andrew D / Morris, Andrew P / Morrison, P / Moskvina, Valentina / Munroe, Patricia B / Murday, V / Newhouse, Stephen J / Newport, Melanie / Nikolov, Ivan / Nimmo, Elaine R / Nutland, Sarah / O'Donovan, Michael C / Onipinla, Abiodun / Onnie, Clive M / Ouwehand, Nilesh J / Ouwehand, Willem H / Owen, Katharine R / Owen, Michael J / Parkes, Miles / Paterson, J / Pembrey, Marcus / Pereira-Gale, Joanne / Perry, John R.B / Pichert, G / Pointon, Jennifer J / Porteous, M / Potter, Catherine / Potter, Simon / Prescott, Natalie J / Prowse, Christopher V / Rahman, N / Rahman, Nazneen / Ravindrarajah, Rathi / Rayner, Nigel W / Ring, Susan M / Rockett, Kirk A / Rogers, M / Rowe, S / Saggar, A / Samani, Michael R / Samani, Nilesh J / Sanderson, Jeremy / Satsangi, Jack / Sawcer, Stephen J / Scott, G / Seal, Sheila / Shanley, S / Shields, Beverley / Side, L / Silman, Alan J / Simmonds, Matthew J / Sirugo, Giorgio / Snadden, L / Spencer, Chris C.A / St. Clair, David / Steel, M / Stevens, Helen E / Stevens, Suzanne / Strachan, David P / Stratton, Michael R / Su, Zhan / Symmons, Deborah P.M / Taylor, Niall C / Teo, Yik Ying / Thomas, M / Thomas, S / Thompson, John R / Thomson, Wendy / Timpson, Nicholas J / Tobin, Martin D / Todd, John A / Todhunter, Catherine E / Tremelling, Mark / Vannberg, Fredrik / Vukcevic, Damjan / Walker, Mark / Walker, Neil M / Wallace, Chris / Walters, Graham R / Watkins, Nicholas A / Webster, John / Weedon, Michael N / Whittaker, Pamela / Widden, Claire / Widmer, Barry / Williamson, Richard / Wilson, Gerry D / Winzer, Thilo / Withers, David / Wordsworth, Paul / Worthington, Jane / Xue, Mingzhan / Young, Allan H / Yuldasheva, Nadira

Science. 2007 June 1, v. 316, no. 5829

2007  

Abstract: The molecular mechanisms involved in the development of type 2 diabetes are poorly understood. Starting from genome-wide genotype data for 1924 diabetic cases and 2938 population controls generated by the Wellcome Trust Case Control Consortium, we set ... ...

Abstract The molecular mechanisms involved in the development of type 2 diabetes are poorly understood. Starting from genome-wide genotype data for 1924 diabetic cases and 2938 population controls generated by the Wellcome Trust Case Control Consortium, we set out to detect replicated diabetes association signals through analysis of 3757 additional cases and 5346 controls and by integration of our findings with equivalent data from other international consortia. We detected diabetes susceptibility loci in and around the genes CDKAL1, CDKN2A/CDKN2B, and IGF2BP2 and confirmed the recently described associations at HHEX/IDE and SLC30A8. Our findings provide insight into the genetic architecture of type 2 diabetes, emphasizing the contribution of multiple variants of modest effect. The regions identified underscore the importance of pathways influencing pancreatic beta cell development and function in the etiology of type 2 diabetes.
Keywords etiology ; genes ; genotype ; islets of Langerhans ; loci ; noninsulin-dependent diabetes mellitus ; risk ; United Kingdom
Language English
Dates of publication 2007-0601
Size p. 1336-1341.
Publishing place American Association for the Advancement of Science
Document type Article
ZDB-ID 128410-1
ISSN 1095-9203 ; 0036-8075
ISSN (online) 1095-9203
ISSN 0036-8075
DOI 10.1126/science.1142364
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Database NAL-Catalogue (AGRICOLA)

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