Article ; Online: Retrospective Cohort Study of Safety Outcomes Associated with Opioid Rotations to Buprenorphine.
Journal of pain & palliative care pharmacotherapy
2023 Volume 37, Issue 3, Page(s) 234–245
Abstract: The objective of this study was to understand the effect buprenorphine rotations have on respiratory risk and other safety outcomes. This was a retrospective observational study evaluating Veterans who underwent an opioid rotation from full-agonist ... ...
| Abstract | The objective of this study was to understand the effect buprenorphine rotations have on respiratory risk and other safety outcomes. This was a retrospective observational study evaluating Veterans who underwent an opioid rotation from full-agonist opioids to buprenorphine products or to alternative opioids. The primary endpoint was change in the Risk Index for Overdose or Serious Opioid-induced Respiratory Depression (RIOSORD) score from baseline to six months post-rotation. Median baseline RIOSORD scores were 26.0 and 18.0 in the Buprenorphine Group and the Alternative Opioid Group, respectively. There was no statistically significant difference between groups in baseline RIOSORD score. At six months post-rotation, median RIOSORD scores were 23.5 and 23.0 in the Buprenorphine Group and Alternative Opioid Group, respectively. The difference in change in RIOSORD scores between groups was not statistically significant ( |
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| MeSH term(s) | Humans ; Buprenorphine/adverse effects ; Analgesics, Opioid/adverse effects ; Retrospective Studies ; Pain Management ; Respiratory Insufficiency/chemically induced ; Opioid-Related Disorders/drug therapy | |||||
| Chemical Substances | Buprenorphine (40D3SCR4GZ) ; Analgesics, Opioid | |||||
| Language | English | |||||
| Publishing date | 2023-04-25 | |||||
| Publishing country | England | |||||
| Document type | Observational Study ; Journal Article | |||||
| ZDB-ID | 2078852-6 | |||||
| ISSN | 1536-0539 ; 1536-0288 | |||||
| ISSN (online) | 1536-0539 | |||||
| ISSN | 1536-0288 | |||||
| DOI | 10.1080/15360288.2023.2200412 | |||||
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| Database | MEDical Literature Analysis and Retrieval System OnLINE |
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