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  1. Book ; Online: The EBMT/EHA CAR-T Cell Handbook

    Kröger, Nicolaus / Gribben, John / Chabannon, Christian / Yakoub-Agha, Ibrahim / Einsele, Hermann

    2022  

    Keywords Nursing ; Clinical & internal medicine ; Surgery ; Biology CAR-T ; Manufacturing CAR-T ; Indications CAR-T ; Complications CAR-T ; Access CAR-T ; Open Access
    Size 1 electronic resource (237 pages)
    Publisher Springer Nature
    Publishing place Cham
    Document type Book ; Online
    Note English ; Open Access
    HBZ-ID HT021290659
    ISBN 9783030943530 ; 3030943534
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  2. Book ; Online: The EBMT/EHA CAR-T Cell Handbook

    Kröger, Nicolaus / Gribben, John / Chabannon, Christian / Yakoub-Agha, Ibrahim / Einsele, Hermann

    2022  

    Author's details edited by Nicolaus Kröger, John Gribben, Christian Chabannon, Ibrahim Yakoub-Agha, Hermann Einsele
    Keywords Nursing ; Internal medicine ; Surgery
    Subject code 610.73
    Language English
    Size 1 Online-Ressource (X, 237 p. 26 illus., 9 illus. in color)
    Edition 1st ed. 2022
    Publisher Springer International Publishing ; Imprint: Springer
    Publishing place Cham
    Document type Book ; Online
    HBZ-ID HT021267501
    ISBN 978-3-030-94353-0 ; 9783030943523 ; 9783030943547 ; 3-030-94353-4 ; 3030943526 ; 3030943542
    DOI 10.1007/978-3-030-94353-0
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  3. Article: Mobilization and collection of CD34 + cells in patients with globin disorders: Providing the starting material to manufacturers of autologous gene therapies.

    Chabannon, Christian / Visentin, Sandrine / Granata, Angéla / Thuret, Isabelle

    Transfusion and apheresis science : official journal of the World Apheresis Association : official journal of the European Society for Haemapheresis

    2024  , Page(s) 103926

    Language English
    Publishing date 2024-04-17
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 2046795-3
    ISSN 1878-1683 ; 1473-0502
    ISSN (online) 1878-1683
    ISSN 1473-0502
    DOI 10.1016/j.transci.2024.103926
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 1739: Show issues Location:
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  4. Article ; Online: Hurdles to the Adoption of Gene Therapy as a Curative Option for Transfusion-Dependent Thalassemia.

    Thuret, Isabelle / Ruggeri, Annalisa / Angelucci, Emanuele / Chabannon, Christian

    Stem cells translational medicine

    2022  Volume 11, Issue 4, Page(s) 407–414

    Abstract: Beta-thalassemia is one of the most common monogenic disorders. Standard treatment of the most severe forms, i.e., transfusion-dependent thalassemia (TDT) with long-term transfusion and iron chelation, represents a considerable medical, psychological, ... ...

    Abstract Beta-thalassemia is one of the most common monogenic disorders. Standard treatment of the most severe forms, i.e., transfusion-dependent thalassemia (TDT) with long-term transfusion and iron chelation, represents a considerable medical, psychological, and economic burden. Allogeneic hematopoietic stem cell transplantation from an HLA-identical donor is a curative treatment with excellent results in children. Recently, several gene therapy approaches were evaluated in academia or industry-sponsored clinical trials as alternative curative options for children and young adults without an HLA-identical donor. Gene therapy by addition of a functional beta-globin gene using self-inactivating lentiviral vectors in autologous stem cells resulted in transfusion independence for a majority of TDT patients across different age groups and genotypes, with a current follow-up of multiple years. More recently, promising results were reported in TDT patients treated with autologous hematopoietic stem cells edited with the clustered regularly interspaced short palindromic repeats-Cas9 technology targeting erythroid BCL11A expression, a key regulator of the normal switch from fetal to adult globin production. Patients achieved high levels of fetal hemoglobin allowing for discontinuation of transfusions. Despite remarkable clinical efficacy, 2 major hurdles to gene therapy access for TDT patients materialized in 2021: (1) a risk of secondary hematological malignancies that is complex and multifactorial in origin and not limited to the risk of insertional mutagenesis, (2) the cost-even in high-income countries-is leading to the arrest of commercialization in Europe of the first gene therapy medicinal product indicated for TDT despite conditional approval by the European Medicines Agency.
    MeSH term(s) Child ; Genetic Therapy/methods ; Hematopoietic Stem Cell Transplantation ; Humans ; Thalassemia/genetics ; Thalassemia/therapy ; Young Adult ; beta-Globins/genetics ; beta-Thalassemia/genetics ; beta-Thalassemia/therapy
    Chemical Substances beta-Globins
    Language English
    Publishing date 2022-03-10
    Publishing country England
    Document type Journal Article
    ZDB-ID 2642270-0
    ISSN 2157-6580 ; 2157-6580
    ISSN (online) 2157-6580
    ISSN 2157-6580
    DOI 10.1093/stcltm/szac007
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article: Chapitre 6. Enjeux juridiques et pour le système de santé du développement d?une nouvelle classe de médicaments de thérapie innovante en onco-immunologie : les "Car-T Cells?

    Rial-Sebbag, Emmanuelle / Chabannon, Christian

    Journal international de bioethique et d'ethique des sciences

    2019  Volume 29, Issue 2, Page(s) 113–128

    Abstract: Car-T Cells are autologous or allogeneic lymphocytes cells, genetically engineered to express a transmembrane receptor called ?chimeric? because it consists of the assembly of different parts of molecules. These new techniques using biotechnologies ( ... ...

    Title translation Chapter 6. Legal issues and for the health system of the development of a new class of innovative therapy in oncoimmunology: the “Car-T CellS”.
    Abstract Car-T Cells are autologous or allogeneic lymphocytes cells, genetically engineered to express a transmembrane receptor called ?chimeric? because it consists of the assembly of different parts of molecules. These new techniques using biotechnologies (cellular engineering and genetic modifications) are developing in a complex legal context integrating the rules of the European Union (EU) and national rules, aiming to guarantee a high level of security for products and techniques but also for patients. This framework can be either considered as a guaranty for the use of new molecules in a highly secure environment or as an impediment, on the one hand regarding those who want to develop them because of a great complexity in identifying the adequate procedures and regarding the scientific prerequisites expected by the control agencies, and on the other hand by patients who have to wait many years for these innovations to be made available. The development of these innovative therapies will thus question first, the way care and healthcare system should be organised (including for their accessibility) and second, the legal regime and the bioethical principles to be applied for their implementation in the market.
    MeSH term(s) Allergy and Immunology ; Chimera ; European Union ; Genetic Engineering ; Health Systems Plans ; Humans ; Immunotherapy ; Neoplasms/therapy ; Patient Safety ; T-Lymphocytes ; Therapies, Investigational
    Language French
    Publishing date 2019-02-14
    Publishing country France
    Document type Journal Article
    ISSN 2608-1008
    ISSN 2608-1008
    DOI 10.3917/jibes.292.0113
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: [No title information]

    Chabannon, Christian / Larghero, Jérôme

    Bulletin du cancer

    2018  Volume 105 Suppl 2, Page(s) S198–S204

    Abstract: Regulatory framework for car-t cells: HOW CAN FRENCH HEALTHCARE PROVIDERS ADAPT THEIR ORGANIZATION TO REQUIREMENTS FOR MANUFACTURING AND DELIVERY OF THESE INNOVATIVE CELL-BASED MEDICINAL PRODUCTS?: More than five years after the first US publications ... ...

    Title translation Réglementations applicables aux CAR-T cells : comment les établissements de santé français peuvent-ils s’organiser pour participer à la production et permettre la délivrance de ces immunothérapies innovantes ?
    Abstract Regulatory framework for car-t cells: HOW CAN FRENCH HEALTHCARE PROVIDERS ADAPT THEIR ORGANIZATION TO REQUIREMENTS FOR MANUFACTURING AND DELIVERY OF THESE INNOVATIVE CELL-BASED MEDICINAL PRODUCTS?: More than five years after the first US publications reporting a significant rate of clinical responses in patients with high-risk or advanced CD19+ lymphoid malignancies, access to treatment with CAR-T Cells at European hospitals in general and at French hospitals in particular remains limited. One - and not the least - hurdle lay in the need to set up a complex and unprecedented organization that complies with European regulations on Advanced Therapy Medicinal Products as well as with national (French) regulations. We here review the organizational framework for two situations: delivery and administration of industry-manufactured CAR-T Cells as well as engineering and distribution of CAR-T Cells produced as investigational drugs to be evaluated in the context of clinical research protocols. Cet article fait partie du numéro supplément Les cellules CAR-T : une révolution thérapeutique ? réalisé avec le soutien institutionnel des partenaires Gilead : Kite et Celgene.
    MeSH term(s) Drugs, Investigational ; European Union ; France ; Health Facility Administration ; Humans ; Immunotherapy, Adoptive/legislation & jurisprudence ; Immunotherapy, Adoptive/statistics & numerical data ; Legislation, Drug ; Receptors, Chimeric Antigen ; T-Lymphocytes/immunology
    Chemical Substances Drugs, Investigational ; Receptors, Chimeric Antigen
    Language French
    Publishing date 2018-10-26
    Publishing country France
    Document type Journal Article ; Review
    ZDB-ID 213270-9
    ISSN 1769-6917 ; 0007-4551
    ISSN (online) 1769-6917
    ISSN 0007-4551
    DOI 10.1016/S0007-4551(19)30050-5
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Uh III Zs.15: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

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  7. Article ; Online: Considerations pertaining to cell collection and administration of industry-manufactured autologous CAR-T cells, in relation to French healthcare organization and regulations.

    Chabannon, Christian / Larghero, Jérôme

    Current research in translational medicine

    2018  Volume 66, Issue 2, Page(s) 59–61

    Abstract: Access to treatment with CAR-T Cells at European hospitals in general and at French hospitals in particular remains limited, when compared with the situation that prevails in the USA or in certain Asian countries. Multiple reasons explain why European ... ...

    Abstract Access to treatment with CAR-T Cells at European hospitals in general and at French hospitals in particular remains limited, when compared with the situation that prevails in the USA or in certain Asian countries. Multiple reasons explain why European investigators lag behind their US or Chinese colleagues in this clinical research area. Some of these reasons are related to the European and French regulatory landscapes that hamper the design and rapid implementation of organizational solutions needed for safe and efficient administration of CAR-T Cells. We here identify some of these pressing issues and propose some possible paths to move forward.
    MeSH term(s) Cell Separation/methods ; Cell Separation/standards ; Cell- and Tissue-Based Therapy/methods ; Cell- and Tissue-Based Therapy/standards ; Clinical Trials as Topic/legislation & jurisprudence ; Clinical Trials as Topic/methods ; Clinical Trials as Topic/organization & administration ; Clinical Trials as Topic/standards ; Commerce ; Delivery of Health Care/legislation & jurisprudence ; Delivery of Health Care/organization & administration ; Delivery of Health Care/standards ; France ; Humans ; Immunotherapy, Adoptive/legislation & jurisprudence ; Immunotherapy, Adoptive/methods ; Immunotherapy, Adoptive/standards ; Legislation, Medical ; Receptors, Chimeric Antigen/therapeutic use ; T-Lymphocytes/transplantation ; Tissue and Organ Harvesting/legislation & jurisprudence ; Tissue and Organ Harvesting/methods ; Tissue and Organ Harvesting/standards
    Chemical Substances Receptors, Chimeric Antigen
    Language English
    Publishing date 2018-04-04
    Publishing country France
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ISSN 2452-3186
    ISSN (online) 2452-3186
    DOI 10.1016/j.retram.2018.03.002
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: The connected worlds of stem cell transplantation and HIV.

    Wensing, Annemarie M J / Chabannon, Christian / Kuball, Jurgen

    The lancet. HIV

    2020  Volume 7, Issue 9, Page(s) e594–e595

    MeSH term(s) HIV Infections/complications ; HIV Infections/drug therapy ; HIV Infections/immunology ; HIV Infections/virology ; Hematopoietic Stem Cell Transplantation/adverse effects ; Hematopoietic Stem Cell Transplantation/methods ; Humans ; Leukemia, Myeloid, Acute/complications ; Leukemia, Myeloid, Acute/mortality ; Leukemia, Myeloid, Acute/therapy ; Stem Cell Transplantation/adverse effects ; Stem Cell Transplantation/methods ; Treatment Outcome
    Language English
    Publishing date 2020-07-07
    Publishing country Netherlands
    Document type Letter
    ISSN 2352-3018
    ISSN (online) 2352-3018
    DOI 10.1016/S2352-3018(20)30170-3
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Welcome to ISCT 2020 Paris Virtual.

    Chabannon, Christian / Ciccocioppo, Rachele / Martin, Ivan

    Cytotherapy

    2020  Volume 22, Issue 5S, Page(s) S3

    Keywords covid19
    Language English
    Publishing date 2020-05-23
    Publishing country England
    Document type Editorial
    ZDB-ID 2039821-9
    ISSN 1477-2566 ; 1465-3249
    ISSN (online) 1477-2566
    ISSN 1465-3249
    DOI 10.1016/j.jcyt.2020.04.096
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 5601: Show issues Location:
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  10. Article ; Online: Identification of hurdles in the development of cell-based therapies.

    Rotolo, Antonia / Chabannon, Christian / Gramignoli, Roberto

    Cytotherapy

    2020  Volume 22, Issue 2, Page(s) 53–56

    Language English
    Publishing date 2020-02-20
    Publishing country England
    Document type Editorial
    ZDB-ID 2039821-9
    ISSN 1477-2566 ; 1465-3249
    ISSN (online) 1477-2566
    ISSN 1465-3249
    DOI 10.1016/j.jcyt.2019.12.009
    Database MEDical Literature Analysis and Retrieval System OnLINE

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