Article ; Online: SARS-CoV-2 and post-donation information: a one-year experience of the French haemovigilance network.
Blood transfusion = Trasfusione del sangue
2022 Volume 20, Issue 5, Page(s) 362–373
Abstract: Background: There is growing evidence to support the hypothesis that SARS-CoV-2 is probably not transmissible by blood transfusion. In this study, we use the data gathered over one year by the French haemovigilance network on post-donation information ... ...
| Abstract | Background: There is growing evidence to support the hypothesis that SARS-CoV-2 is probably not transmissible by blood transfusion. In this study, we use the data gathered over one year by the French haemovigilance network on post-donation information related to SARS-CoV-2, and virological investigations on corresponding plasma to explore viral transmission by transfusion. Materials and methods: Whenever a donor reported COVID-19 symptoms and/or a positive SARS-CoV-2 nasopharyngeal (NP) PCR test, information regarding diagnosis and symptoms was collected using a specific questionnaire, and repository plasmas were screened using the SARS-COV-2 R-GENE Results: We investigated 1,092 SARS-CoV-2-related post-donation information (PDI) reports. PDI donors were younger than the global donor population and donated more often in the Paris region. Sixty-eight percent reported a positive NP real-time (RT)-PCR or antigenic testing and 22% of these also had symptoms at the time of testing. Thirty-seven (3.4%) donations tested positive for SARS-CoV-2 RNA, 11 (30%) were confirmed by another molecular assay, and 7 (19%) by sequencing, confirming low viral level. Most RNAemic blood donors donated in southern regions and in Paris. There was no difference in demographic data or duration parameter between RNAemic and non-RNAemic donors. Duration parameter was determined as the time elapsed between donation and: i) the onset of symptoms; ii) a positive NP RT-PCR; and iii) PDI. Cell culture experiments did not show any infectivity related to RNAemic plasmas. Discussion: SARS-CoV-2 RNA can be detected in a small fraction of blood donors with PDI, reporting very low levels of RNA. The corresponding plasma is probably not infectious. These findings highlight the value of haemovigilance and PDI to guide blood safety strategies. |
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| MeSH term(s) | Blood Donors ; Blood Safety ; COVID-19/epidemiology ; Humans ; RNA, Viral ; SARS-CoV-2 |
| Chemical Substances | RNA, Viral |
| Language | English |
| Publishing date | 2022-01-21 |
| Publishing country | Italy |
| Document type | Journal Article |
| ZDB-ID | 2135732-8 |
| ISSN | 2385-2070 ; 0041-1787 ; 1723-2007 |
| ISSN (online) | 2385-2070 |
| ISSN | 0041-1787 ; 1723-2007 |
| DOI | 10.2450/2022.0266-21 |
| Database | MEDical Literature Analysis and Retrieval System OnLINE |
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