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  1. AU="Chachar, Aijaz Zeeshan Khan"
  2. AU=Forster H V
  3. AU=Yang G-F
  4. AU="Kaplan, Robert C"
  5. AU="Rood, Julian I."
  6. AU="Manhes, Caroline"
  7. AU="Jacobsen, Cristiane Cavalcanti"
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  9. AU="Zhang, N"
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  13. AU="Razolli, Daniela S"
  14. AU="Asif, Mohsin"
  15. AU="Choudhary, Diksha"
  16. AU="Liu, Yongmei"
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  39. AU="Notoya, A"
  40. AU="Williams, Olajide A"
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  42. AU="Tortolani, Christina C"
  43. AU="Patel, Jenil R"
  44. AU="Aires, Rafaela"
  45. AU="Habibelahi, Abbas"
  46. AU="Temes, Javier"
  47. AU="Miwa, Toru"
  48. AU="Jaller, Elvira"
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  1. Artikel ; Online: Berardinelli-Seip Congenital Lipodystrophy - A Case Report and Review of Literature.

    Munir, Atif / Haider, Miqdad / Chachar, Aijaz Zeeshan Khan

    Journal of the College of Physicians and Surgeons--Pakistan : JCPSP

    2022  Band 32, Heft 6, Seite(n) 817–819

    Abstract: Berardinelli-Seip Congenital Lipodystrophy (BSCL), also known as congenital generalised lipodystrophy, is a genetic disorder where there is an absolute deficiency of adipose tissue. It affects the development of adipocytes and ultimately leads to an ... ...

    Abstract Berardinelli-Seip Congenital Lipodystrophy (BSCL), also known as congenital generalised lipodystrophy, is a genetic disorder where there is an absolute deficiency of adipose tissue. It affects the development of adipocytes and ultimately leads to an inability to store fat in adipocytes. It is extremely rare. Most of the cases reported are from Africa and North America. Only a handful of cases have been reported in the world. The aim of this case report is to highlight the significance of this rare metabolic disorder, which should be considered whilst managing young patients with severe insulin resistance. We present a case of a young Asian child with an increasing need for insulin for his diabetes. He was previously managed on the lines of type 1 diabetes mellitus and his insulin requirements kept on increasing. Diagnosis on the basis of genetic studies was not possible due to the non-availability of the test in Pakistan. BSCL is an infrequent condition leading to several cardiometabolic complications. Timely diagnosis can lead to better management and prevention of complications. Keywords: Insulin resistance, Lipodystrophy, Acanthosis nigricans, Hypertriglyceridemia, Genetic disease.
    Mesh-Begriff(e) Acanthosis Nigricans ; Child ; Humans ; Insulin/therapeutic use ; Insulin Resistance ; Lipodystrophy, Congenital Generalized/complications ; Lipodystrophy, Congenital Generalized/diagnosis ; Lipodystrophy, Congenital Generalized/genetics ; Male ; Rare Diseases
    Chemische Substanzen Insulin
    Sprache Englisch
    Erscheinungsdatum 2022-01-04
    Erscheinungsland Pakistan
    Dokumenttyp Case Reports ; Review
    ZDB-ID 2276646-7
    ISSN 1681-7168 ; 1022-386X
    ISSN (online) 1681-7168
    ISSN 1022-386X
    DOI 10.29271/jcpsp.2022.06.817
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  2. Artikel: "Tocilizumab-an option for patients with COVID-19 associated cytokine release syndrome: A single center experience", a retrospective study-original article.

    Chachar, Aijaz Zeeshan Khan / Khan, Khurshid Ahmed / Iqbal, Javeid / Shahid, Adnan Hussain / Asif, Mohsin / Fatima, Syeda Arzinda / Khan, Asma Afzal / Younis, Bilal Bin

    Annals of medicine and surgery (2012)

    2021  Band 63, Seite(n) 102165

    Abstract: Background: The first case of Infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) was diagnosed in Wuhan, China in 2019. In the first half of 2020, this disease has already converted into a global pandemic. This study aimed to ... ...

    Abstract Background: The first case of Infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) was diagnosed in Wuhan, China in 2019. In the first half of 2020, this disease has already converted into a global pandemic. This study aimed to find that treatment of patients with COVID-19 pneumonia with Tocilizumab or steroids was associated with better outcomes.
    Study design: Quasi-experimental.
    Duration of study: From May 12, 2020 to June 12, 2020.
    Patients & methods sample size and technique: Sample size was 93; 33 patients were kept in the experimental group, given Tocilizumab, 8 mg/kg intravenously or 162 mg subcutaneously, and the rest of the 60 patients were given corticosteroids, methylprednisolone 80 mg/day. Consecutive sampling. Failure of therapy was labeled when patients were intubated or died, and the endpoints were failure-free survival which was the primary endpoint, and overall survival secondary at the time of discharge.
    Results: A total of 93 patients were enrolled, the Tocilizumab (TCZ) group (case) and Corticosteroid (CS) group (Control). The median age was 58 years (IQR-21), 37 (39.8%) patients with diabetes mellitus, 11 (11.8%) in the TCZ group, and 26 (28%) in the CS group. On the whole, the total median hospital stay in days was 7 with IQR (4), a total of 83 (89.2%) patients recovered successfully and discharged, 27 (29%) in the TCZ group and 56 (60.2%) in the CS group. Total 10 (10.8%) patients died, out of which 6 (6.5%) belonged to the TCZ group and 4 (4.3%) belonged to the CS group The median Oxygen requirement with IQR was 8 (9) in both the groups and in total as well, p-value (0.714).
    Conclusions: Tocilizumab is a quite effective treatment option for critically sick patients of Covid-19 by reducing their oxygen requirement drastically and so the ICU stay, median hospital stay and so the mortality as well.
    Clinicals trials registration: UIN # NCT04730323.
    Sprache Englisch
    Erscheinungsdatum 2021-02-08
    Erscheinungsland England
    Dokumenttyp Journal Article
    ZDB-ID 2745440-X
    ISSN 2049-0801
    ISSN 2049-0801
    DOI 10.1016/j.amsu.2021.02.011
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  3. Artikel: Pulmonary renal syndrome in a patient with vasculitis: Case report and review of literature.

    Chachar, Aijaz Zeeshan Khan / Sabir, Omer / Haider, Irfan / Tanvir, Imrana / Rafique, Kashif / Tarif, Nauman

    Pakistan journal of medical sciences

    2016  Band 31, Heft 6, Seite(n) 1545–1548

    Abstract: Granulomatosis with polyangiitis (GPA) previously known as Wegner's granulomatosis, is a small vessel vasculitis that preferentially involves capillaries, arterioles and venules, presenting as multisystemic disease classically with alveolar haemorrhage ... ...

    Abstract Granulomatosis with polyangiitis (GPA) previously known as Wegner's granulomatosis, is a small vessel vasculitis that preferentially involves capillaries, arterioles and venules, presenting as multisystemic disease classically with alveolar haemorrhage and renal insufficiency. We report a case of GPA diagnosed on history, clinical findings and supported by imaging and very high levels of C-ANCA. Renal biopsy confirmed the typical histopathological findings. We discuss herein the management of the case and review of literature.
    Sprache Englisch
    Erscheinungsdatum 2016-02-11
    Erscheinungsland Pakistan
    Dokumenttyp Case Reports
    ZDB-ID 2032827-8
    ISSN 1681-715X ; 1682-024X ; 1017-4699
    ISSN (online) 1681-715X
    ISSN 1682-024X ; 1017-4699
    DOI 10.12669/pjms.316.8391
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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    Verfügbar in ZB MED Köln/Königswinter

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