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  1. Article ; Online: Local Drd1-neurons input to subgroups of arcuate AgRP/NPY-neurons.

    Chadwick, Sean R / Güler, Ali D

    iScience

    2022  Volume 25, Issue 7, Page(s) 104605

    Abstract: Obesity is a pandemic afflicting more than 300 million people worldwide, driven by consumption of calorically dense and highly rewarding foods. Dopamine (DA) signaling has been implicated in neural responses to highly palatable nutrients, but the exact ... ...

    Abstract Obesity is a pandemic afflicting more than 300 million people worldwide, driven by consumption of calorically dense and highly rewarding foods. Dopamine (DA) signaling has been implicated in neural responses to highly palatable nutrients, but the exact mechanisms through which DA modulates homeostatic feeding circuits remains unknown. A subpopulation of arcuate (ARC) agouti-related peptide (AgRP)/neuropeptide Y (NPY) (ARC
    Language English
    Publishing date 2022-06-15
    Publishing country United States
    Document type Journal Article
    ISSN 2589-0042
    ISSN (online) 2589-0042
    DOI 10.1016/j.isci.2022.104605
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Efficacy and Safety of Iloperidone in Bipolar Mania: A Double-Blind, Placebo-Controlled Study.

    Torres, Rosarelis / Czeisler, Emily L / Chadwick, Sean R / Stahl, Stephen M / Smieszek, Sandra P / Xiao, Changfu / Polymeropoulos, Christos M / Birznieks, Gunther / Polymeropoulos, Mihael H

    The Journal of clinical psychiatry

    2024  Volume 85, Issue 1

    Abstract: Objective:: Methods:: Results:: Conclusions:: Trial Registration: ...

    Abstract Objective:
    Methods:
    Results:
    Conclusions:
    Trial Registration:
    MeSH term(s) Adult ; Humans ; Bipolar Disorder/diagnosis ; Mania ; Treatment Outcome ; Antipsychotic Agents/adverse effects ; Double-Blind Method ; Psychiatric Status Rating Scales ; Isoxazoles ; Piperidines
    Chemical Substances iloperidone (VPO7KJ050N) ; Antipsychotic Agents ; Isoxazoles ; Piperidines
    Language English
    Publishing date 2024-01-15
    Publishing country United States
    Document type Randomized Controlled Trial ; Clinical Trial, Phase III ; Journal Article
    ZDB-ID 716287-x
    ISSN 1555-2101 ; 0160-6689
    ISSN (online) 1555-2101
    ISSN 0160-6689
    DOI 10.4088/JCP.23m14966
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.B 108: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)
    Zs.MO 247: Show issues

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  3. Article ; Online: Dopamine Signaling in the Suprachiasmatic Nucleus Enables Weight Gain Associated with Hedonic Feeding.

    Grippo, Ryan M / Tang, Qijun / Zhang, Qi / Chadwick, Sean R / Gao, Yingnan / Altherr, Everett B / Sipe, Laura / Purohit, Aarti M / Purohit, Nidhi M / Sunkara, Meghana D / Cios, Krystyna J / Sidikpramana, Michael / Spano, Anthony J / Campbell, John N / Steele, Andrew D / Hirsh, Jay / Deppmann, Christopher D / Wu, Martin / Scott, Michael M /
    Güler, Ali D

    Current biology : CB

    2020  Volume 30, Issue 7, Page(s) 1352–1355

    Language English
    Publishing date 2020-04-07
    Publishing country England
    Document type Published Erratum
    ZDB-ID 1071731-6
    ISSN 1879-0445 ; 0960-9822
    ISSN (online) 1879-0445
    ISSN 0960-9822
    DOI 10.1016/j.cub.2020.03.034
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 3208: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  4. Article ; Online: Dopamine Signaling in the Suprachiasmatic Nucleus Enables Weight Gain Associated with Hedonic Feeding.

    Grippo, Ryan M / Tang, Qijun / Zhang, Qi / Chadwick, Sean R / Gao, Yingnan / Altherr, Everett B / Sipe, Laura / Purohit, Aarti M / Purohit, Nidhi M / Sunkara, Meghana D / Cios, Krystyna J / Sidikpramana, Michael / Spano, Anthony J / Campbell, John N / Steele, Andrew D / Hirsh, Jay / Deppmann, Christopher D / Wu, Martin / Scott, Michael M /
    Güler, Ali D

    Current biology : CB

    2020  Volume 30, Issue 2, Page(s) 196–208.e8

    Abstract: The widespread availability of energy-dense, rewarding foods is correlated with the increased incidence of obesity across the globe. Overeating during mealtimes and unscheduled snacking disrupts timed metabolic processes, which further contribute to ... ...

    Abstract The widespread availability of energy-dense, rewarding foods is correlated with the increased incidence of obesity across the globe. Overeating during mealtimes and unscheduled snacking disrupts timed metabolic processes, which further contribute to weight gain. The neuronal mechanism by which the consumption of energy-dense food restructures the timing of feeding is poorly understood. Here, we demonstrate that dopaminergic signaling within the suprachiasmatic nucleus (SCN), the central circadian pacemaker, disrupts the timing of feeding, resulting in overconsumption of food. D1 dopamine receptor (Drd1)-null mice are resistant to diet-induced obesity, metabolic disease, and circadian disruption associated with energy-dense diets. Conversely, genetic rescue of Drd1 expression within the SCN restores diet-induced overconsumption, weight gain, and obesogenic symptoms. Access to rewarding food increases SCN dopamine turnover, and elevated Drd1-signaling decreases SCN neuronal activity, which we posit disinhibits downstream orexigenic responses. These findings define a connection between the reward and circadian pathways in the regulation of pathological calorie consumption.
    MeSH term(s) Animals ; Dopamine/physiology ; Eating ; Feeding Behavior ; Gene Expression ; Male ; Mice ; Mice, Inbred C57BL ; Random Allocation ; Receptors, Dopamine D1/genetics ; Receptors, Dopamine D1/metabolism ; Reward ; Signal Transduction ; Suprachiasmatic Nucleus/physiology ; Weight Gain/genetics ; Weight Gain/physiology
    Chemical Substances Drd1 protein, mouse ; Receptors, Dopamine D1 ; Dopamine (VTD58H1Z2X)
    Language English
    Publishing date 2020-01-02
    Publishing country England
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 1071731-6
    ISSN 1879-0445 ; 0960-9822
    ISSN (online) 1879-0445
    ISSN 0960-9822
    DOI 10.1016/j.cub.2019.11.029
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 3208: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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