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Article ; Online: Aging phenotype in AD brain organoids: Track to success and challenges.

Hossain, Muhammad Kamal / Kim, Hyung-Ryong / Chae, Han Jung

2024 Volume 96, Page(s) 102256

Abstract: Alzheimer's disease (AD) poses a complex challenge, with abnormal protein accumulation in the brain causing memory loss and cognitive decline. Traditional models fall short in AD research, prompting interest in 3D brain organoids (BOs) from human stem ... ...

Abstract	Alzheimer's disease (AD) poses a complex challenge, with abnormal protein accumulation in the brain causing memory loss and cognitive decline. Traditional models fall short in AD research, prompting interest in 3D brain organoids (BOs) from human stem cells. These findings hold promise for unveiling the mechanisms of AD, especially in relation to aging. However, an understanding of the aging impact of AD remains elusive. BOs offer insight but face challenges. This review delves into the role of BOs in deciphering aging-related AD and acknowledges limitations. Strategies to enhance BOs for accurate aging modeling in AD brains are suggested. Strengthened by molecular advancements, BOs have the potential to uncover the aging phenotype, advancing AD research.
MeSH term(s)	Humans ; Alzheimer Disease ; Brain ; Aging ; Organoids ; Phenotype
Language	English
Publishing date	2024-03-07
Publishing country	England
Document type	Journal Article ; Review
ZDB-ID	2075672-0
ISSN	1872-9649 ; 1568-1637
ISSN (online)	1872-9649
ISSN	1568-1637
DOI	10.1016/j.arr.2024.102256
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Zs.A 5579: Show issues

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Jg. 1995 - 2021: Lesesall (2.OG)
ab Jg. 2022: Lesesaal (EG)

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Article: Glucose-lowering effect of Gryllus bimaculatus powder on streptozotocin-induced diabetes through the AKT/mTOR pathway

Park, Seon Ah / lee, geumhwa / Lee, Hwa-Young / Hoang The, Hiep / Chae, Han-Jung

Food Science & Nutrition, 8(1):402-409

2019

Abstract: This study was carried out to elucidate the antidiabetic effects of Gryllus bimaculatus powder using a streptozotocin (STZ)-induced rat model of type I diabetes. Administration of the insect powder significantly rescued representative diabetes markers (i. ...

Abstract	This study was carried out to elucidate the antidiabetic effects of Gryllus bimaculatus powder using a streptozotocin (STZ)-induced rat model of type I diabetes. Administration of the insect powder significantly rescued representative diabetes markers (i.e., insulin and C-peptide) in STZ-treated rats. Improved glucose tolerance test (GTT) and insulin tolerance test (ITT) results were also observed, indicating that Gryllus bimaculatus powder exerts antidiabetic effects. Gryllus bimaculatus powder administration rescued STZ-induced alterations in both islet morphology and insulin staining patterns. The extract increased antiapoptotic Bcl2 expression and decreased proapoptotic Bax and active caspase 3 expressions. In addition, the Gryllus bimaculatus powder supplementation enhanced AKT/mTOR pathway, a key marker of the state of anabolic metabolism, and its downstream effector, mTOR. Collectively, our results suggest that Gryllus bimaculatus contributes to the maintenance of pancreatic β-cell function and morphology against a diabetic state through the regulations against apoptosis and anabolic metabolism.
Keywords	AKT/mTOR ; Bax ; Bcl2 ; Gryllus bimaculatus ; Diabetes
Language	English
Document type	Article
Database	Repository for Life Sciences

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Article ; Online: Canonical and Noncanonical ER Stress-Mediated Autophagy Is a Bite the Bullet in View of Cancer Therapy.

Alam, Rashedul / Kabir, Mohammad Fazlul / Kim, Hyung-Ryong / Chae, Han-Jung

Cells

2022 Volume 11, Issue 23

Abstract: Cancer cells adapt multiple mechanisms to counter intense stress on their way to growth. Tumor microenvironment stress leads to canonical and noncanonical endoplasmic stress (ER) responses, which mediate autophagy and are engaged during proteotoxic ... ...

Abstract	Cancer cells adapt multiple mechanisms to counter intense stress on their way to growth. Tumor microenvironment stress leads to canonical and noncanonical endoplasmic stress (ER) responses, which mediate autophagy and are engaged during proteotoxic challenges to clear unfolded or misfolded proteins and damaged organelles to mitigate stress. In these conditions, autophagy functions as a cytoprotective mechanism in which malignant tumor cells reuse degraded materials to generate energy under adverse growing conditions. However, cellular protection by autophagy is thought to be complicated, contentious, and context-dependent; the stress response to autophagy is suggested to support tumorigenesis and drug resistance, which must be adequately addressed. This review describes significant findings that suggest accelerated autophagy in cancer, a novel obstacle for anticancer therapy, and discusses the UPR components that have been suggested to be untreatable. Thus, addressing the UPR or noncanonical ER stress components is the most effective approach to suppressing cytoprotective autophagy for better and more effective cancer treatment.
Language	English
Publishing date	2022-11-25
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2661518-6
ISSN	2073-4409 ; 2073-4409
ISSN (online)	2073-4409
ISSN	2073-4409
DOI	10.3390/cells11233773
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: IBF-R Regulates IRE1α Post-Translational Modifications and ER Stress in High-Fat Diet-Induced Obese Mice

Lee, Hwa-Young / Lee, Geum-Hwa / Yoon, Young / Hoang, The-Hiep / Chae, Han-Jung

Nutrients. 2022 Jan. 04, v. 14, no. 1

2022

Abstract: Obesity is a global health issue linked to the heightened risk of several chronic diseases. Rhus verniciflua (RV) is a traditional food supplement used for a range of pharmacological effects such as antitumor, antioxidant, α-glucosidase inhibitory ... ...

Abstract	Obesity is a global health issue linked to the heightened risk of several chronic diseases. Rhus verniciflua (RV) is a traditional food supplement used for a range of pharmacological effects such as antitumor, antioxidant, α-glucosidase inhibitory effects, hepatitis, and arthritis. Despite the traditional medicinal values, scientific evidence for its application in obesity is inadequate and unclear. Thus, this investigation was designed to evaluate the anti-obesity effects of IBF-R, an RV extract, using a high-fat diet (HFD) model. The study has six groups: chow diet group; chow diet with 80 mg/kg IBF-R; HFD group; IBF-R group with 20, 40, and 80 mg/kg. IBF-R supplementation significantly regulated the weight gain than the HFD fed mice. Further, IBF-R supplementation lowered the expressions of adipogenic transcription factors such as SREBP-1c, C/EBPα, FAS, and PPAR-γ in white adipose tissue (WAT) of diet-induced obese mice. In addition, IBF-R supplementation reduced the lipogenic gene expression while enhancing genes was related to fatty acid oxidation. Obesity is linked to redox-based post-translational modifications (PTMs) of IRE1α such as S-nitrosylation, endoplasmic reticulum (ER) stress, and chronic metabolic inflammation. The administration of IBF-R inhibits these PTMs. Notably, IBF-R administration significantly enhanced the expression of AMPK and sirtuin 1 in WAT of HFD-fed mice. Together, these findings reveal the IRE1α S-nitrosylation-inflammation axis as a novel mechanism behind the positive implications of IBF-R on obesity. In addition, it lays a firm foundation for the development of Rhus verniciflua extract as a functional ingredient in the food and pharmaceutical industries.
Keywords	S-nitrosylation ; Toxicodendron vernicifluum ; antioxidants ; arthritis ; beta oxidation ; dietary supplements ; endoplasmic reticulum ; gene expression ; hepatitis ; high fat diet ; inflammation ; obesity ; risk ; sirtuins ; traditional foods ; weight gain ; white adipose tissue
Language	English
Dates of publication	2022-0104
Publishing place	Multidisciplinary Digital Publishing Institute
Document type	Article
ZDB-ID	2518386-2
ISSN	2072-6643
ISSN	2072-6643
DOI	10.3390/nu14010217
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: The aftermath of the interplay between the endoplasmic reticulum stress response and redox signaling.

Bhattarai, Kashi Raj / Riaz, Thoufiqul Alam / Kim, Hyung-Ryong / Chae, Han-Jung

Experimental & molecular medicine

2021 Volume 53, Issue 2, Page(s) 151–167

Abstract: The endoplasmic reticulum (ER) is an essential organelle of eukaryotic cells. Its main functions include protein synthesis, proper protein folding, protein modification, and the transportation of synthesized proteins. Any perturbations in ER function, ... ...

Abstract	The endoplasmic reticulum (ER) is an essential organelle of eukaryotic cells. Its main functions include protein synthesis, proper protein folding, protein modification, and the transportation of synthesized proteins. Any perturbations in ER function, such as increased demand for protein folding or the accumulation of unfolded or misfolded proteins in the ER lumen, lead to a stress response called the unfolded protein response (UPR). The primary aim of the UPR is to restore cellular homeostasis; however, it triggers apoptotic signaling during prolonged stress. The core mechanisms of the ER stress response, the failure to respond to cellular stress, and the final fate of the cell are not yet clear. Here, we discuss cellular fate during ER stress, cross talk between the ER and mitochondria and its significance, and conditions that can trigger ER stress response failure. We also describe how the redox environment affects the ER stress response, and vice versa, and the aftermath of the ER stress response, integrating a discussion on redox imbalance-induced ER stress response failure progressing to cell death and dynamic pathophysiological changes.
MeSH term(s)	Animals ; Disease Progression ; Disease Susceptibility ; Endoplasmic Reticulum/metabolism ; Endoplasmic Reticulum Stress ; Humans ; Mitochondria/metabolism ; Oxidation-Reduction ; Protein Transport ; Reactive Oxygen Species/metabolism ; Signal Transduction ; Unfolded Protein Response
Chemical Substances	Reactive Oxygen Species
Language	English
Publishing date	2021-02-08
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Review
ZDB-ID	1328915-9
ISSN	2092-6413 ; 1226-3613 ; 0378-8512
ISSN (online)	2092-6413
ISSN	1226-3613 ; 0378-8512
DOI	10.1038/s12276-021-00560-8
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Zs.A 4775: Show issues

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Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
Jg. 1995 - 2021: Lesesall (2.OG)
ab Jg. 2022: Lesesaal (EG)

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Article ; Online: IBF-R Regulates IRE1α Post-Translational Modifications and ER Stress in High-Fat Diet-Induced Obese Mice.

Lee, Hwa-Young / Lee, Geum-Hwa / Yoon, Young / Hoang, The-Hiep / Chae, Han-Jung

Nutrients

2022 Volume 14, Issue 1

Abstract: Obesity is a global health issue linked to the heightened risk of several chronic diseases. ...

Abstract	Obesity is a global health issue linked to the heightened risk of several chronic diseases.
MeSH term(s)	Adipogenesis/drug effects ; Animals ; Anti-Obesity Agents ; Diet, High-Fat ; Endoplasmic Reticulum Stress/drug effects ; Endoribonucleases/metabolism ; Lipid Metabolism/drug effects ; Male ; Mice ; Mice, Inbred C57BL ; Obesity/drug therapy ; Obesity/etiology ; Obesity/metabolism ; Plant Extracts/administration & dosage ; Protein Processing, Post-Translational/drug effects ; Protein Serine-Threonine Kinases/metabolism ; Rhus/chemistry ; Weight Gain/drug effects
Chemical Substances	Anti-Obesity Agents ; Plant Extracts ; Ern1 protein, mouse (EC 2.7.11.1) ; Protein Serine-Threonine Kinases (EC 2.7.11.1) ; Endoribonucleases (EC 3.1.-)
Language	English
Publishing date	2022-01-04
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2518386-2
ISSN	2072-6643 ; 2072-6643
ISSN (online)	2072-6643
ISSN	2072-6643
DOI	10.3390/nu14010217
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Ixeris dentata and Lactobacillus gasseri media protect against periodontitis through Nrf2-HO-1 signalling pathway.

Lee, Hwa-Young / Lee, Geum-Hwa / Kim, Ji-Hyun / Cheng, Jinhua / Cho, Joo-Hyung / Suh, Joo-Won / Chae, Han-Jung

Scientific reports

2023 Volume 13, Issue 1, Page(s) 12861

Abstract: Periodontitis is an infectious inflammation in the gums characterized by loss of periodontal ligaments and alveolar bone. Its persistent inflammation could result in tooth loss and other health issues. Ixeris dentata (IXD) and Lactobacillus gasseri media ...

Abstract	Periodontitis is an infectious inflammation in the gums characterized by loss of periodontal ligaments and alveolar bone. Its persistent inflammation could result in tooth loss and other health issues. Ixeris dentata (IXD) and Lactobacillus gasseri media (LGM) demonstrated strong antioxidant activity, which may prevent oxidative and inflammatory periodontitis. Here, IXD and LGM extracts were investigated for antioxidative activity against oral discomfort and evaluated for their synergistic effect against oxidative and inflammatory periodontitis in a mouse model. IXD/LGM suppressed pro-inflammatory cytokines like interleukin (IL)-1β, IL-6, and TNF-α. Additionally, it reduced pro-inflammatory mediators, nitric oxide, iNOS (inducible nitric oxide synthase), and COX-2 (cyclooxygenase-2) and enhanced AKT, Nrf2, and HO-1 activation. Similarly, IXD/LGM treatment elevated osteogenic proteins and mRNAs; alkaline phosphatase, collagen type 1 (COL1), osteopontin (OPN), and runt-related transcription factor 2 (RUNX2). Hematoxylin and Eosin (H&E) staining and micro-CT analysis confirm the positive impact of IXD/LGM on the periodontal structure and its associated inflammation. These findings demonstrate that IXD/LGM inhibits oxidative stress, periodontal inflammation, and its resultant alveolar bone loss in which Akt (also known as protein kinase B)-nuclear factor-erythroid 2-related factor 2 (Nrf2)-hemoxygenase-1 (HO-1) signaling is involved. Thus, IXD/LGM is a potential candidate against oxidative/inflammatory stress-associated periodontitis.
MeSH term(s)	Mice ; Animals ; Proto-Oncogene Proteins c-akt ; NF-E2-Related Factor 2/metabolism ; Lactobacillus gasseri ; Periodontitis/prevention & control ; Inflammation ; Antioxidants ; Asteraceae/metabolism ; Heme Oxygenase-1
Chemical Substances	Proto-Oncogene Proteins c-akt (EC 2.7.11.1) ; NF-E2-Related Factor 2 ; Antioxidants ; Heme Oxygenase-1 (EC 1.14.14.18)
Language	English
Publishing date	2023-08-08
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2615211-3
ISSN	2045-2322 ; 2045-2322
ISSN (online)	2045-2322
ISSN	2045-2322
DOI	10.1038/s41598-023-39853-5
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: The Role of Reactive Oxygen Species, Inflammation, and Endoplasmic Reticulum Stress Response in the Finasteride Protective Effect against Benign Prostate Hyperplasia.

Lee, Geum-Hwa / Lee, Hwa-Young / Zhao, Luo / Rashid, Mohammad Mamun Ur / Kim, Myung Ki / Jeong, Young Beom / Chae, Han-Jung / Shin, Yu Seob

The world journal of men's health

2023

Abstract: Purpose: Benign prostate hyperplasia (BPH) is a common age-related chronic condition. Its pathogenesis involves androgen imbalance, inflammation, oxidative stress, and endoplasmic reticulum (ER) stress. This study aims to assess the protective effect of ...

Abstract	Purpose: Benign prostate hyperplasia (BPH) is a common age-related chronic condition. Its pathogenesis involves androgen imbalance, inflammation, oxidative stress, and endoplasmic reticulum (ER) stress. This study aims to assess the protective effect of finasteride, a 5α-reductase inhibitor, against testosterone propionate (TP)-induced BPH in rats and explore its potential mechanism of action. Materials and methods: TP-induced BPH rats received either saline or finasteride (1 mg/kg) orally once a day for 7 weeks. Prior to sacrificing the animals, blood samples were collected. After sacrifice, prostate and tissue around the prostate were dissected from seminal vesical for further analysis. Body weight, prostate weight, dihydrotestosterone (DHT), 5α-reductase type 2 (5-AR2), and prostate-specific antigen (PSA) levels were measured. In addition, HIF-1α, VEGF, MMP-2 expressions in prostate, oxidative stress, inflammation, and ER stress responses were analyzed to understand the mechanism of action of finasteride. Results: Finasteride administration inhibited prostate enlargement, DHT, 5-AR2, and PSA levels in BPH rats. Additionally, finasteride inhibited angiogenesis markers such as HIF-1α, VEGF, and MMP-2. Moreover, components of oxidative stress, inflammation, and ER stress responses were significantly regulated by finasteride treatment. Conclusions: This study suggests that finasteride prevents BPH-associated symptoms by regulating angiogenesis, reactive oxygen species, ER stress responses, and inflammation, another mechanism to explain the effect of the 5α-reductase against BPH.
Language	English
Publishing date	2023-10-16
Publishing country	Korea (South)
Document type	Journal Article
ZDB-ID	2719786-4
ISSN	2287-4690 ; 2287-4208
ISSN (online)	2287-4690
ISSN	2287-4208
DOI	10.5534/wjmh.230122
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Author Correction: Bax Inhibitor-1 regulates hepatic lipid accumulation via ApoB secretion.

Lee, Hwa Young / Lee, Geum-Hwa / Bhattarai, Kashi Raj / Park, Byung-Hyun / Koo, Seung-Hoi / Kim, Hyung-Ryong / Chae, Han Jung

Scientific reports

2023 Volume 13, Issue 1, Page(s) 22864

Language	English
Publishing date	2023-12-21
Publishing country	England
Document type	Published Erratum
ZDB-ID	2615211-3
ISSN	2045-2322 ; 2045-2322
ISSN (online)	2045-2322
ISSN	2045-2322
DOI	10.1038/s41598-023-49504-4
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Ototoxicity of polystyrene nanoplastics in mice, HEI-OC1 cells and zebrafish.

Wu, Yuancheng / Li, Lianzhen / Tang, Lihuan / Peijnenburg, Willie / Zhang, Huangruici / Xie, Daoli / Geng, Ruishuang / Zheng, Tihua / Bi, Liyan / Wei, Xiaodan / Chae, Han-Jung / Wang, Lan / Zhao, Li / Li, Bo / Zheng, Qingyin

Frontiers in molecular neuroscience

2024 Volume 17, Page(s) 1345536

Abstract: Polystyrene nanoplastics are a novel class of pollutants. They are easily absorbed by living organisms, and their potential toxicity has raised concerns. However, the impact of polystyrene nanoplastics on auditory organs remains unknown. Here, our ... ...

Abstract	Polystyrene nanoplastics are a novel class of pollutants. They are easily absorbed by living organisms, and their potential toxicity has raised concerns. However, the impact of polystyrene nanoplastics on auditory organs remains unknown. Here, our results showed that polystyrene nanoplastics entered the cochlea of mice, HEI-OC1 cells, and lateral line hair cells of zebrafish, causing cellular injury and increasing apoptosis. Additionally, we found that exposure to polystyrene nanoplastics resulted in a significant elevation in the auditory brainstem response thresholds, a loss of auditory sensory hair cells, stereocilia degeneration and a decrease in expression of Claudin-5 and Occludin proteins at the blood-lymphatic barrier in mice. We also observed a significant decrease in the acoustic alarm response of zebrafish after exposure to polystyrene nanoplastics. Mechanistic analysis revealed that polystyrene nanoplastics induced up-regulation of the Nrf2/HO-1 pathway, increased levels of malondialdehyde, and decreased superoxide dismutase and catalase levels in cochlea and HEI-OC1 cells. Furthermore, we observed that the expression of ferroptosis-related indicators GPX4 and SLC7A11 decreased as well as increased expression of ACLS4 in cochlea and HEI-OC1 cells. This study also revealed that polystyrene nanoplastics exposure led to increased expression of the inflammatory factors TNF-α, IL-1β and COX2 in cochlea and HEI-OC1 cells. Further research found that the cell apoptosis, ferroptosis and inflammatory reactions induced by polystyrene nanoplastics in HEI-OC1 cells was reversed through the pretreatment with N-acetylcysteine, a reactive oxygen species inhibitor. Overall, our study first discovered and systematically revealed the ototoxicity of polystyrene nanoplastics and its underlying mechanism.
Language	English
Publishing date	2024-02-19
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2452967-9
ISSN	1662-5099
ISSN	1662-5099
DOI	10.3389/fnmol.2024.1345536
Database	MEDical Literature Analysis and Retrieval System OnLINE

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