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Article ; Online: A Case of Sporadic Multiple Colonic Polyps in a Young Woman.

Sin, Seung Ho / Yoon, Jung Hwan / Kim, Sang Woo / Park, Won Sang / Chae, Hiun Suk

2023 Volume 30, Issue 2, Page(s) 1293–1299

Abstract: Sporadic colorectal cancer arises from an adenoma. As mutations in the adenomatous polyposis coli (APC) tumor suppressor gene have been frequently detected in colorectal adenomas, the APC gene is considered a gatekeeper in colorectal carcinogenesis. Here, ...

Abstract	Sporadic colorectal cancer arises from an adenoma. As mutations in the adenomatous polyposis coli (APC) tumor suppressor gene have been frequently detected in colorectal adenomas, the APC gene is considered a gatekeeper in colorectal carcinogenesis. Here, we report a case of sporadic multiple colonic adenomas that were accompanied by an APC-truncating mutation. A 25-year-old Korean woman presented with dozens of incidentally found colonic polyps. There was no family history of colorectal polyposis or colon cancer in her first or second-degree relatives. All the polyps were removed endoscopically at once, and their pathological examination revealed tubular adenoma. Mutational analysis showed a 2-bp deletion mutation at codon 443, which generates a premature stop codon at codon 461 of the APC gene, and Western blot analysis demonstrated both wild-type and truncated APC proteins in adenoma tissue. This study suggests that a single truncating mutation of the APC gene may initiate adenoma formation.
MeSH term(s)	Female ; Humans ; Adult ; Colonic Polyps/genetics ; Adenomatous Polyposis Coli/genetics ; Adenomatous Polyposis Coli/pathology ; Colorectal Neoplasms/pathology ; Adenoma/genetics ; Colonic Neoplasms/genetics ; Codon
Chemical Substances	Codon
Language	English
Publishing date	2023-01-17
Publishing country	Switzerland
Document type	Case Reports ; Research Support, Non-U.S. Gov't
ZDB-ID	1236972-x
ISSN	1718-7729 ; 1198-0052
ISSN (online)	1718-7729
ISSN	1198-0052
DOI	10.3390/curroncol30020100
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Article ; Online: The Effect of Intervention for Improving Colonoscopy Quality Is Associated with the Personality Traits of Endoscopists.

Choi, Hyun Ho / Sung, Soo-Yoon / Lee, Bo-In / Cho, Hyun / Jung, Yunho / Park, Jae Myung / Cho, Young-Seok / Lee, Kang-Moon / Kim, Sang Woo / Choi, Hwang / Chae, Hiun-Suk / Choi, Myung-Gyu

Gut and liver

2023 Volume 18, Issue 2, Page(s) 265–274

Abstract: Background/aims: This study investigated whether the personality traits of endoscopists are associated with the effect of interventions for the improvement of colonoscopy quality.: Methods: This prospective, multicenter, single-blind study was ... ...

Abstract	Background/aims: This study investigated whether the personality traits of endoscopists are associated with the effect of interventions for the improvement of colonoscopy quality. Methods: This prospective, multicenter, single-blind study was performed with 13 endoscopists in three health screening centers over a 12-month period. Quality indicators (QIs), including adenoma detection rate (ADR), polyp detection rate (PDR), and withdrawal time, were measured every 3 months. Consecutive interventions for the improvement of colonoscopy quality were conducted every 3 months, which included the personal notification of QIs, the in-group notification of QIs, and finally a targeted "quality education" session. The personality traits of each endoscopist were evaluated for perfectionism, fear of negative evaluation, and cognitive flexibility after the last QI assessment. Results: A total of 4,095 colonoscopies were evaluated to measure the QIs of the individual endoscopists for 12 months. The mean ADR, PDR, and withdrawal time of the 13 endoscopists were 32.3%, 47.7%, and 394 seconds at baseline and increased to 39.0%, 55.1%, and 430 seconds by the end of the study (p=0.003, p=0.006, and p=0.004, respectively). Among the three interventions, only quality education significantly improved QIs: ADR, 36.0% to 39.0% (odds ratio, 1.28; 95% confidence interval, 1.01 to 1.63). The improvement of ADR and PDR by education was significantly associated with perfectionism (r=0.617, p=0.033 and r=0.635, p=0.027, respectively) and fear of negative evaluation (r=0.704, p=0.011 and r=0.761, p=0.004, respectively). Conclusions: Education can improve colonoscopy quality, and its effect size is associated with an endoscopist's personal traits such as perfectionism and fear of negative evaluation (Clinical-Trials.gov Registry NCT03796169).
MeSH term(s)	Humans ; Colonic Polyps/diagnosis ; Prospective Studies ; Single-Blind Method ; Colonoscopy ; Adenoma/diagnosis ; Personality ; Colorectal Neoplasms/diagnosis ; Early Detection of Cancer
Language	English
Publishing date	2023-05-09
Publishing country	Korea (South)
Document type	Multicenter Study ; Journal Article
ZDB-ID	2399010-7
ISSN	2005-1212 ; 1976-2283
ISSN (online)	2005-1212
ISSN	1976-2283
DOI	10.5009/gnl220280
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Article ; Online: Nationwide analysis of the relationships between mental health, body mass index and tinnitus in premenopausal female adults in Korea: 2010-2012 KNHANES.

Lee, Dong-Hee / Kim, Young Soo / Chae, Hiun Suk / Han, Kyungdo

Scientific reports

2018 Volume 8, Issue 1, Page(s) 7028

Abstract: Tinnitus is related to serious comorbidities such as suicidal ideation and attempts. Body mass index (BMI) is associated with auditory symptoms including hearing loss. The aim of this nationwide, population-based, cross-sectional study was to evaluate ... ...

Abstract	Tinnitus is related to serious comorbidities such as suicidal ideation and attempts. Body mass index (BMI) is associated with auditory symptoms including hearing loss. The aim of this nationwide, population-based, cross-sectional study was to evaluate the relationship between mental health, body mass index and tinnitus in a Korean premenopausal female population. This study analyzed data from the Korea National Health and Nutrition Examination Surveys in 2010-2012. Data were collected from 4628 19 years or older, premenopausal women. After adjustments, underweight premenopausal women exhibited a higher odds ratio for tinnitus (odd ratio = 1.54; 95% confidence interval = 1.14-2.08) compared with women of normal weight. Moderate and severe tinnitus was highly prevalent in underweight as well as extremely obese women. The prevalence of perceived stress, melancholy, and suicide ideation was significantly higher in women with tinnitus. The prevalence of perceived stress and suicide ideation was significantly higher in underweight women with tinnitus, but that of melancholy was significantly lower. This study demonstrated that underweight premenopausal Korean women had a higher risk of tinnitus, which has grown in importance as a public health issue. Women with tinnitus experience perceived stress and suicide ideation more frequently, but melancholy less frequently than women without.
MeSH term(s)	Body Mass Index ; Cross-Sectional Studies ; Female ; History, 21st Century ; Humans ; Life Style ; Menopause ; Mental Health/statistics & numerical data ; Nutrition Surveys ; Odds Ratio ; Prevalence ; Public Health Surveillance ; Republic of Korea/epidemiology ; Risk Factors ; Tinnitus/epidemiology ; Tinnitus/history
Language	English
Publishing date	2018-05-04
Publishing country	England
Document type	Historical Article ; Journal Article
ZDB-ID	2615211-3
ISSN	2045-2322 ; 2045-2322
ISSN (online)	2045-2322
ISSN	2045-2322
DOI	10.1038/s41598-018-25576-5
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Article: Changing Disease Trends in the Northern Gyeonggi-do Province of South Korea from 2002 to 2013: A Big Data Study Using National Health Information Database Cohort.

Kim, Young Soo / Lee, Dong-Hee / Chae, Hiun Suk / Han, Kyungdo

Osong public health and research perspectives

2018 Volume 9, Issue 5, Page(s) 248–254

Abstract: Objectives: To investigate the chronological patterns of diseases in Northern Gyeonggi-do province, South Korea, and compare these with national data.: Methods: A National Health Insurance cohort based on the National Health Information Database ( ... ...

Abstract	Objectives: To investigate the chronological patterns of diseases in Northern Gyeonggi-do province, South Korea, and compare these with national data. Methods: A National Health Insurance cohort based on the National Health Information Database (NHID Cohort 2002-2013) was used to perform a retrospective, population-based study (46,605,433 of the target population, of which 1,025,340 were randomly sampled) to identify disease patterns from 2002 to 2013. Common diseases including malaria, cancer (uterine cervix, urinary bladder, colon), diabetes mellitus, psychiatric disorders, hypertension, intracranial hemorrhage, bronchitis/bronchiolitis, peptic ulcer, and end stage renal disease were evaluated. Results: Uterine cervix cancer, urinary bladder cancer and colon cancer had the greatest rate of increase in Northern Gyeonggi-do province compared with the rest of the country, but by 2013 the incidence of these cancers had dropped dramatically. Acute myocardial infarction and end stage renal disease also increased over the study period. Psychiatric disorders, diabetes mellitus, hypertension and peptic ulcers showed a gradual increase over time. No obvious differences were found for intracranial hemorrhage or bronchitis/bronchiolitis between the Northern Gyeonggi-do province and the remaining South Korean provinces. Malaria showed a unique time trend, only observed in the Northern Gyeonggi province, peaking in 2004, 2007 and 2009 to 2010. Conclusion: This study showed that the Northern Gyeonggi-do province population had a different disease profile over time, compared with collated data for the remaining provinces in South Korea. "Big data" studies using the National Health Insurance cohort database can provide insight into the healthcare environment for healthcare providers, stakeholders and policymakers.
Language	English
Publishing date	2018-11-01
Publishing country	Korea (South)
Document type	Journal Article
ZDB-ID	2656431-2
ISSN	2233-6052 ; 2210-9099
ISSN (online)	2233-6052
ISSN	2210-9099
DOI	10.24171/j.phrp.2018.9.5.06
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Article ; Online: A novel technique using endoscopic band ligation for removal of long-stalked (>10 mm) pedunculated colon polyps: A prospective pilot study.

Choi, Hyun Ho / Kim, Chang Whan / Kim, Hyung-Keun / Kim, Sang Woo / Han, Sok Won / Seo, Kyung Jin / Chae, Hiun-Suk

Saudi journal of gastroenterology : official journal of the Saudi Gastroenterology Association

2021 Volume 27, Issue 5, Page(s) 296–301

Abstract: Background: Endoscopic removal of large and thick-stalked pedunculated colonic polyps, often leads to massive hemorrhage. Several techniques to minimize this complication have not been widely adopted due to some caveats. In order to prevent ... ...

Abstract	Background: Endoscopic removal of large and thick-stalked pedunculated colonic polyps, often leads to massive hemorrhage. Several techniques to minimize this complication have not been widely adopted due to some caveats. In order to prevent postpolypectomy bleeding, we invented a novel technique to dissect long-stalked pedunculated colonic polyps using endoscopic band ligation (EBL) by laterally approaching the stalk. Methods: In this prospective single-center study, 17 pedunculated polyps in 15 patients were removed between April 2012 and January 2016. We targeted pedunculated polyps with a long stalk length (>10 mm) and a large head (>10 mm) located in the distal colon. After identifying lesions with a colonoscope, we reapproached the middle part of the stalk of the targeted polyp with an EBL-equipped gastroscope to ligate it. Snare polypectomy was performed just above the ligation site of the stalk. Results: EBL-assisted polypectomy removed all of the lesions successfully, which were confirmed pathologically. There was little technical difficulty associated with the endoscopic procedures, regardless of polyp size and stalk thickness, except for one case with a very large polyp that impeded the visualization of the ligation site. We observed a positive correlation between procedure time and the diameter of the head (spearman ρ = 0.52, P = 0.034). After dissection of the polyp, the EBL bands remained fastened to the dissected stalks in all cases. There was no complication associated with polypectomy for 1 month. Conclusion: EBL-assisted polypectomy is an easy, safe, and effective technique to remove long-stalked pedunculated colonic polyps without postpolypectomy bleeding.
MeSH term(s)	Colon ; Colonic Polyps/diagnostic imaging ; Colonic Polyps/surgery ; Colonoscopy ; Humans ; Pilot Projects ; Prospective Studies
Language	English
Publishing date	2021-02-19
Publishing country	India
Document type	Journal Article
ZDB-ID	2299174-8
ISSN	1998-4049 ; 1319-3767
ISSN (online)	1998-4049
ISSN	1319-3767
DOI	10.4103/sjg.sjg_625_20
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Zs.A 6710: Show issues

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Article: Simultaneous Integrated Boost Volumetric Modulated Arc Therapy for Rectal Cancer: Long-Term Results after Protocol-Based Treatment.

Lee, Dong Soo / Oh, Seong-Taek / Ahn, Chang-Hyeok / Lee, Jaeim / Lee, Kil-Yong / Chae, Hiun Suk / Kim, Sung Soo / Kim, Sang Woo / Seo, Kyung Jin

Journal of oncology

2022 Volume 2022, Page(s) 6986267

Abstract: Background: Volumetric modulated arc therapy (VMAT) with simultaneous integrated boost (SIB) is an advanced form of radiotherapy (RT) technology. The purpose of this study was to report long-term treatment outcomes in patients with locally advanced ... ...

Abstract	Background: Volumetric modulated arc therapy (VMAT) with simultaneous integrated boost (SIB) is an advanced form of radiotherapy (RT) technology. The purpose of this study was to report long-term treatment outcomes in patients with locally advanced rectal cancer undergoing VMAT-SIB based concurrent chemoradiotherapy (CRT). Methods: Between January 2016 and January 2018, a total of 22 patients with operable stage II-III rectal adenocarcinoma were recruited for the pre-designed VMAT-SIB RT protocol. All patients underwent standard diagnostic and staging work-up. The RT target volumes included the following areas: PTV1 = mesorectum that contained gross tumors and enlarged lymph node regions and PTV2 = mesorectum and regional lymphatics from L4-5/S1 to 3-4 cm below the tumor or levator ani muscle, excluding PTV1. The VMAT-SIB dose prescription was as follows: PTV1 = 52.5 Gy/daily 2.1 Gy/25 fractions, PTV2 = 45 Gy/daily 1.8 Gy/25 fractions. Results: The mean age of the study population was 64 (range, 18-84) years, and 15 (68.2%) patients were male. Radical operation (total mesorectal excision) was performed by either low anterior resection, ultralow anterior resection, or abdominal perineal resection. All five (22.7%) of the patients with confirmed increasing serum carcinoembryonic antigen (CEA) level at diagnosis showed normalization of serum CEA level after the planned treatment. Among 20 patients who underwent preoperative CRT and surgery, tumor down staging in T- and N-stages was achieved in 10 patients (50%) and 13 patients (65%), respectively, with 20% of ypT0/Tis. With a median follow-up of 54.2 (range, 22.6-61.1) months, the 5-year disease-free survival, overall survival, and local control rates were 64.6%, 81.8%, and 84.4%, respectively. Five patients developed distant metastasis and one developed local recurrence as a first event. Two cases with anastomosis site leakage, three with adhesive ileus, and two with abscess formation were observed during postoperative periods. Conclusions: The current VMAT-SIB-based CRT protocol provided acceptable treatment and toxicity outcomes.
Language	English
Publishing date	2022-04-07
Publishing country	Egypt
Document type	Journal Article
ZDB-ID	2461349-6
ISSN	1687-8469 ; 1687-8450
ISSN (online)	1687-8469
ISSN	1687-8450
DOI	10.1155/2022/6986267
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Article ; Online: In vitro

Oh, Hui Yeong / Choi, Hyun Ho / Kim, Eui Jin / Choi, Ji Hye / Choi, Sung Sook / Lee, Hae Kyung / Kim, Hyung-Keun / Kim, Sang Woo / Park, Won Sang H / Chae, Hiun Suk

Saudi journal of gastroenterology : official journal of the Saudi Gastroenterology Association

2022 Volume 29, Issue 1, Page(s) 53–58

Abstract: Background: Methylene blue (MB) is used endoscopically to demarcate tumors and as a photosensitizer in photodynamic therapy (PDT). However, there are few in vivo studies about its toxicity in healthy stomach tissue. We performed sequential in vitro and ... ...

Abstract	Background: Methylene blue (MB) is used endoscopically to demarcate tumors and as a photosensitizer in photodynamic therapy (PDT). However, there are few in vivo studies about its toxicity in healthy stomach tissue. We performed sequential in vitro and in vivo analyses of MB-induced phototoxicity. Methods: We performed in vitro experiments using the AGS human gastric cancer cell line treated with light-emitting diode (LED) irradiation (3.6 J/cm Results: In vitro, increased concentrations of MB led to higher TUNEL scores. However, cell viability was significantly lower after MB plus LED irradiation than after treatment with MB alone (P < 0.001). In vivo, the TUNEL score was highest immediately after treatment with 0.1% or 0.5% MB plus light irradiation, and the score was significantly higher in the LED illumination plus MB group than in the control group (P < 0.05). The elevated TUNEL score was maintained for 3 days in the MB plus light irradiation group but returned to normal levels on day 10. Conclusions: : Endoscopic light application with MB 0.5% concentration to the stomach may be regarded as a safe procedure despite some DNA injuries in the early period.
MeSH term(s)	Dogs ; Animals ; Humans ; Methylene Blue/pharmacology ; Methylene Blue/therapeutic use ; Photochemotherapy/methods ; Photosensitizing Agents/toxicity ; Photosensitizing Agents/therapeutic use ; Cell Line ; Gastric Mucosa
Chemical Substances	Methylene Blue (T42P99266K) ; Photosensitizing Agents
Language	English
Publishing date	2022-12-26
Publishing country	India
Document type	Journal Article
ZDB-ID	2299174-8
ISSN	1998-4049 ; 1319-3767
ISSN (online)	1998-4049
ISSN	1319-3767
DOI	10.4103/sjg.sjg_315_22
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Article ; Online: Colonoscopy decreases mortality in colorectal cancer patients compared with fecal immunochemical test.

Sung, Soo-Yoon / Choi, Hyun Ho / Kim, Sukil / Park, Bo Ram / Kim, Young Ki / Kim, Hyung-Keun / Cho, Young-Seok / Kim, Sang Woo / Kim, Sung Soo / Chae, Hiun-Suk

Journal of gastroenterology and hepatology

2022 Volume 37, Issue 10, Page(s) 1991–1997

Abstract: Background and aim: Colonoscopy and fecal immunochemical test (FIT) are commonly used screening methods for the detection of colorectal cancer (CRC), but their effects on survival have not been compared. We compared survival outcomes in patients with ... ...

Abstract	Background and aim: Colonoscopy and fecal immunochemical test (FIT) are commonly used screening methods for the detection of colorectal cancer (CRC), but their effects on survival have not been compared. We compared survival outcomes in patients with CRC according to the exposure history to colonoscopy or FIT before diagnosis of CRC. Methods: We performed a nationwide population-based retrospective cohort study using Korean national-insurance claims data. In total, 24 875 patients with CRC diagnosed in 2012 were included. The patients were divided into three groups in terms of examinations performed during the 10 years prior to CRC diagnosis: the colonoscopy group, the FIT group, and the never-screened group. Survival outcomes were compared among the three groups. The colonoscopy group and FIT group were matched using propensity score-matching method. Results: The cohort consisted of 9619 patients in the colonoscopy group, 6936 patients in the FIT group, and 8320 patients in the never-screened group. The 5-year overall survival rates were 74.1% in the colonoscopy group, 65.9% in the FIT group, and 59.6% in the never-screened group (P < 0.001). The adjusted hazard ratios for death were 0.56 (95% confidence interval [CI], 0.53-0.59) in the colonoscopy group and 0.78 (95% CI, 0.74-0.82) in the FIT group compared with the never-screened group. In the matched cohort, the adjusted hazard ratios for death was 0.76 (95% CI, 0.72-0.81) in the colonoscopy group compared with the FIT group. Conclusion: Colonoscopy is a more effective method for reducing mortality in patients with CRC compared with FIT.
MeSH term(s)	Colonoscopy ; Colorectal Neoplasms/diagnosis ; Early Detection of Cancer/methods ; Feces ; Humans ; Mass Screening/methods ; Occult Blood ; Retrospective Studies
Language	English
Publishing date	2022-07-03
Publishing country	Australia
Document type	Journal Article
ZDB-ID	632882-9
ISSN	1440-1746 ; 0815-9319
ISSN (online)	1440-1746
ISSN	0815-9319
DOI	10.1111/jgh.15924
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Article: In Vitro

Choi, Sung Sook / Oh, Hui Yeong / Kim, Eui Jin / Lee, Hae Kyung / Kim, Hyung Keun / Choi, Hyun Ho / Kim, Sang Woo / Chae, Hiun Suk

Pathogens (Basel, Switzerland)

2020 Volume 9, Issue 4

Abstract: Surface disinfection in health-care facilities is critical to prevent dissemination ... ...

Abstract	Surface disinfection in health-care facilities is critical to prevent dissemination of
Language	English
Publishing date	2020-04-11
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2695572-6
ISSN	2076-0817
ISSN	2076-0817
DOI	10.3390/pathogens9040279
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Article: <i>In Vitro</i> Bactericidal Effects of Photodynamic Therapy Combined with Four Tetracyclines against <i>Clostridioides difficile</i> KCTC5009 in Planktonic Cultures

Choi, Sung Sook / Oh, Hui Yeong / Kim, Eui Jin / Lee, Hae Kyung / Kim, Hyung Keun / Choi, Hyun Ho / Kim, Sang Woo / Chae, Hiun Suk

Pathogens. 2020 Apr. 11, v. 9, no. 4

2020

Abstract: Surface disinfection in health-care facilities is critical to prevent dissemination of ... Clostridioides difficile ... ( ... C. difficile ... ). Tetracyclines (TCs) are broad-spectrum antibiotics that are associated with a low risk of development of ... C. ... ...

Abstract	Surface disinfection in health-care facilities is critical to prevent dissemination of Clostridioides difficile (C. difficile). Tetracyclines (TCs) are broad-spectrum antibiotics that are associated with a low risk of development of C. difficile infection (CDI) and are used as photosensitizers (PS) in photodynamic therapy (PDT). We evaluated whether TCs may be useful environmental cleansing agents. We compared the in vitro ability to kill C. difficile of four TCs (TC, doxycycline, minocycline, and tigecycline) combined with PDT using ultraviolet A (UVA). We included chitosan, a cationic material, as a booster to increase the photodynamic bactericidal efficacy of TCs. PDT-induced bactericidal effects were assessed by the number of viable cells and the degree of DNA damage and membrane integrity. To avoid the intrinsic antibacterial activity of TCs at high concentrations, we used low concentrations of TCs (0.05 and 0.1 mg/mL). The bactericidal effect of treatment with chitosan plus PDT was over 100 times higher than that with PDT alone for each of the four TCs. DNA damage measured by ethidium bromide monoazide and real-time quantitative polymerase chain reaction was also greater for PDT plus chitosan treatment than for PDT alone or under control conditions: the threshold cycle (Ct) values for the control, PDT, and PDT plus chitosan were 14.67 ± 0.22, 20.46 ± 0.12, and 25.54 ± 0.17, respectively. All four TCs caused similar levels of severe cell membrane damage during PDT compared with control conditions. These data suggest that PDT combined with any of the four TCs plus chitosan might be an available tool to kill efficiently planktonic form of C. difficile.
Keywords	Clostridium difficile ; DNA damage ; antibacterial properties ; cell membranes ; cell viability ; chitosan ; disinfection ; doxycycline ; ethidium ; health services ; infection ; minocycline ; pathogens ; photochemotherapy ; photosensitizing agents ; plankton ; risk ; tigecycline ; ultraviolet radiation
Language	English
Dates of publication	2020-0411
Publishing place	Multidisciplinary Digital Publishing Institute
Document type	Article
Note	NAL-light
ZDB-ID	2695572-6
ISSN	2076-0817
ISSN	2076-0817
DOI	10.3390/pathogens9040279
Database	NAL-Catalogue (AGRICOLA)

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