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  1. Article ; Online: Asian Sand Dust Particles Enhance the Development of

    Shin, Seung-Heon / Ye, Mi-Kyung / Lee, Dong-Won / Chae, Mi-Hyun

    International journal of molecular sciences

    2022  Volume 23, Issue 6

    Abstract: Background: Asian sand dust (ASD) and : Methods: Primary nasal epithelial cells were cultured with : Results: ASD and : Conclusions: ASD ... ...

    Abstract Background: Asian sand dust (ASD) and
    Methods: Primary nasal epithelial cells were cultured with
    Results: ASD and
    Conclusions: ASD and
    MeSH term(s) Aspergillus fumigatus/metabolism ; Biofilms ; Concanavalin A/pharmacology ; Dust ; Epithelial Cells/metabolism ; Gentian Violet/metabolism ; Gentian Violet/pharmacology ; Inflammation Mediators/metabolism ; Interleukin-6/metabolism ; Interleukin-8/metabolism ; Nasal Mucosa/metabolism ; Sand
    Chemical Substances Dust ; Inflammation Mediators ; Interleukin-6 ; Interleukin-8 ; Sand ; Concanavalin A (11028-71-0) ; Gentian Violet (J4Z741D6O5)
    Language English
    Publishing date 2022-03-11
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms23063030
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Chamaecyparis obtusa Essential Oil Inhibits House Dust Mite Induced Nasal Epithelial Cell Activation and Immune Responses.

    Shin, Seung-Heon / Ye, Mi-Kyung / Chae, Mi-Hyun / Lee, Dong-Won

    Journal of oleo science

    2021  Volume 70, Issue 3, Page(s) 431–438

    Abstract: Essential oils extracted from plants contain protective volatile compounds and are known to processes antibacterial, antifungal, anti-oxidative, and anti-inflammatory effects. This study was conducted to explore the immunomodulatory effects of essential ... ...

    Abstract Essential oils extracted from plants contain protective volatile compounds and are known to processes antibacterial, antifungal, anti-oxidative, and anti-inflammatory effects. This study was conducted to explore the immunomodulatory effects of essential oil extracted from Chamaecyparis obtusa (EOCO) on house dust mite-induced mucosal inflammation. Cultured primary nasal epithelial cells were stimulated with Dermatophagoides pteronyssinus (DP), and Dermatophagoides farina (DF) for 48 h. The production of interleukin (IL)-25, IL-33, and thymic stromal lymphopoietin (TSLP) was measured by enzyme-linked immunosorbent assay, and the expression levels of nuclear factor (NF)-κB, activator protein (AP)-1, and mitogen-activated protein kinase (MAPK) were determined by western blot analysis. To examine the effect of EOCO on the production of chemical mediators and the expression of transcription factors, epithelial cells were pretreated with EOCO for 1 h before stimulation. Peripheral blood mononuclear cells (PBMCs) were cultured in nasal epithelial cell conditioned media (NECM) for 72 h, after which the levels of IL-5, interferon (IFN)-γ, and tumor necrosis factor (TNF)-α were measured. DP and DF enhanced the production of IL-25, IL-33, and TSLP, and EOCO pretreatment inhibited their production from nasal epithelial cells. EOCO pretreatment also significantly suppressed the expression of NF-κB and AP-1. NECM induced the production of IL-5, IFN- γ, and TNF-α from PBMCs, and only TNF-α production was significantly inhibited by EOCO pretreatment. EOCO pretreatment inhibited the DP and DF induced nasal epithelial cell derived cytokine production and TNF-α production from PBMCs. These results indicate the potential value of EOCO in the treatment of airway inflammatory or immunological diseases.
    MeSH term(s) Adult ; Animals ; Cells, Cultured ; Chamaecyparis/chemistry ; Cytokines/metabolism ; Depression, Chemical ; Epithelial Cells/drug effects ; Epithelial Cells/immunology ; Epithelial Cells/metabolism ; Female ; Humans ; Immunity/drug effects ; Immunologic Factors ; Male ; Middle Aged ; Nasal Mucosa/cytology ; Oils, Volatile/chemistry ; Oils, Volatile/isolation & purification ; Oils, Volatile/pharmacology ; Pyroglyphidae/immunology ; Tumor Necrosis Factor-alpha/metabolism
    Chemical Substances Cytokines ; Immunologic Factors ; Oils, Volatile ; Tumor Necrosis Factor-alpha
    Language English
    Publishing date 2021-03-04
    Publishing country Japan
    Document type Journal Article
    ZDB-ID 2218264-0
    ISSN 1347-3352 ; 1345-8957
    ISSN (online) 1347-3352
    ISSN 1345-8957
    DOI 10.5650/jos.ess20240
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Korean Red Ginseng and Ginsenoside Rg3 Suppress Asian Sand Dust-Induced Epithelial-Mesenchymal Transition in Nasal Epithelial Cells.

    Shin, Seung-Heon / Ye, Mi-Kyung / Lee, Dong-Won / Chae, Mi-Hyun / Hwang, You-Jin

    Molecules (Basel, Switzerland)

    2022  Volume 27, Issue 9

    Abstract: Chronic rhinosinusitis (CRS) is characterized by chronic inflammation of the sinonasal mucosa with epithelial dedifferentiation toward the mesenchymal phenotype, known as the epithelial-mesenchymal transition (EMT). Asian sand dust (ASD) can induce nasal ...

    Abstract Chronic rhinosinusitis (CRS) is characterized by chronic inflammation of the sinonasal mucosa with epithelial dedifferentiation toward the mesenchymal phenotype, known as the epithelial-mesenchymal transition (EMT). Asian sand dust (ASD) can induce nasal mucosal inflammation and cause the development of EMT. Korean red ginseng (KRG) and ginsenoside Rg3 have been used as traditional herbal medicines to treat various diseases. The aim of this study was to investigate their effect on ASD-induced EMT in nasal epithelial cells. Primary nasal epithelial cells were incubated with ASD with or without KRG or Rg3, and the production of transforming growth factor-β1 (TGF-β1) and interleukin (IL)-8 was measured. EMT markers were determined by RT-PCR, Western blot analysis, and confocal microscopy, and transcription factor expression by Western blot analysis. The effect on cell migration was evaluated using the wound scratch assay. Results showed ASD-induced TGF-β1 production, downregulation of E-cadherin, and upregulation of fibronectin in nasal epithelial cells. KRG and Rg3 suppressed TGF-β1 production (31.7% to 43.1%), upregulated the expression of E-cadherin (26.4% to 88.3% in mRNA), and downregulated that of fibronectin (14.2% to 46.2% in mRNA and 52.3% to 70.2% in protein). In addition, they suppressed the ASD-induced phosphorylation of ERK, p38, and mTOR, as well as inhibiting the ASD-induced migration of nasal epithelial cells (25.2% to 41.5%). The results of this study demonstrate that KRG and Rg3 inhibit ASD-induced EMT by suppressing the activation of ERK, p38, and mTOR signaling pathways in nasal epithelial cells.
    MeSH term(s) Cadherins/metabolism ; Cell Movement ; Dust ; Epithelial Cells ; Epithelial-Mesenchymal Transition ; Fibronectins/metabolism ; Ginsenosides ; Humans ; Inflammation/metabolism ; Panax/metabolism ; RNA, Messenger/metabolism ; Sand ; TOR Serine-Threonine Kinases/metabolism ; Transforming Growth Factor beta1/metabolism
    Chemical Substances Cadherins ; Dust ; Fibronectins ; Ginsenosides ; RNA, Messenger ; Sand ; Transforming Growth Factor beta1 ; ginsenoside Rg3 (227D367Y57) ; TOR Serine-Threonine Kinases (EC 2.7.11.1)
    Language English
    Publishing date 2022-04-20
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 1413402-0
    ISSN 1420-3049 ; 1431-5165 ; 1420-3049
    ISSN (online) 1420-3049
    ISSN 1431-5165 ; 1420-3049
    DOI 10.3390/molecules27092642
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Effect of Korean Red Ginseng and Rg3 on Asian Sand Dust-Induced MUC5AC, MUC5B, and MUC8 Expression in Bronchial Epithelial Cells.

    Shin, Seung-Heon / Ye, Mi-Kyung / Lee, Dong-Won / Kang, Byung-Jun / Chae, Mi-Hyun

    Molecules (Basel, Switzerland)

    2021  Volume 26, Issue 7

    Abstract: Korean Red ginseng (KRG), commonly used in traditional medicine, has anti-inflammatory, anti- oxidative, and anti-tumorigenic properties. Asian sand dust (ASD) is known to aggravate upper and lower airway inflammatory responses. BEAS-2B cells were ... ...

    Abstract Korean Red ginseng (KRG), commonly used in traditional medicine, has anti-inflammatory, anti- oxidative, and anti-tumorigenic properties. Asian sand dust (ASD) is known to aggravate upper and lower airway inflammatory responses. BEAS-2B cells were exposed to ASD with or without KRG or ginsenoside Rg3. Mucin 5AC (MUC5AC), MUC5B, and MUC8 mRNA and protein expression levels were determined using quantitative RT-PCR and enzyme-linked immunosorbent assay. Nuclear factor kappa B (NF-κB), activator protein 1, and mitogen-activated protein kinase expression and activity were determined using western blot analysis. ASD induced MUC5AC, MUC5B, and MUC8 mRNA and protein expression in BEAS-2B cells, which was significantly inhibited by KRG and Rg3. Although ASD-induced mucin expression was associated with NF-κB and p38 mitogen-activated protein kinase (MAPK) activity, KRG and Rg3 significantly suppressed only ASD-induced NF-κB expression and activity. KRG and Rg3 inhibited ASD-induced mucin gene expression and protein production from bronchial epithelial cells. These results suggest that KRG and Rg3 have potential for treating mucus-producing airway inflammatory diseases.
    MeSH term(s) Cell Line ; Cell Survival/drug effects ; Cells, Cultured ; Dust ; Epithelial Cells/drug effects ; Epithelial Cells/metabolism ; Gene Expression Regulation ; Ginsenosides/chemistry ; Ginsenosides/pharmacology ; Humans ; Molecular Structure ; Mucin 5AC/biosynthesis ; Mucin 5AC/genetics ; Mucin-5B/biosynthesis ; Mucin-5B/genetics ; Mucins/biosynthesis ; Mucins/genetics ; Panax/chemistry ; Respiratory Mucosa/drug effects ; Respiratory Mucosa/metabolism ; Sand
    Chemical Substances Dust ; Ginsenosides ; MUC8 protein, human ; Mucin 5AC ; Mucin-5B ; Mucins ; Sand ; ginsenoside Rg3 (227D367Y57)
    Language English
    Publishing date 2021-04-01
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 1413402-0
    ISSN 1420-3049 ; 1431-5165 ; 1420-3049
    ISSN (online) 1420-3049
    ISSN 1431-5165 ; 1420-3049
    DOI 10.3390/molecules26072002
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Development and immunopathological characteristics of an Alternaria-induced chronic rhinosinusitis mouse model.

    Shin, Seung-Heon / Ye, Mi-Kyung / Lee, Dong-Won / Chae, Mi-Hyun / Choi, Sung-Yong

    PloS one

    2020  Volume 15, Issue 6, Page(s) e0234731

    Abstract: Airborne fungi are associated with upper and lower airway inflammatory diseases. Alternaria is commonly found in nasal secretions and induces the production of chemical mediators from sinonasal mucosa. This study aimed to establish an Alternaria-induced ... ...

    Abstract Airborne fungi are associated with upper and lower airway inflammatory diseases. Alternaria is commonly found in nasal secretions and induces the production of chemical mediators from sinonasal mucosa. This study aimed to establish an Alternaria-induced chronic rhinosinusitis (CRS) mouse model and determine the influence of host allergic background on the immunopathological characteristics of CRS. BALB/c mice were used for establishing the CRS model. Alternaria was intranasally instilled for 8 or 16 weeks with or without ovalbumin (OVA) presensitization. Total serum IgE and Alternaria-specific IgE levels were measured by enzyme-linked immunosorbent assay (ELISA). Interleukin (IL)-4, IL-10, interferon (IFN)-γ, and tumor necrosis factor (TNF)-α levels in nasal lavage fluid (NLF) and splenocytes were measured by ELISA and their mRNAs and levels of associated transcription factors in sinonasal mucosa were determined with quantitative reverse-transcriptase polymerase chain reaction (RT-PCR). Hematoxylin-eosin staining and periodic acid-Schiff staining were performed to evaluate histological changes. Total serum IgE was increased in both allergic and non-allergic CRS. IL-4 was strongly expressed in NLF in both allergic and non-allergic CRS at 16 weeks and not only eosinophils but also neutrophils were increased in NLF of non-allergic CRS mice. The levels of Th1, Th2, and Treg cytokines and transcription factor mRNAs were significantly increased in sinonasal mucosa of non-allergic CRS mice. Both inflammatory cell infiltration and goblet cell hyperplasia were increased in CRS mice. Repeated intranasal instillation of Alternaria results in sinonasal inflammation with inflammatory cell infiltration. The sinonasal mucosal immune responses against Alternaria were shown to differ depending on the host allergic background.
    MeSH term(s) Alternaria/immunology ; Alternaria/pathogenicity ; Animals ; Chronic Disease ; Disease Models, Animal ; Female ; Immunoglobulin E/blood ; Interleukin-10/analysis ; Interleukin-10/genetics ; Interleukin-10/metabolism ; Interleukin-4/analysis ; Interleukin-4/genetics ; Interleukin-4/metabolism ; Mice ; Mice, Inbred BALB C ; Nasal Lavage Fluid/chemistry ; Nasal Mucosa/metabolism ; Nasal Mucosa/pathology ; RNA, Messenger/metabolism ; Rhinitis/immunology ; Rhinitis/pathology ; Sinusitis/immunology ; Sinusitis/pathology ; Spleen/metabolism ; Spleen/microbiology ; Transcription Factors/genetics ; Transcription Factors/metabolism ; Tumor Necrosis Factor-alpha/analysis ; Tumor Necrosis Factor-alpha/genetics ; Tumor Necrosis Factor-alpha/metabolism
    Chemical Substances RNA, Messenger ; Transcription Factors ; Tumor Necrosis Factor-alpha ; Interleukin-10 (130068-27-8) ; Interleukin-4 (207137-56-2) ; Immunoglobulin E (37341-29-0)
    Language English
    Publishing date 2020-06-16
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ISSN 1932-6203
    ISSN (online) 1932-6203
    DOI 10.1371/journal.pone.0234731
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  6. Article ; Online: Effects of Lidocaine-Derived Organic Compounds on Eosinophil Activation and Survival.

    Shin, Seung-Heon / Ye, Mi-Kyung / Chae, Mi-Hyun / Geum, Sang-Yen / Aboraia, Ahmed S / Abdel-Aal, Abu-Baker M / Qayed, Wesam S / Abd El-Wahab, Hend A A / Abou-Ghadir, Ola F / Aboul-Fadl, Tarek

    Molecules (Basel, Switzerland)

    2023  Volume 28, Issue 15

    Abstract: Lidocaine, a local anesthetic, is known to possess anti-inflammatory properties. However, its clinical use is limited by inconveniences, such as its local synesthetic effects. This study evaluated lidocaine analogs designed and synthesized to overcome ... ...

    Abstract Lidocaine, a local anesthetic, is known to possess anti-inflammatory properties. However, its clinical use is limited by inconveniences, such as its local synesthetic effects. This study evaluated lidocaine analogs designed and synthesized to overcome the disadvantages of lidocaine, having anti-inflammatory properties. Interleukin 5 (IL-5)-induced eosinophil activation and survival were evaluated using 36 lidocaine analogs with modified lidocaine structure on the aromatic or the acyl moiety or both. Eosinophil survival was evaluated using a CellTiter 96
    MeSH term(s) Eosinophils ; Superoxides/metabolism ; Lidocaine/pharmacology ; Interleukin-5/metabolism ; Interleukin-5/pharmacology ; Interleukin-8/metabolism ; Platelet Activating Factor/metabolism ; Anti-Inflammatory Agents/pharmacology ; Anti-Inflammatory Agents/metabolism
    Chemical Substances Superoxides (11062-77-4) ; Lidocaine (98PI200987) ; Interleukin-5 ; Interleukin-8 ; Platelet Activating Factor ; Anti-Inflammatory Agents
    Language English
    Publishing date 2023-07-27
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 1413402-0
    ISSN 1420-3049 ; 1431-5165 ; 1420-3049
    ISSN (online) 1420-3049
    ISSN 1431-5165 ; 1420-3049
    DOI 10.3390/molecules28155696
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  7. Article ; Online: Nasal Epithelial Cells Activated with

    Shin, Seung-Heon / Ye, Mi-Kyung / Lee, Dong-Won / Chae, Mi-Hyun / Han, Ba-Da

    International journal of molecular sciences

    2020  Volume 21, Issue 8

    Abstract: Chronic rhinosinusitis (CRS) is a heterogeneous disease characterized by mucosal inflammation. Airborne allergens are associated with upper and lower airway inflammatory disease. We investigated the effects of airborne allergen stimulation in the nasal ... ...

    Abstract Chronic rhinosinusitis (CRS) is a heterogeneous disease characterized by mucosal inflammation. Airborne allergens are associated with upper and lower airway inflammatory disease. We investigated the effects of airborne allergen stimulation in the nasal epithelial cells and their effect on the peripheral blood mononuclear cells' (PBMCs) Th immune polarization. Interleukin (IL)-10, IL-25, IL-33, and thymic stromal lymphopoietin (TSLP) levels were determined using the enzyme-linked immunosorbent assay (ELISA) in nasal polyp tissues. Cultured primary nasal epithelial cells were stimulated with
    MeSH term(s) Alternaria/immunology ; Animals ; Cytokines/metabolism ; Disease Susceptibility/immunology ; Humans ; Immunity, Innate ; Inflammation Mediators/metabolism ; Leukocytes, Mononuclear/immunology ; Leukocytes, Mononuclear/metabolism ; Nasal Mucosa/immunology ; Nasal Mucosa/metabolism ; Pyroglyphidae/immunology ; Rhinitis/etiology ; Rhinitis/metabolism ; Rhinitis/pathology ; Sinusitis/etiology ; Sinusitis/metabolism ; Sinusitis/pathology ; T-Lymphocyte Subsets/immunology ; T-Lymphocyte Subsets/metabolism ; Th1 Cells/immunology ; Th1 Cells/metabolism ; Th2 Cells/immunology ; Th2 Cells/metabolism
    Chemical Substances Cytokines ; Inflammation Mediators
    Language English
    Publishing date 2020-04-13
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms21082693
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  8. Article ; Online: The biological effects of topical alginate treatment in an animal model of skin wound healing.

    Lee, Woo-Ram / Park, Ji-Hyun / Kim, Kyung-Hyun / Kim, Soo-Jung / Park, Dae-Hwan / Chae, Mi-Hyun / Suh, Soong-Hyuck / Jeong, Seung-Won / Park, Kwan-Kyu

    Wound repair and regeneration : official publication of the Wound Healing Society [and] the European Tissue Repair Society

    2009  Volume 17, Issue 4, Page(s) 505–510

    Abstract: Wound healing is a dynamic and complex process of tissue repair that involves a number of cellular and molecular events. It proceeds from inflammatory response to reepithelialization and finally to formation of a permanent scar. Alginate is a polymer of ... ...

    Abstract Wound healing is a dynamic and complex process of tissue repair that involves a number of cellular and molecular events. It proceeds from inflammatory response to reepithelialization and finally to formation of a permanent scar. Alginate is a polymer of guluronic and mannuronic acid that is used as a scaffolding material in biomedical applications. For the purpose of studying wound healing, full-thickness skin defects were produced on the dorsal area in rats. We measured the relative sizes of the wounds on days 3, 5, 7, 14, and 28. The wound sizes were decreased in the alginate-treated group compared with the control group and the vaseline-treated group. The expressions of transforming growth factor-beta1, fibronectin, and vascular endothelial growth factor were significantly decreased in the alginate-treated group compared with the control group, while the expression of collagen-I was increased in the alginate-treated group, as indicated by Western blotting and immunohistochemical staining. These data suggest that alginate has significant wound healing promoting activity. The results from the present study indicate that the effect of alginate on wound healing may involve biological mechanisms associated with the expression of transforming growth factor-beta1, fibronectin, vascular endothelial growth factor, and collagen-I.
    MeSH term(s) Administration, Topical ; Alginates/administration & dosage ; Animals ; Blotting, Western ; Collagen Type I/metabolism ; Fibronectins/metabolism ; Glucuronic Acid/administration & dosage ; Hexuronic Acids/administration & dosage ; Male ; Rats ; Skin/injuries ; Tissue Adhesives/administration & dosage ; Transforming Growth Factor beta1/metabolism ; Vascular Endothelial Growth Factor A/metabolism ; Wound Healing/drug effects
    Chemical Substances Alginates ; Collagen Type I ; Fibronectins ; Hexuronic Acids ; Tissue Adhesives ; Transforming Growth Factor beta1 ; Vascular Endothelial Growth Factor A ; vascular endothelial growth factor A, rat ; Glucuronic Acid (8A5D83Q4RW) ; alginic acid (8C3Z4148WZ)
    Language English
    Publishing date 2009-07
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 1174873-4
    ISSN 1524-475X ; 1067-1927
    ISSN (online) 1524-475X
    ISSN 1067-1927
    DOI 10.1111/j.1524-475X.2009.00496.x
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