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  1. Article: Meta-Analysis of Risk Factors and Incidence of Interstitial Pneumonia With CHOP-Like Regimens for Non-Hodgkin Lymphoma.

    Yang, Jing / Chai, Limin / Jia, Junting / Su, Liping / Hao, Zhiying

    Frontiers in oncology

    2022  Volume 12, Page(s) 880144

    Abstract: Objectives: Interstitial pneumonitis (IP), a potentially fatal complication of non-Hodgkin Lymphoma (NHL) patients received CHOP (cyclophosphamide and doxorubicin and vincristine and prednisone)-like chemotherapy, negatively affected patients' clinical ... ...

    Abstract Objectives: Interstitial pneumonitis (IP), a potentially fatal complication of non-Hodgkin Lymphoma (NHL) patients received CHOP (cyclophosphamide and doxorubicin and vincristine and prednisone)-like chemotherapy, negatively affected patients' clinical outcome and quality of life. We aimed to explore patient-related, disease-related and drug-related risk factors associated with IP and gain a better understanding of the incidence in NHL patients.
    Methods: Databases, including PubMed, Ovid, China National Knowledge Internet (CNKI), and Wanfang Database from inception to January 20, 2022, were searched to identify studies evaluating the risk factors and incidence of IP. The included studies were assessed by Newcastle-Ottawa Quality Scale and above 7 points was considered high quality. The statistical analysis of risk factors was assessed by RevMan software (version 5.3) and incidence of IP was calculated by R software (version 4.1.2). Fixed-or random-effects models were applied to estimated the relative risks (RRs) and 95% confidence interval (Cl).
    Results: A total of 12 studies comprised of 3423 NHL patients were included in the analysis. Among the 3 available patient-related risk factors, 6 disease-related risk factors and 3 drug-related risk factors, it was found that only drug-related risk factors were significantly associated with IP development: pegylated liposomes doxorubicin (PLD) replacement (RR = 3.25, 95% CI = 1.69-6.27,
    Conclusion: PLD replacement, RTX addition and G-CSF administration were significant risk factors of IP for NHL patients received the CHOP-like chemotherapy. Clinicians should focus on these patients to detect and treat the IP development timely, which might bring benefit in patients' survival.
    Systematic review registration: PROSPERO, identifier CRD42022309884.
    Language English
    Publishing date 2022-06-01
    Publishing country Switzerland
    Document type Systematic Review
    ZDB-ID 2649216-7
    ISSN 2234-943X
    ISSN 2234-943X
    DOI 10.3389/fonc.2022.880144
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: The global burden of ischemic heart disease attributed to high fasting plasma glucose: Data from 1990 to 2019.

    Shen, Nirui / Liu, Jin / Wang, Yan / Qiu, Yuanjie / Li, Danyang / Wang, Qingting / Chai, Limin / Chen, Yuqian / Hu, Huizhong / Li, Manxiang

    Heliyon

    2024  Volume 10, Issue 5, Page(s) e27065

    Abstract: Background: Ischemic heart disease (IHD) is the leading cause of death worldwide. High fasting plasma glucose (FPG) is an increasing risk factor for IHD. We aimed to explore the long-term trends of high FPG-attributed IHD mortality during 1990-2019.: ... ...

    Abstract Background: Ischemic heart disease (IHD) is the leading cause of death worldwide. High fasting plasma glucose (FPG) is an increasing risk factor for IHD. We aimed to explore the long-term trends of high FPG-attributed IHD mortality during 1990-2019.
    Methods: Data were obtained from the Global Burden of Disease Study 2019 database. Deaths, disability-adjusted life-years (DALYs), the age-standardized mortality rate (ASMR) and age-standardized DALY rate (ASDR) of IHD attributable to high FPG were estimated by sex, socio-demographic index (SDI), regions and age. Estimated annual percentage changes (EAPCs) were calculated to assess the trends of ASMR and ASDR of IHD attributable to high FPG.
    Results: IHD attributable to high FPG deaths increased from 1.04 million (0.62-1.63) in 1990 to 2.35 million (1.4-3.7) in 2019, and the corresponding DALYs rose from 19.82 million (12.68-29.4) to 43.3 million (27.8-64.2). In 2019, ASMR and ASDR of IHD burden attributable to high FPG were 30.45 (17.09-49.03) and 534.8 (340.7-792.2), respectively. The highest ASMR and ASDR of IHD attributable to high FPG occurred in low-middle SDI quintiles, with 39.28 (22.40-62.76) and 742.3 (461.5-1117.5), respectively, followed by low SDI quintiles and middle SDI quintiles. Males had higher ASMR and ASDR compared to females across the past 30 years. In addition, ASRs of DALYs and deaths were highest in those over 95 years old.
    Conclusion: High FPG-attributed IHD mortality and DALYs have increased dramatically and globally, particularly in low, low-middle SDI quintiles and among the elderly. High FPG remains a great concern on the global burden of IHD and effective prevention and interventions are urgently needed to curb the ranking IHD burden, especially in lower SDI regions.
    Language English
    Publishing date 2024-03-06
    Publishing country England
    Document type Journal Article
    ZDB-ID 2835763-2
    ISSN 2405-8440
    ISSN 2405-8440
    DOI 10.1016/j.heliyon.2024.e27065
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Activation of PPAR-γ prevents TERT-mediated pulmonary vascular remodeling in MCT-induced pulmonary hypertension

    Hussain, Tafseel / Chai, Limin / Wang, Yan / Zhang, Qianqian / Wang, Jian / Shi, Wenhua / Wang, Qingting / Li, Manxiang / Xie, Xinming

    Heliyon. 2023 Mar., v. 9, no. 3 p.e14173-

    2023  

    Abstract: It has been demonstrated that elevated telomerase reverse transcriptase (TERT) expression or activity is implicated in pulmonary hypertension (PH). In addition, activation of peroxisome-proliferator-activated receptor γ (PPAR-γ) has been found to prevent ...

    Abstract It has been demonstrated that elevated telomerase reverse transcriptase (TERT) expression or activity is implicated in pulmonary hypertension (PH). In addition, activation of peroxisome-proliferator-activated receptor γ (PPAR-γ) has been found to prevent PH progression. However, the molecular mechanism responsible for the protective effect of PPAR-γ activation on TERT expression in the pathogenesis of PH remains unknown. This study was performed to address these issues. Intraperitoneal injection of monocrotaline (MCT) was used to establish PH. BIBR1532 was applied to inhibit the activity of telomerase. The right ventricular systolic pressure (RVSP) and histological analysis were used to detect the development of PH. The protein levels of p-Akt, t-Akt, c-Myc and TERT were determined by western blotting. Pharmacological inhibition of TERT by BIBR1532 effectively suppressed RVSP, RVHI and the WT% in MCT-induced PH rats. Pharmacological inhibition of Akt/c-Myc pathway by LY294002 diminished TERT upregulation, RVSP, RVHI and WT% in MCT-PH rats. Activation of PPAR-γ by pioglitazone inhibited p-Akt and c-Myc expressions and further downregulated TERT, thus to reduced RVSP, RVHI and WT% in MCT-treated PH rats. In conclusion, TERT upregulation contributes to PH development in MCT-treated rats. Activation of PPAR-γ prevents pulmonary arterial remodeling through Akt/c-Myc/TERT axis suppression.
    Keywords histology ; hypertension ; intraperitoneal injection ; monocrotaline ; pathogenesis ; protective effect ; pulmonary artery ; telomerase ; Pulmonary vascular remodeling ; Peroxisome proliferator-activated receptor γ ; Pulmonary artery hypertension ; Telomerase reverse transcriptase ; Akt/c-Myc
    Language English
    Dates of publication 2023-03
    Publishing place Elsevier Ltd
    Document type Article ; Online
    Note Use and reproduction
    ZDB-ID 2835763-2
    ISSN 2405-8440
    ISSN 2405-8440
    DOI 10.1016/j.heliyon.2023.e14173
    Database NAL-Catalogue (AGRICOLA)

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  4. Article: Activation of PPAR-γ prevents TERT-mediated pulmonary vascular remodeling in MCT-induced pulmonary hypertension.

    Hussain, Tafseel / Chai, Limin / Wang, Yan / Zhang, Qianqian / Wang, Jian / Shi, Wenhua / Wang, Qingting / Li, Manxiang / Xie, Xinming

    Heliyon

    2023  Volume 9, Issue 3, Page(s) e14173

    Abstract: Background: It has been demonstrated that elevated telomerase reverse transcriptase (TERT) expression or activity is implicated in pulmonary hypertension (PH). In addition, activation of peroxisome-proliferator-activated receptor γ (PPAR-γ) has been ... ...

    Abstract Background: It has been demonstrated that elevated telomerase reverse transcriptase (TERT) expression or activity is implicated in pulmonary hypertension (PH). In addition, activation of peroxisome-proliferator-activated receptor γ (PPAR-γ) has been found to prevent PH progression. However, the molecular mechanism responsible for the protective effect of PPAR-γ activation on TERT expression in the pathogenesis of PH remains unknown. This study was performed to address these issues.
    Methods: Intraperitoneal injection of monocrotaline (MCT) was used to establish PH. BIBR1532 was applied to inhibit the activity of telomerase. The right ventricular systolic pressure (RVSP) and histological analysis were used to detect the development of PH. The protein levels of p-Akt, t-Akt, c-Myc and TERT were determined by western blotting. Pharmacological inhibition of TERT by BIBR1532 effectively suppressed RVSP, RVHI and the WT% in MCT-induced PH rats.
    Results: Pharmacological inhibition of Akt/c-Myc pathway by LY294002 diminished TERT upregulation, RVSP, RVHI and WT% in MCT-PH rats. Activation of PPAR-γ by pioglitazone inhibited p-Akt and c-Myc expressions and further downregulated TERT, thus to reduced RVSP, RVHI and WT% in MCT-treated PH rats.
    Conclusions: In conclusion, TERT upregulation contributes to PH development in MCT-treated rats. Activation of PPAR-γ prevents pulmonary arterial remodeling through Akt/c-Myc/TERT axis suppression.
    Language English
    Publishing date 2023-03-04
    Publishing country England
    Document type Journal Article
    ZDB-ID 2835763-2
    ISSN 2405-8440
    ISSN 2405-8440
    DOI 10.1016/j.heliyon.2023.e14173
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: CEMIP as a prognostic biomarker for cancers: a meta- and bioinformatic analysis.

    Chen, Huan / Wang, Qingting / Liu, Jin / Chen, Yuqian / Zhang, Qianqian / Chai, Limin / Wang, Yan / Li, Danyang / Qiu, Yuanjie / Li, Manxiang

    Expert review of molecular diagnostics

    2023  Volume 22, Issue 12, Page(s) 1107–1115

    Abstract: Objective: Cell migration-inducing and hyaluronan-binding protein (: Methods: Relevant published studies were systematically searched in four databases. The role of : Results: 11 literatures with 1355 patients were included in this meta-analysis. ... ...

    Abstract Objective: Cell migration-inducing and hyaluronan-binding protein (
    Methods: Relevant published studies were systematically searched in four databases. The role of
    Results: 11 literatures with 1355 patients were included in this meta-analysis. The results showed that overexpression of
    Conclusion: The results demonstrated that
    MeSH term(s) Humans ; Biomarkers, Tumor/genetics ; Lymphatic Metastasis ; Neoplasms/genetics ; Odds Ratio ; Prognosis ; RNA, Long Noncoding/genetics
    Chemical Substances Biomarkers, Tumor ; RNA, Long Noncoding ; CEMIP protein, human (EC 3.2.1.35)
    Language English
    Publishing date 2023-01-17
    Publishing country England
    Document type Systematic Review ; Meta-Analysis ; Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2112530-2
    ISSN 1744-8352 ; 1473-7159
    ISSN (online) 1744-8352
    ISSN 1473-7159
    DOI 10.1080/14737159.2022.2168191
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 6073: Show issues Location:
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  6. Article ; Online: Chinese herbal formula, modified Xianfang Huoming Yin, alleviates the inflammatory proliferation of rat synoviocytes induced by IL-1β through regulating the migration and differentiation of T lymphocytes.

    Li, Dongyang / Liu, Wei / Sun, Song / Zhang, Yingkai / Zhang, Pingxin / Feng, Guiyu / Wei, Jie / Chai, Limin

    Journal of ethnopharmacology

    2023  Volume 309, Page(s) 116297

    Abstract: Ethnopharmacological relevance: Xianfang Huoming Yin (XFH) is a traditional Chinese herbal formula, which has the effect of clearing heat and detoxifying toxins, dispersing swellings, activating blood circulation, and relieving pain. It is usually ... ...

    Abstract Ethnopharmacological relevance: Xianfang Huoming Yin (XFH) is a traditional Chinese herbal formula, which has the effect of clearing heat and detoxifying toxins, dispersing swellings, activating blood circulation, and relieving pain. It is usually applied to treat various autoimmune diseases, including Rheumatoid arthritis (RA).
    Aim of the study: The migration of T lymphocytes plays an indispensable role in the pathogenesis of RA. Our previous studies demonstrated that modified Xianfang Huoming Yin (XFHM) could modulate the differentiation of T, B, and NK cells, and contribute to the restoration of immunologic balance. It also could downregulate the production of pro-inflammatory cytokines by regulating the activation of NF-κ B and JAK/STAT signaling pathways in the collagen-induced arthritis mouse model. In this study, we want to investigate whether XFHM has therapeutic effects on the inflammatory proliferation of rat fibroblast-like synovial cells (FLSs) by interfering with the migration of T lymphocytes in vitro experiments.
    Materials and methods: High performance liquid chromatography-electrospray ionization/mass spectrometer system was used to identify the constituents of the XFHM formula. A co-culture system of rat fibroblast-like synovial cells (RSC-364 cells) and peripheral blood lymphocytes stimulated by interleukin-1 beta (IL-1β) was used as the cell model. IL-1β inhibitor (IL-1βRA) was used as a positive control medicine, and two concentrations (100 μg/mL and 250 μg/mL) of freeze-dried XFHM powder were used as intervention measure. The lymphocyte migration levels were analyzed by the Real-time xCELLigence analysis system after 24 h and 48 h of treatment. The percentage of CD3
    Results: Twenty-one different components in XFHM were identified. The migration CI index of T cells was significantly decreased in treatment with XFHM. XFHM also could significantly downregulate the levels r of CD3
    Conclusion: XFHM could attenuate the inflammation of synovium by inhibiting T lymphocyte cell migration, regulating differentiation of T cells through modulating the activation of the NF-κ B signaling pathway.
    MeSH term(s) Mice ; Rats ; Animals ; Synoviocytes ; NF-kappa B/metabolism ; Intercellular Adhesion Molecule-1/metabolism ; P-Selectin/metabolism ; CD8-Positive T-Lymphocytes/metabolism ; Interleukin-1beta/metabolism ; Vascular Cell Adhesion Molecule-1/metabolism ; Arthritis, Rheumatoid/pathology ; Cytokines/metabolism ; Inflammation/pathology ; Cell Differentiation ; Cells, Cultured ; Cell Proliferation ; Fibroblasts
    Chemical Substances NF-kappa B ; Intercellular Adhesion Molecule-1 (126547-89-5) ; P-Selectin ; Interleukin-1beta ; Vascular Cell Adhesion Molecule-1 ; Cytokines
    Language English
    Publishing date 2023-02-26
    Publishing country Ireland
    Document type Journal Article
    ZDB-ID 134511-4
    ISSN 1872-7573 ; 0378-8741
    ISSN (online) 1872-7573
    ISSN 0378-8741
    DOI 10.1016/j.jep.2023.116297
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 1494: Show issues Location:
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  7. Article ; Online: Activation of CaMKII/HDAC4 by SDF1 contributes to pulmonary arterial hypertension via stabilization Runx2.

    Chen, Yuqian / Liu, Jin / Zhang, Qianqian / Chai, Limin / Chen, Huan / Li, Danyang / Wang, Yan / Qiu, Yuanjie / Shen, Nirui / Zhang, Jia / Wang, Qingting / Wang, Jian / Xie, Xinming / Li, Shaojun / Li, Manxiang

    European journal of pharmacology

    2024  Volume 970, Page(s) 176483

    Abstract: Stromal derived factor 1 (SDF1) has been shown to be involved in the pathogenesis of pulmonary artery hypertension (PAH). However, the detailed molecular mechanisms remain unclear. To address this, we utilized primary cultured rat pulmonary artery smooth ...

    Abstract Stromal derived factor 1 (SDF1) has been shown to be involved in the pathogenesis of pulmonary artery hypertension (PAH). However, the detailed molecular mechanisms remain unclear. To address this, we utilized primary cultured rat pulmonary artery smooth muscle cells (PASMCs) and monocrotaline (MCT)-induced PAH rat models to investigate the mechanisms of SDF1 driving PASMCs proliferation and pulmonary arterial remodeling. SDF1 increased runt-related transcription factor 2 (Runx2) acetylation by Calmodulin (CaM)-dependent protein kinase II (CaMKII)-dependent HDAC4 cytoplasmic translocation, elevation of Runx2 acetylation conferred its resistance to proteasome-mediated degradation. The accumulation of Runx2 further upregulated osteopontin (OPN) expression, finally leading to PASMCs proliferation. Blocking SDF1, suppression of CaMKII, inhibition the nuclear export of HDAC4 or silencing Runx2 attenuated pulmonary arterial remodeling and prevented PAH development in MCT-induced PAH rat models. Our study provides novel sights for SDF1 induction of PASMCs proliferation and suggests that targeting SDF1/CaMKII/HDAC4/Runx2 axis has potential value in the management of PAH.
    MeSH term(s) Rats ; Animals ; Pulmonary Arterial Hypertension/pathology ; Calcium-Calmodulin-Dependent Protein Kinase Type 2/metabolism ; Core Binding Factor Alpha 1 Subunit/metabolism ; Vascular Remodeling/physiology ; Cell Proliferation ; Pulmonary Artery/pathology ; Familial Primary Pulmonary Hypertension/pathology ; Myocytes, Smooth Muscle ; Monocrotaline/adverse effects ; Disease Models, Animal ; Histone Deacetylases/metabolism
    Chemical Substances Calcium-Calmodulin-Dependent Protein Kinase Type 2 (EC 2.7.11.17) ; Core Binding Factor Alpha 1 Subunit ; Monocrotaline (73077K8HYV) ; Runx2 protein, rat ; HDAC4 protein, rat (EC 3.5.1.98) ; Histone Deacetylases (EC 3.5.1.98)
    Language English
    Publishing date 2024-03-11
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 80121-5
    ISSN 1879-0712 ; 0014-2999
    ISSN (online) 1879-0712
    ISSN 0014-2999
    DOI 10.1016/j.ejphar.2024.176483
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 522: Show issues Location:
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  8. Article ; Online: Global burden of MDR-TB and XDR-TB attributable to high fasting plasma glucose from 1990 to 2019: a retrospective analysis based on the global burden of disease study 2019.

    Chen, Yuqian / Liu, Jin / Zhang, Qianqian / Chen, Huan / Chai, Limin / Wang, Yan / Zhang, Jia / Qiu, Yuanjie / Shen, Nirui / Shi, Xiangyu / Wang, Qingting / Wang, Jian / Li, Shaojun / Li, Manxiang

    European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology

    2024  Volume 43, Issue 4, Page(s) 747–765

    Abstract: Purpose: High fasting plasma glucose (HFPG) has been identified as a risk factor for drug-resistant tuberculosis incidence and mortality. However, the epidemic characteristics of HFPG-attributable multidrug-resistant tuberculosis (MDR-TB) and ... ...

    Abstract Purpose: High fasting plasma glucose (HFPG) has been identified as a risk factor for drug-resistant tuberculosis incidence and mortality. However, the epidemic characteristics of HFPG-attributable multidrug-resistant tuberculosis (MDR-TB) and extensively drug-resistant tuberculosis (XDR-TB) remain unclear. We aimed to analyze the global spatial patterns and temporal trends of HFPG-attributable MDR-TB and XDR-TB from 1990 to 2019.
    Methods: Utilizing data from the Global Burden of Disease 2019 project, annual deaths and disability-adjusted life years (DALYs) of HFPG-attributable MDR-TB and XDR-TB were conducted from 1990 to 2019. Joinpoint regression was employed to quantify trends over time.
    Results: From 1990 to 2019, the deaths and DALYs due to HFPG-attributable MDR-TB and XDR-TB globally showed an overall increasing trend, with a significant increase until 2003 to 2004, followed by a gradual decline or stability thereafter. The low sociodemographic index (SDI) region experienced the most significant increase over the past 30 years. Regionally, Sub-Saharan Africa, Central Asia and Oceania remained the highest burden. Furthermore, there was a sex and age disparity in the burden of HFPG-attributable MDR-TB and XDR-TB, with young males in the 25-34 age group experiencing higher mortality, DALYs burden and a faster increasing trend than females. Interestingly, an increasing trend followed by a stable or decreasing pattern was observed in the ASMR and ASDR of HFPG-attributable MDR-TB and XDR-TB with SDI increasing.
    Conclusion: The burden of HFPG-attributable MDR-TB and XDR-TB rose worldwide from 1990 to 2019. These findings emphasize the importance of routine bi-directional screening and integrated management for drug-resistant TB and diabetes.
    MeSH term(s) Male ; Female ; Humans ; Extensively Drug-Resistant Tuberculosis ; Blood Glucose ; Retrospective Studies ; Global Burden of Disease ; Tuberculosis, Multidrug-Resistant/epidemiology ; Tuberculosis, Multidrug-Resistant/diagnosis ; Fasting
    Chemical Substances Blood Glucose
    Language English
    Publishing date 2024-02-17
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 603155-9
    ISSN 1435-4373 ; 0934-9723 ; 0722-2211
    ISSN (online) 1435-4373
    ISSN 0934-9723 ; 0722-2211
    DOI 10.1007/s10096-024-04779-x
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    Zs.A 1732: Show issues Location:
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  9. Article ; Online: Management of adverse effects associated with pegylated Escherichia coli asparaginase on coagulation in the treatment of patients with NK/T-cell lymphoma.

    Yang, Jing / Guo, Xiangyun / Guo, Sutang / Yan, Hongxia / Chai, Limin / Guo, Yimeng / Li, Zhenhua / Hao, Zhiying / Su, Liping

    Medicine

    2022  Volume 101, Issue 10, Page(s) e25578

    Abstract: Abstract: Natural killer/T-cell lymphoma (NK/TL) is a chemotherapy-sensitive disease, and asparaginase-based chemotherapy has become the standard primary treatment for patients with this malignancy recently. The objective of this study was to evaluate ... ...

    Abstract Abstract: Natural killer/T-cell lymphoma (NK/TL) is a chemotherapy-sensitive disease, and asparaginase-based chemotherapy has become the standard primary treatment for patients with this malignancy recently. The objective of this study was to evaluate the adverse reactions on blood coagulation of the administered pegylated Escherichia coli (E coli) asparaginase (PEG-ASP) to the NK/TL patients. Clinical data of 71 NK/TL patients (range 13-73 years), who received 239 cycles of chemotherapy treatment containing PEG-ASP in the Hematology Department of Shanxi Province Cancer Hospital of China from January 2016 to December 2019 were analyzed retrospectively. Data of prothrombin time (PT), activated partial thromboplastin time (APTT), fibrinogen (FBG), and antithrombinIII (ATIII) were obtained at the time points routinely and statistically analyzed. There were statistical differences between the monitored parameters of baseline day0 (the day before use of PEG-ASP, named day0) and those of day3 (the 3rd day after treatment) to day6, and data showed all of the indicators could recover within 21 days. The events included PT prolonged in 33 patients (46.5%), APPT prolonged in 41 patients (57.7%, 20 patients with APTT >60 seconds), FBG decreased in 49 patients (69.0%, 12 patients with FBG <1 g/L), and ATIII decreased in 52 patients (73.2%). The patients' average number of cycles received was 2.3 for PT (>14 seconds), 2.5 for APTT (>35 seconds), 2.7 for FBG (<2 g/L), and 2.6 for D-dimer (>550 ng/mL). Compared with those at day0, PT and APTT prolonged sharply at day3 (P < .05), reached the peak at day12, maintained the prolonged level from day3 to day15, and gradually recovered at day 21. FBG and ATIII significantly decreased at day6 and day3 respectively (P < .05), both of them fell to the minimum at day12, and then returned the normal. The D-dimer levels were no significantly change during the whole treatment course. The APTT >60 seconds or FBG <1 g/L side effects were improved by symptomatic treatment of supplementation of fresh frozen plasma or cryoprecipitate infusion, no concomitant bleeding or thrombotic events emerging. Our data suggested although chemotherapy including PEG-ASP impacted moderately on the coagulation function of NK/TL patients, clinically monitored regularly were necessary and most NK/TL patients can complete the chemotherapy cycles successfully.
    MeSH term(s) Asparaginase/adverse effects ; Blood Coagulation ; Drug-Related Side Effects and Adverse Reactions ; Escherichia coli ; Fibrinogen ; Humans ; Lymphoma, T-Cell, Peripheral ; Polyethylene Glycols/adverse effects ; Retrospective Studies
    Chemical Substances Polyethylene Glycols (3WJQ0SDW1A) ; Fibrinogen (9001-32-5) ; Asparaginase (EC 3.5.1.1)
    Language English
    Publishing date 2022-03-11
    Publishing country United States
    Document type Journal Article
    ZDB-ID 80184-7
    ISSN 1536-5964 ; 0025-7974
    ISSN (online) 1536-5964
    ISSN 0025-7974
    DOI 10.1097/MD.0000000000025578
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article: The Herbal Combination of

    Feng, Guiyu / Li, Dongyang / Liu, Juan / Sun, Song / Zhang, Pingxin / Liu, Wei / Zhang, Yingkai / Meng, Boyang / Li, Jinyu / Chai, Limin

    Frontiers in pharmacology

    2022  Volume 13, Page(s) 964559

    Abstract: Type 2 innate lymphocytes (ILC2s), promoting inflammation resolution, was a potential target for rheumatoid arthritis (RA) treatment. Our previous studies confirmed ... ...

    Abstract Type 2 innate lymphocytes (ILC2s), promoting inflammation resolution, was a potential target for rheumatoid arthritis (RA) treatment. Our previous studies confirmed that
    Language English
    Publishing date 2022-07-19
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2587355-6
    ISSN 1663-9812
    ISSN 1663-9812
    DOI 10.3389/fphar.2022.964559
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    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

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