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  1. Article ; Online: Beta-blocker and calcium-channel blocker toxicity: current evidence on evaluation and management.

    Goldfine, Charlotte E / Troger, Andrew / Erickson, Timothy B / Chai, Peter R

    European heart journal. Acute cardiovascular care

    2024  Volume 13, Issue 2, Page(s) 247–253

    Abstract: Beta-blocker and calcium-channel blocker overdoses are associated with severe morbidity and mortality; therefore, it is important to recognize and appropriately treat individuals with toxicity. The most common clinical findings in toxicity are ... ...

    Abstract Beta-blocker and calcium-channel blocker overdoses are associated with severe morbidity and mortality; therefore, it is important to recognize and appropriately treat individuals with toxicity. The most common clinical findings in toxicity are bradycardia and hypotension. In addition to supportive care and cardiac monitoring, specific treatment includes administration of calcium salts, vasopressors, and high-dose insulin euglycaemia treatment. Other advanced treatments (e.g. ECMO) may be indicated depending on the severity of toxicity and specific agents involved.
    MeSH term(s) Humans ; Calcium Channel Blockers ; Calcium ; Vasoconstrictor Agents ; Adrenergic beta-Antagonists/therapeutic use
    Chemical Substances Calcium Channel Blockers ; Calcium (SY7Q814VUP) ; Vasoconstrictor Agents ; Adrenergic beta-Antagonists
    Language English
    Publishing date 2024-02-19
    Publishing country England
    Document type Journal Article
    ZDB-ID 2663340-1
    ISSN 2048-8734 ; 2048-8726
    ISSN (online) 2048-8734
    ISSN 2048-8726
    DOI 10.1093/ehjacc/zuad138
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Scaling Up Point-of-Care Fentanyl Testing - A Step Forward.

    Barnett, Brian S / Chai, Peter R / Suzuki, Joji

    The New England journal of medicine

    2023  Volume 389, Issue 18, Page(s) 1643–1645

    MeSH term(s) Humans ; Analgesics, Opioid/analysis ; Analgesics, Opioid/therapeutic use ; Fentanyl/analysis ; Health Services/trends ; Point-of-Care Systems/trends
    Chemical Substances Analgesics, Opioid ; Fentanyl (UF599785JZ)
    Language English
    Publishing date 2023-10-28
    Publishing country United States
    Document type Journal Article
    ZDB-ID 207154-x
    ISSN 1533-4406 ; 0028-4793
    ISSN (online) 1533-4406
    ISSN 0028-4793
    DOI 10.1056/NEJMp2308525
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  3. Article ; Online: Individuals with fibromyalgia report greater pain sensitivity than healthy adults while listening to their favorite music: the contribution of negative affect.

    Wilson, Jenna M / Franqueiro, Angelina R / Edwards, Robert R / Chai, Peter R / Schreiber, Kristin L

    Pain medicine (Malden, Mass.)

    2024  Volume 25, Issue 5, Page(s) 352–361

    Abstract: Objective: We investigated the impact of favorite music on pain processing among individuals with fibromyalgia. We also examined differences in pain processing between individuals with fibromyalgia and healthy controls (HC) while listening to favorite ... ...

    Abstract Objective: We investigated the impact of favorite music on pain processing among individuals with fibromyalgia. We also examined differences in pain processing between individuals with fibromyalgia and healthy controls (HC) while listening to favorite music and explored whether psychosocial factors contributed to these differences.
    Methods: Individuals with fibromyalgia and HC completed baseline psychosocial questionnaires and then underwent quantitative sensory testing (QST) during 3 randomized music conditions (meditative music, favorite music, white noise). Among individuals with fibromyalgia, Friedman tests were used to investigate differences in QST across conditions. Analyses of Covariance were used to examine group (HC vs fibromyalgia) differences in QST during favorite music. Correlations were conducted to explore associations of baseline psychosocial factors with QST during favorite music. Mediation analyses were conducted to explore whether psychosocial factors contributed to greater pain sensitivity among individuals with fibromyalgia compared to HC during favorite music.
    Results: Individuals with fibromyalgia were less sensitive to pressure pain while listening to their favorite music compared to white noise. Compared to HC, individuals with fibromyalgia reported higher baseline negative affect and lower pain thresholds and tolerances during favorite music. Negative affect partially mediated the relationship between pain status (HC vs fibromyalgia) and pain sensitivity during favorite music.
    Conclusions: Individuals with fibromyalgia were less pain sensitive while listening to favorite music than white noise, although they were more sensitive than HC. Greater negative affect endorsed by individuals with fibromyalgia contributed to their greater pain sensitivity. Future studies should explore the impact of favorite music on clinical pain.
    Clinical trails registration: This study was registered with ClinicalTrials.gov (NCT04087564) and began on 6/13/2019.
    MeSH term(s) Humans ; Fibromyalgia/psychology ; Female ; Music/psychology ; Male ; Middle Aged ; Adult ; Pain Threshold/physiology ; Affect/physiology ; Pain Measurement/methods
    Language English
    Publishing date 2024-01-29
    Publishing country England
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 2015903-1
    ISSN 1526-4637 ; 1526-2375
    ISSN (online) 1526-4637
    ISSN 1526-2375
    DOI 10.1093/pm/pnae005
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  4. Article ; Online: Complex Management of AV Nodal Agent Toxicity in Patients with Cardiac Devices: Massive Calcium Channel Antagonist Overdose in a Patient with a Permanent Pacemaker.

    Gibbons, Patric W / Chai, Peter R / Erickson, Timothy B

    Journal of cardiology case reports

    2022  Volume 5, Issue 1

    Abstract: We present a unique case of a massive calcium channel antagonist overdose in a patient with a permanent pacemaker. Upon presentation after the acute overdose, the patient's cardiac device was found to be pacing to an adequate rate (75 beats per minute) ... ...

    Abstract We present a unique case of a massive calcium channel antagonist overdose in a patient with a permanent pacemaker. Upon presentation after the acute overdose, the patient's cardiac device was found to be pacing to an adequate rate (75 beats per minute) and she was admitted to the cardiac intensive care unit. Approximately 24 hours after her ingestion, she acutely decompensated and became hypotensive. The patient was started on infusions of norepinephrine, epinephrine, phenylephrine, and vasopressin. Her mean arterial pressure was unresponsive to multi-vasopressor therapy. She was then given a bolus of methylene blue and high-dose insulin euglycemic therapy. Despite these treatments, the patient remained hypotensive Therefore, intralipid emulsion therapy and IV epinephrine pushes were also administered. As a result of her shock and hemodynamic instability, her course was further complicated by hypoxemic respiratory failure for which she required ventilatory support and developed oliguric renal failure for which she was initiated on continuous veno-venous hemofiltration. This case emphasizes the challenges in managing complex physiology associated with nodal agent toxicity and is the first, to our knowledge, to describe management in a patient who already had a pacemaker, though it was ultimately ineffective in avoiding the patient's profound decompensation.
    Language English
    Publishing date 2022-01-27
    Publishing country England
    Document type Journal Article
    ISSN 2631-9934
    ISSN (online) 2631-9934
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  5. Article ; Online: Health and Safety Threats to Ukraine From Nonconventional Weapons: A Clear and Present Danger.

    Goralnick, Eric / Chai, Peter R / Erickson, Timothy B

    JAMA

    2022  

    Language English
    Publishing date 2022-12-05
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2958-0
    ISSN 1538-3598 ; 0254-9077 ; 0002-9955 ; 0098-7484
    ISSN (online) 1538-3598
    ISSN 0254-9077 ; 0002-9955 ; 0098-7484
    DOI 10.1001/jama.2022.22661
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  6. Article ; Online: Tweetchats, Disseminating Information, and Sparking Further Scientific Discussion with Social Media.

    Chary, Michael A / Chai, Peter R

    Journal of medical toxicology : official journal of the American College of Medical Toxicology

    2020  Volume 16, Issue 2, Page(s) 109–111

    MeSH term(s) Editorial Policies ; Group Processes ; Humans ; Information Dissemination ; Periodicals as Topic ; Scholarly Communication ; Social Media ; Toxicology
    Language English
    Publishing date 2020-02-24
    Publishing country United States
    Document type Editorial ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 2435016-3
    ISSN 1937-6995 ; 1556-9039
    ISSN (online) 1937-6995
    ISSN 1556-9039
    DOI 10.1007/s13181-020-00760-0
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    Zs.A 6682: Show issues Location:
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  7. Article ; Online: Wearable Devices and Biosensing: Future Frontiers.

    Chai, Peter R

    Journal of medical toxicology : official journal of the American College of Medical Toxicology

    2016  Volume 12, Issue 4, Page(s) 332–334

    Language English
    Publishing date 2016-12
    Publishing country United States
    Document type Editorial
    ZDB-ID 2435016-3
    ISSN 1937-6995 ; 1556-9039
    ISSN (online) 1937-6995
    ISSN 1556-9039
    DOI 10.1007/s13181-016-0569-1
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  8. Article ; Online: The Journal of Medical Toxicology: Our Once and Future Journal.

    Greller, Howard A / Chai, Peter R / Neumann, Natalie R / Mycyk, Mark B

    Journal of medical toxicology : official journal of the American College of Medical Toxicology

    2022  Volume 18, Issue 3, Page(s) 181–182

    MeSH term(s) Humans ; Publishing
    Language English
    Publishing date 2022-05-23
    Publishing country United States
    Document type Editorial ; Research Support, Non-U.S. Gov't ; Research Support, N.I.H., Extramural
    ZDB-ID 2435016-3
    ISSN 1937-6995 ; 1556-9039
    ISSN (online) 1937-6995
    ISSN 1556-9039
    DOI 10.1007/s13181-022-00898-z
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  9. Article ; Online: The Acceptability of Adherence Support via Mobile Phones for Antituberculosis Treatment in South India: Exploratory Study.

    Jose, Nisha K / Vaz, Clint / Chai, Peter R / Rodrigues, Rashmi

    JMIR formative research

    2022  Volume 6, Issue 5, Page(s) e37124

    Abstract: Background: India has the greatest burden of tuberculosis (TB). However, over 15% of the people on antitubercular therapy (ATT) in India are nonadherent. Several adherence monitoring techniques deployed in India to enhance ATT adherence have had modest ... ...

    Abstract Background: India has the greatest burden of tuberculosis (TB). However, over 15% of the people on antitubercular therapy (ATT) in India are nonadherent. Several adherence monitoring techniques deployed in India to enhance ATT adherence have had modest effects. Increased adoption of mobile phones and other technologies pose potential solutions to measuring and intervening in ATT adherence. Several technology-based interventions around ATT adherence have been demonstrated in other countries.
    Objective: The objective of our study was to understand the acceptance of mobile phone adherence supports for ATT using self-administered quantitative measures among patients with TB in South India.
    Methods: This exploratory study was conducted at a TB treatment center (TTC) at a tertiary care center in Thrissur District, Kerala, India. We recruited 100 patients with TB on ATT using convenience sampling after obtaining written informed consent. Trained study staff administered the questionnaire in Malayalam, commonly spoken in Kerala, India. We used frequency, mean, median, and SD or IQR to describe the data.
    Results: Of the 100 participants diagnosed with TB on ATT, 90% used mobile phones routinely, and 84% owned a mobile phone. Ninety-five percent of participants knew how to use the calling function, while 65% of them did not know how to use the SMS function on their mobile phone. Overall, 89% of the participants did not consider mobile phone-based ATT adherence interventions an intrusion in their privacy, and 93% did not fear stigma if the adherence reminder was received by someone else. Most (95%) of the study participants preferred mobile phone reminders instead of directly observed treatment, short-course. Voice calls (n=80, 80%) were the more preferred reminder modality than SMS reminders (n=5, 5%).
    Conclusions: Mobile phones are likely an acceptable platform to deliver ATT adherence interventions among individuals with TB in South India. Preference of voice call reminders may inform the architecture of future adherence interventions surrounding ATT in South India.
    Language English
    Publishing date 2022-05-13
    Publishing country Canada
    Document type Journal Article
    ISSN 2561-326X
    ISSN (online) 2561-326X
    DOI 10.2196/37124
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  10. Article ; Online: Enriching the Toxicology Experience through Twitter.

    Chai, Peter R

    Journal of medical toxicology : official journal of the American College of Medical Toxicology

    2015  Volume 11, Issue 4, Page(s) 385–387

    MeSH term(s) Academies and Institutes ; Confidentiality ; Humans ; Internet ; Toxicology/education
    Language English
    Publishing date 2015-12
    Publishing country United States
    Document type Editorial
    ZDB-ID 2435016-3
    ISSN 1937-6995 ; 1556-9039
    ISSN (online) 1937-6995
    ISSN 1556-9039
    DOI 10.1007/s13181-015-0508-6
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