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  1. Article ; Online: Fructooligosaccharides and fructans from Platycodon grandiflorum: Structural characterization, lung-oriented guidance and targetability.

    Liang, Jun / Wang, Wen-Fei / Zhang, Yi / Chai, Yan-Qun / Li, Ya-Ge / Jiang, Si-Liang / Zhu, Xin-Hua / Guo, Yu-Li / Wei, Zhen / Sun, Xi-Zhe / Kuang, Hai-Xue / Xia, Yong-Gang

    Carbohydrate polymers

    2023  Volume 323, Page(s) 121457

    Abstract: Platycodon grandiflorum (PG) has been widely applied as a conductant drug by ancient and modern traditional Chinese medicine practitioners during long-term clinical practice. However, determining how to guide other medicines to the targeted lungs in ... ...

    Abstract Platycodon grandiflorum (PG) has been widely applied as a conductant drug by ancient and modern traditional Chinese medicine practitioners during long-term clinical practice. However, determining how to guide other medicines to the targeted lungs in traditional Chinese medicine (TCM) prescription remains unclear. An ethanol soluble fraction (Fr. B) was obtained by macroporous resin and 75 % ethanol precipitate. The components were unambiguously determined as fructooligosaccharides and small molecule weight (M
    MeSH term(s) Platycodon/chemistry ; Tandem Mass Spectrometry ; Lung ; Ethanol/metabolism
    Chemical Substances fructooligosaccharide ; Ethanol (3K9958V90M)
    Language English
    Publishing date 2023-10-04
    Publishing country England
    Document type Journal Article
    ZDB-ID 1501516-6
    ISSN 1879-1344 ; 0144-8617
    ISSN (online) 1879-1344
    ISSN 0144-8617
    DOI 10.1016/j.carbpol.2023.121457
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Revealing the "Yin-Jing" mystery veil of Platycodon grandiflorum by potentiating therapeutic effects and lung-oriented guidance property.

    Liang, Jun / Li, Ya-Ge / Chai, Yan-Qun / Zhang, Yi / Gao, Xue / Zhu, Xin-Hua / Sun, Xi-Zhe / Wang, Wen-Fei / Kuang, Hai-Xue / Xia, Yong-Gang

    Journal of ethnopharmacology

    2023  Volume 322, Page(s) 117587

    Abstract: ETHNIC PHARMACOLOGICAL RELEVANCE: "Yin-Jing" medicine (YJM) has been widely used by both ancient and modern Chinese medicine practitioners during long-term clinical practice. However, it remains unclear how to best guide other medicines to the targeted ... ...

    Abstract ETHNIC PHARMACOLOGICAL RELEVANCE: "Yin-Jing" medicine (YJM) has been widely used by both ancient and modern Chinese medicine practitioners during long-term clinical practice. However, it remains unclear how to best guide other medicines to the targeted organs in a traditional Chinese medicine (TCM) prescription. Here, in an attempt to explain the scientific connotation of the YJM property (YJMP) attributed to a basic TCM theory, Platycodon grandiflorum (PG) was chosen as a case study to reveal the mystery of YJMP theory.
    Aim of the study: The main purpose of this study is to employ modern chemical and molecular biology methods to confirm the "Yin-Jing" effect of PG, and further clarify its material basis and related possible mechanism.
    Materials and methods: The ammonia-induced lung injury rat model was utilized to determine the optimal dosage of traditional prescription Hui Yan Zhu Yu decoction (HYZYD) using Wright Giemsa staining, HE staining, Masson staining, and TUNEL analysis. With the same way, PG was confirmed to have potentiating therapeutic effect (PTE) by comparison with HYZYD and [HYZYD-PG]. TMT proteomics was used to reveal the "Yin-Jing" mechanism of action. Western blot assay (WB) was employed for verification of differentially expressed proteins. Additionally, four non-crossing fragmentations (Fr. A-D) were characterized by RPLC/SEC-ELSD and HILIC-ESI
    Results: The HYZYD-M (medium dose group) significantly improved the lung injury level in a pneumonia model of rats. PG enhanced the therapeutic effect of HYZYD ascribed to Yin-Jing PTE functions. TMT proteomics revealed a category of differentially expressed proteins ascribed to Golgi-ER between HYZYD and [HYZYD-PG]. Fr. C (i.e., saponins) and Fr. D (i.e., lipids) were determined as therapeutic fragmentations via the LPS-induced A549 cell injury model; however, Fr. B (fructooligosaccharides and small M
    Conclusions: Fr. B is believed to be a key YJMP material basis of PG attributed to Yin-Jing PTE with characteristic of lung-oriented guidance property, whereas another abound Fr. C was determined to have synergistic effects rather than Yin-Jing material basis.
    MeSH term(s) Rats ; Animals ; Platycodon/chemistry ; Lung Injury ; Medicine, Chinese Traditional ; Chromatography, High Pressure Liquid/methods ; Lung
    Language English
    Publishing date 2023-12-16
    Publishing country Ireland
    Document type Journal Article
    ZDB-ID 134511-4
    ISSN 1872-7573 ; 0378-8741
    ISSN (online) 1872-7573
    ISSN 0378-8741
    DOI 10.1016/j.jep.2023.117587
    Database MEDical Literature Analysis and Retrieval System OnLINE

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