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  1. Article ; Online: Stabilization of Antioxidant and Anti-Inflammatory Activities of Nano-Selenium Using

    Buacheen, Pensiri / Chaipuang, Angkana / Karinchai, Jirarat / Nuchuchua, Onanong / Imsumran, Arisa / Wongnoppavich, Ariyaphong / Pimpha, Nuttaporn / Pitchakarn, Pornsiri

    Nutrients

    2023  Volume 15, Issue 4

    Abstract: Anoectochilus ... ...

    Abstract Anoectochilus burmannicus
    MeSH term(s) Antioxidants/pharmacology ; Selenium/pharmacology ; Nanoparticles ; Anti-Inflammatory Agents
    Chemical Substances Antioxidants ; Selenium (H6241UJ22B) ; Anti-Inflammatory Agents
    Language English
    Publishing date 2023-02-17
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2518386-2
    ISSN 2072-6643 ; 2072-6643
    ISSN (online) 2072-6643
    ISSN 2072-6643
    DOI 10.3390/nu15041018
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: Inhibiting Metastasis and Improving Chemosensitivity via Chitosan-Coated Selenium Nanoparticles for Brain Cancer Therapy.

    Dana, Paweena / Pimpha, Nuttaporn / Chaipuang, Angkana / Thumrongsiri, Nutthanit / Tanyapanyachon, Prattana / Taweechaipaisankul, Anukul / Chonniyom, Walailuk / Watcharadulyarat, Natsorn / Sathornsumetee, Sith / Saengkrit, Nattika

    Nanomaterials (Basel, Switzerland)

    2022  Volume 12, Issue 15

    Abstract: Selenium nanoparticles (SeNPs) were synthesized to overcome the limitations of selenium, such as its narrow safe range and low water solubility. SeNPs reduce the toxicity and improve the bioavailability of selenium. Chitosan-coated SeNPs (Cs-SeNPs) were ... ...

    Abstract Selenium nanoparticles (SeNPs) were synthesized to overcome the limitations of selenium, such as its narrow safe range and low water solubility. SeNPs reduce the toxicity and improve the bioavailability of selenium. Chitosan-coated SeNPs (Cs-SeNPs) were developed to further stabilize SeNPs and to test their effects against glioma cells. The effects of Cs-SeNPs on cell growth were evaluated in monolayer and 3D-tumor spheroid culture. Cell migration and cell invasion were determined using a trans-well assay. The effect of Cs-SeNPs on chemotherapeutic drug 5-fluorouracil (5-FU) sensitivity of glioma cells was determined in tumor spheroids. An in vitro blood-brain barrier (BBB) model was established to test the permeability of Cs-SeNPs. SeNPs and Cs-SeNPs can reduce the cell viability of glioma cells in a dose-dependent manner. Compared with SeNPs, Cs-SeNPs more strongly inhibited 3D-tumor spheroid growth. Cs-SeNPs exhibited stronger effects in inhibiting cell migration and cell invasion than SeNPs. Improved 5-FU sensitivity was observed in Cs-SeNP-treated cells. Cellular uptake in glioma cells indicated a higher uptake rate of coumarin-6-labeled Cs-SeNPs than SeNPs. The capability of coumarin-6 associated Cs-SeNPs to pass through the BBB was confirmed. Taken together, Cs-SeNPs provide exceptional performance and are a potential alternative therapeutic strategy for future glioma treatment.
    Language English
    Publishing date 2022-07-29
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2662255-5
    ISSN 2079-4991
    ISSN 2079-4991
    DOI 10.3390/nano12152606
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

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