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  1. Article ; Online: Inflammatory perspectives of polycystic ovary syndrome

    Rajen Dey / Koushik Bhattacharya / Asim Kumar Basak / Nimisha Paul / Raktima Bandyopadhyay / Gargi Ray Chaudhuri / Mahuya Patra Purkait / Aniruddha Bhattacharjee / Chaitali Bose / Nandini Shukla / Rama Bhaduri / Soumya Sinha Roy / Alak Kumar Syamal

    Middle East Fertility Society Journal, Vol 28, Iss 1, Pp 1-

    role of specific mediators and markers

    2023  Volume 12

    Abstract: Abstract Polycystic ovary syndrome (PCOS) is indeed one of the most common gynecological endocrine disorders, affecting a significant number of females in their reproductive age. While the exact cause of PCOS is not fully understood, several factors are ... ...

    Abstract Abstract Polycystic ovary syndrome (PCOS) is indeed one of the most common gynecological endocrine disorders, affecting a significant number of females in their reproductive age. While the exact cause of PCOS is not fully understood, several factors are believed to contribute to its onset. The relationship between polycystic ovary syndrome (PCOS) and low-grade chronic inflammation is complex and not fully understood. While there is evidence to suggest an association between PCOS and inflammation, the exact cause and causal nature of this relationship are still under investigation. Several inflammatory markers, including IL-6 (interleukin-6), TNF-α (tumor necrosis factor-alpha), IL-17 (interleukin-17), CRP (C-reactive protein), NLR (neutrophil-to-lymphocyte ratio), and PLR (platelet-to-lymphocyte ratio), have been studied about PCOS. These markers are substances produced by the immune system in response to inflammation. Increased levels of IL-17, IL-1, and IL-8 were correlated with PCO. CRP to albumin ratio can be employed as a precise bio-marker for PCOS. The neutrophil-to-lymphocyte ratio (NLR) indicates poor cardiovascular health and metabolic syndrome (MS) and can be considered a negative regulator for FSH which indirectly stimulates testosterone production. Platelet/lymphocyte ratio (PLR) and mean platelet volume (MPV) are also recently found to be associated with PCOS. The literature explaining the underlying mechanisms with specific inflammatory markers and how inflammation relates to PCOS will be highlighted in this review article. It will also discuss the roles of inflammation and the association of different inflammatory markers in the pathogenesis of PCOS, which may usher in a new era in the treatment approach for PCOS.
    Keywords PCOS ; Inflammation ; Metabolic syndrome ; Hyperandrogenism ; Inflammatory markers ; Medicine (General) ; R5-920 ; Reproduction ; QH471-489
    Subject code 610
    Language English
    Publishing date 2023-12-01T00:00:00Z
    Publisher SpringerOpen
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  2. Article ; Online: Oral pyogenic granuloma

    Suryakanta Narendra / Chaitali Bose / Niranjan Rout

    International Journal of Research in Medical Sciences, Vol 3, Iss 12, Pp 3863-

    one reactive hyperplastic lesion of the gingiva

    2015  Volume 3868

    Abstract: The term pyogenic granuloma refers to a disorder of the skin, oral mucosa and the gingiva, that usually presents as a solitary polypoid capillary hemangioma like growth often resulting from local irritation and trauma. It is manifested as an inflammatory ...

    Abstract The term pyogenic granuloma refers to a disorder of the skin, oral mucosa and the gingiva, that usually presents as a solitary polypoid capillary hemangioma like growth often resulting from local irritation and trauma. It is manifested as an inflammatory response with similar characteristics to those of a granuloma. Different terminologies are used for this lesion by different investigators like, benign vascular tumor of pregnancy, granuloma pediculatum benignum, granuloma pyogenicum, Crocker and hartzells disease. This lesion even if looks like a tumor, is non neoplastic in nature and present itself in various clinical and histological forms. Lack of association of pyogenic etiopathogenesis does not justify the use of terminology of pyogenic granuloma. In this article we are presenting a case series of pyogenic granuloma in different locations giving an insight into their myriad of etiologies and presenting the review of literature for its inclusion as one classified hyperplastic lesion of oral cavity. [Int J Res Med Sci 2015; 3(12.000): 3863-3868]
    Keywords Fibrous hyperplasia ; Peripheral giant cell granuloma ; Peripheral ossifying fibroma ; Pyogenic granuloma ; Reactive hyperplastic lesions ; Medicine (General) ; R5-920 ; Medicine ; R
    Subject code 610
    Language English
    Publishing date 2015-12-01T00:00:00Z
    Publisher Medip Academy
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  3. Article ; Online: Role of anti-Mullerian hormone in polycystic ovary syndrome

    Koushik Bhattacharya / Ishita Saha / Debanjana Sen / Chaitali Bose / Gargi Ray Chaudhuri / Sulagna Dutta / Pallav Sengupta / Soumita Bhattacharya / Sharit Shekhar Barman / Alak Kumar Syamal

    Middle East Fertility Society Journal, Vol 27, Iss 1, Pp 1-

    2022  Volume 10

    Abstract: Abstract Polycystic ovary syndrome (PCOS) is the most common gynecological endocrine disorders affecting up to 10% of all females in their reproductive age, and its cause of onset is still elusive. A spectrum of recent research reflected diverse ... ...

    Abstract Abstract Polycystic ovary syndrome (PCOS) is the most common gynecological endocrine disorders affecting up to 10% of all females in their reproductive age, and its cause of onset is still elusive. A spectrum of recent research reflected diverse associations between increased plasma level of anti-Mullerian hormone (AMH) and different clinical features of PCOS. Since AMH levels reflect the pool of growing follicles that potentially can ovulate, it can be stated that serum AMH levels can be used to assess the “functional ovarian reserve,” rather mentioning it as the “ovarian reserve.” AMH also appears to be a premier endocrine parameter for the assessment of atrophied ovarian follicular pool in response to age of individuals. AMH hinders the follicular development as well as the follicular recruitment and ultimately resulting in follicular arrest which is the key pathophysiologic condition for the onset of PCOS. Furthermore, FSH-induced aromatase activity remains inhibited by AMH that aids emergence of other associated clinical signs of PCOS, such as excess androgen, followed by insulin resistance among the PCOS individuals. Given the versatile association of AMH with PCOS and scarcity in literature explaining the underling mechanisms how AMH relates with PCOS, this review article will discuss the roles of AMH in the pathogenesis of PCOS which may introduce a new era in treatment approach of PCOS.
    Keywords Anti-Mullerian hormone ; Folliculogenesis ; Gonadotropins ; Ovarian reserve ; Polycystic ovary syndrome ; Insulin resistance ; Medicine (General) ; R5-920 ; Reproduction ; QH471-489
    Language English
    Publishing date 2022-10-01T00:00:00Z
    Publisher SpringerOpen
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  4. Article ; Online: Changing spectrum of Zimmerman-Laband syndrome

    Suryakanta Narendra / Surendra nath Senapaty / Chaitali Bose / Deepti Samanta / Dhirendranath Moharana

    International Journal of Research in Medical Sciences, Vol 3, Iss 11, Pp 3402-

    a six years follow up case report of a family

    2015  Volume 3405

    Abstract: The Zimmermann-Laband syndrome (ZLS) is a rare genetic disorder inherited as an autosomal dominant fashion, with clinical characters like, gingival fibromatosis, bulbous soft nose, thick floppy ears, nail dysplasia, joint hyperextensibility, ... ...

    Abstract The Zimmermann-Laband syndrome (ZLS) is a rare genetic disorder inherited as an autosomal dominant fashion, with clinical characters like, gingival fibromatosis, bulbous soft nose, thick floppy ears, nail dysplasia, joint hyperextensibility, hepatosplenomegaly, skeletal anomalies and occasional mental retardation. Idiopathic gingival enlargement is a hereditary condition; it can be expressed as autosomal dominant inheritance. Here association of Idiopathic gingival enlargement has been reported in a family, with an autosomal dominant inheritance diagnosed to be ZLS. Other clinical features associated are, hypertrichosis, bulbous soft nose, thick floppy ears, nail dysplasia, joint hyper extensibility, bimaxillary protrusion and enlarged palm and fingers with flat feet. The unusual clinical presentations of massive gingival fibromatosis, unusual length of upper limbs and bimaxillary protrusion supported the variable spectrum of phenotype expression of the ZLS. The Biopsy report confirmed the diagnosis of gingival fibromatosis. Gingivectomy was carried out in all four quadrants for exposing the natural teeth and to bring back the original contour of the gingiva. But there was recurrence of the enlargement found to be associated during 6 years follow up. [Int J Res Med Sci 2015; 3(11.000): 3402-3405]
    Keywords Autosomal dominant inheritance ; Idiopathic gingival Enlargement ; Zimmerman-Laband syndrome ; Medicine (General) ; R5-920 ; Medicine ; R
    Language English
    Publishing date 2015-11-01T00:00:00Z
    Publisher Medip Academy
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  5. Article ; Online: Clear cell adenocarcinoma of the uterine cervix with malignant pleural effusion in a 29-year old female- A case report

    Dipti R. Samanta / Chaitali Bose / Saikat Sheet / Ashish Upadhyay / Surendra N. Senapati

    International Journal of Research in Medical Sciences, Vol 3, Iss 7, Pp 1795-

    2015  Volume 1797

    Abstract: Primary adenocarcinoma of cervix constitute about 7-15% of all cervical cancer. Clear cell carcinoma, a form of cervical adenocarcinoma is a very rare tumor constituting only 4% of cervical carcinoma. Risk factor and pathogenesis of this disease are not ... ...

    Abstract Primary adenocarcinoma of cervix constitute about 7-15% of all cervical cancer. Clear cell carcinoma, a form of cervical adenocarcinoma is a very rare tumor constituting only 4% of cervical carcinoma. Risk factor and pathogenesis of this disease are not exactly revealed. Intrauterine exposure to diethylstilbestrol and associated non-steroidal estrogen during pregnancy before 18 weeks is the only risk factor. Here we report an unusual case of clear cell carcinoma of cervix presented with bilateral pleural effusion, cytology of which shows adenocarcinoma. This is a rare case since patient had no history of diethylstilbestrol exposure and presented with bilateral pleural effusion. This is the first described case report of clear cell carcinoma of cervix with upfront malignant pleural effusion. [Int J Res Med Sci 2015; 3(7.000): 1795-1797]
    Keywords Cervix ; Clear cell carcinoma ; Pleural effusion ; Medicine (General) ; R5-920 ; Medicine ; R
    Subject code 610
    Language English
    Publishing date 2015-07-01T00:00:00Z
    Publisher Medip Academy
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  6. Article ; Online: Ectopic Male Breast Cancer

    Dipti Rani Samanta / Chaitali Bose / Ashish Upadhyay / Saikat Sheet / Surendra Nath Senapati

    Journal of Clinical and Diagnostic Research, Vol 9, Iss 8, Pp XD08-XD

    A Case Report

    2015  Volume 10

    Abstract: Carcinoma of male breast constitutes 1% of total breast malignancy. Carcinoma arising from ectopic breast tissue in male is an extremely rare entity and can be misdiagnosed. Ectopic breast tissue may be supernumerary or aberrant one. Despite morphologic ... ...

    Abstract Carcinoma of male breast constitutes 1% of total breast malignancy. Carcinoma arising from ectopic breast tissue in male is an extremely rare entity and can be misdiagnosed. Ectopic breast tissue may be supernumerary or aberrant one. Despite morphologic difference, ectopic breast tissue presents characteristics analogous to orthoptic breast in terms of functional and pathologic degeneration. Most of the ectopic breast tissue occurs in thoracic or abdominal portion of milk line. If found in a location outside the milk line, it proves a diagnostic dilemma. We are reporting a case of 60-year-old male who presented with a fixed mass of size 10cm×8cm, in right chest wall infraclavicular area of 6 months duration. Histopathology of the mass revealed invasive duct carcinoma. He had no evidence of malignant or occult primary lesion in the bilateral mammary glands. Due to the paucity of the literature, incidence of ectopic male breast cancer and its management is not well understood. There is high probability of misdiagnosis of this disease. To the best of our knowledge this is the first described case of ectopic male breast cancer in the chest wall, not along the milk line, which is being reported here for documentation.
    Keywords ectopic breast tissue ; chest wall ; supernumerary ; Medicine ; R
    Subject code 616
    Language English
    Publishing date 2015-08-01T00:00:00Z
    Publisher JCDR Research and Publications Private Limited
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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