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Book ; Online: Comparative Philosophy without Borders

Chakrabarti, Arindam / Weber, Ralph

2015

Language	English
Size	Online-Ressource (257 p)
Publisher	Bloomsbury Publishing
Publishing place	London
Document type	Book ; Online
Note	Description based upon print version of record
Database	Library catalogue of the German National Library of Science and Technology (TIB), Hannover

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Article ; Online: The protein kinase R modifies gut physiology to limit colitis.

Yim, Howard Chi Ho / Chakrabarti, Arindam / Kessler, Sean / Morimoto, Hiroyuki / Wang, Die / Sooraj, Dhanya / Ahmed, Afsar U / de la Motte, Carol / Silverman, Robert H / Williams, Bryan Rg / Sadler, Anthony J

Frontiers in immunology

2023 Volume 14, Page(s) 1106737

Abstract: Here we investigate the function of the innate immune molecule protein kinase R (PKR) in intestinal inflammation. To model a colitogenic role of PKR, we determine the physiological response to dextran sulfate sodium (DSS) of wild-type and two transgenic ... ...

Abstract	Here we investigate the function of the innate immune molecule protein kinase R (PKR) in intestinal inflammation. To model a colitogenic role of PKR, we determine the physiological response to dextran sulfate sodium (DSS) of wild-type and two transgenic mice strains mutated to express either a kinase-dead PKR or to ablate expression of the kinase. These experiments recognize kinase-dependent and -independent protection from DSS-induced weight loss and inflammation, against a kinase-dependent increase in the susceptibility to DSS-induced injury. We propose these effects arise through PKR-dependent alteration of gut physiology, evidenced as altered goblet cell function and changes to the gut microbiota at homeostasis that suppresses inflammasome activity by controlling autophagy. These findings establish that PKR functions as both a protein kinase and a signaling molecule in instituting immune homeostasis in the gut.
MeSH term(s)	Animals ; Mice ; Colitis ; Inflammation ; Homeostasis ; Autophagy ; Mice, Transgenic ; Protein Kinases
Chemical Substances	Protein Kinases (EC 2.7.-)
Language	English
Publishing date	2023-02-17
Publishing country	Switzerland
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, N.I.H., Extramural
ZDB-ID	2606827-8
ISSN	1664-3224 ; 1664-3224
ISSN (online)	1664-3224
ISSN	1664-3224
DOI	10.3389/fimmu.2023.1106737
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: A generalized method of estimation of critical exponents through an indigenous susceptometry setup for YBCO materials

Chakrabarti, Arindam / Neogy, Chirantan

Cryogenics. 2013 , v. 55-56

2013

Abstract: The real and imaginary parts of complex susceptibility values of bulk ceramic YBCO materials have been extracted at different frequencies and temperatures by measuring impedances using a single-coil swept-ac method. From these susceptibility components, ... ...

Abstract	The real and imaginary parts of complex susceptibility values of bulk ceramic YBCO materials have been extracted at different frequencies and temperatures by measuring impedances using a single-coil swept-ac method. From these susceptibility components, the ac conductivity and its loss angle have been derived numerically. The dynamic and static critical exponents, z and ν obtained from the scaling of conductivity loss angle based on FFH’s vortex glass (VG) model were found to be in agreement with the values obtained by other workers, in different methods characterizing a continuous phase transition and revealing a stronger correlation in HTS materials. To verify their universality, it has been shown that the exponent values support the scaling features of ac-conductivity (or resistivity) very well and can scale susceptibility also at the proximity of critical temperature. It is highly expected that this simpler and straight forward method of extraction and evaluation of these critical exponents discussed here may be applicable to any other High Temperature Superconductors or other complex materials in bulk form.
Keywords	ceramics ; glass ; models ; phase transition ; temperature
Language	English
Dates of publication	2013-05
Size	p. 35-46.
Publishing place	Elsevier Ltd
Document type	Article
ISSN	0011-2275
DOI	10.1016/j.cryogenics.2013.02.003
Database	NAL-Catalogue (AGRICOLA)

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Article: A bronchial gene signature specific for severe COPD that is retained in the nose.

van Nijnatten, Jos / Faiz, Alen / Timens, Wim / Guryev, Victor / Slebos, Dirk-Jan / Klooster, Karin / Hartman, Jorine E / Kole, Tessa / Choy, David F / Chakrabarti, Arindam / Grimbaldeston, Michele / Rosenberger, Carrie M / Kerstjens, Huib / Brandsma, Corry-Anke / van den Berge, Maarten

ERJ open research

2023 Volume 9, Issue 6

Abstract: Introduction: A subset of COPD patients develops advanced disease with severe airflow obstruction, hyperinflation and extensive emphysema. We propose that the pathogenesis in these patients differs from mild-moderate COPD and is reflected by bronchial ... ...

Abstract	Introduction: A subset of COPD patients develops advanced disease with severe airflow obstruction, hyperinflation and extensive emphysema. We propose that the pathogenesis in these patients differs from mild-moderate COPD and is reflected by bronchial gene expression. The aim of the present study was to identify a unique bronchial epithelial gene signature for severe COPD patients. Methods: We obtained RNA sequencing data from bronchial brushes from 123 ex-smokers with severe COPD, 23 with mild-moderate COPD and 23 non-COPD controls. We identified genes specific to severe COPD by comparing severe COPD to non-COPD controls, followed by removing genes that were also differentially expressed between mild-moderate COPD and non-COPD controls. Next, we performed a pathway analysis on these genes and evaluated whether this signature is retained in matched nasal brushings. Results: We identified 219 genes uniquely differentially expressed in severe COPD. Interaction network analysis identified Conclusions: We found a unique severe COPD bronchial gene signature with key roles for
Language	English
Publishing date	2023-11-27
Publishing country	England
Document type	Journal Article
ZDB-ID	2827830-6
ISSN	2312-0541
ISSN	2312-0541
DOI	10.1183/23120541.00354-2023
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Article: Effective filtering for collaborative publishing

Chakrabarti, Arindam

Internet and network economics : first international workshop, WINE 2005, Hong Kong, China, December 15-17, 2005 ; proceedings , p. 424-433

2005 , Page(s) 424–433

Author's details	Arindam Chakrabarti
Language	English
Size	graph. Darst
Publisher	Springer
Publishing place	Berlin [u.a.]
Document type	Article
Note	Literaturangaben
Database	ECONomics Information System

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Article ; Online: Tailor-made thermoreversible functional polymer via RAFT polymerization in an ionic liquid: a remarkably fast polymerization process

Singha, Nikhil K. / Pramanik, Nabendu B. / Behera, Prasanta K. / Chakrabarti, Arindam / Mays, Jimmy W.

Green chemistry. 2016 Nov. 7, v. 18, no. 22 p.6115-6122

2016

Abstract: Tailor-made poly(furfuryl methacrylate) (PFMA) was prepared via RAFT polymerization of furfuryl methacrylate (FMA) using ionic liquid (IL) as a solvent and 2-cyano-2-propyl dodecyl trithiocarbonate (CPDTC) as a RAFT reagent. The polymerization reaction ... ...

Abstract	Tailor-made poly(furfuryl methacrylate) (PFMA) was prepared via RAFT polymerization of furfuryl methacrylate (FMA) using ionic liquid (IL) as a solvent and 2-cyano-2-propyl dodecyl trithiocarbonate (CPDTC) as a RAFT reagent. The polymerization reaction was much faster in IL than the same reaction carried out in toluene. After the polymerization, the IL was recovered from the reaction mixture and recycled IL was successfully reused for the RAFT polymerization of FMA. The polymers were characterized by GPC, ¹H-NMR and MALDI-TOF-MS analyses. A thermoreversible functional polymer was prepared via the Diels-Alder (DA) and reverse (rDA) reaction between the PFMA and POSS maleimide isobutyl (POSS-M) and was studied by FT-IR and ¹H-NMR analyses. The DA polymer product showed a higher water contact angle (WCA) value of 103.1° reflecting the presence of hydrophobic POSS moieties and demonstrating hydrophobic characteristics of the modified functional polymer.
Keywords	Fourier transform infrared spectroscopy ; contact angle ; cycloaddition reactions ; green chemistry ; hydrophobicity ; ionic liquids ; matrix-assisted laser desorption-ionization mass spectrometry ; moieties ; nuclear magnetic resonance spectroscopy ; polymerization ; polymers ; toluene
Language	English
Dates of publication	2016-1107
Size	p. 6115-6122.
Publishing place	The Royal Society of Chemistry
Document type	Article ; Online
ZDB-ID	2006274-6
ISSN	1463-9270 ; 1463-9262
ISSN (online)	1463-9270
ISSN	1463-9262
DOI	10.1039/c6gc01677d
Database	NAL-Catalogue (AGRICOLA)

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Article: High serum granulocyte-colony stimulating factor characterises neutrophilic COPD exacerbations associated with dysbiosis.

Chakrabarti, Arindam / Mar, Jordan S / Choy, David F / Cao, Yi / Rathore, Nisha / Yang, Xiaoying / Tew, Gaik W / Li, Olga / Woodruff, Prescott G / Brightling, Christopher E / Grimbaldeston, Michele / Christenson, Stephanie A / Bafadhel, Mona / Rosenberger, Carrie M

ERJ open research

2021 Volume 7, Issue 3

Abstract: Introduction: COPD exacerbations are heterogeneous and can be triggered by bacterial, viral, or noninfectious insults. Exacerbations are also heterogeneous in neutrophilic or eosinophilic inflammatory responses. A noninvasive peripheral biomarker of ... ...

Abstract	Introduction: COPD exacerbations are heterogeneous and can be triggered by bacterial, viral, or noninfectious insults. Exacerbations are also heterogeneous in neutrophilic or eosinophilic inflammatory responses. A noninvasive peripheral biomarker of COPD exacerbations characterised by bacterial/neutrophilic inflammation is lacking. Granulocyte-colony stimulating factor (G-CSF) is a key cytokine elevated during bacterial infection and mediates survival, proliferation, differentiation and function of neutrophils. Objective: We hypothesised that high peripheral G-CSF would be indicative of COPD exacerbations with a neutrophilic and bacterial phenotype associated with microbial dysbiosis. Methods: Serum G-CSF was measured during hospitalised exacerbation (day 0 or D0) and after 30 days of recovery (Day30 or D30) in 37 subjects. In a second cohort, serum and sputum cytokines were measured in 59 COPD patients during stable disease, at exacerbation, and at 2-weeks and 6-weeks following exacerbation. Results: Serum G-CSF was increased during exacerbation in a subset of patients. These exacerbations were enriched for bacterial but not viral or type-2 biologies. The median serum G-CSF level was 1.6-fold higher in bacterial exacerbation compared to nonbacterial exacerbation (22 pg·mL Conclusions: High serum G-CSF enriches for COPD exacerbations characterised by neutrophilic inflammation with underlying bacterial dysbiosis.
Language	English
Publishing date	2021-08-02
Publishing country	England
Document type	Journal Article
ZDB-ID	2827830-6
ISSN	2312-0541
ISSN	2312-0541
DOI	10.1183/23120541.00836-2020
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Article ; Online: Serum Lysophosphatidic Acid Measurement by Liquid Chromatography-Mass Spectrometry in COPD Patients.

Li, Qingling / Wong, Weng R / Chakrabarti, Arindam / Birnberg, Andrew / Yang, Xiaoying / Verschueren, Erik / Neighbors, Margaret / Rosenberger, Carrie / Grimbaldeston, Michele / Tew, Gaik W / Sandoval, Wendy

Journal of the American Society for Mass Spectrometry

2021 Volume 32, Issue 8, Page(s) 1987–1997

Abstract: Lysophospholipids are bioactive signaling molecules derived from cell membrane glycerophospholipids or sphingolipids and are highly regulated under normal physiological conditions. Lysophosphatidic acids (LPAs) are a class of lysophospholipids that act ... ...

Abstract	Lysophospholipids are bioactive signaling molecules derived from cell membrane glycerophospholipids or sphingolipids and are highly regulated under normal physiological conditions. Lysophosphatidic acids (LPAs) are a class of lysophospholipids that act on G-protein-coupled receptors to exert a variety of cellular functions. Dysregulation of phospholipase activity and consequently LPA synthesis in serum have been linked to inflammation, such as seen in chronic obstructive pulmonary disease (COPD). The accurate measurement of phospholipids is critical for evaluating their dysregulation in disease. In this study, we optimized experimental parameters for the sensitive measurement of LPAs. We validated the method based on matrix, linearity, accuracy, precision, and stability. An investigation into sample extraction processes emphasized that the common practice of including low concentration of hydrochloric acid in the extraction buffer causes an overestimation of lipid recovery. The liquid chromatography gradient was optimized to separate various lysophospholipid classes. After optimization, detection limits of LPA were sufficiently sensitive for subsequent analysis, ranging from 2 to 8 nM. The validated workflow was applied to a cohort of healthy donor and COPD patient sera. Eight LPA species were identified, and five unique species of LPA were quantified. Most LPA species increased significantly in COPD patients compared to healthy donors. The correlation between LPAs and other demographic parameters was further investigated in a sample set of over 200 baseline patient sera from a COPD clinical trial. For the first time, LPAs other than the two most abundant and readily detectable moieties are quantified in COPD patients using validated methods, opening the door to downstream biomarker evaluation in respiratory disease.
MeSH term(s)	Age Factors ; Aged ; Biomarkers/blood ; Blood Chemical Analysis/methods ; Body Mass Index ; Case-Control Studies ; Chromatography, Liquid/methods ; Cohort Studies ; Female ; Humans ; Limit of Detection ; Lysophospholipids/blood ; Lysophospholipids/isolation & purification ; Male ; Mass Spectrometry/methods ; Middle Aged ; Pulmonary Disease, Chronic Obstructive/blood ; Pulmonary Disease, Chronic Obstructive/etiology ; Reproducibility of Results ; Vital Capacity ; Workflow
Chemical Substances	Biomarkers ; Lysophospholipids ; lysophosphatidic acid (PG6M3969SG)
Language	English
Publishing date	2021-03-23
Publishing country	United States
Document type	Journal Article ; Randomized Controlled Trial
ZDB-ID	1073671-2
ISSN	1879-1123 ; 1044-0305
ISSN (online)	1879-1123
ISSN	1044-0305
DOI	10.1021/jasms.0c00429
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Article ; Online: Lysophosphatidic acid species are associated with exacerbation in chronic obstructive pulmonary disease.

Li, Qingling / Wong, Weng / Birnberg, Andrew / Chakrabarti, Arindam / Yang, Xiaoying / Choy, David F / Olsson, Julie / Verschueren, Erik / Neighbors, Margaret / Sandoval, Wendy / Rosenberger, Carrie M / Grimbaldeston, Michele A / Tew, Gaik W

BMC pulmonary medicine

2021 Volume 21, Issue 1, Page(s) 301

Abstract: Background: Chronic obstructive pulmonary disease (COPD) exacerbations are heterogenous and profoundly impact the disease trajectory. Bioactive lipid lysophosphatidic acid (LPA) has been implicated in airway inflammation but the significance of LPA in ... ...

Abstract	Background: Chronic obstructive pulmonary disease (COPD) exacerbations are heterogenous and profoundly impact the disease trajectory. Bioactive lipid lysophosphatidic acid (LPA) has been implicated in airway inflammation but the significance of LPA in COPD exacerbation is not known. The aim of the study was to investigate the utility of serum LPA species (LPA16:0, 18:0, 18:1, 18:2, 20:4) as biomarkers of COPD exacerbation. Patients and methods: LPA species were measured in the baseline placebo sera of a COPD randomized controlled trial. Tertile levels of each LPA were used to assign patients into biomarker high, medium, and low subgroups. Exacerbation rate and risk were compared among the LPA subgroups. Results: The levels of LPA species were intercorrelated (rho 0.29-0.91). Patients with low and medium levels of LPA (LPA16:0, 20:4) had significantly higher exacerbation rate compared to the respective LPA-high patients [estimated rate per patient per year (95% CI)]: LPA16:0-low = 1.2 (0.8-1.9) (p = 0.019), LPA16:0-medium = 1.3 (0.8-2.0) (p = 0.013), LPA16:0-high = 0.5 (0.2-0.9); LPA20:4-low = 1.4 (0.9-2.1) (p = 0.0033), LPA20:4-medium = 1.2 (0.8-1.8) (p = 0.0089), LPA20:4-high = 0.4 (0.2-0.8). These patients also had earlier time to first exacerbation (hazard ratio (95% CI): LPA16:0-low = 2.6 (1.1-6.0) (p = 0.028), LPA16:0-medium = 2.7 (1.2-6.3) (p = 0.020); LPA20.4-low = 2.8 (1.2-6.6) (p = 0.017), LPA20:4-medium = 2.7 (1.2-6.4) (p = 0.021). Accordingly, these patients had a significant increased exacerbation risk compared to the respective LPA-high subgroups [odd ratio (95% CI)]: LPA16:0-low = 3.1 (1.1-8.8) (p = 0.030), LPA16:0-medium = 3.0 (1.1-8.3) (p = 0.031); LPA20:4-low = 3.8 (1.3-10.9) (p = 0.012), LPA20:4-medium = 3.3 (1.2-9.5) (p = 0.025). For the other LPA species (LPA18:0, 18:1, 18:2), the results were mixed; patients with low and medium levels of LPA18:0 and 18:2 had increased exacerbation rate, but only LPA18:0-low patients had significant increase in exacerbation risk and earlier time to first exacerbation compared to the LPA18:0-high subgroup. Conclusions: The study provided evidence of association between systemic LPA levels and exacerbation in COPD. Patients with low and medium levels of specific LPA species (LPA16:0, 20:4) had increased exacerbation rate, risk, and earlier time to first exacerbation. These non-invasive biomarkers may aid in identifying high risk patients with dysregulated LPA pathway to inform risk management and drug development.
MeSH term(s)	Aged ; Biomarkers/blood ; Disease Progression ; Female ; Humans ; Logistic Models ; Lysophospholipids/blood ; Male ; Middle Aged ; Proportional Hazards Models ; Pulmonary Disease, Chronic Obstructive/blood ; Pulmonary Disease, Chronic Obstructive/physiopathology ; Randomized Controlled Trials as Topic ; Severity of Illness Index
Chemical Substances	Biomarkers ; Lysophospholipids ; lysophosphatidic acid (PG6M3969SG)
Language	English
Publishing date	2021-09-23
Publishing country	England
Document type	Journal Article
ZDB-ID	2059871-3
ISSN	1471-2466 ; 1471-2466
ISSN (online)	1471-2466
ISSN	1471-2466
DOI	10.1186/s12890-021-01670-9
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Article ; Online: Exercise-induced alterations in phospholipid hydrolysis, airway surfactant, and eicosanoids and their role in airway hyperresponsiveness in asthma.

Murphy, Ryan C / Lai, Ying / Nolin, James D / Aguillon Prada, Robier A / Chakrabarti, Arindam / Novotny, Michael V / Seeds, Michael C / Altemeier, William A / Gelb, Michael H / Hite, Robert Duncan / Hallstrand, Teal S

American journal of physiology. Lung cellular and molecular physiology

2021 Volume 320, Issue 5, Page(s) L705–L714

Abstract: The mechanisms responsible for driving endogenous airway hyperresponsiveness (AHR) in the form of exercise-induced bronchoconstriction (EIB) are not fully understood. We examined alterations in airway phospholipid hydrolysis, surfactant degradation, and ... ...

Abstract	The mechanisms responsible for driving endogenous airway hyperresponsiveness (AHR) in the form of exercise-induced bronchoconstriction (EIB) are not fully understood. We examined alterations in airway phospholipid hydrolysis, surfactant degradation, and lipid mediator release in relation to AHR severity and changes induced by exercise challenge. Paired induced sputum (
MeSH term(s)	Adolescent ; Adult ; Asthma/complications ; Bronchoconstriction ; Eicosanoids/metabolism ; Exercise ; Female ; Group X Phospholipases A2/metabolism ; Humans ; Hydrolysis ; Male ; Osmotic Pressure ; Phospholipids/metabolism ; Respiratory Hypersensitivity/etiology ; Respiratory Hypersensitivity/metabolism ; Respiratory Hypersensitivity/pathology ; Sputum ; Surface-Active Agents/metabolism ; Young Adult
Chemical Substances	Eicosanoids ; Phospholipids ; Surface-Active Agents ; Group X Phospholipases A2 (EC 3.1.1.4) ; PLA2G10 protein, human (EC 3.1.1.4)
Language	English
Publishing date	2021-02-03
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural
ZDB-ID	1013184-x
ISSN	1522-1504 ; 1040-0605
ISSN (online)	1522-1504
ISSN	1040-0605
DOI	10.1152/ajplung.00546.2020
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