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Article ; Online: Overview of diagnostics on a small-scale RF source for fusion (ROBIN) and the one planned for the diagnostic beam for ITER.

Bandyopadhyay, M / Singh, M J / Pandya, K / Bhuyan, M / Tyagi, H / Bharathi, P / Shah, Sejal / Chakraborty, A K

2022 Volume 93, Issue 2, Page(s) 23504

Abstract: India is responsible for the supply of diagnostic neutral beam systems for ITER to diagnose its helium ash during the deuterium-tritium plasma phase using the charge exchange recombination spectroscopy technique. Considering the many first of its kind in ...

Abstract	India is responsible for the supply of diagnostic neutral beam systems for ITER to diagnose its helium ash during the deuterium-tritium plasma phase using the charge exchange recombination spectroscopy technique. Considering the many first of its kind in terms of technologies and beam development aspects, ITER Indian domestic agency has adopted a strategy of developing the technology and beam experimentation in parallel. On the beam development front three test beds, namely, the ROBIN (Rf Operated Beam source in India for Negative ion research), the TWIN (TWo rf driver-based Indigenously built Negative ion source), and the INTF (INdian Test Facility) are presently in their various phases of operation, optimization, and setting up at IPR, respectively. Experiments related to plasma production, beam production, and acceleration up to 30 keV in volume and surface mode have been performed on ROBIN. The maximum negative hydrogen ion current density to a tune of 27 mA/cm
Language	English
Publishing date	2022-03-01
Publishing country	United States
Document type	Journal Article
ZDB-ID	209865-9
ISSN	1089-7623 ; 0034-6748
ISSN (online)	1089-7623
ISSN	0034-6748
DOI	10.1063/5.0076009
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Article: Epidemiology of tuberculosis: current status in India.

Chakraborty, A K

The Indian journal of medical research

2004 Volume 120, Issue 4, Page(s) 248–276

Abstract: India is classified along with the sub-Saharan African countries to be among those with a high burden and the least prospects of a favourable time trend of the disease as of now (Group IV countries). The average prevalence of all forms of tuberculosis in ...

Abstract	India is classified along with the sub-Saharan African countries to be among those with a high burden and the least prospects of a favourable time trend of the disease as of now (Group IV countries). The average prevalence of all forms of tuberculosis in India is estimated to be 5.05 per thousand, prevalence of smear-positive cases 2.27 per thousand and average annual incidence of smear-positive cases at 84 per 1,00,000 annually. The credibility and use of the estimates are discussed in detail. Reports on recent studies on the time trend of the disease from some areas in India, e.g., Chingleput in Tamil Nadu are discussed. They confirm the slow downward trend over a fairly long period of observation, as in the rural areas around Bangalore. It also outlines the serious escalation of disease burden in a tribal population group in Car Nicobar over a period 1986-2002, and highlights the nature and extent of the emerging threats. Some epidemiologists forecast a rise of 20 per cent in incidence in the next 20 yr, for India, with a cumulative rise of 46 million cases of tuberculosis during that period, largely as a consequence of HIV epidemic. The Governmental efforts at intervention through Revised National Tuberculosis Control Programme (RNTCP) and at monitoring the epidemiology of intervention through organising routine reporting are highlighted, and data are presented and evaluated on these. RNTCP needs to be used as an effective instrument to bring a change in epidemiological situation, through fast expansion and achievement of global target. The present review describes the global tuberculosis situation, and views it in the context of the goal of the antituberculosis intervention activities. It presents the epidemiological situation in India, comments on the current trend and discusses the efforts taken towards making projections on the likely burden of disease in India over time.
MeSH term(s)	AIDS-Related Opportunistic Infections/epidemiology ; Demography ; Forecasting ; HIV Infections/epidemiology ; Humans ; India/epidemiology ; Models, Theoretical ; Prevalence ; Tuberculosis/epidemiology ; Tuberculosis/prevention & control
Language	English
Publishing date	2004-10
Publishing country	India
Document type	Journal Article ; Review
ZDB-ID	390883-5
ISSN	0971-5916 ; 0019-5340
ISSN	0971-5916 ; 0019-5340
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Article: Si-incorporated alumina phases formed out of diphasic mullite gels

Chakraborty, A. K

Journal of materials science. 2008 Aug., v. 43, no. 15

2008

Abstract: The diphasic mullite gel forms o-mullite on heating via intermediate spinel phase. Characterization of the latter phase with various physico-chemical techniques is concisely reviewed. It is noticeable that XRD intensity of both the amorphous scattering ... ...

Abstract	The diphasic mullite gel forms o-mullite on heating via intermediate spinel phase. Characterization of the latter phase with various physico-chemical techniques is concisely reviewed. It is noticeable that XRD intensity of both the amorphous scattering band and the diffraction peak of Al–Si spinel phase changes during each step of transformation processes of diphasic gel. Accordingly, the integrated area of the intensity peak of amorphous band and that of Al–Si spinel phase generated during heating diphasic gels were measured by XRD technique with the help of X’Pert Graphics and Profit softwares. The amount of free SiO₂ (A) content present at various stages of heating diphasic gels was estimated by classical alkali leaching study standardized earlier. The results show that diphasic gel which forms an aluminosilicate (A) phase initially by dehydration and dehydroxylation, subsequently crystallizes to Al–Si spinel phase. In consequence, the ratio of XRD peak of spinal phase to that of amorphous band increases in the temperature range of 600–1000 °C. This study confirms the earlier view of incorporation of silica into the alumina structure with formation of Al–Si spinal phase. Complementary alkali leaching study indicates the existence of non-crystalline silica-rich aluminous phase other than free non-crystalline silica during heating diphasic gel at ~1000 °C.
Keywords	X-ray diffraction ; aluminum ; aluminum oxide ; gels ; heat ; leaching ; phase transition ; silica ; silicon ; temperature
Language	English
Dates of publication	2008-08
Size	p. 5313-5324.
Publishing place	Springer US
Document type	Article
ZDB-ID	2015305-3
ISSN	1573-4803 ; 0022-2461
ISSN (online)	1573-4803
ISSN	0022-2461
DOI	10.1007/s10853-008-2775-y
Database	NAL-Catalogue (AGRICOLA)

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Article: Identification of microsatellite length polymorphism by a polymerase chain reaction-based assay at IL-1beta gene locus in cancer cells.

Chakraborty, A K

Cancer letters

2000 Volume 157, Issue 1, Page(s) 93–97

Abstract: It has long been considered that genetic instability is an integral component of human neoplasia, however the frequency of microsatellite instability in human melanoma and non-melanoma skin cancer was less evidenced. We report here an alteration at the ... ...

Abstract	It has long been considered that genetic instability is an integral component of human neoplasia, however the frequency of microsatellite instability in human melanoma and non-melanoma skin cancer was less evidenced. We report here an alteration at the complex dinucleotide repeat (TC)n sequence in the interleukin 1-beta gene locus by polymerase chain reaction (PCR)-based assay in mouse melanoma as well as in various cancer cells, which may provide a simple, rapid, non-radioactive screening assay for cancer detection.
MeSH term(s)	Animals ; DNA/genetics ; DNA, Neoplasm/genetics ; Interleukin-1/genetics ; Lymphoma/genetics ; Macrophages, Peritoneal/chemistry ; Macrophages, Peritoneal/metabolism ; Mammary Neoplasms, Experimental/genetics ; Melanoma, Experimental/genetics ; Mice ; Mice, Inbred DBA ; Microsatellite Repeats/genetics ; Polymerase Chain Reaction ; Polymorphism, Genetic/genetics
Chemical Substances	DNA, Neoplasm ; Interleukin-1 ; DNA (9007-49-2)
Language	English
Publishing date	2000-08-31
Publishing country	Ireland
Document type	Journal Article
ZDB-ID	195674-7
ISSN	1872-7980 ; 0304-3835
ISSN (online)	1872-7980
ISSN	0304-3835
DOI	10.1016/s0304-3835(00)00475-4
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Article: Canine parvovirus infection in immunized and non-immunized diarrhoeic dogs

Deka, Devajani / Phukan, A. / Sarma, D.K. / Chakraborty, A.K. / Das, Sutopa

Indian journal of veterinary pathology. 2015 June 1, v. 39, no. 2

2015

Abstract: Vaccination is the ideal and cost effective method to control the canine parvoviralgastroenteritis and both live attenuated and killed vaccines are available to control the disease in dogs. Inspite of wide spread vaccination practice, the disease has ... ...

Abstract	Vaccination is the ideal and cost effective method to control the canine parvoviralgastroenteritis and both live attenuated and killed vaccines are available to control the disease in dogs. Inspite of wide spread vaccination practice, the disease has been reported in both vaccinated and unvaccinated dogs. Canine parvovirus (CPV) infection was tested in faecal and serum samples of 178 diarrhoeic dogs from Kamrup district of Assam by using ELISA. The CPV infection was recorded as 9.52% in vaccinated and 30.15% in unvaccinated dogs by sandwich ELISA with case fatality rate of 17.78%. Indirect ELISA detected 66.67% vaccinated and 33.82% unvaccinated dogs sero-positive against CPV and the antibody levels ranged from 1.00 to 2.806 with higher level of antibody in unvaccinated dogs than vaccinated dogs, which suggested the strong boosting of immunity following natural infection. The high rate of infections in both vaccinated and unvaccinated dogs indicated the need of detailed study of the field strains of the virus which may probably differ from the present vaccine strain.
Keywords	Carnivore protoparvovirus 1 ; animal pathology ; antibodies ; blood serum ; cost effectiveness ; dogs ; enzyme-linked immunosorbent assay ; immunity ; live vaccines ; mortality ; seroprevalence ; vaccination ; viruses ; India
Language	English
Dates of publication	2015-0601
Size	p. 125-128.
Publishing place	Indian Association of Veterinary Pathologists
Document type	Article
ISSN	0973-970X
DOI	10.5958/0973-970X.2015.00029.2
Database	NAL-Catalogue (AGRICOLA)

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Book: Expansion of the tuberculosis programme in India

Chakraborty, A. K

the policy evolution towards decentralization and integration (including a highlight on related research issues)

2003

Institution	Centre for Health Research and Development (India) Maharashtra Association of Anthropological Sciences
Author's details	by A.K. Chakraborty
MeSH term(s)	Tuberculosis, Pulmonary/prevention & control ; Program Development ; Health Policy
Keywords	India
Language	English
Size	66 p. :, ill.
Publisher	Centre for Health Research and Development ; Maharashtra Association of Anthropological Sciences
Publishing place	Maharashtra, India
Document type	Book
Note	"February 2003."
Database	Catalogue of the US National Library of Medicine (NLM)

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Article ; Online: Identification of a novel cluster of PCV2 isolates from Meghalaya, India indicates possible recombination along with changes in capsid protein.

Mukherjee, P / Karam, A / Chakraborty, A K / Baruah, S / Pegu, R / Das, S / Milton, A A P / Puro, K / Sanjukta, R / Ghatak, S / Shakuntala, I / Laha, R G / Sen, A

Infection, genetics and evolution : journal of molecular epidemiology and evolutionary genetics in infectious diseases

2019 Volume 71, Page(s) 7–15

Abstract: Documentation of the emergence of Porcine circovirus 2 (PCV2) infection and economic losses incurred due to high mortality has been reported worldwide. The prevalence and genetic diversity of the virus has been reported in Northeast India including the ... ...

Abstract	Documentation of the emergence of Porcine circovirus 2 (PCV2) infection and economic losses incurred due to high mortality has been reported worldwide. The prevalence and genetic diversity of the virus has been reported in Northeast India including the possible chances of Classical swine fever virus (CSFV) vaccine failure in pig population in this region resulting in major disease outbreak. Irrespective of the genetic variability, the emergence of a novel cluster (based on the ORF2 phylogeny) was reported last year. The present study describes a state-wide (Meghalaya, India) molecular epidemiological investigation of PCV2 strains in pig population by amplification, sequencing and undertaking phylogenetic analyses. The results indicate the identification of a novel cluster of PCV2 originating from the inter-genotypic recombination between PCV2c and PCV2d. Multiple sequence alignment of amino acids indicates possible substitution in the A, B and C domains of the capsid protein. Molecular structural modelling of the capsid protein of PCV2 indicated possible motif variations in the secondary structure including presence of a tunnel, encountered at the interface region on each chain facilitating in transportation of molecules and acting as an active site for attachment and penetration. The baseline data strengthens the existing control programme of PCV2 and is possibly helpful in the planning of active surveillance strategy in this region.
MeSH term(s)	Animals ; Capsid Proteins/genetics ; Circoviridae Infections/epidemiology ; Circoviridae Infections/veterinary ; Circoviridae Infections/virology ; Circovirus/genetics ; Genetic Variation ; India/epidemiology ; Models, Molecular ; Molecular Epidemiology ; Phylogeny ; Recombination, Genetic ; Swine ; Swine Diseases/epidemiology ; Swine Diseases/virology
Chemical Substances	Capsid Proteins
Language	English
Publishing date	2019-02-23
Publishing country	Netherlands
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2037068-4
ISSN	1567-7257 ; 1567-1348
ISSN (online)	1567-7257
ISSN	1567-1348
DOI	10.1016/j.meegid.2019.02.026
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Article: Drugs are not enough: the dynamics of antituberculosis treatment in India.

Chakraborty, A K

Tubercle and lung disease : the official journal of the International Union against Tuberculosis and Lung Disease

1994 Volume 75, Issue 4, Page(s) 316–318

MeSH term(s)	Humans ; India ; National Health Programs ; Patient Compliance ; Program Evaluation ; Tuberculosis/drug therapy
Language	English
Publishing date	1994-08
Publishing country	Scotland
Document type	Comment ; Letter
ZDB-ID	1108019-x
ISSN	0962-8479
ISSN	0962-8479
DOI	10.1016/0962-8479(94)90140-6
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Article: Dr. B.C. Das Gupta Oration Address. AIDS--a challenge to public health in India.

Chakraborty, A K

Indian journal of public health

1993 Volume 37, Issue 3, Page(s) 72–76

MeSH term(s)	Acquired Immunodeficiency Syndrome/epidemiology ; Acquired Immunodeficiency Syndrome/prevention & control ; Acquired Immunodeficiency Syndrome/transmission ; Adult ; Child ; Female ; Global Health ; Humans ; India/epidemiology ; Male ; Population Surveillance ; Public Health
Language	English
Publishing date	1993-07
Publishing country	India
Document type	Journal Article
ZDB-ID	800737-8
ISSN	2229-7693 ; 0019-557X
ISSN (online)	2229-7693
ISSN	0019-557X
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Article: GnT-V, macrophage and cancer metastasis: a common link.

Chakraborty, A K / Pawelek, J M

Clinical & experimental metastasis

2003 Volume 20, Issue 4, Page(s) 365–373

Abstract: GnT-V generated, beta1,6-branched polylactosamines are a common feature shared by normal granulocytes, monocytes, and a variety of malignant cells. Furthermore, activation of GnT-V in oncogenic transformation induces invasiveness and metastatic potential ...

Abstract	GnT-V generated, beta1,6-branched polylactosamines are a common feature shared by normal granulocytes, monocytes, and a variety of malignant cells. Furthermore, activation of GnT-V in oncogenic transformation induces invasiveness and metastatic potential in mice as well as in humans. In view of the common expression of lymphocytic/monocytic trait, motility, and GnT-V by metastatic cancer cells, macrophage fusion hybrids were generated in vitro with Cloudman S91 mouse melanoma cells to test whether the parental traits are co-expressed in hybrids and how those are related to altered phenotypes in relation to metastasis. In fact, the fusion hybrids are highly metastatic in vivo, motile in vitro, and express macrophage-associated traits of increased GnT-V activity, beta1,6 branching, and polylactosamine content. A Spontaneously formed lung melanoma metastases have been identified and characterized as host x tumor hybrid containing higher DNA content than parental cells and increased GnT-V activity. The results, taken together, could reflect prior fusion of tumor-associated macrophages with cells of the primary tumor, and therefore establish a possible common link between elevated expression of GnT-V and malignant transformation, a well-known report. Moreover, the fusion hybrids with metastatic potential ranging from high to low offer a genetically matched model system, for identification and characterization of differentially expressed genes in association with metastasis, since the fusion partners are derived from the same species of mouse (DBA/2J).
MeSH term(s)	Animals ; Cell Transformation, Neoplastic ; Humans ; Hybrid Cells ; Macrophages/metabolism ; Mice ; N-Acetylglucosaminyltransferases/physiology ; Neoplasm Metastasis/pathology ; Neoplasms/metabolism
Chemical Substances	N-Acetylglucosaminyltransferases (EC 2.4.1.-) ; alpha-1,6-mannosylglycoprotein beta 1,6-N-acetylglucosaminyltransferase (EC 2.4.1.155)
Language	English
Publishing date	2003-12-02
Publishing country	Netherlands
Document type	Journal Article ; Review
ZDB-ID	604952-7
ISSN	0262-0898
ISSN	0262-0898
DOI	10.1023/a:1024007915938
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