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  1. Article: Emerging Therapies for Hepatocellular Carcinoma (HCC).

    Chakraborty, Eesha / Sarkar, Devanand

    Cancers

    2022  Volume 14, Issue 11

    Abstract: Hepatocellular carcinoma (HCC) arises from hepatocytes and accounts for 90% of primary liver cancer. According to Global Cancer Incidence, Mortality and Prevalence (GLOBOCAN) 2020, globally HCC is the sixth most common cancer and the third most common ... ...

    Abstract Hepatocellular carcinoma (HCC) arises from hepatocytes and accounts for 90% of primary liver cancer. According to Global Cancer Incidence, Mortality and Prevalence (GLOBOCAN) 2020, globally HCC is the sixth most common cancer and the third most common cause of cancer-related deaths. Reasons for HCC prognosis remaining dismal are that HCC is asymptomatic in its early stages, leading to late diagnosis, and it is markedly resistant to conventional chemo- and radiotherapy. Liver transplantation is the treatment of choice in early stages, while surgical resection, radiofrequency ablation (RFA) and trans arterial chemoembolization (TACE) are Food and Drug Administration (FDA)-approved treatments for advanced HCC. Additional first line therapy for advanced HCC includes broad-spectrum tyrosine kinase inhibitors (TKIs), such as sorafenib and lenvatinib, as well as a combination of immunotherapy and anti-angiogenesis therapy, namely atezolizumab and bevacizumab. However, these strategies provide nominal extension in the survival curve, cause broad spectrum toxic side effects, and patients eventually develop therapy resistance. Some common mutations in HCC, such as in telomerase reverse transcriptase (
    Language English
    Publishing date 2022-06-04
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2527080-1
    ISSN 2072-6694
    ISSN 2072-6694
    DOI 10.3390/cancers14112798
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: BRD4 Inhibition as a Strategy to Prolong the Response to Standard of Care in Estrogen Receptor-Positive Breast Cancer.

    Elshazly, Ahmed M / Sinanian, Melanie M / Neely, Victoria / Chakraborty, Eesha / Alshehri, Muruj A / McGrath, Michael K / Harada, Hisashi / Schoenlein, Patricia V / Gewirtz, David A

    Cancers

    2023  Volume 15, Issue 16

    Abstract: Breast cancer is the most commonly occurring malignancy in women and the second most common cause of cancer-related deaths. ... ...

    Abstract Breast cancer is the most commonly occurring malignancy in women and the second most common cause of cancer-related deaths. ER
    Language English
    Publishing date 2023-08-11
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2527080-1
    ISSN 2072-6694
    ISSN 2072-6694
    DOI 10.3390/cancers15164066
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article: The Combination of Radiation with PARP Inhibition Enhances Senescence and Sensitivity to the Senolytic, Navitoclax, in Triple Negative Breast Tumor Cells.

    Softah, Abrar / Alotaibi, Moureq R / Alhoshani, Ali R / Saleh, Tareq / Alhazzani, Khalid / Almutairi, Mashal M / AlRowis, Raed / Alshehri, Samiyah / Albekairy, Norah A / Harada, Hisashi / Boyd, Rowan / Chakraborty, Eesha / Gewirtz, David A / As Sobeai, Homood M

    Biomedicines

    2023  Volume 11, Issue 11

    Abstract: Despite significant advances in the treatment of triple-negative breast cancer, this disease continues to pose a clinical challenge, with many patients ultimately suffering from relapse. Tumor cells that recover after entering into a state of senescence ... ...

    Abstract Despite significant advances in the treatment of triple-negative breast cancer, this disease continues to pose a clinical challenge, with many patients ultimately suffering from relapse. Tumor cells that recover after entering into a state of senescence after chemotherapy or radiation have been shown to develop a more aggressive phenotype, and to contribute to disease recurrence. By combining the PARP inhibitor (PARPi), talazoparib, with radiation, senescence was enhanced in 4T1 and MDA-MB-231 triple-negative breast cancer cell lines (based on SA-β-gal upregulation, increased expression of
    Language English
    Publishing date 2023-11-16
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2720867-9
    ISSN 2227-9059
    ISSN 2227-9059
    DOI 10.3390/biomedicines11113066
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Altered virulence potential of Salmonella Enteritidis cultured in different foods: A cumulative effect of differential gene expression and immunomodulation.

    Jaiswal, Sangeeta / Sahoo, Prakash Kumar / Ryan, Daniel / Das, Jugal Kishore / Chakraborty, Eesha / Mohakud, Nirmal Kumar / Suar, Mrutyunjay

    International journal of food microbiology

    2016  Volume 230, Page(s) 64–72

    Abstract: Salmonella enterica serovars Enteritidis (S. Enteritidis) is one of the most common causes of food borne illness. Bacterial growth environment plays an important role in regulating gene expression thereby affecting the virulence profile of the bacteria. ... ...

    Abstract Salmonella enterica serovars Enteritidis (S. Enteritidis) is one of the most common causes of food borne illness. Bacterial growth environment plays an important role in regulating gene expression thereby affecting the virulence profile of the bacteria. Different foods present diverse growth conditions which may affect the pathogenic potential of the bacteria. In the present study, the effect of food environments on the pathogenic potential of S. Enteritidis has been evaluated. S. Enteritidis was grown in different foods e.g. egg white, peanut butter and milk, and virulent phenotypes were compared to those grown in Luria Bertani broth. In-vivo experiments in C57BL/6 mice revealed S. Enteritidis grown in egg white did not induce significant (p<0.001) production of proinflammatory cytokines in mice and were unable to cause colitis despite efficient colonization in cecum, mesenteric lymph node, spleen and liver. Further studies revealed that bacteria grown in LB activated MAP Kinase and NFκB pathways efficiently, while those grown in egg white poorly activated the above pathways which can account for the decreased production of proinflammatory cytokines. qRT PCR analysis revealed SPI-1 effectors were downregulated in bacteria grown in egg white. Interestingly, bacteria grown in egg white showed reversal of phenotype upon change in growth media to LB. Additionally, bacteria grown in milk and peanut butter showed different degrees of virulence in mice as compared to those grown in LB media. Thus, the present study demonstrates that, S. Enteritidis grown in egg white colonizes systemic sites without causing colitis in a mouse model, while bacteria grown in milk and peanut butter show different pathogenicity profiles suggesting that food environments significantly affect the pathogenicity of S. Enteritidis.
    MeSH term(s) Animals ; Arachis/microbiology ; Cecum/microbiology ; Chickens ; Colitis/microbiology ; Egg White/microbiology ; Foodborne Diseases/microbiology ; Immunomodulation ; Mice ; Mice, Inbred C57BL ; Milk/microbiology ; Peptides/metabolism ; Salmonella Infections, Animal/microbiology ; Salmonella enteritidis/genetics ; Salmonella enteritidis/pathogenicity ; Virulence/genetics ; Virulence Factors/genetics
    Chemical Substances Peptides ; Virulence Factors ; lambda Spi-1 (129712-62-5)
    Language English
    Publishing date 2016-08-02
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 87122-9
    ISSN 1879-3460 ; 0168-1605
    ISSN (online) 1879-3460
    ISSN 0168-1605
    DOI 10.1016/j.ijfoodmicro.2016.04.012
    Database MEDical Literature Analysis and Retrieval System OnLINE

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