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Article ; Online: Red emitting fluorogenic dye as an efficient turn-on probe for milk allergen.

Chakraborty, Goutam

International journal of biological macromolecules

2022 Volume 221, Page(s) 1527–1535

Abstract: Development of simple, fast and non-destructive technique such as fluorescence based method for the quantification of milk allergens in various dairy products is a highly rewarding task. In this contribution, a red emitting fluorogenic dye, quinaldine ... ...

Abstract	Development of simple, fast and non-destructive technique such as fluorescence based method for the quantification of milk allergens in various dairy products is a highly rewarding task. In this contribution, a red emitting fluorogenic dye, quinaldine red (QR) is reported for the detection and quantification of a milk allergen, beta lactoglobulin (β-LG) in milk and whey matrices, utilizing its high selectivity and sensitivity towards β-LG. Detail spectroscopic investigation reveals that binding of QR to the hydrophobic calyx site of β-LG protein substantially reduces the torsional agility and propensity of TICT state formation of QR, rendering the dye highly fluorescent in nature. This enables estimation of β-LG with LOD 52.1(±0.9) nM in buffer solution and 0.21(±0.01) μM in 5 % bovine milk matrix respectively. Additionally, high selectivity and sensitivity, excellent repeatability, quick response, and emission in the biologically favorable red spectral region make QR based fluorometric quantification of β-LG a highly attractive choice. Finally, the estimated β-LG concentrations in milk and whey matrices from fluorometric titration and densitometry methods are found to match excellently with each other, suggesting potential of QR as an efficient turn-on fluorescent probe for the quantification of β-LG (milk allergen) in various dairy products.
MeSH term(s)	Animals ; Milk/chemistry ; Allergens/chemistry ; Lactoglobulins/chemistry ; Whey Proteins ; Fluorescent Dyes
Chemical Substances	Allergens ; Lactoglobulins ; Whey Proteins ; Fluorescent Dyes
Language	English
Publishing date	2022-09-16
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	282732-3
ISSN	1879-0003 ; 0141-8130
ISSN (online)	1879-0003
ISSN	0141-8130
DOI	10.1016/j.ijbiomac.2022.09.130
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Article: Red emitting fluorogenic dye as an efficient turn-on probe for milk allergen

Chakraborty, Goutam

International journal of biological macromolecules. 2022 Nov. 30, v. 221

2022

Abstract	Development of simple, fast and non-destructive technique such as fluorescence based method for the quantification of milk allergens in various dairy products is a highly rewarding task. In this contribution, a red emitting fluorogenic dye, quinaldine red (QR) is reported for the detection and quantification of a milk allergen, beta lactoglobulin (β-LG) in milk and whey matrices, utilizing its high selectivity and sensitivity towards β-LG. Detail spectroscopic investigation reveals that binding of QR to the hydrophobic calyx site of β-LG protein substantially reduces the torsional agility and propensity of TICT state formation of QR, rendering the dye highly fluorescent in nature. This enables estimation of β-LG with LOD 52.1(±0.9) nM in buffer solution and 0.21(±0.01) μM in 5 % bovine milk matrix respectively. Additionally, high selectivity and sensitivity, excellent repeatability, quick response, and emission in the biologically favorable red spectral region make QR based fluorometric quantification of β-LG a highly attractive choice. Finally, the estimated β-LG concentrations in milk and whey matrices from fluorometric titration and densitometry methods are found to match excellently with each other, suggesting potential of QR as an efficient turn-on fluorescent probe for the quantification of β-LG (milk allergen) in various dairy products.
Keywords	allergens ; calyx ; densitometry ; fluorescence ; fluorescent dyes ; fluorometry ; hydrophobicity ; milk ; nondestructive methods ; spectral analysis ; titration ; whey
Language	English
Dates of publication	2022-1130
Size	p. 1527-1535.
Publishing place	Elsevier B.V.
Document type	Article
ZDB-ID	282732-3
ISSN	1879-0003 ; 0141-8130
ISSN (online)	1879-0003
ISSN	0141-8130
DOI	10.1016/j.ijbiomac.2022.09.130
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Article ; Online: Surfactant-based supramolecular dye assembly: A highly selective and economically viable platform for quantification of heparin antidote.

Sarkar, Soumyadeep / Chakraborty, Goutam / Pal, Haridas

Colloids and surfaces. B, Biointerfaces

2024 Volume 237, Page(s) 113839

Abstract: Herein, we have employed a supramolecular assembly of a cationic dye, LDS-698 and a common surfactant sodium dodecyl sulfate (SDS) as a turn-on fluorescent sensor for protamine (Pr) detection. Addition of cationic Pr to the solution of dye-surfactant ... ...

Abstract	Herein, we have employed a supramolecular assembly of a cationic dye, LDS-698 and a common surfactant sodium dodecyl sulfate (SDS) as a turn-on fluorescent sensor for protamine (Pr) detection. Addition of cationic Pr to the solution of dye-surfactant complex brings negatively charged SDS molecules together through strong electrostatic interaction, assisting aggregation of SDS way before its critical micellar concentration (CMC). These aggregates encapsulate the dye molecules within their hydrophobic region, arresting non-radiative decay channels of the excited dye. Thus, the LDS-698•SDS assembly displays substantial enhancement in fluorescence intensity that follows a nice linear trend with Pr concentration, providing limit of detection (LOD) for Pr as low as 3.84(±0.11) nM in buffer, 124.4(±6.7) nM in 1% human serum and 28.3(±0.5) nM in 100% human urine. Furthermore, high selectivity, low background signal, large stokes shift, and emission in the biologically favorable deep-red region make the studied assembly a promising platform for Pr sensing. As of our knowledge it is the first ever Pr sensory platform, using a very common surfactant (SDS), which is economically affordable and very easily available in the market. This innovative approach can replace the expensive, exotic and specialized chemicals considered for the purpose and thus showcase its potential in practical applications.
MeSH term(s)	Humans ; Surface-Active Agents/chemistry ; Antidotes ; Heparin ; Sodium Dodecyl Sulfate/chemistry ; Pulmonary Surfactants ; Cations/chemistry
Chemical Substances	Surface-Active Agents ; Antidotes ; Heparin (9005-49-6) ; Sodium Dodecyl Sulfate (368GB5141J) ; Pulmonary Surfactants ; Cations
Language	English
Publishing date	2024-03-12
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	1500523-9
ISSN	1873-4367 ; 0927-7765
ISSN (online)	1873-4367
ISSN	0927-7765
DOI	10.1016/j.colsurfb.2024.113839
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Article ; Online: Epigenetic mechanisms underlying subtype heterogeneity and tumor recurrence in prostate cancer.

Chakraborty, Goutam / Gupta, Kasmira / Kyprianou, Natasha

Nature communications

2023 Volume 14, Issue 1, Page(s) 567

MeSH term(s)	Male ; Humans ; Neoplasm Recurrence, Local/genetics ; Neoplasm Recurrence, Local/pathology ; Prostatic Neoplasms/genetics ; Prostatic Neoplasms/pathology ; Epigenesis, Genetic
Language	English
Publishing date	2023-02-02
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, N.I.H., Extramural ; Research Support, U.S. Gov't, Non-P.H.S.
ZDB-ID	2553671-0
ISSN	2041-1723 ; 2041-1723
ISSN (online)	2041-1723
ISSN	2041-1723
DOI	10.1038/s41467-023-36253-1
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Article ; Online: Polymer-mediated tuning of the monomer-aggregate equilibrium of a coumarin derivative for ratiometric sensing of protamine.

Mal, Dibya Kanti / Chittela, Rajani Kant / Chakraborty, Goutam

Organic & biomolecular chemistry

2023 Volume 21, Issue 24, Page(s) 5079–5089

Abstract: Amongst the various existing methods of analyte quantification, fluorescent-based methods, especially the ratiometric methods, continue to gain significant attention due to their high reproducibility, low environmental influence, and self-calibrating ... ...

Abstract	Amongst the various existing methods of analyte quantification, fluorescent-based methods, especially the ratiometric methods, continue to gain significant attention due to their high reproducibility, low environmental influence, and self-calibrating behavior. This paper presents the modulation in a monomer-aggregate equilibrium of coumarin-7 (C7) dye at pH ∼ 3, under the influence of a multi-anionic polymer, poly(styrene sulfonate) (PSS), leading to a significant modification in the ratiometric optical signal of the dye. At pH ∼ 3, cationic C7 formed aggregates in the presence of PSS
Language	English
Publishing date	2023-06-21
Publishing country	England
Document type	Journal Article
ZDB-ID	2097583-1
ISSN	1477-0539 ; 1477-0520
ISSN (online)	1477-0539
ISSN	1477-0520
DOI	10.1039/d3ob00547j
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Article ; Online: Trajectory tracking control of a pneumatically actuated continuum manipulator in the presence of obstacles by using terminal sliding mode control.

Mishra, Mrunal Kanti / Chakraborty, Goutam / Samantaray, Arun Kumar

ISA transactions

2023 Volume 143, Page(s) 79–93

Abstract: This paper proposes an efficient trajectory planning and dynamic tracking controller scheme for a pneumatic continuum manipulator under the effect of material hysteresis. First of all, generalized governing nonlinear dynamic equations in the form of ... ...

Abstract	This paper proposes an efficient trajectory planning and dynamic tracking controller scheme for a pneumatic continuum manipulator under the effect of material hysteresis. First of all, generalized governing nonlinear dynamic equations in the form of partial differential equations for pneumatic continuum manipulator dynamics are developed by using discrete Cosserat-rod theory, where the manipulator material hysteresis is modeled by using a fractional order Bouc-Wen model. Then, the trajectory planning for the end-effector of a continuum manipulator is proposed, which accounts for the static obstacles in the workspace and the Jacobian singularity. Subsequently, an adaptive terminal sliding mode controller for the joint space control combined with a simple PI controller for task space control is proposed. The proposed controller guarantees exponential convergence of the manipulator tip positional error in finite time, even in the existence of external disturbances and model uncertainties, without any need for prior knowledge of their upper bounds. Finally, the proposed controller is applied to a two-segment continuum manipulator, the trunk of Robotino-XT, through numerical simulations and the performance gain over two controllers proposed in the literature for similar pneumatic continuum manipulators is demonstrated.
Language	English
Publishing date	2023-08-24
Publishing country	United States
Document type	Journal Article
ZDB-ID	2012746-7
ISSN	1879-2022 ; 0019-0578
ISSN (online)	1879-2022
ISSN	0019-0578
DOI	10.1016/j.isatra.2023.08.024
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Article ; Online: Optimal design of a helical coil support for dewars in fuel cell applications

Nitin, Baby / Sandilya, Pavitra / Chakraborty, Goutam

Environ Sci Pollut Res. 2023 Feb., v. 30, no. 10 p.24963-24974

2023

Abstract: Fuel cells are gaining popularity because of their efficient energy production without causing environmental pollution. Recently, DRDO has developed a fuel cell-based air-independent propulsion (AIP) system. In this system, the hydrogen is produced ... ...

Abstract	Fuel cells are gaining popularity because of their efficient energy production without causing environmental pollution. Recently, DRDO has developed a fuel cell-based air-independent propulsion (AIP) system. In this system, the hydrogen is produced onboard while oxygen is carried in liquefied form (LOX) from the land in specially designed insulated storage vessels called dewars. Such vessels are needed because LOX has a low boiling point (NBP ~ 90 K) and heat of vaporization (~ 213 kJ/kg), due to which it boils off easily even when there is a small amount of heat inleak from the ambient. A typical dewar consists of two vessels separated by insulation. Support members are used to hold the two vessels together. Heat inleak through the supports and the insulation of the dewar causes the boiling of LOX. The vessels are subjected to dynamic loads during the voyage due to the filling and consumption of LOX. Therefore, the support system should be designed to withstand the dynamic loads experienced by the dewar. While the support system should have enough mechanical strength to withstand the loads it is subjected to, it should also restrict the heat inleak from the ambient to minimize the LOX boil-off. To meet this requirement, we need to optimize the support system design. Design optimization of support systems is especially critical in submarines to reduce the snorkeling frequency. Even though the dewars are available commercially for various applications, their design methodologies are not available in the open literature. Cylindrical rods are generally used as support members. In earlier studies, the authors have shown that helical coils give better thermal performance than tension rods as dewar supports. These two support systems involve different design criteria. It is important to evolve an optimal design of the support system to maximize the mechanical strength of the support while minimizing the heat inleak through the support. In this paper, we present a design methodology for optimizing helical support. We have proposed a modified optimization technique derived from the classical genetic algorithm (GA) for this purpose. The modification has been done by ensuring the design feasibility of the coil at each step of the algorithm. The proposed optimization technique has been tested on a LOX dewar, and an optimal design of the helical coil support has been obtained.
Keywords	algorithms ; energy ; fuel cells ; fuels ; heat ; hydrogen ; insulating materials ; oxygen ; pollution ; strength (mechanics) ; systems engineering ; volatilization
Language	English
Dates of publication	2023-02
Size	p. 24963-24974.
Publishing place	Springer Berlin Heidelberg
Document type	Article ; Online
ZDB-ID	1178791-0
ISSN	1614-7499 ; 0944-1344
ISSN (online)	1614-7499
ISSN	0944-1344
DOI	10.1007/s11356-022-20286-y
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Article ; Online: Optimal design of a helical coil support for dewars in fuel cell applications.

Nitin, Baby / Sandilya, Pavitra / Chakraborty, Goutam

Environmental science and pollution research international

2022 Volume 30, Issue 10, Page(s) 24963–24974

Abstract	Fuel cells are gaining popularity because of their efficient energy production without causing environmental pollution. Recently, DRDO has developed a fuel cell-based air-independent propulsion (AIP) system. In this system, the hydrogen is produced onboard while oxygen is carried in liquefied form (LOX) from the land in specially designed insulated storage vessels called dewars. Such vessels are needed because LOX has a low boiling point (NBP ~ 90 K) and heat of vaporization (~ 213 kJ/kg), due to which it boils off easily even when there is a small amount of heat inleak from the ambient. A typical dewar consists of two vessels separated by insulation. Support members are used to hold the two vessels together. Heat inleak through the supports and the insulation of the dewar causes the boiling of LOX. The vessels are subjected to dynamic loads during the voyage due to the filling and consumption of LOX. Therefore, the support system should be designed to withstand the dynamic loads experienced by the dewar. While the support system should have enough mechanical strength to withstand the loads it is subjected to, it should also restrict the heat inleak from the ambient to minimize the LOX boil-off. To meet this requirement, we need to optimize the support system design. Design optimization of support systems is especially critical in submarines to reduce the snorkeling frequency. Even though the dewars are available commercially for various applications, their design methodologies are not available in the open literature. Cylindrical rods are generally used as support members. In earlier studies, the authors have shown that helical coils give better thermal performance than tension rods as dewar supports. These two support systems involve different design criteria. It is important to evolve an optimal design of the support system to maximize the mechanical strength of the support while minimizing the heat inleak through the support. In this paper, we present a design methodology for optimizing helical support. We have proposed a modified optimization technique derived from the classical genetic algorithm (GA) for this purpose. The modification has been done by ensuring the design feasibility of the coil at each step of the algorithm. The proposed optimization technique has been tested on a LOX dewar, and an optimal design of the helical coil support has been obtained.
MeSH term(s)	Environmental Pollution ; Hot Temperature ; Algorithms ; Hydrogen
Chemical Substances	Hydrogen (7YNJ3PO35Z)
Language	English
Publishing date	2022-04-22
Publishing country	Germany
Document type	Journal Article
ZDB-ID	1178791-0
ISSN	1614-7499 ; 0944-1344
ISSN (online)	1614-7499
ISSN	0944-1344
DOI	10.1007/s11356-022-20286-y
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Fluorogenic gemcitabine based light up sensor for serum albumin detection in complex biological matrices.

Gadly, Trilochan / Patro, Birija S / Chakraborty, Goutam

Colloids and surfaces. B, Biointerfaces

2022 Volume 220, Page(s) 112865

Abstract: Herein we report fluorogenic derivative of gemcitabine (GEM-DNS), synthesized from gemcitabine hydrochloride and dansyl chloride in a single step. Owing to its large stoke shift of ∼200 nm and intriguing photophysical properties, the said dye has been ... ...

Abstract	Herein we report fluorogenic derivative of gemcitabine (GEM-DNS), synthesized from gemcitabine hydrochloride and dansyl chloride in a single step. Owing to its large stoke shift of ∼200 nm and intriguing photophysical properties, the said dye has been utilized to estimate albumin concentration in complex bio-media such as human urine and blood serum. High sensitivity and selectivity towards albumin make the aforementioned dye a powerful diagnostic tool to detect ailments such as liver cirrhosis, diabetes, hypertension etc.
MeSH term(s)	Humans ; Serum Albumin ; Deoxycytidine
Chemical Substances	gemcitabine (B76N6SBZ8R) ; Serum Albumin ; Deoxycytidine (0W860991D6)
Language	English
Publishing date	2022-09-24
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	1500523-9
ISSN	1873-4367 ; 0927-7765
ISSN (online)	1873-4367
ISSN	0927-7765
DOI	10.1016/j.colsurfb.2022.112865
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Article: Fluorogenic gemcitabine based light up sensor for serum albumin detection in complex biological matrices

Gadly, Trilochan / Patro, Birija.S. / Chakraborty, Goutam

Colloids and surfaces. 2022 Dec., v. 220

2022

Abstract	Herein we report fluorogenic derivative of gemcitabine (GEM-DNS), synthesized from gemcitabine hydrochloride and dansyl chloride in a single step. Owing to its large stoke shift of ∼200 nm and intriguing photophysical properties, the said dye has been utilized to estimate albumin concentration in complex bio-media such as human urine and blood serum. High sensitivity and selectivity towards albumin make the aforementioned dye a powerful diagnostic tool to detect ailments such as liver cirrhosis, diabetes, hypertension etc.
Keywords	blood serum ; chlorides ; diabetes ; diagnostic techniques ; dyes ; humans ; hypertension ; liver cirrhosis ; serum albumin ; urine
Language	English
Dates of publication	2022-12
Publishing place	Elsevier B.V.
Document type	Article
ZDB-ID	1500523-9
ISSN	1873-4367 ; 0927-7765
ISSN (online)	1873-4367
ISSN	0927-7765
DOI	10.1016/j.colsurfb.2022.112865
Database	NAL-Catalogue (AGRICOLA)

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