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  1. Article ; Online: British Thoracic Society Clinical Statement on chronic cough in adults.

    Parker, Sean M / Smith, Jaclyn Ann / Birring, Surinder S / Chamberlain-Mitchell, Sarah / Gruffydd-Jones, Kevin / Haines, Jemma / Hennessey, Sarah / McGarvey, Lorcan P / Marsden, Paul / Martin, Matthew James / Morice, Alyn / O'Hara, James / Thomas, Mike

    Thorax

    2023  Volume 78, Issue Suppl 6, Page(s) s3–s19

    MeSH term(s) Adult ; Humans ; Cough/diagnosis ; Cough/etiology ; Cough/therapy ; Chronic Disease
    Language English
    Publishing date 2023-12-06
    Publishing country England
    Document type Journal Article
    ZDB-ID 204353-1
    ISSN 1468-3296 ; 0040-6376
    ISSN (online) 1468-3296
    ISSN 0040-6376
    DOI 10.1136/thorax-2023-220592
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Ui III Zs.83: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
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  2. Article ; Online: Physical Inactivity in Pulmonary Sarcoidosis.

    Cho, Peter S P / Vasudevan, Sharmila / Maddocks, Matthew / Spinou, Arietta / Chamberlain Mitchell, Sarah / Wood, Claire / Jolley, Caroline J / Birring, Surinder S

    Lung

    2019  Volume 197, Issue 3, Page(s) 285–293

    Abstract: Purpose: Reduced physical activity in many chronic diseases is consistently associated with increased morbidity. Little is known about physical activity in sarcoidosis. The aim of this study was to objectively assess physical activity in patients with ... ...

    Abstract Purpose: Reduced physical activity in many chronic diseases is consistently associated with increased morbidity. Little is known about physical activity in sarcoidosis. The aim of this study was to objectively assess physical activity in patients with pulmonary sarcoidosis and investigate its relationship with lung function, exercise capacity, symptom burden, and health status.
    Methods: Physical activity was assessed over one week in 15 patients with pulmonary sarcoidosis and 14 age-matched healthy controls with a tri-axial accelerometer (ActivPal™) and the International Physical Activity Questionnaire (IPAQ). All participants underwent pulmonary function tests, 6-min walk test (6MWT) and completed the Fatigue Assessment Scale (FAS), Medical Research Council (MRC) Dyspnoea Scale and the King's Sarcoidosis Questionnaire (KSQ).
    Results: Patients with sarcoidosis had significantly lower daily step counts than healthy controls; mean (SD) 5624 (1875) versus 10,429 (2942) steps (p < 0.01) and a trend towards fewer sit-to-stand transitions each day (p = 0.095). Only two patients (13%) self-reported undertaking vigorous physical activity (IPAQ) compared to half of healthy individuals (p < 0.01). Daily step count was significantly associated with 6MWT distance in sarcoidosis (r = 0.634, p = 0.01), but not with forced vital capacity (r = 0.290), fatigue (r = 0.041), dyspnoea (r = -0.466) or KSQ health status (r = 0.099-0.484). Time spent upright was associated with fatigue (r = -0.630, p = 0.012) and health status (KSQ Lung scores r = 0.524, p = 0.045), and there was a significant correlation between the number of sit-to-stand transitions and MRC dyspnoea score (r = -0.527, p = 0.044).
    Conclusion: Physical activity is significantly reduced in sarcoidosis and is associated with reduced functional exercise capacity (6MWD). Fatigue, exertional symptoms and health status were more closely associated with time spent upright and the number of bouts of physical activity, as compared to step counts. Further studies are warranted to identify the factors that determine different physical activity profiles in sarcoidosis.
    MeSH term(s) Accelerometry ; Adult ; Aged ; Case-Control Studies ; Dyspnea/physiopathology ; Exercise ; Exercise Tolerance ; Fatigue/physiopathology ; Humans ; Middle Aged ; Sarcoidosis, Pulmonary/physiopathology ; Sedentary Behavior ; Vital Capacity ; Walk Test
    Language English
    Publishing date 2019-03-19
    Publishing country United States
    Document type Journal Article
    ZDB-ID 6165-7
    ISSN 1432-1750 ; 0341-2040
    ISSN (online) 1432-1750
    ISSN 0341-2040
    DOI 10.1007/s00408-019-00215-6
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Uh II Zs.20: Show issues Location:
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  3. Article ; Online: Physiotherapy, and speech and language therapy intervention for patients with refractory chronic cough: a multicentre randomised control trial.

    Chamberlain Mitchell, Sarah A F / Garrod, Rachel / Clark, Lynne / Douiri, Abdel / Parker, Sean M / Ellis, Jenny / Fowler, Stephen J / Ludlow, Siobhan / Hull, James H / Chung, Kian Fan / Lee, Kai K / Bellas, H / Pandyan, Anand / Birring, Surinder S

    Thorax

    2016  Volume 72, Issue 2, Page(s) 129–136

    Abstract: Background: Physiotherapy, and speech and language therapy are emerging non-pharmacological treatments for refractory chronic cough. We aimed to investigate the efficacy of a physiotherapy, and speech and language therapy intervention (PSALTI) to ... ...

    Abstract Background: Physiotherapy, and speech and language therapy are emerging non-pharmacological treatments for refractory chronic cough. We aimed to investigate the efficacy of a physiotherapy, and speech and language therapy intervention (PSALTI) to improve health-related quality of life (HRQoL) and to reduce cough frequency in patients with refractory chronic cough.
    Methods: In this multicentre randomised controlled trial, patients with refractory chronic cough were randomised to four weekly 1:1 sessions of either PSALTI consisting of education, laryngeal hygiene and hydration, cough suppression techniques, breathing exercises and psychoeducational counselling or control intervention consisting of healthy lifestyle advice. We assessed the change in HRQoL at week 4 with the Leicester Cough Questionnaire (LCQ). Secondary efficacy outcomes included 24-hour objective cough frequency (Leicester Cough Monitor) and cough reflex sensitivity. The primary analysis used an analysis of covariance adjusted for baseline measurements with the intention-to-treat population. This study was registered at UK Clinical Research Network (UKCRN ID 10678).
    Findings: Between December 2011 and April 2014, we randomly assigned 75 participants who underwent baseline assessment (34 PSALTI and 41 controls). In the observed case analysis, HRQoL (LCQ) improved on average by 1.53 (95% CI 0.21 to 2.85) points more in PSALTI group than with control (p=0.024). Cough frequency decreased by 41% (95% CI 36% to 95%) in PSALTI group relative to control (p=0.030). The improvements within the PSALTI group were sustained up to 3 months. There was no significant difference between groups in the concentration of capsaicin causing five or more coughs.
    Interpretation: Greater improvements in HRQoL and cough frequency were observed with PSALTI intervention. Our findings support the use of PSALTI for patients with refractory chronic cough.
    Trial registration number: UKCRN ID 10678 and ISRCTN 73039760; Results.
    MeSH term(s) Aged ; Chronic Disease ; Cough/therapy ; Counseling ; Female ; Humans ; Language Therapy ; Male ; Middle Aged ; Physical Therapy Modalities ; Quality of Life ; Single-Blind Method ; Speech Therapy ; Treatment Outcome
    Language English
    Publishing date 2016-09-28
    Publishing country England
    Document type Journal Article ; Multicenter Study ; Randomized Controlled Trial ; Research Support, Non-U.S. Gov't
    ZDB-ID 204353-1
    ISSN 1468-3296 ; 0040-6376
    ISSN (online) 1468-3296
    ISSN 0040-6376
    DOI 10.1136/thoraxjnl-2016-208843
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Ui III Zs.83: Show issues Location:
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    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

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