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  1. Article ; Online: Association of atopic dermatitis with depression and sleep quality in an Asian general population cohort of 8887 participants.

    Yew, Yik Weng / Chang, Bill Rong Qin / Mina, Theresia / Riboli, Elio / Lee, Eng Sing / Ngeow, Joanne / Elliott, Paul / Chambers, John C / Lee, Jimmy / Loh, Marie

    Journal of the European Academy of Dermatology and Venereology : JEADV

    2024  

    Language English
    Publishing date 2024-02-19
    Publishing country England
    Document type Letter
    ZDB-ID 1128828-0
    ISSN 1468-3083 ; 0926-9959
    ISSN (online) 1468-3083
    ISSN 0926-9959
    DOI 10.1111/jdv.19836
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  2. Article ; Online: Investigating causal relationships between Body Mass Index and risk of atopic dermatitis: a Mendelian randomization analysis.

    Yew, Yik Weng / Loh, Marie / Thng, Steven Tien Guan / Chambers, John C

    Scientific reports

    2020  Volume 10, Issue 1, Page(s) 15279

    Abstract: Population studies suggest that atopic dermatitis (AD) is associated with an increased risk of obesity, however a causal relationship between these two conditions remains to be established. We therefore use Mendelian randomization (MR) to evaluate ... ...

    Abstract Population studies suggest that atopic dermatitis (AD) is associated with an increased risk of obesity, however a causal relationship between these two conditions remains to be established. We therefore use Mendelian randomization (MR) to evaluate whether obesity and AD are causally interlinked. We used summary statistics extracted from genome wide association studies of Body Mass Index (BMI) and AD. MR analysis was performed in both directions to establish the direction of causality between BMI and AD. We find that genetically determined increase in adiposity is associated with increased risk of AD (odds ratio of AD 1.08 [95% CI 1.01 to 1.14; p = 0.015] per unit increase in BMI). Conversely, genetically determined increased risk of AD is not associated with a higher BMI (change in BMI attributable to AD based on genetic information: 0.00; 95% CI - 0.02 to 0.02; p = 0.862). There was no evidence for confounding of these genetic analyses by horizontal pleiotropy. Our results indicate that the association of AD with obesity is likely to reflect a causal role for adiposity in the development of AD. Our findings enhance understanding of the etiology of AD, and the basis for experimental studies to evaluate the mechanistic pathways by which adiposity promotes AD.
    MeSH term(s) Adiposity/genetics ; Body Mass Index ; Dermatitis, Atopic/etiology ; Dermatitis, Atopic/genetics ; Female ; Genome-Wide Association Study/methods ; Humans ; Male ; Mendelian Randomization Analysis ; Obesity/complications ; Obesity/genetics ; Risk
    Language English
    Publishing date 2020-09-17
    Publishing country England
    Document type Journal Article
    ZDB-ID 2615211-3
    ISSN 2045-2322 ; 2045-2322
    ISSN (online) 2045-2322
    ISSN 2045-2322
    DOI 10.1038/s41598-020-72301-2
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  3. Article ; Online: Mechanistic basis for potassium efflux-driven activation of the human NLRP1 inflammasome.

    Rozario, Pritisha / Pinilla, Miriam / Gorse, Leana / Vind, Anna Constance / Robinson, Kim S / Toh, Gee Ann / Firdaus, Muhammad Jasrie / Martínez, José Francisco / Kerk, Swat Kim / Lin, Zhewang / Chambers, John C / Bekker-Jensen, Simon / Meunier, Etienne / Zhong, Franklin

    Proceedings of the National Academy of Sciences of the United States of America

    2024  Volume 121, Issue 2, Page(s) e2309579121

    Abstract: Nigericin, an ionophore derived ... ...

    Abstract Nigericin, an ionophore derived from
    MeSH term(s) Humans ; Inflammasomes/metabolism ; NLR Family, Pyrin Domain-Containing 3 Protein/metabolism ; Nigericin/pharmacology ; Potassium/metabolism ; Immunity, Innate ; Ionophores ; NLR Proteins
    Chemical Substances Inflammasomes ; NLR Family, Pyrin Domain-Containing 3 Protein ; Nigericin (RRU6GY95IS) ; Potassium (RWP5GA015D) ; Ionophores ; NLRP1 protein, human ; NLR Proteins
    Language English
    Publishing date 2024-01-04
    Publishing country United States
    Document type Journal Article
    ZDB-ID 209104-5
    ISSN 1091-6490 ; 0027-8424
    ISSN (online) 1091-6490
    ISSN 0027-8424
    DOI 10.1073/pnas.2309579121
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  4. Article ; Online: Hospices and CPR guidelines. CPR in a hospice in perspective.

    Chambers, John C

    BMJ (Clinical research ed.)

    2009  Volume 338, Page(s) b2344

    MeSH term(s) Cardiopulmonary Resuscitation/methods ; Hospice Care/methods ; Humans
    Language English
    Publishing date 2009-06-09
    Publishing country England
    Document type Letter
    ZDB-ID 1362901-3
    ISSN 1756-1833 ; 0959-8154 ; 0959-8146 ; 0959-8138 ; 0959-535X ; 1759-2151
    ISSN (online) 1756-1833
    ISSN 0959-8154 ; 0959-8146 ; 0959-8138 ; 0959-535X ; 1759-2151
    DOI 10.1136/bmj.b2344
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  5. Article: Bacterial parotitis secondary to antisecretory medication.

    Chambers, John C

    Palliative medicine

    2008  Volume 22, Issue 4, Page(s) 394

    MeSH term(s) Aged ; Amoxicillin-Potassium Clavulanate Combination/therapeutic use ; Anorexia/etiology ; Anti-Bacterial Agents/therapeutic use ; Bacterial Infections/drug therapy ; Bacterial Infections/etiology ; Gastric Outlet Obstruction/complications ; Humans ; Male ; Parotitis/drug therapy ; Parotitis/etiology ; Treatment Outcome ; Weight Loss
    Chemical Substances Anti-Bacterial Agents ; Amoxicillin-Potassium Clavulanate Combination (74469-00-4)
    Language English
    Publishing date 2008-06
    Publishing country England
    Document type Case Reports ; Letter
    ZDB-ID 639247-7
    ISSN 1477-030X ; 0269-2163
    ISSN (online) 1477-030X
    ISSN 0269-2163
    DOI 10.1177/0269216307087321
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  6. Article ; Online: Doctors and climate change: Impact of medical ethics.

    Chambers, John C

    BMJ (Clinical research ed.)

    2008  Volume 336, Issue 7639, Page(s) 291–292

    MeSH term(s) Ethics, Medical ; Greenhouse Effect
    Language English
    Publishing date 2008-02-07
    Publishing country England
    Document type Letter
    ZDB-ID 1362901-3
    ISSN 1756-1833 ; 0959-8154 ; 0959-8146 ; 0959-8138 ; 0959-535X ; 1759-2151
    ISSN (online) 1756-1833
    ISSN 0959-8154 ; 0959-8146 ; 0959-8138 ; 0959-535X ; 1759-2151
    DOI 10.1136/bmj.39479.533125.3A
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  7. Article: Magnesium sulfate via a mucous fistula in the management of short bowel syndrome.

    Chambers, John C

    Journal of pain and symptom management

    2008  Volume 35, Issue 6, Page(s) 569–571

    MeSH term(s) Adenocarcinoma/complications ; Adenocarcinoma/surgery ; Colonic Neoplasms/complications ; Colonic Neoplasms/surgery ; Fatal Outcome ; Fistula ; Humans ; Ileostomy ; Ileum/surgery ; Magnesium Deficiency/etiology ; Magnesium Deficiency/therapy ; Magnesium Sulfate/administration & dosage ; Magnesium Sulfate/therapeutic use ; Male ; Middle Aged ; Mucous Membrane/surgery ; Short Bowel Syndrome/complications ; Short Bowel Syndrome/drug therapy ; Short Bowel Syndrome/metabolism
    Chemical Substances Magnesium Sulfate (7487-88-9)
    Language English
    Publishing date 2008-06
    Publishing country United States
    Document type Case Reports ; Letter
    ZDB-ID 639142-4
    ISSN 0885-3924
    ISSN 0885-3924
    DOI 10.1016/j.jpainsymman.2008.01.003
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  8. Article ; Online: Investigating causal relationships between obesity and skin barrier function in a multi-ethnic Asian general population cohort.

    Yew, Yik Weng / Mina, Theresia / Ng, Hong Kiat / Lam, Benjamin Chih Chiang / Riboli, Elio / Lee, Eng Sing / Lee, Jimmy / Ngeow, Joanne / Elliott, Paul / Thng, Steven Tien Guan / Chambers, John C / Loh, Marie

    International journal of obesity (2005)

    2023  Volume 47, Issue 10, Page(s) 963–969

    Abstract: Background: Skin diseases impact significantly on the quality of life and psychology of patients. Obesity has been observed as a risk factor for skin diseases. Skin epidermal barrier dysfunctions are typical manifestations across several dermatological ... ...

    Abstract Background: Skin diseases impact significantly on the quality of life and psychology of patients. Obesity has been observed as a risk factor for skin diseases. Skin epidermal barrier dysfunctions are typical manifestations across several dermatological disturbances.
    Objectives: We aim to establish the association between obesity and skin physiology measurements and investigate whether obesity may play a possible causal role on skin barrier dysfunction.
    Methods: We investigated the relationship of obesity with skin physiology measurements, namely transepidermal water loss (TEWL), skin surface moisture and skin pH in an Asian population cohort (n = 9990). To assess for a possible causal association between body mass index (BMI) and skin physiology measurements, we performed Mendelian Randomization (MR), along with subsequent additional analyses to assess the potential causal impact of known socioeconomic and comorbidities of obesity on TEWL.
    Results: Every 1 kg/m2 increase in BMI was associated with a 0.221% (95%CI: 0.144-0.298) increase in TEWL (P = 2.82E-08), a 0.336% (95%CI: 0.148-0.524) decrease in skin moisture (P = 4.66E-04) and a 0.184% (95%CI: 0.144-0.224) decrease in pH (P = 1.36E-19), adjusting for age, gender, and ethnicity. Relationships for both TEWL and pH with BMI remained strong (Beta 0.354; 95%CI: 0.189-0.520 and Beta -0.170; 95%CI: -0.253 to -0.087, respectively) even after adjusting for known confounders, with MR experiments further supporting BMI's possible causal relationship with TEWL. Based on additional MR performed, none of the socioeconomic and comorbidities of obesity investigated are likely to have possible causal relationships with TEWL.
    Conclusion: We establish strong association of BMI with TEWL and skin pH, with MR results suggestive of a possible causal relationship of obesity with TEWL. It emphasizes the potential impact of obesity on skin barrier function and therefore opportunity for primary prevention.
    MeSH term(s) Humans ; Causality ; Obesity/complications ; Obesity/epidemiology ; Risk Factors ; Water Loss, Insensible ; Skin Physiological Phenomena ; Asian People
    Language English
    Publishing date 2023-07-21
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 752409-2
    ISSN 1476-5497 ; 0307-0565
    ISSN (online) 1476-5497
    ISSN 0307-0565
    DOI 10.1038/s41366-023-01343-z
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  9. Article ; Online: Prophylactic heparin in palliative care: ...to a challenging idea.

    Chambers, John C

    BMJ (Clinical research ed.)

    2006  Volume 332, Issue 7543, Page(s) 729

    MeSH term(s) Anticoagulants/therapeutic use ; Heparin, Low-Molecular-Weight/therapeutic use ; Humans ; Neoplasms/complications ; Palliative Care/methods ; Thromboembolism/prevention & control
    Chemical Substances Anticoagulants ; Heparin, Low-Molecular-Weight
    Language English
    Publishing date 2006-03-25
    Publishing country England
    Document type Comment ; Letter
    ZDB-ID 1362901-3
    ISSN 1756-1833 ; 0959-8154 ; 0959-8146 ; 0959-8138 ; 0959-535X ; 1759-2151
    ISSN (online) 1756-1833
    ISSN 0959-8154 ; 0959-8146 ; 0959-8138 ; 0959-535X ; 1759-2151
    DOI 10.1136/bmj.332.7543.729
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  10. Article ; Online: Strange things happen when we never qualify the frequency.

    Chambers, John C

    BMJ (Clinical research ed.)

    2006  Volume 333, Issue 7567, Page(s) 550

    MeSH term(s) Aged ; Anti-Inflammatory Agents, Non-Steroidal/adverse effects ; Humans ; Risk Assessment ; Risk Factors
    Chemical Substances Anti-Inflammatory Agents, Non-Steroidal
    Language English
    Publishing date 2006-09-09
    Publishing country England
    Document type Letter
    ZDB-ID 1362901-3
    ISSN 1756-1833 ; 0959-8154 ; 0959-8146 ; 0959-8138 ; 0959-535X ; 1759-2151
    ISSN (online) 1756-1833
    ISSN 0959-8154 ; 0959-8146 ; 0959-8138 ; 0959-535X ; 1759-2151
    DOI 10.1136/bmj.333.7567.550-b
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