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  1. Article ; Online: Temporal and thermal profiling of the

    Herneisen, Alice L / Li, Zhu-Hong / Chan, Alex W / Moreno, Silvia N J / Lourido, Sebastian

    eLife

    2022  Volume 11

    Abstract: Apicomplexan parasites cause persistent mortality and morbidity worldwide through diseases including malaria, toxoplasmosis, and cryptosporidiosis. ... ...

    Abstract Apicomplexan parasites cause persistent mortality and morbidity worldwide through diseases including malaria, toxoplasmosis, and cryptosporidiosis. Ca
    MeSH term(s) Animals ; Parasites/metabolism ; Protein Phosphatase 1/metabolism ; Proteome/metabolism ; Protozoan Proteins/metabolism ; Toxoplasma/metabolism
    Chemical Substances Proteome ; Protozoan Proteins ; Protein Phosphatase 1 (EC 3.1.3.16)
    Language English
    Publishing date 2022-08-17
    Publishing country England
    Document type Journal Article ; Research Support, U.S. Gov't, Non-P.H.S. ; Research Support, N.I.H., Extramural
    ZDB-ID 2687154-3
    ISSN 2050-084X ; 2050-084X
    ISSN (online) 2050-084X
    ISSN 2050-084X
    DOI 10.7554/eLife.80336
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: Analysis of CDPK1 targets identifies a trafficking adaptor complex that regulates microneme exocytosis in

    Chan, Alex W / Broncel, Malgorzata / Yifrach, Eden / Haseley, Nicole / Chakladar, Sundeep / Andree, Elena / Herneisen, Alice L / Shortt, Emily / Treeck, Moritz / Lourido, Sebastian

    bioRxiv : the preprint server for biology

    2023  

    Abstract: Apicomplexan parasites use ... ...

    Abstract Apicomplexan parasites use Ca
    Language English
    Publishing date 2023-08-29
    Publishing country United States
    Document type Preprint
    DOI 10.1101/2023.01.11.523553
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Analysis of CDPK1 targets identifies a trafficking adaptor complex that regulates microneme exocytosis in

    Chan, Alex W / Broncel, Malgorzata / Yifrach, Eden / Haseley, Nicole R / Chakladar, Sundeep / Andree, Elena / Herneisen, Alice L / Shortt, Emily / Treeck, Moritz / Lourido, Sebastian

    eLife

    2023  Volume 12

    Abstract: Apicomplexan parasites use ... ...

    Abstract Apicomplexan parasites use Ca
    MeSH term(s) Animals ; Toxoplasma/metabolism ; Microneme ; Parasites/metabolism ; Organelles/metabolism ; Endosomes/metabolism ; Exocytosis ; Protozoan Proteins/metabolism
    Chemical Substances Protozoan Proteins
    Language English
    Publishing date 2023-11-07
    Publishing country England
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, U.S. Gov't, Non-P.H.S. ; Research Support, Non-U.S. Gov't
    ZDB-ID 2687154-3
    ISSN 2050-084X ; 2050-084X
    ISSN (online) 2050-084X
    ISSN 2050-084X
    DOI 10.7554/eLife.85654
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  4. Article ; Online: A positive feedback loop controls Toxoplasma chronic differentiation.

    Licon, M Haley / Giuliano, Christopher J / Chan, Alex W / Chakladar, Sundeep / Eberhard, Julia N / Shallberg, Lindsey A / Chandrasekaran, Sambamurthy / Waldman, Benjamin S / Koshy, Anita A / Hunter, Christopher A / Lourido, Sebastian

    Nature microbiology

    2023  Volume 8, Issue 5, Page(s) 889–904

    Abstract: Successful infection strategies must balance pathogen amplification and persistence. In the obligate intracellular parasite Toxoplasma gondii this is accomplished through differentiation into dedicated cyst-forming chronic stages that avoid clearance by ... ...

    Abstract Successful infection strategies must balance pathogen amplification and persistence. In the obligate intracellular parasite Toxoplasma gondii this is accomplished through differentiation into dedicated cyst-forming chronic stages that avoid clearance by the host immune system. The transcription factor BFD1 is both necessary and sufficient for stage conversion; however, its regulation is not understood. In this study we examine five factors that are transcriptionally activated by BFD1. One of these is a cytosolic RNA-binding protein of the CCCH-type zinc-finger family, which we name bradyzoite formation deficient 2 (BFD2). Parasites lacking BFD2 fail to induce BFD1 and are consequently unable to fully differentiate in culture or in mice. BFD2 interacts with the BFD1 transcript under stress, and deletion of BFD2 reduces BFD1 protein levels but not messenger RNA abundance. The reciprocal effects on BFD2 transcription and BFD1 translation outline a positive feedback loop that enforces the chronic-stage gene-expression programme. Thus, our findings help explain how parasites both initiate and commit to chronic differentiation. This work provides new mechanistic insight into the regulation of T. gondii persistence, and can be exploited in the design of strategies to prevent and treat these key reservoirs of human infection.
    MeSH term(s) Mice ; Animals ; Humans ; Toxoplasma/metabolism ; Feedback ; Gene Expression Regulation ; Transcription Factors/genetics
    Chemical Substances Transcription Factors
    Language English
    Publishing date 2023-04-20
    Publishing country England
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ISSN 2058-5276
    ISSN (online) 2058-5276
    DOI 10.1038/s41564-023-01358-2
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Author Correction: A positive feedback loop controls Toxoplasma chronic differentiation.

    Licon, M Haley / Giuliano, Christopher J / Chan, Alex W / Chakladar, Sundeep / Eberhard, Julia N / Shallberg, Lindsey A / Chandrasekaran, Sambamurthy / Waldman, Benjamin S / Koshy, Anita A / Hunter, Christopher A / Lourido, Sebastian

    Nature microbiology

    2023  Volume 9, Issue 4, Page(s) 1145

    Language English
    Publishing date 2023-08-14
    Publishing country England
    Document type Published Erratum
    ISSN 2058-5276
    ISSN (online) 2058-5276
    DOI 10.1038/s41564-023-01467-y
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article: Extraversion, individualism and M&A activities

    Chan, Alex W. H / Cheung, Hoi Yan

    International business review : the official journal of the European International Business Academy Vol. 25, No. 1 , p. 356-369

    2016  Volume 25, Issue 1, Page(s) 356–369

    Author's details Alex W.H. Chan, Hoi Yan Cheung
    Keywords Mergers and acquisitions ; Hofstede's cultural dimensions ; Individualism ; Extraversion ; Reverse causation hypothesis
    Language English
    Publisher Elsevier
    Publishing place Amsterdam [u.a.]
    Document type Article
    ZDB-ID 1164338-9
    ISSN 0969-5931
    Database ECONomics Information System

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  7. Article ; Online: Long-term evaluation of cantilevered versus fixed-fixed resin-bonded fixed partial dentures for missing maxillary incisors.

    Botelho, Michael G / Chan, Alex W K / Leung, Nic C H / Lam, Walter Y H

    Journal of dentistry

    2016  Volume 45, Page(s) 59–66

    Abstract: Objectives: To evaluate the long-term longevity and patient-reported outcomes of two-unit cantilevered (CL2) and three-unit fixed-fixed (FF3) resin-bonded fixed partial dentures (RBFPDs) for the replacement of a maxillary permanent incisor.: Materials ...

    Abstract Objectives: To evaluate the long-term longevity and patient-reported outcomes of two-unit cantilevered (CL2) and three-unit fixed-fixed (FF3) resin-bonded fixed partial dentures (RBFPDs) for the replacement of a maxillary permanent incisor.
    Materials and methods: Twenty-eight subjects were randomly assigned to receive either a CL2 or FF3 RBFPD placed by one operator. Prosthesis longevity was determined by clinical examination and history. Success was defined as absence of complications requiring intervention and survival as retention of the original prosthesis in mouth. Subjects' satisfaction was assessed using visual analogue scale (VAS) and oral health-related quality of life (OHRQoL) using Oral Health Impact Profile (OHIP-49). Outcomes were analysed with t-test/Mann-Whitney U test, chi-square and log-rank test at significance level α=0.05.
    Results: Twenty-two subjects were reviewed. Thirteen of fifteen CL2 and ten of fourteen FF3 RBFPDs were examined (79.3 percent response rate) with a mean service life of 216.5±20.8months. All CL2 RBFPDs survived with no complications while only 10 percent of FF3 experienced no complications and only 50 percent of them survived (both P=0.000). CL2 had a significantly better success and survival rate than FF3 (P=0.000 and P=0.009, respectively). There was no significant difference in subjects' satisfaction and OHRQoL apart from CL2 group subjects had a higher satisfaction in cleaning of the prosthesis (84.1±13.6) than FF3 group (72.6±11.7) (P=0.05).
    Conclusions: Two-unit cantilevered RBFPDs were observed to have a significantly better success and survival than the FF3 design for the replacement of a maxillary incisor. Good patient-reported outcomes have been found for RBFPDs in single-tooth replacement in aesthetic zone.
    MeSH term(s) Adult ; Dental Abutments ; Dental Bonding ; Dental Restoration Failure ; Denture Design ; Denture Retention ; Denture, Partial, Fixed ; Denture, Partial, Fixed, Resin-Bonded/statistics & numerical data ; Humans ; Incisor ; Male ; Maxilla ; Middle Aged ; Patient Satisfaction ; Prospective Studies ; Quality of Life ; Tooth Loss ; Treatment Outcome
    Language English
    Publishing date 2016-02
    Publishing country England
    Document type Journal Article ; Randomized Controlled Trial
    ZDB-ID 186068-9
    ISSN 1879-176X ; 0300-5712
    ISSN (online) 1879-176X
    ISSN 0300-5712
    DOI 10.1016/j.jdent.2015.12.006
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    Zs.A 860: Show issues Location:
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    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
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  8. Article ; Online: Zebrafish expression reporters and mutants reveal that the IgSF cell adhesion molecule Dscamb is required for feeding and survival.

    Julien, Donald P / Chan, Alex W / Barrios, Joshua / Mathiaparanam, Jaffna / Douglass, Adam / Wolman, Marc A / Sagasti, Alvaro

    Journal of neurogenetics

    2018  Volume 32, Issue 4, Page(s) 336–352

    Abstract: Down syndrome cell adhesion molecules (DSCAMs) are broadly expressed in nervous systems and play conserved roles in programmed cell death, neuronal migration, axon guidance, neurite branching and spacing, and synaptic targeting. However, DSCAMs appear to ...

    Abstract Down syndrome cell adhesion molecules (DSCAMs) are broadly expressed in nervous systems and play conserved roles in programmed cell death, neuronal migration, axon guidance, neurite branching and spacing, and synaptic targeting. However, DSCAMs appear to have distinct functions in different vertebrate animals, and little is known about their functions outside the retina. We leveraged the genetic tractability and optical accessibility of larval zebrafish to investigate the expression and function of a DSCAM family member, dscamb. Using targeted genome editing to create transgenic reporters and loss-of-function mutant alleles, we discovered that dscamb is expressed broadly throughout the brain, spinal cord, and peripheral nervous system, but is not required for overall structural organization of the brain. Despite the absence of obvious anatomical defects, homozygous dscamb mutants were deficient in their ability to ingest food and rarely survived to adulthood. Thus, we have discovered a novel function for dscamb in feeding behavior. The mutant and transgenic lines generated in these studies will provide valuable tools for identifying the molecular and cellular bases of these behaviors.
    MeSH term(s) Animals ; Animals, Genetically Modified ; Cell Adhesion Molecules/metabolism ; Feeding Behavior/physiology ; Zebrafish ; Zebrafish Proteins/metabolism
    Chemical Substances Cell Adhesion Molecules ; Zebrafish Proteins ; dscama protein, zebrafish
    Language English
    Publishing date 2018-09-11
    Publishing country England
    Document type Journal Article ; Research Support, N.I.H., Extramural
    ZDB-ID 605543-6
    ISSN 1563-5260 ; 0167-7063
    ISSN (online) 1563-5260
    ISSN 0167-7063
    DOI 10.1080/01677063.2018.1493479
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    Zs.A 1878: Show issues Location:
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  9. Article: Unusual maxillary lateral incisors: case reports.

    Low, Danny / Chan, Alex W K

    Australian endodontic journal : the journal of the Australian Society of Endodontology Inc

    2004  Volume 30, Issue 1, Page(s) 15–19

    Abstract: Root canal morphology is often complex and the number of root canals may vary for any type of tooth. Abnormalities in the root canal morphology of maxillary lateral inciors are rare. Maxillary lateral incisors can have two root canals, even though the ... ...

    Abstract Root canal morphology is often complex and the number of root canals may vary for any type of tooth. Abnormalities in the root canal morphology of maxillary lateral inciors are rare. Maxillary lateral incisors can have two root canals, even though the dental literature supports their 100% single-canal anatomy. It is vital to consider the possibility of extra root canal(s), even in teeth with a low frequency of abnormal root canal anatomy. This report presents two cases of maxillary lateral incisors with two root canals.
    MeSH term(s) Adult ; Dental Caries/therapy ; Dental Pulp Cavity/abnormalities ; Female ; Follow-Up Studies ; Humans ; Incisor/abnormalities ; Male ; Maxilla ; Periapical Periodontitis/therapy ; Root Canal Therapy
    Language English
    Publishing date 2004-04-19
    Publishing country Australia
    Document type Case Reports ; Journal Article
    ZDB-ID 2146484-4
    ISSN 1747-4477 ; 1329-1947
    ISSN (online) 1747-4477
    ISSN 1329-1947
    DOI 10.1111/j.1747-4477.2004.tb00161.x
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    Zs.A 5877: Show issues Location:
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  10. Article: The currency board in Hong Kong

    Chan, Alex W. H

    Exchange rate regimes and macroeconomic stability , p. 215-246

    operational weaknesses and a proposed refinement scheme

    2003  , Page(s) 215–246

    Author's details Alex W. H. Chan
    Keywords Currency-Board-System ; Spekulation ; Währungsreserven ; Wechselkurspolitik ; Hongkong ; Finanzkrise
    Language English
    Size graph. Darst
    Publisher Kluwer Acad. Publ.
    Publishing place Boston [u.a.]
    Document type Article
    Database ECONomics Information System

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