LIVIVO - The Search Portal for Life Sciences

zur deutschen Oberfläche wechseln
Advanced search

Search results

Result 1 - 10 of total 67

Search options

  1. Book: Immunotherapeutics

    Chan, Andrew C.

    (Immunological reviews ; 223)

    2008  

    Author's details Andrew C. Chan, guest ed
    Series title Immunological reviews ; 223
    Collection
    Language English
    Size 421 S. : Ill., graph. Darst.
    Publisher Blackwell Munksgaard
    Publishing place Oxford
    Publishing country Great Britain
    Document type Book
    HBZ-ID HT015721570
    Database Catalogue ZB MED Medicine, Health

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    Se 160 -223- verfügbar in Königswinter Königswinter

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  2. Article ; Online: Ocrelizumab: A New Therapeutic Paradigm for Multiple Sclerosis

    Chin, Peter / Chan, Andrew C

    Biochemistry

    2018  Volume 57, Issue 5, Page(s) 474–476

    MeSH term(s) Animals ; Antibodies, Monoclonal, Humanized/therapeutic use ; Antigens, CD20/immunology ; B-Lymphocytes/drug effects ; B-Lymphocytes/immunology ; B-Lymphocytes/pathology ; Biochemistry ; Clinical Trials as Topic ; Drug Approval ; Humans ; Immunity, Cellular/drug effects ; Immunologic Factors/therapeutic use ; Multiple Sclerosis/drug therapy ; Multiple Sclerosis/immunology ; Multiple Sclerosis/pathology
    Chemical Substances Antibodies, Monoclonal, Humanized ; Antigens, CD20 ; Immunologic Factors ; ocrelizumab (A10SJL62JY)
    Language English
    Publishing date 2018--06
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1108-3
    ISSN 1520-4995 ; 0006-2960
    ISSN (online) 1520-4995
    ISSN 0006-2960
    DOI 10.1021/acs.biochem.7b00796
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.A 217: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  3. Article ; Online: 30 Years of Biotherapeutics Development-What Have We Learned?

    Ghilardi, Nico / Pappu, Rajita / Arron, Joseph R / Chan, Andrew C

    Annual review of immunology

    2020  Volume 38, Page(s) 249–287

    Abstract: Since the birth of biotechnology, hundreds of biotherapeutics have been developed and approved by the US Food and Drug Administration (FDA) for human use. These novel medicines not only bring significant benefit to patients but also represent precision ... ...

    Abstract Since the birth of biotechnology, hundreds of biotherapeutics have been developed and approved by the US Food and Drug Administration (FDA) for human use. These novel medicines not only bring significant benefit to patients but also represent precision tools to interrogate human disease biology. Accordingly, much has been learned from the successes and failures of hundreds of high-quality clinical trials. In this review, we discuss general and broadly applicable themes that have emerged from this collective experience. We base our discussion on insights gained from exploring some of the most important target classes, including interleukin-1 (IL-1), tumor necrosis factor α (TNF-α), IL-6, IL-12/23, IL-17, IL-4/13, IL-5, immunoglobulin E (IgE), integrins and B cells. We also describe current challenges and speculate about how emerging technological capabilities may enable the discovery and development of the next generation of biotherapeutics.
    MeSH term(s) Animals ; Biological Products/history ; Biological Products/pharmacology ; Biological Products/therapeutic use ; Biological Therapy/history ; Biological Therapy/methods ; Biotechnology/history ; Biotechnology/methods ; Clinical Trials as Topic ; Drug Development/history ; Drug Discovery/history ; Drug Discovery/methods ; Drug Evaluation, Preclinical ; History, 20th Century ; History, 21st Century ; Humans
    Chemical Substances Biological Products
    Language English
    Publishing date 2020-05-18
    Publishing country United States
    Document type Historical Article ; Journal Article ; Review
    ZDB-ID 604953-9
    ISSN 1545-3278 ; 0732-0582
    ISSN (online) 1545-3278
    ISSN 0732-0582
    DOI 10.1146/annurev-immunol-101619-031510
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Se 849: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  4. Article ; Online: Rituximab's new therapeutic target: the podocyte actin cytoskeleton.

    Chan, Andrew C

    Science translational medicine

    2011  Volume 3, Issue 85, Page(s) 85ps21

    Abstract: Therapeutic off-target activities are well recognized for small-molecule drugs. In contrast, monoclonal antibodies (mAbs) traditionally are believed to act specifically and lack off-target therapeutic effects. In this issue of Science Translational ... ...

    Abstract Therapeutic off-target activities are well recognized for small-molecule drugs. In contrast, monoclonal antibodies (mAbs) traditionally are believed to act specifically and lack off-target therapeutic effects. In this issue of Science Translational Medicine, Fornoni et al. show therapeutic benefit, through an off-target-mediated mechanism, of the mAb drug rituximab in recurrent focal segmental glomerulosclerosis (FSGS) after kidney transplantation. These data shed new light on FSGS pathogenesis and suggest new therapeutic interventions for proteinuric diseases.
    MeSH term(s) Adolescent ; Antibodies, Monoclonal, Murine-Derived/pharmacology ; Antibodies, Monoclonal, Murine-Derived/therapeutic use ; Antigens, CD20/metabolism ; Apoptosis/drug effects ; Child ; Female ; Glomerulosclerosis, Focal Segmental/drug therapy ; Glomerulosclerosis, Focal Segmental/metabolism ; Humans ; Male ; Podocytes/cytology ; Podocytes/drug effects ; Podocytes/metabolism ; Rituximab ; Sphingomyelin Phosphodiesterase/metabolism
    Chemical Substances Antibodies, Monoclonal, Murine-Derived ; Antigens, CD20 ; Rituximab (4F4X42SYQ6) ; SMPDL3B protein, human (EC 3.1.4.12) ; Sphingomyelin Phosphodiesterase (EC 3.1.4.12)
    Language English
    Publishing date 2011-06-01
    Publishing country United States
    Document type Comment ; Journal Article
    ZDB-ID 2518854-9
    ISSN 1946-6242 ; 1946-6234
    ISSN (online) 1946-6242
    ISSN 1946-6234
    DOI 10.1126/scitranslmed.3002429
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.A 6941: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  5. Article ; Online: B cell immunotherapy in autoimmunity--2010 update.

    Chan, Andrew C

    Molecular immunology

    2011  Volume 48, Issue 11, Page(s) 1344–1347

    Abstract: B cells play important roles in normal immunity and human disease. While much has been learned from elegant studies utilizing genetically modified mice or with immunotherapy in normal and in autoimmune mice, we are merely at the start of learning about ... ...

    Abstract B cells play important roles in normal immunity and human disease. While much has been learned from elegant studies utilizing genetically modified mice or with immunotherapy in normal and in autoimmune mice, we are merely at the start of learning about the mechanism(s) by which B cells contribute to human autoimmune disease. Here, I will review the most recent insights obtained with immunomodulatory therapies in human disease highlighting the clinical and immunological lessons we have learned with B cell depleting (e.g., rituximab) and immunomodulatory (e.g., BAFF/BLys neutralization through belimumab) therapies.
    MeSH term(s) Antibodies, Monoclonal/therapeutic use ; Antibodies, Monoclonal, Humanized ; Antibodies, Monoclonal, Murine-Derived/therapeutic use ; Autoimmune Diseases/therapy ; Autoimmunity/immunology ; B-Lymphocytes/immunology ; Diabetes Mellitus, Type 1/therapy ; Humans ; Immunologic Factors/therapeutic use ; Immunomodulation ; Immunotherapy ; Lupus Erythematosus, Systemic/therapy ; Randomized Controlled Trials as Topic ; Rituximab
    Chemical Substances Antibodies, Monoclonal ; Antibodies, Monoclonal, Humanized ; Antibodies, Monoclonal, Murine-Derived ; Immunologic Factors ; Rituximab (4F4X42SYQ6) ; belimumab (73B0K5S26A)
    Language English
    Publishing date 2011-06
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 424427-8
    ISSN 1872-9142 ; 0161-5890
    ISSN (online) 1872-9142
    ISSN 0161-5890
    DOI 10.1016/j.molimm.2010.11.021
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.A 166: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  6. Article ; Online: A golden era of opportunity in immunotherapy discovery and development.

    Chan, Andrew C

    Immunological reviews

    2008  Volume 223, Page(s) 5–6

    MeSH term(s) Animals ; Drug Design ; Humans ; Immune System/immunology ; Immune System/pathology ; Immunologic Factors/therapeutic use ; Immunotherapy/trends
    Chemical Substances Immunologic Factors
    Language English
    Publishing date 2008-06
    Publishing country England
    Document type Introductory Journal Article
    ZDB-ID 391796-4
    ISSN 1600-065X ; 0105-2896
    ISSN (online) 1600-065X
    ISSN 0105-2896
    DOI 10.1111/j.1600-065X.2008.00642.x
    Database MEDical Literature Analysis and Retrieval System OnLINE

    Full text online

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Se 160: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  7. Article ; Online: Personalizing medicine for autoimmune and inflammatory diseases.

    Chan, Andrew C / Behrens, Timothy W

    Nature immunology

    2013  Volume 14, Issue 2, Page(s) 106–109

    Abstract: Therapies that target molecular pathways do not provide uniform benefits for all patients at present. New transformative therapies for autoimmune and inflammatory diseases require greater molecular understanding of patient subsets and the ability to ... ...

    Abstract Therapies that target molecular pathways do not provide uniform benefits for all patients at present. New transformative therapies for autoimmune and inflammatory diseases require greater molecular understanding of patient subsets and the ability to personalize targeted therapies for each subset.
    MeSH term(s) Antineoplastic Agents/economics ; Antineoplastic Agents/therapeutic use ; Autoimmune Diseases/genetics ; Autoimmune Diseases/immunology ; Autoimmune Diseases/therapy ; Genetic Heterogeneity ; Humans ; Immunosuppressive Agents/economics ; Immunosuppressive Agents/therapeutic use ; Inflammation/genetics ; Inflammation/immunology ; Inflammation/therapy ; Molecular Targeted Therapy ; Neoplasms/genetics ; Neoplasms/immunology ; Neoplasms/therapy ; Precision Medicine
    Chemical Substances Antineoplastic Agents ; Immunosuppressive Agents
    Language English
    Publishing date 2013-01-18
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2016987-5
    ISSN 1529-2916 ; 1529-2908
    ISSN (online) 1529-2916
    ISSN 1529-2908
    DOI 10.1038/ni.2473
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.A 5294: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)
    Zs.MG 42: Show issues

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  8. Article: B cell immunotherapy in autoimmunity – 2010 update

    Chan, Andrew C

    Molecular immunology. 2011 June, v. 48, no. 11

    2011  

    Abstract: B cells play important roles in normal immunity and human disease. While much has been learned from elegant studies utilizing genetically modified mice or with immunotherapy in normal and in autoimmune mice, we are merely at the start of learning about ... ...

    Abstract B cells play important roles in normal immunity and human disease. While much has been learned from elegant studies utilizing genetically modified mice or with immunotherapy in normal and in autoimmune mice, we are merely at the start of learning about the mechanism(s) by which B cells contribute to human autoimmune disease. Here, I will review the most recent insights obtained with immunomodulatory therapies in human disease highlighting the clinical and immunological lessons we have learned with B cell depleting (e.g., rituximab) and immunomodulatory (e.g., BAFF/BLys neutralization through belimumab) therapies.
    Keywords autoimmune diseases ; autoimmunity ; human diseases ; humans ; immunotherapy ; learning ; mice ; neutralization
    Language English
    Dates of publication 2011-06
    Size p. 1344-1347.
    Publishing place Elsevier Ltd
    Document type Article
    ZDB-ID 424427-8
    ISSN 1872-9142 ; 0161-5890
    ISSN (online) 1872-9142
    ISSN 0161-5890
    DOI 10.1016/j.molimm.2010.11.021
    Database NAL-Catalogue (AGRICOLA)

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.A 166: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  9. Article ; Online: Improving Health Equity in Rheumatology Through Workforce Diversification and Support for Health Equity Research and Education.

    Vassileva, Maria T / Suresh, Vandana / Chan, Andrew C / Akinsete, Alisha Valdez / Blanco, Irene / Blazer, Ashira / Criscione-Schreiber, Lisa / Dowell, Sharon / Feldman, Candace H / FitzGerald, John / Gilbert, Mileka / Hughes, Grant / Husni, M Elaine / Kerr, Gail / Kwan, Olivia / Mantilla, Bryanna / Nilson, Susanne / Rivadeneira, Alfredo Carlos / Rodríguez, Martha /
    Smith, Benjamin J / Soulsby, William Daniel / Wong, Stephen Chee-Yung / Yazdany, Jinoos / Ross, Will

    Arthritis & rheumatology (Hoboken, N.J.)

    2024  

    Language English
    Publishing date 2024-01-19
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2756371-6
    ISSN 2326-5205 ; 2326-5191
    ISSN (online) 2326-5205
    ISSN 2326-5191
    DOI 10.1002/art.42804
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.A 24: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  10. Book: Immunotherapeutics

    Chan, Andrew C

    (Immunological reviews ; 223)

    2008  

    Author's details Andrew C. Chan, guest ed
    Series title Immunological reviews ; 223
    Language English
    Size 421 S., Ill., graph. Darst.
    Publisher Blackwell Munksgaard
    Publishing place Oxford
    Document type Book
    Note Literaturangaben
    Database Former special subject collection: coastal and deep sea fishing

    More links

    Kategorien

    Inter-library loan at ZB MED

    Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

To top