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Book ; Online ; E-Book: Immunotherapy for head and neck cancer

Chan, Anthony T. C. / Ma, Brigette B.Y.

(Cancer immunotherapy ; 1)

2023

Author's details	Anthony T. C. Chan, Brigette B.Y. Ma editors
Series title	Cancer immunotherapy ; 1
Collection
Keywords	Immunotherapy ; Oncology ; Radiation Oncology ; Surgery ; Otorhinolaryngology ; Medical radiology
Subject code	615.37 ; 571.96
Language	English
Size	1 Online-Ressource (VIII, 147 Seiten), Illustrationen
Publisher	Springer
Publishing place	Cham
Publishing country	Switzerland
Document type	Book ; Online ; E-Book
Remark	Zugriff für angemeldete ZB MED-Nutzerinnen und -Nutzer
HBZ-ID	HT030702740
ISBN	978-3-031-29223-1 ; 9783031292255 ; 3-031-29223-5 ; 3031292251
Database	ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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Article ; Online: Nasopharyngeal cancer screening with an anti-BNLF2b antibody: a new arrow in the quiver?

Lam, W K Jacky / Chan, Anthony T C

Nature reviews. Clinical oncology

2023 Volume 21, Issue 1, Page(s) 6–7

MeSH term(s)	Humans ; Nasopharyngeal Neoplasms/diagnosis ; Early Detection of Cancer ; Nasopharyngeal Carcinoma/diagnosis
Language	English
Publishing date	2023-10-04
Publishing country	England
Document type	Journal Article
ZDB-ID	2491410-1
ISSN	1759-4782 ; 1759-4774
ISSN (online)	1759-4782
ISSN	1759-4774
DOI	10.1038/s41571-023-00827-1
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Article: Clinical Experience of Intrafractional Motion Monitoring of Patients Under Head and Neck Radiation Therapy Using ExacTrac Dynamic System.

Chow, Vivian U Y / Cheung, Michael L M / Kan, Monica W K / Chan, Anthony T C

Advances in radiation oncology

2023 Volume 9, Issue 3, Page(s) 101390

Abstract: Purpose: The combination of surface-guided radiation therapy (SGRT) and image-guided radiation therapy (IGRT) can provide complementary information of patient positioning throughout treatments. The ExacTrac Dynamic (EXTD) system is a combined SGRT and ... ...

Abstract	Purpose: The combination of surface-guided radiation therapy (SGRT) and image-guided radiation therapy (IGRT) can provide complementary information of patient positioning throughout treatments. The ExacTrac Dynamic (EXTD) system is a combined SGRT and IGRT system that can provide real-time motion detection via optical surface and thermal tracking during treatment delivery, with stereoscopic x-ray for positional verification. The purpose of this study was to examine the performance of EXTD for intrafractional motion monitoring using real clinical cases. Methods and materials: Treatment log files exported from EXTD for 40 patients with 335 fractions were retrospectively analyzed. Frequency of beam-hold triggered during treatments were recorded, with the comparison of shifts detected by optical surface tracking (EXTD_Thml) and x-ray verification (EXTD_Xray). Results: Among the 335 fractions, automatic beam-holds were triggered 41 times, followed by x-ray positional verification with internal anatomy. The difference of shifts detected by EXTD_Thml and EXTD_Xray were less than 1 mm and 1° in translational and rotational directions, respectively. After x-ray verification, none of them required the application of positional correction. Conclusions: The availability of x-ray imaging with optical surface tracking in EXTD is essential to verify whether geometric shifts are required to correct patient position. Considering the ability of continuous monitoring of patient positions with optical surface tracking and internal imaging, EXTD is an effective tool for intrafractional motion monitoring during radiation therapy.
Language	English
Publishing date	2023-10-21
Publishing country	United States
Document type	Journal Article
ISSN	2452-1094
ISSN	2452-1094
DOI	10.1016/j.adro.2023.101390
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Article ; Online: The expanding universe of checkpoint inhibitors for nasopharyngeal cancer.

Ma, Brigette B Y / Hui, Edwin P / Chan, Anthony T C

Nature medicine

2021 Volume 27, Issue 9, Page(s) 1512–1513

MeSH term(s)	Humans ; Nasopharyngeal Carcinoma/drug therapy ; Nasopharyngeal Neoplasms/drug therapy
Language	English
Publishing date	2021-09-13
Publishing country	United States
Document type	Journal Article ; Comment
ZDB-ID	1220066-9
ISSN	1546-170X ; 1078-8956
ISSN (online)	1546-170X
ISSN	1078-8956
DOI	10.1038/s41591-021-01482-8
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Article ; Online: The effect of material assignment in nasal cavity on dose calculation for nasopharyngeal carcinoma (NPC) using Acuros XB.

Cheung, Michael L M / Chow, Vivian U Y / Kan, Monica W K / Chan, Anthony T C

Journal of applied clinical medical physics

2022 Volume 23, Issue 8, Page(s) e13698

Abstract: Purpose: To evaluate the effect of material assignment in nasal cavity on dose calculation for the volumetric modulated arc therapy (VMAT) of nasopharyngeal carcinoma (NPC) using Acuros XB (AXB) algorithm.: Methods: The VMAT plans of 30 patients with ...

Abstract	Purpose: To evaluate the effect of material assignment in nasal cavity on dose calculation for the volumetric modulated arc therapy (VMAT) of nasopharyngeal carcinoma (NPC) using Acuros XB (AXB) algorithm. Methods: The VMAT plans of 30 patients with NPC were calculated using AXB with material auto-assignment of nasal cavity to lung and reassignment to air respectively. The doses to the planning target volumes (PTVs) overlapping with nasal cavity with material auto-assignment of lung (AXB_Lung) were compared to the values obtained when nasal cavity was reassigned to air (AXB_Air) under the dose-to-medium (D Results: For dose calculated under AXB_Lung, the D Conclusions: Significant dose difference calculated by AXB between the material assignment of lung and air in nasal cavity for NPC cases might imply the possibility of underdosage to the PTVs that overlap with inhomogeneity. Therefore, attention should be put to ensure that accurate material assignment for dose calculation under AXB such that optimal dosage was given for tumor control.
MeSH term(s)	Algorithms ; Humans ; Nasal Cavity ; Nasopharyngeal Carcinoma/radiotherapy ; Nasopharyngeal Neoplasms/radiotherapy ; Phantoms, Imaging ; Radiotherapy Dosage ; Radiotherapy Planning, Computer-Assisted ; Radiotherapy, Intensity-Modulated
Language	English
Publishing date	2022-06-14
Publishing country	United States
Document type	Journal Article
ZDB-ID	2010347-5
ISSN	1526-9914 ; 1526-9914
ISSN (online)	1526-9914
ISSN	1526-9914
DOI	10.1002/acm2.13698
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Article ; Online: Shift detection discrepancy between ExacTrac Dynamic system and cone-beam computed tomography.

Chow, Vivian U Y / Cheung, Michael L M / Kan, Monica W K / Chan, Anthony T C

Journal of applied clinical medical physics

2022 Volume 23, Issue 5, Page(s) e13567

Abstract: Accurate detection of patient shift is essential during radiation therapy such that optimal dose is delivered to the tumor while minimizing radiation to surrounding normal tissues. The shift detectability of a newly developed optical surface and thermal ... ...

Abstract	Accurate detection of patient shift is essential during radiation therapy such that optimal dose is delivered to the tumor while minimizing radiation to surrounding normal tissues. The shift detectability of a newly developed optical surface and thermal tracking system, which was known as ExacTrac Dynamic (EXTD), was evaluated by comparing its performance with the image guidance under cone-beam computed tomography (CBCT). Anthropomorphic cranial and pelvis phantoms with internal bone-like structures and external heat pad were utilized to study the shift detection discrepancy between EXTD system and CBCT. Random displacements within the range of ± 2 cm for translations and ± 2 degrees for rotations were intentionally applied to the phantom. Positional shifts detected by optical surface and thermal tracking (EXTD_Thml), stereoscopic X-ray (EXTD_Xray), and CBCT were compared in 6 degrees of freedom. The translational difference between EXTD_Thml and CBCT was 0.57 ± 0.41 mm and 0.66 ± 0.40 mm for cranial and pelvis phantom, respectively, while it was 0.60 ± 0.43 mm and 0.76 ± 0.49 mm between EXTD_Xray and CBCT, respectively. For rotational movement, the difference between EXTD_Thml and CBCT was 0.19 ± 0.16° and 0.19 ± 0.22° for cranial and pelvis phantom, respectively, while it was 0.13 ± 0.18° and 0.65 ± 0.46° between EXTD_Xray and CBCT, respectively. This study demonstrated that the EXTD system with thermal mapping ability could offer comparable accuracy for shift detection with CBCT on both cranial and pelvis phantoms.
MeSH term(s)	Cone-Beam Computed Tomography/methods ; Humans ; Neoplasms ; Phantoms, Imaging ; Radiography ; Radiosurgery/methods
Language	English
Publishing date	2022-02-21
Publishing country	United States
Document type	Journal Article
ZDB-ID	2010347-5
ISSN	1526-9914 ; 1526-9914
ISSN (online)	1526-9914
ISSN	1526-9914
DOI	10.1002/acm2.13567
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Article ; Online: The emerging data on choice of optimal therapy for locally advanced nasopharyngeal carcinoma.

Hui, Edwin Pun / Ma, Brigette B Y / Chan, Anthony T C

Current opinion in oncology

2020 Volume 32, Issue 3, Page(s) 187–195

Abstract: Purpose of review: We focus on the emerging data from randomized clinical trials for optimal integration of induction, concurrent, and/or adjuvant chemotherapy with intensity-modulated radiotherapy in locally advanced nasopharyngeal carcinoma (NPC), and ...

Abstract	Purpose of review: We focus on the emerging data from randomized clinical trials for optimal integration of induction, concurrent, and/or adjuvant chemotherapy with intensity-modulated radiotherapy in locally advanced nasopharyngeal carcinoma (NPC), and the use of plasma Epstein-Barr virus (EBV) DNA for risk stratification. Recent findings: Several phase 3 trials have shown that induction chemotherapy followed by concurrent chemoradiation (CRT) improved overall survival or disease-free survival when compared to CRT alone in stage III/IV NPC who is at high risk of distant metastases. The benefit of adjuvant chemotherapy following CRT when compared to CRT alone is uncertain. There are increasing clinical data supporting the use of plasma EBV DNA for risk stratification. There are growing clinical data supporting the integration of immune checkpoint inhibitors into the induction, concurrent, and/or adjuvant/maintenance phase of treatment in locally advanced NPC. Summary: Concurrent chemoradiation remains the standard treatment backbone in locally advanced NPC. There is level 1 evidence for induction chemotherapy followed by CRT in stage III/IV NPC. There is increasing evidence against the indiscriminate use of adjuvant chemotherapy following CRT. With the increasing treatment intensification, future treatment algorithm in NPC should incorporate plasma EBV DNA and other biomarkers for risk stratification and treatment selection.
MeSH term(s)	Chemoradiotherapy ; Clinical Trials, Phase III as Topic ; Humans ; Induction Chemotherapy ; Nasopharyngeal Neoplasms/drug therapy ; Nasopharyngeal Neoplasms/pathology ; Nasopharyngeal Neoplasms/radiotherapy ; Neoplasm Staging ; Radiotherapy, Intensity-Modulated ; Randomized Controlled Trials as Topic
Language	English
Publishing date	2020-01-24
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Review
ZDB-ID	1049384-0
ISSN	1531-703X ; 1040-8746
ISSN (online)	1531-703X
ISSN	1040-8746
DOI	10.1097/CCO.0000000000000622
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Article ; Online: Patient-specific quality assurance using machine log files analysis for stereotactic body radiation therapy (SBRT).

Chow, Vivian U Y / Kan, Monica W K / Chan, Anthony T C

Journal of applied clinical medical physics

2020 Volume 21, Issue 11, Page(s) 179–187

Abstract: An in-house trajectory log analysis program (LOGQA) was developed to evaluate the delivery accuracy of volumetric-modulated arc therapy (VMAT) for stereotactic body radiation therapy (SBRT). Methods have been established in LOGQA to provide analysis on ... ...

Abstract	An in-house trajectory log analysis program (LOGQA) was developed to evaluate the delivery accuracy of volumetric-modulated arc therapy (VMAT) for stereotactic body radiation therapy (SBRT). Methods have been established in LOGQA to provide analysis on dose indices, gantry angles, and multi-leaf collimator (MLC) positions. Between March 2019 and May 2020, 120 VMAT SBRT plans of various treatment sites using flattening filter-free (FFF) mode were evaluated using both LOGQA and phantom measurements. Gantry angles, dose indices, and MLC positions were extracted from log and compared with each plan. Integrated transient fluence map (ITFM) was reconstructed from log to examine the deviation of delivered fluence against the planned one. Average correlation coefficient of dose index versus gantry angle and ITFM for all patients were 1.0000, indicating that the delivered beam parameters were in good agreement with planned values. Maximum deviation of gantry angles and monitor units (MU) of all patients were less than 0.2 degree and 0.03 % respectively. Regarding MLC positions, maximum and root-mean-square (RMS) deviations from planned values were less than 0.6 mm and 0.3 mm respectively, indicating that MLC positions during delivery followed planned values in precise manner. Results of LOGQA were consistent with measurement, where all gamma-index passing rates were larger than 95 %, with 2 %/2 mm criteria. Three types of intentional errors were introduced to patient plan for software validation. LOGQA was found to recognize the introduced errors of MLC positions, gantry angles, and dose indices with magnitudes of 1 mm, 1 degree, and 5 %, respectively, which were masked in phantom measurement. LOGQA was demonstrated to have the potential to reduce or even replace patient-specific QA measurements for SBRT plan delivery provided that the frequency and amount of measurement-based machine-specific QA can be increased to ensure the log files record real values of machine parameters.
MeSH term(s)	Humans ; Particle Accelerators ; Phantoms, Imaging ; Radiosurgery ; Radiotherapy Dosage ; Radiotherapy Planning, Computer-Assisted ; Radiotherapy, Intensity-Modulated
Language	English
Publishing date	2020-10-19
Publishing country	United States
Document type	Journal Article
ZDB-ID	2010347-5
ISSN	1526-9914 ; 1526-9914
ISSN (online)	1526-9914
ISSN	1526-9914
DOI	10.1002/acm2.13053
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Article ; Online: Magnetic-field-modulated radiotherapy (MagMRT) in inhomogeneous medium and its potential applications.

Chu, Vivien W S / Kan, Monica W K / Lee, Louis K Y / Wong, Kenneth C W / Chan, Anthony T C

Biomedical physics & engineering express

2022 Volume 8, Issue 6

Abstract: Objective. ...

Abstract	Objective.
MeSH term(s)	Lung/radiation effects ; Magnetic Fields ; Monte Carlo Method ; Phantoms, Imaging ; Water
Chemical Substances	Water (059QF0KO0R)
Language	English
Publishing date	2022-09-29
Publishing country	England
Document type	Journal Article
ISSN	2057-1976
ISSN (online)	2057-1976
DOI	10.1088/2057-1976/ac9390
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Article ; Online: Opportunities and challenges in combining immunotherapy and radiotherapy in head and neck cancers.

Wong, Kenneth C W / Johnson, David / Hui, Edwin P / Lam, Rachel C T / Ma, Brigette B Y / Chan, Anthony T C

Cancer treatment reviews

2022 Volume 105, Page(s) 102361

Abstract: Locally advanced and recurrent/ metastatic (R/M) head and neck cancers have poor prognosis generally. Radiotherapy (RT) is known to have multiple immunomodulatory effects, and various immune checkpoint inhibitors (ICIs) have been shown to be efficacious ... ...

Abstract	Locally advanced and recurrent/ metastatic (R/M) head and neck cancers have poor prognosis generally. Radiotherapy (RT) is known to have multiple immunomodulatory effects, and various immune checkpoint inhibitors (ICIs) have been shown to be efficacious in the R/M setting in recent years. Hence, it is logical to combine RT and ICIs to improve the outlook for such patients, especially in view of the promising pre-clinical data on this novel combination. In this review, we highlighted the key mechanisms underlying the immunostimulatory and immunoinhibitory effects of RT, with a view to suggesting strategies to overcome radioresistance. We also discussed how the unique immune landscapes of virus-induced cancers, namely Epstein-Barr virus-induced nasopharyngeal carcinoma and human papillomavirus-mediated oropharyngeal cancer, could be exploited with ICIs. The landmark clinical trials in both the locally advanced and R/M settings were reviewed, and these trials showed that the combination of RT and ICIs is generally well tolerated. The potential reasons behind the largely negative results of these studies were also explored, focusing on various parameters including dose fractionation, sequencing, irradiated volume and the use of predictive biomarkers.
MeSH term(s)	Epstein-Barr Virus Infections/complications ; Head and Neck Neoplasms/drug therapy ; Head and Neck Neoplasms/radiotherapy ; Herpesvirus 4, Human ; Humans ; Immunotherapy/methods ; Nasopharyngeal Neoplasms ; Neoplasm Recurrence, Local/drug therapy ; Squamous Cell Carcinoma of Head and Neck
Language	English
Publishing date	2022-02-16
Publishing country	Netherlands
Document type	Journal Article ; Review
ZDB-ID	125102-8
ISSN	1532-1967 ; 0305-7372
ISSN (online)	1532-1967
ISSN	0305-7372
DOI	10.1016/j.ctrv.2022.102361
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