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  1. Article ; Online: Pyrene-based heparin sensors in competitive aqueous media - the role of self-assembled multivalency (SAMul).

    Chan, Ching W / Smith, David K

    Chemical communications (Cambridge, England)

    2016  Volume 52, Issue 19, Page(s) 3785–3788

    Abstract: Amine-functionalised pyrene derivatives are reported and their ability to detect heparin via a fluorescent response determined - different responses are observed dependent on whether self-assembled multivalent binding between sensor and analyte takes ... ...

    Abstract Amine-functionalised pyrene derivatives are reported and their ability to detect heparin via a fluorescent response determined - different responses are observed dependent on whether self-assembled multivalent binding between sensor and analyte takes place, and ratiometric heparin sensors which can detect this surgically-relevant polyanion in competitive media are reported.
    Language English
    Publishing date 2016-03-07
    Publishing country England
    Document type Journal Article
    ZDB-ID 1472881-3
    ISSN 1364-548X ; 1359-7345 ; 0009-241X
    ISSN (online) 1364-548X
    ISSN 1359-7345 ; 0009-241X
    DOI 10.1039/c6cc00163g
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: Pyrene-based heparin sensors in competitive aqueous media – the role of self-assembled multivalency (SAMul)

    Chan, Ching W / David K. Smith

    Chemical communications. 2016 Feb. 25, v. 52, no. 19

    2016  

    Abstract: Amine-functionalised pyrene derivatives are reported and their ability to detect heparin via a fluorescent response determined – different responses are observed dependent on whether self-assembled multivalent binding between sensor and analyte takes ... ...

    Abstract Amine-functionalised pyrene derivatives are reported and their ability to detect heparin via a fluorescent response determined – different responses are observed dependent on whether self-assembled multivalent binding between sensor and analyte takes place, and ratiometric heparin sensors which can detect this surgically-relevant polyanion in competitive media are reported.
    Keywords anions ; chemical compounds ; chemical reactions ; fluorescence ; heparin
    Language English
    Dates of publication 2016-0225
    Size p. 3785-3788.
    Publishing place The Royal Society of Chemistry
    Document type Article
    ZDB-ID 1472881-3
    ISSN 1364-548X ; 1359-7345 ; 0009-241X
    ISSN (online) 1364-548X
    ISSN 1359-7345 ; 0009-241X
    DOI 10.1039/c6cc00163g
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  3. Article: Chiral recognition at self-assembled multivalent (SAMul) nanoscale interfaces – enantioselectivity in polyanion binding

    Chan, Ching W / Laurini, Erik / Posocco, Paola / Pricl, Sabrina / Smith, David K

    Chemical communications. 2016 Aug. 18, v. 52, no. 69

    2016  

    Abstract: Self-assembled multivalent (SAMul) ligands based on palmitic acid functionalised with cationic l/d-lysine bind polyanionic heparin or DNA with no chiral preference. Inserting a glycine spacer unit switches on chiral discrimination – a rare example of ... ...

    Abstract Self-assembled multivalent (SAMul) ligands based on palmitic acid functionalised with cationic l/d-lysine bind polyanionic heparin or DNA with no chiral preference. Inserting a glycine spacer unit switches on chiral discrimination – a rare example of controlled chiral recognition at a SAMul nanoscale interface.
    Keywords DNA ; anions ; chemical reactions ; enantioselectivity ; heparin ; ligands ; palmitic acid
    Language English
    Dates of publication 2016-0818
    Size p. 10540-10543.
    Publishing place The Royal Society of Chemistry
    Document type Article
    ZDB-ID 1472881-3
    ISSN 1364-548X ; 1359-7345 ; 0009-241X
    ISSN (online) 1364-548X
    ISSN 1359-7345 ; 0009-241X
    DOI 10.1039/c6cc04470k
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  4. Article ; Online: Chiral recognition at self-assembled multivalent (SAMul) nanoscale interfaces - enantioselectivity in polyanion binding.

    Chan, Ching W / Laurini, Erik / Posocco, Paola / Pricl, Sabrina / Smith, David K

    Chemical communications (Cambridge, England)

    2016  Volume 52, Issue 69, Page(s) 10540–10543

    Abstract: Self-assembled multivalent (SAMul) ligands based on palmitic acid functionalised with cationic l/d-lysine bind polyanionic heparin or DNA with no chiral preference. Inserting a glycine spacer unit switches on chiral discrimination - a rare example of ... ...

    Abstract Self-assembled multivalent (SAMul) ligands based on palmitic acid functionalised with cationic l/d-lysine bind polyanionic heparin or DNA with no chiral preference. Inserting a glycine spacer unit switches on chiral discrimination - a rare example of controlled chiral recognition at a SAMul nanoscale interface.
    Language English
    Publishing date 2016-08-18
    Publishing country England
    Document type Journal Article
    ZDB-ID 1472881-3
    ISSN 1364-548X ; 1359-7345 ; 0009-241X
    ISSN (online) 1364-548X
    ISSN 1359-7345 ; 0009-241X
    DOI 10.1039/c6cc04470k
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article: Analysis of the flavonoid component of bioactive New Zealand mānuka (Leptospermum scoparium) honey and the isolation, characterisation and synthesis of an unusual pyrrole

    Chan, Ching W / Deadman, Benjamin J / Manley-Harris, Merilyn / Wilkins, Alistair L / Alber, Dagmar G / Harry, Elizabeth

    Food chemistry. 2013 Dec. 1, v. 141, no. 3

    2013  

    Abstract: The flavonoid components of New Zealand mānuka (Leptospermum scoparium) honey have been quantified in a series of 31 honeys of varying non-peroxide antibacterial activity to clarify discrepancies between previous studies reported in the literature. Total ...

    Abstract The flavonoid components of New Zealand mānuka (Leptospermum scoparium) honey have been quantified in a series of 31 honeys of varying non-peroxide antibacterial activity to clarify discrepancies between previous studies reported in the literature. Total flavonoid content was 1.16mg/100g honey. The principal flavonoids present were pinobanksin, pinocembrin, luteolin and chrysin and together these represented 61% of the total flavonoid content. 1, 2-formyl-5-(2-methoxyphenyl)-pyrrole, which was weakly correlated with the non-peroxide antibacterial activity, was isolated from the flavonoid fraction and separately synthesised. 1 did not display inhibitory activity against Staphylococcus aureus in vitro and thus the origin of the correlation, which is still unknown, is not a direct contribution.
    Keywords Leptospermum scoparium ; Staphylococcus aureus ; antibacterial properties ; honey ; New Zealand
    Language English
    Dates of publication 2013-1201
    Size p. 1772-1781.
    Publishing place Elsevier Ltd
    Document type Article
    ZDB-ID 243123-3
    ISSN 1873-7072 ; 0308-8146
    ISSN (online) 1873-7072
    ISSN 0308-8146
    DOI 10.1016/j.foodchem.2013.04.092
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    In stock of ZB MED Bonn / Germany

    Z 3634: Show issues

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  6. Article ; Online: Triple negative breast cancer in Asia: An insider's view.

    Wang, Chao / Kar, Shreya / Lai, Xianning / Cai, Wanpei / Arfuso, Frank / Sethi, Gautam / Lobie, Peter E / Goh, Boon C / Lim, Lina H K / Hartman, Mikael / Chan, Ching W / Lee, Soo C / Tan, Sing H / Kumar, Alan P

    Cancer treatment reviews

    2017  Volume 62, Page(s) 29–38

    Abstract: While tremendous improvement has been made for the treatment of breast cancers, the treatment of triple negative breast cancer (TNBC) still remains a challenge due to its aggressive characteristics and limited treatment options. Most of the studies on ... ...

    Abstract While tremendous improvement has been made for the treatment of breast cancers, the treatment of triple negative breast cancer (TNBC) still remains a challenge due to its aggressive characteristics and limited treatment options. Most of the studies on TNBC were conducted in Western population and TNBC is reported to be more frequent in the African women. This review encapsulates the studies conducted on TNBC patients in Asian population and elucidates the similarities and differences between these two regions. The current treatment of TNBC includes surgery, radiotherapy and chemotherapy. In addition to the current chemotherapies, which mainly include cytotoxic agents, such as taxanes and anthracyclines, many clinical trials are investigating the potential use of other chemotherapy drugs, targeted therapeutics and combinational therapies to treat TNBC. Moreover, this review also integrates the studies involving novel markers, which will help us to dissect the pathologic process of TNBC and in turn facilitate the development of better treatment strategies to combat TNBC.
    Language English
    Publishing date 2017-11-10
    Publishing country Netherlands
    Document type Journal Article ; Review
    ZDB-ID 125102-8
    ISSN 1532-1967 ; 0305-7372
    ISSN (online) 1532-1967
    ISSN 0305-7372
    DOI 10.1016/j.ctrv.2017.10.014
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1022: Show issues Location:
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    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
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    Zs.MO 611: Show issues

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  7. Article: Analysis of the flavonoid component of bioactive New Zealand mānuka (Leptospermum scoparium) honey and the isolation, characterisation and synthesis of an unusual pyrrole.

    Chan, Ching W / Deadman, Benjamin J / Manley-Harris, Merilyn / Wilkins, Alistair L / Alber, Dagmar G / Harry, Elizabeth

    Food chemistry

    2013  Volume 141, Issue 3, Page(s) 1772–1781

    Abstract: The flavonoid components of New Zealand mānuka (Leptospermum scoparium) honey have been quantified in a series of 31 honeys of varying non-peroxide antibacterial activity to clarify discrepancies between previous studies reported in the literature. Total ...

    Abstract The flavonoid components of New Zealand mānuka (Leptospermum scoparium) honey have been quantified in a series of 31 honeys of varying non-peroxide antibacterial activity to clarify discrepancies between previous studies reported in the literature. Total flavonoid content was 1.16 mg/100 g honey. The principal flavonoids present were pinobanksin, pinocembrin, luteolin and chrysin and together these represented 61% of the total flavonoid content. 1, 2-formyl-5-(2-methoxyphenyl)-pyrrole, which was weakly correlated with the non-peroxide antibacterial activity, was isolated from the flavonoid fraction and separately synthesised. 1 did not display inhibitory activity against Staphylococcus aureus in vitro and thus the origin of the correlation, which is still unknown, is not a direct contribution.
    MeSH term(s) Anti-Bacterial Agents/chemical synthesis ; Anti-Bacterial Agents/chemistry ; Anti-Bacterial Agents/pharmacology ; Flavonoids/chemistry ; Flavonoids/isolation & purification ; Flavonoids/pharmacology ; Honey/analysis ; Leptospermum/chemistry ; Microbial Sensitivity Tests ; Pyrroles/chemical synthesis ; Pyrroles/chemistry ; Pyrroles/isolation & purification ; Pyrroles/pharmacology ; Staphylococcus aureus/drug effects
    Chemical Substances Anti-Bacterial Agents ; Flavonoids ; Pyrroles
    Language English
    Publishing date 2013-12-01
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 243123-3
    ISSN 1873-7072 ; 0308-8146
    ISSN (online) 1873-7072
    ISSN 0308-8146
    DOI 10.1016/j.foodchem.2013.04.092
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Bonn / Germany

    Z 3634: Show issues

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  8. Article ; Online: The functional ALDH2 polymorphism is associated with breast cancer risk: A pooled analysis from the Breast Cancer Association Consortium.

    Ugai, Tomotaka / Milne, Roger L / Ito, Hidemi / Aronson, Kristan J / Bolla, Manjeet K / Chan, Tsun / Chan, Ching W / Choi, Ji-Yeob / Conroy, Don M / Dennis, Joe / Dunning, Alison M / Easton, Douglas F / Gaborieau, Valerie / Gonzalez-Neira, Anna / Hartman, Mikael / Healey, Catherine S / Iwasaki, Motoki / John, Esther M / Kang, Daehee /
    Kim, Sung-Won / Kwong, Ava / Lophatananon, Artitaya / Michailidou, Kyriaki / Taib, Nur Aishah Mohd / Muir, Kenneth / Park, Sue K / Pharoah, Paul D P / Sangrajrang, Suleeporn / Shen, Chen-Yang / Shu, Xiao-Ou / Spinelli, John J / Teo, Soo H / Tessier, Daniel C / Tseng, Chiu-Chen / Tsugane, Shoichiro / Vincent, Daniel / Wang, Qin / Wu, Anna H / Wu, Pei-Ei / Zheng, Wei / Matsuo, Keitaro

    Molecular genetics & genomic medicine

    2019  Volume 7, Issue 6, Page(s) e707

    Abstract: Background: Epidemiological studies consistently indicate that alcohol consumption is an independent risk factor for female breast cancer (BC). Although the aldehyde dehydrogenase 2 (ALDH2) polymorphism (rs671: Glu>Lys) has a strong effect on ... ...

    Abstract Background: Epidemiological studies consistently indicate that alcohol consumption is an independent risk factor for female breast cancer (BC). Although the aldehyde dehydrogenase 2 (ALDH2) polymorphism (rs671: Glu>Lys) has a strong effect on acetaldehyde metabolism, the association of rs671 with BC risk and its interaction with alcohol intake have not been fully elucidated. We conducted a pooled analysis of 14 case-control studies, with individual data on Asian ancestry women participating in the Breast Cancer Association Consortium.
    Methods: We included 12,595 invasive BC cases and 12,884 controls for the analysis of rs671 and BC risk, and 2,849 invasive BC cases and 3,680 controls for the analysis of the gene-environment interaction between rs671 and alcohol intake for BC risk. The pooled odds ratios (OR) with 95% confidence intervals (CI) associated with rs671 and its interaction with alcohol intake for BC risk were estimated using logistic regression models.
    Results: The Lys/Lys genotype of rs671 was associated with increased BC risk (OR = 1.16, 95% CI 1.03-1.30, p = 0.014). According to tumor characteristics, the Lys/Lys genotype was associated with estrogen receptor (ER)-positive BC (OR = 1.19, 95% CI 1.05-1.36, p = 0.008), progesterone receptor (PR)-positive BC (OR = 1.19, 95% CI 1.03-1.36, p = 0.015), and human epidermal growth factor receptor 2 (HER2)-negative BC (OR = 1.25, 95% CI 1.05-1.48, p = 0.012). No evidence of a gene-environment interaction was observed between rs671 and alcohol intake (p = 0.537).
    Conclusion: This study suggests that the Lys/Lys genotype confers susceptibility to BC risk among women of Asian ancestry, particularly for ER-positive, PR-positive, and HER2-negative tumor types.
    MeSH term(s) Adult ; Aged ; Alcohol Drinking/epidemiology ; Aldehyde Dehydrogenase, Mitochondrial/genetics ; Asian People/genetics ; Breast Neoplasms/epidemiology ; Breast Neoplasms/genetics ; Female ; Gene-Environment Interaction ; Humans ; Middle Aged ; Polymorphism, Single Nucleotide
    Chemical Substances ALDH2 protein, human (EC 1.2.1.3) ; Aldehyde Dehydrogenase, Mitochondrial (EC 1.2.1.3)
    Language English
    Publishing date 2019-05-07
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Research Support, U.S. Gov't, Non-P.H.S.
    ZDB-ID 2734884-2
    ISSN 2324-9269 ; 2324-9269
    ISSN (online) 2324-9269
    ISSN 2324-9269
    DOI 10.1002/mgg3.707
    Database MEDical Literature Analysis and Retrieval System OnLINE

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