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Article ; Online: Gallionellaceae pangenomic analysis reveals insight into phylogeny, metabolic flexibility, and iron oxidation mechanisms.

Hoover, Rene L / Keffer, Jessica L / Polson, Shawn W / Chan, Clara S

mSystems

2023 Volume 8, Issue 6, Page(s) e0003823

Abstract: Importance: Neutrophilic iron-oxidizing bacteria (FeOB) produce copious iron (oxyhydr)oxides that can profoundly influence biogeochemical cycles, notably the fate of carbon and many metals. To fully understand environmental microbial iron oxidation, we ... ...

Abstract	Importance: Neutrophilic iron-oxidizing bacteria (FeOB) produce copious iron (oxyhydr)oxides that can profoundly influence biogeochemical cycles, notably the fate of carbon and many metals. To fully understand environmental microbial iron oxidation, we need a thorough accounting of iron oxidation mechanisms. In this study, we show the Gallionellaceae FeOB genomes encode both characterized iron oxidases as well as uncharacterized multiheme cytochromes (MHCs). MHCs are predicted to transfer electrons from extracellular substrates and likely confer metabolic capabilities that help Gallionellaceae occupy a range of different iron- and mineral-rich niches. Gallionellaceae appear to specialize in iron oxidation, so it would be advantageous for them to have multiple mechanisms to oxidize various forms of iron, given the many iron minerals on Earth, as well as the physiological and kinetic challenges faced by FeOB. The multiple iron/mineral oxidation mechanisms may help drive the widespread ecological success of Gallionellaceae.
MeSH term(s)	Iron/metabolism ; Gallionellaceae ; Phylogeny ; Oxidation-Reduction ; Minerals/metabolism
Chemical Substances	Iron (E1UOL152H7) ; Minerals
Language	English
Publishing date	2023-10-26
Publishing country	United States
Document type	Journal Article
ISSN	2379-5077
ISSN (online)	2379-5077
DOI	10.1128/msystems.00038-23
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Gallionellaceae pangenomic analysis reveals insight into phylogeny, metabolic flexibility, and iron oxidation mechanisms.

Hoover, Rene L / Keffer, Jessica L / Polson, Shawn W / Chan, Clara S

bioRxiv : the preprint server for biology

2023

Abstract: The iron-oxidizing Gallionellaceae drive a wide variety of biogeochemical cycles through their metabolisms and biominerals. To better understand the environmental impacts of Gallionellaceae, we need to improve our knowledge of their diversity and ... ...

Abstract	The iron-oxidizing Gallionellaceae drive a wide variety of biogeochemical cycles through their metabolisms and biominerals. To better understand the environmental impacts of Gallionellaceae, we need to improve our knowledge of their diversity and metabolisms, especially any novel iron oxidation mechanisms. Here, we used a pangenomic analysis of 103 genomes to resolve Gallionellaceae phylogeny and explore the range of genomic potential. Using a concatenated ribosomal protein tree and key gene patterns, we determined Gallionellaceae has four genera, divided into two groups-iron-oxidizing bacteria (FeOB)
Language	English
Publishing date	2023-02-08
Publishing country	United States
Document type	Preprint
DOI	10.1101/2023.01.26.525709
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Article ; Online: Mixotrophy broadens the ecological niche range of the iron oxidizer Sideroxydans sp. CL21 isolated from an iron-rich peatland.

Cooper, Rebecca E / Finck, Jessica / Chan, Clara / Küsel, Kirsten

FEMS microbiology ecology

2023 Volume 99, Issue 2

Abstract: Sideroxydans sp. CL21 is a microaerobic, acid-tolerant Fe(II)-oxidizer, isolated from the Schlöppnerbrunnen fen. Since the genome size of Sideroxydans sp. CL21 is 21% larger than that of the neutrophilic Sideroxydans lithotrophicus ES-1, we hypothesized ... ...

Abstract	Sideroxydans sp. CL21 is a microaerobic, acid-tolerant Fe(II)-oxidizer, isolated from the Schlöppnerbrunnen fen. Since the genome size of Sideroxydans sp. CL21 is 21% larger than that of the neutrophilic Sideroxydans lithotrophicus ES-1, we hypothesized that strain CL21 contains additional metabolic traits to thrive in the fen. The common genomic content of both strains contains homologs of the putative Fe(II) oxidation genes, mtoAB and cyc2. A large part of the accessory genome in strain CL21 contains genes linked to utilization of alternative electron donors, including NiFe uptake hydrogenases, and genes encoding lactate uptake and utilization proteins, motility and biofilm formation, transposable elements, and pH homeostasis mechanisms. Next, we incubated the strain in different combinations of electron donors and characterized the fen microbial communities. Sideroxydans spp. comprised 3.33% and 3.94% of the total relative abundance in the peatland soil and peatland water, respectively. Incubation results indicate Sideroxydans sp. CL21 uses H2 and thiosulfate, while lactate only enhances growth when combined with Fe, H2, or thiosulfate. Rates of H2 utilization were highest in combination with other substrates. Thus, Sideroxydans sp. CL21 is a mixotroph, growing best by simultaneously using substrate combinations, which helps to thrive in dynamic and complex habitats.
MeSH term(s)	Iron/metabolism ; Thiosulfates ; Oxidation-Reduction ; Ecosystem ; Ferrous Compounds/metabolism
Chemical Substances	Iron (E1UOL152H7) ; Thiosulfates ; Ferrous Compounds
Language	English
Publishing date	2023-01-09
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, U.S. Gov't, Non-P.H.S.
ZDB-ID	283722-5
ISSN	1574-6941 ; 0168-6496
ISSN (online)	1574-6941
ISSN	0168-6496
DOI	10.1093/femsec/fiac156
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Article ; Online: The Efficacy and Safety of Standard versus Soft Topical Steroids after Cataract Surgery: A Systematic Review and Meta-analysis.

Noyman, Dror Ben Ephraim / Chan, Clara C / Mimouni, Michael / Safir, Margarita

Ophthalmology

2023 Volume 131, Issue 5, Page(s) 595–610

Abstract: Topic: Review of the efficacy and safety of standard versus soft topical steroid application after cataract surgery.: Clinical relevance: The control of postoperative inflammation is the mainstay of treatment after cataract surgery. However, no ... ...

Abstract	Topic: Review of the efficacy and safety of standard versus soft topical steroid application after cataract surgery. Clinical relevance: The control of postoperative inflammation is the mainstay of treatment after cataract surgery. However, no consensus exists regarding the postoperative steroid of choice. Basing the choice of topical postoperative steroidal treatment on high-quality data regarding both risks and benefits of various drugs would be advantageous for both patients and clinicians. Methods: A systematic search of the PubMed, Scopus, and Embase electronic databases for all peer-reviewed published randomized control trials that included clinical outcomes of topical steroidal treatment after uneventful cataract surgery was performed. Individual study data were extracted and evaluated in a weighted pooled analysis including grading of total anterior chamber (AC) inflammation, AC cells, AC flare, postoperative visual acuity (VA), intraocular pressure (IOP), and rate of adverse events (AEs). Results: Overall, 508 studies were found, of which 7 were eligible for the systematic review and ultimately were included for analysis, reporting on 593 patients from 5 countries. Age of included patients, when available, ranged between 3.7 and 73.4 years. Follow-up data were available for analysis at 1, 7, and 28 days after surgery. Except for a significantly lower grade of AC flare in the standard steroid group at day 7 (standardized mean difference, 0.26; 95% confidence interval, 0.05-0.47; I Discussion: The findings of this study suggest that for the average patient, both groups produce a comparable effect on both AC inflammation and postoperative IOP and VA. Financial disclosure(s): The author(s) have no proprietary or commercial interest in any materials discussed in this article.
MeSH term(s)	Humans ; Child, Preschool ; Child ; Adolescent ; Young Adult ; Adult ; Middle Aged ; Aged ; Cataract Extraction/adverse effects ; Glaucoma/surgery ; Steroids ; Inflammation/etiology ; Cataract/etiology
Chemical Substances	Steroids
Language	English
Publishing date	2023-11-23
Publishing country	United States
Document type	Meta-Analysis ; Systematic Review ; Journal Article
ZDB-ID	392083-5
ISSN	1549-4713 ; 0161-6420
ISSN (online)	1549-4713
ISSN	0161-6420
DOI	10.1016/j.ophtha.2023.11.022
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Ul II Zs.83: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular ab Jg. 2022: Lesesaal (EG)
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Article ; Online: Spontaneous hyphema in a patient receiving acalabrutinib.

Alsarhani, Waleed K / AlShaker, Sara / Lichter, Myrna / Chan, Clara C

Canadian journal of ophthalmology. Journal canadien d'ophtalmologie

2023 Volume 58, Issue 5, Page(s) e211–e213

MeSH term(s)	Humans ; Hyphema ; Iris ; Benzamides ; Pyrazines
Chemical Substances	acalabrutinib (I42748ELQW) ; Benzamides ; Pyrazines
Language	English
Publishing date	2023-05-13
Publishing country	England
Document type	Letter
ZDB-ID	80091-0
ISSN	1715-3360 ; 0008-4182
ISSN (online)	1715-3360
ISSN	0008-4182
DOI	10.1016/j.jcjo.2023.04.010
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Zs.A 588: Show issues

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Article ; Online: "Smoldering" Rejection of Keratolimbal Allograft.

Gouvea, Larissa / Slomovic, Allan R / Chan, Clara C

Cornea

2022 Volume 41, Issue 5, Page(s) 651–653

Abstract: Purpose: The purpose of this study was to report a case of "smoldering" keratolimbal allograft (KLAL) rejection in a patient with subtherapeutic levels of systemic immunosuppression in temporal association with BNT162b2 messenger RNA vaccination for ... ...

Abstract	Purpose: The purpose of this study was to report a case of "smoldering" keratolimbal allograft (KLAL) rejection in a patient with subtherapeutic levels of systemic immunosuppression in temporal association with BNT162b2 messenger RNA vaccination for severe acute respiratory syndrome coronavirus 2. Methods: This was a case report. Observations: A 72-year-old man presented with circumferential perilimbal engorgement, stagnation, and tortuosity of vessels with mild chemosis in his right eye KLAL segments 1 month after receiving the BNT162b2 messenger RNA vaccine while his tacrolimus trough blood levels were subtherapeutic measuring <2 ng/mL. He had undergone KLAL 6.5 years before for total limbal stem cell deficiency from a chemical injury and had been stable without any history of rejection. The donor was blood type O, and the patient had no systemic comorbidities. The patient was treated with hourly difluprednate 0.05% and increasing of his oral tacrolimus dose to 2 mg twice a day with improvement of rejection signs. Conclusions: There may be a temporal association between KLAL rejection after immunization against severe acute respiratory syndrome coronavirus 2 in patients with subtherapeutic levels of systemic immunosuppression. Patients should be on alert for any ocular signs or symptoms postimmunization and present for treatment immediately.
MeSH term(s)	Aged ; Allografts ; BNT162 Vaccine ; COVID-19 ; Corneal Diseases/diagnosis ; Corneal Diseases/etiology ; Graft Rejection/etiology ; Humans ; Limbus Corneae ; Male ; Stem Cell Transplantation/adverse effects ; Vaccines, Synthetic ; mRNA Vaccines
Chemical Substances	Vaccines, Synthetic ; mRNA Vaccines ; BNT162 Vaccine (N38TVC63NU)
Language	English
Publishing date	2022-04-06
Publishing country	United States
Document type	Case Reports ; Journal Article
ZDB-ID	604826-2
ISSN	1536-4798 ; 0277-3740
ISSN (online)	1536-4798
ISSN	0277-3740
DOI	10.1097/ICO.0000000000002978
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Zs.A 1790: Show issues

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Article: Ligand Effects on Biotic and Abiotic Fe(II) Oxidation by the Microaerophile Sideroxydans lithotrophicus

Zhou, Nanqing / Luther, George W. / Chan, Clara S.

Environmental science & technology. 2021 June 10, v. 55, no. 13

2021

Abstract: Organic ligands are widely distributed and can affect microbially driven Fe biogeochemical cycles, but effects on microbial iron oxidation have not been well quantified. Our work used a model microaerophilic Fe(II)-oxidizing bacterium Sideroxydans ... ...

Abstract	Organic ligands are widely distributed and can affect microbially driven Fe biogeochemical cycles, but effects on microbial iron oxidation have not been well quantified. Our work used a model microaerophilic Fe(II)-oxidizing bacterium Sideroxydans lithotrophicus ES-1 to quantify biotic Fe(II) oxidation rates in the presence of organic ligands at 0.02 atm O₂ and pH 6.0. We used two common Fe chelators with different binding strengths: citrate (log KFₑ₍II₎₋cᵢₜᵣₐₜₑ = 3.20) and nitrilotriacetic acid (NTA) (log KFₑ₍II₎₋NTA = 8.09) and two standard humic substances, Pahokee peat humic acid (PPHA) and Suwannee River fulvic acid (SRFA). Our results provide rate constants for biotic and abiotic Fe(II) oxidation over different ligand concentrations and furthermore demonstrate that various models and natural iron-binding ligands each have distinct effects on abiotic versus biotic Fe(II) oxidation rates. We show that NTA accelerates abiotic oxidation and citrate has negligible effects, making it a better laboratory chelator. The humic substances only affect biotic Fe(II) oxidation, via a combination of chelation and electron transfer. PPHA accelerates biotic Fe(II) oxidation, while SRFA decelerates or accelerates the rate depending on concentration. The specific nature of organic-Fe microbe interactions may play key roles in environmental Fe(II) oxidation, which have cascading influences on cycling of nutrients and contaminants that associate with Fe oxide minerals.
Keywords	bacteria ; chelating agents ; chelation ; citrates ; electron transfer ; environmental science ; fulvic acids ; humic acids ; ligands ; nitrilotriacetic acid ; oxidation ; pH ; peat ; rivers ; technology
Language	English
Dates of publication	2021-0610
Size	p. 9362-9371.
Publishing place	American Chemical Society
Document type	Article
ISSN	1520-5851
DOI	10.1021/acs.est.1c00497
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: Ligand Effects on Biotic and Abiotic Fe(II) Oxidation by the Microaerophile

Zhou, Nanqing / Luther, George W / Chan, Clara S

Environmental science & technology

2021 Volume 55, Issue 13, Page(s) 9362–9371

Abstract	Organic ligands are widely distributed and can affect microbially driven Fe biogeochemical cycles, but effects on microbial iron oxidation have not been well quantified. Our work used a model microaerophilic Fe(II)-oxidizing bacterium
Language	English
Publishing date	2021-06-10
Publishing country	United States
Document type	Journal Article
ISSN	1520-5851
ISSN (online)	1520-5851
DOI	10.1021/acs.est.1c00497
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: 16S rRNA Gene Amplicon Sequencing Data from Flooded Rice Paddy Mesocosms Treated with Different Silicon-Rich Soil Amendments.

Dykes, Gretchen E / Chan, Clara S / Seyfferth, Angelia L

Microbiology resource announcements

2021 Volume 10, Issue 27, Page(s) e0017821

Abstract: How silicon-rich soil amendments impact the microbial community is unresolved. We report 16S rRNA gene sequencing data from flooded rice paddy mesocosms treated with different silicon amendments sampled over the growing season. We generated 11,678 ... ...

Abstract	How silicon-rich soil amendments impact the microbial community is unresolved. We report 16S rRNA gene sequencing data from flooded rice paddy mesocosms treated with different silicon amendments sampled over the growing season. We generated 11,678 operational taxonomic units (OTUs) and found that microbial communities were significantly different across treatments, time points, and biospheres.
Language	English
Publishing date	2021-07-08
Publishing country	United States
Document type	Journal Article
ISSN	2576-098X
ISSN (online)	2576-098X
DOI	10.1128/MRA.00178-21
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Article ; Online: Lifitegrast Ophthalmic Solution 5.0% for Treatment of Dry Eye Disease: Overview of Clinical Trial Program.

Chan, Clara C / Prokopich, C Lisa

Journal of pharmacy & pharmaceutical sciences : a publication of the Canadian Society for Pharmaceutical Sciences, Societe canadienne des sciences pharmaceutiques

2019 Volume 22, Issue 1, Page(s) 49–56

Abstract: Dry eye disease (DED) is a common inflammatory disorder of the ocular surface. Millions of people are affected by DED worldwide. Lifitegrast is a novel drug designed to inhibit DED-associated ocular inflammation. Four clinical trials have shown that ... ...

Abstract	Dry eye disease (DED) is a common inflammatory disorder of the ocular surface. Millions of people are affected by DED worldwide. Lifitegrast is a novel drug designed to inhibit DED-associated ocular inflammation. Four clinical trials have shown that lifitegrast is well tolerated and effective in improving symptoms and signs of DED over 12 weeks. A fifth trial showed long-term safety over 1 year. Lifitegrast has been in clinical use for more than one year in the United States and was recently approved in Canada (in December 2017). In this review, we discuss lifitegrast's novel mechanism of action and provide an overview of its clinical trial program.
MeSH term(s)	Animals ; Clinical Trials as Topic ; Dry Eye Syndromes/drug therapy ; Humans ; Ophthalmic Solutions/therapeutic use ; Phenylalanine/analogs & derivatives ; Phenylalanine/therapeutic use ; Sulfones/therapeutic use ; Treatment Outcome
Chemical Substances	Ophthalmic Solutions ; Sulfones ; lifitegrast (038E5L962W) ; Phenylalanine (47E5O17Y3R)
Language	English
Publishing date	2019-01-09
Publishing country	Canada
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Review
ISSN	1482-1826
ISSN (online)	1482-1826
DOI	10.18433/jpps29895
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