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  1. Article: Surgical management of pleuro-peritoneal fistula in chronic renal failure patient-safety and effectiveness.

    Chen, Hei-Yu Matthew / Chan, Ho-Yan Howard / Chan, Hoi-Ming Herman / Cheung, Hung-Leong

    Journal of thoracic disease

    2021  Volume 13, Issue 5, Page(s) 2979–2985

    Abstract: Background: Pleuro-peritoneal fistula (PPF) is a known complication arising in patients receiving continuous ambulatory peritoneal dialysis (CAPD) as a form of renal replacement therapy with an incidence of approximately 2% (1). Previous literature has ... ...

    Abstract Background: Pleuro-peritoneal fistula (PPF) is a known complication arising in patients receiving continuous ambulatory peritoneal dialysis (CAPD) as a form of renal replacement therapy with an incidence of approximately 2% (1). Previous literature has shown that the recurrence rate of non-operative management of PPF to be ~45%. Video-assisted thoracoscopic surgery (VATS) has been shown to be an effective and safe means of treating patients with PPF. However, to the author's knowledge, there is currently no sizeable case series that discuss the various intra-operative findings, operative techniques employed, post-operative complications, duration of peritoneal dialysis suspension and fistula recurrence in this particular patient group.
    Methods: From January 2009 to January 2019, patients who underwent VATS for the repair of PPF at The Department of Cardiothoracic Surgery, Queen Elizabeth Hospital, Hong Kong were retrieved from the Clinical Data Analysis and Reporting System (CDARS). Patient's epidemiological data, comorbidities and surgical data were analyzed.
    Results: There were 35 patients who underwent VATS PPF repair in our series. The mean age was 60.8 years (44 to 82 years), the (54.3%), mean operative time was 60.8 minutes (15-224 minutes). There were 8 patients (25.8%) who suffered from recurrence of pleural effusion after re-initiation of CAPD. Concomitant use of mechanical and talc pleurodesis was statistically significant in preventing PPF recurrence with an odds ratio of 0.1201 when compared to non-operative techniques. One patient suffered from hemothorax requiring re-operation on post-operative day one. There were no 30-day mortalities.
    Conclusions: VATS appears to be a safe and effective surgical treatment to prevent recurrence of continuous peritoneal dialysis associated PPF. Concomitant mechanical and talc pleurodesis appears to have additional benefit.
    Language English
    Publishing date 2021-05-31
    Publishing country China
    Document type Journal Article
    ZDB-ID 2573571-8
    ISSN 2077-6624 ; 2072-1439
    ISSN (online) 2077-6624
    ISSN 2072-1439
    DOI 10.21037/jtd-20-3327
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Comparison of Characteristics of Breast Cancer Detected through Different Imaging Modalities in a Large Cohort of Hong Kong Chinese Women: Implication of Imaging Choice on Upcoming Local Screening Program.

    Chan, Yik Shuen / Hung, Wai Ka / Yuen, Lok Wa / Chan, Ho Yan Yolanda / Chu, Chiu Wing Winnie / Cheung, Polly Suk Yee

    The breast journal

    2022  Volume 2022, Page(s) 3882936

    Abstract: Background: We compared the clinico-radio-pathological characteristics of breast cancer detected through mammogram (MMG) and ultrasound (USG) and discuss the implication of the choice of imaging as the future direction of our recently launched local ... ...

    Abstract Background: We compared the clinico-radio-pathological characteristics of breast cancer detected through mammogram (MMG) and ultrasound (USG) and discuss the implication of the choice of imaging as the future direction of our recently launched local screening program.
    Methods: Retrospective study of 14613 Hong Kong Chinese female patients with histologically confirmed breast cancer registered in the Hong Kong Breast Cancer Registry between January 2006 and February 2020. Patients were classified into four groups based on the mode of breast cancer detection (detectable by both mammogram and ultrasound (MMG+/USG+), mammogram only (MMG+/USG-), ultrasound only (MMG-/USG+), or not detectable by either (MMG-/USG-). Characteristics of breast cancer detected were compared, including patient demographics, breast density on MMG, mode of presentation, tumour size, histological type, and staging. Types of mammographic abnormalities were also evaluated for MMG+ subgroups.
    Results: 85% of the cancers were detectable by MMG, while USG detected an additional 9%. MMG+/USG+ cancers were larger, more advanced in stage, often of symptomatic presentation, and commonly manifested as mammographic mass. MMG+/USG- cancers were more likely of asymptomatic presentation, manifested as microcalcifications, and of earlier stage and to be ductal carcinoma in situ. MMG-/USG+ cancers were more likely seen in young patients and those with denser breasts and more likely of symptomatic presentation. MMG-/USG- cancers were often smaller and found in denser breasts.
    Conclusion: Mammogram has a good detection rate of cancers in our local population. It has superiority in detecting early cancers by detecting microcalcifications. Our current study agrees that ultrasound is one of the key adjunct tools of breast cancer detection.
    MeSH term(s) Female ; Humans ; Breast Neoplasms/pathology ; Retrospective Studies ; Hong Kong/epidemiology ; East Asian People ; Early Detection of Cancer/methods ; Mammography ; Calcinosis ; Mass Screening
    Language English
    Publishing date 2022-10-31
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1289960-4
    ISSN 1524-4741 ; 1075-122X
    ISSN (online) 1524-4741
    ISSN 1075-122X
    DOI 10.1155/2022/3882936
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article: The Contemporary Role of Photodynamic Therapy in the Treatment of Pachychoroid Diseases.

    Iu, Lawrence P L / Chan, Ho Yan / Ho, Mary / Lai, Frank H P / Mak, Andrew C Y / Wong, Raymond L M / Young, Alvin L

    Journal of ophthalmology

    2021  Volume 2021, Page(s) 6590230

    Abstract: Recent advances in retinal imaging technology have improved our understanding in the pathogenesis and evolvement of various chorioretinal diseases. Central serous chorioretinopathy and polypoidal choroidal vasculopathy are now recognized to belong to the ...

    Abstract Recent advances in retinal imaging technology have improved our understanding in the pathogenesis and evolvement of various chorioretinal diseases. Central serous chorioretinopathy and polypoidal choroidal vasculopathy are now recognized to belong to the same spectrum of disorders known as pachychoroid diseases. Pachychoroid diseases have similar pathogenesis pathway and common characteristics of thickened choroid, dilated outer choroidal vessels, and thinning of choriocapillaris. More disease entities have been identified to belong to this disease spectrum. Photodynamic therapy can induce choroidal hypoperfusion, remodeling of abnormal choroidal vessels, and reduction of choroidal congestion. It is known to be an effective treatment for chronic central serous chorioretinopathy and polypoidal choroidal vasculopathy. Many new studies are being performed to investigate its efficacy in other pachychoroid diseases. In this review, we provided an overview of the rationale, efficacy, and treatment strategies of photodynamic therapy in different pachychoroid diseases and discussed its role in the management along with other treatment modalities with most updated clinical evidence.
    Language English
    Publishing date 2021-10-23
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 2546525-9
    ISSN 2090-0058 ; 2090-004X
    ISSN (online) 2090-0058
    ISSN 2090-004X
    DOI 10.1155/2021/6590230
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Acute postoperative endophthalmitis after cataract operation: result of early vitrectomy within 24 hours of presentation.

    Iu, Lawrence Pui Leung / Chan, Ho Yan / Li, Gabriel Ka Hin / Ho, Mary / Mak, Andrew Chun Yue / Wong, Posey Po Yin / Kam, Ka Wai / Chen, Li Jia / Brelen, Marten / Young, Alvin Lerrmann

    Eye (London, England)

    2022  Volume 37, Issue 11, Page(s) 2344–2350

    Abstract: Objectives: To evaluate result of early pars plana vitrectomy (PPV) within 24 hours of presentation for acute postoperative endophthalmitis after cataract operation, and to determine factors that predict visual outcome.: Methods: Consecutive patients ...

    Abstract Objectives: To evaluate result of early pars plana vitrectomy (PPV) within 24 hours of presentation for acute postoperative endophthalmitis after cataract operation, and to determine factors that predict visual outcome.
    Methods: Consecutive patients who developed acute postoperative endophthalmitis within 6 weeks after cataract operation were reviewed. Patients were divided into two groups for analysis: (1) those receiving PPV within 24 hours of presentation (early PPV group), and (2) those receiving initial intravitreal antibiotics only without PPV within 24 hours of presentation (IVA group).
    Results: Out of 41,411 cataract operations, 22 eyes developed acute postoperative endophthalmitis. Presenting VA was hand-movement or worse in 72.7%. The most common organisms were Staphylococcus (40.9%), Streptococcus (13.6%) and Enterococcus (13.6%). 22.7% of eyes had good final VA ≥ 20/30 and 27.3% had poor final VA < 20/400. Early PPV group had significantly lower rate of requiring additional treatments to control infection (25% versus 80%, P = 0.030), higher rate of retinal detachment (25% versus 0%, P = 0.221) and similar final logMAR VA (1.08 ± 1.08 versus 0.80 ± 0.80, P = 0.489) compared to IVA. Multivariate linear regression analysis showed that worse final VA was significantly associated with Streptococcus (ß = 1.92, P = 0.007) and retinal detachment (ß = 1.72, P = 0.005) but not with early PPV (P = 0.225).
    Conclusion: Early PPV was superior to initial intravitreal antibiotics alone as it required fewer additional treatments to control infection. Visual outcome was similar between early PPV and initial intravitreal antibiotics alone despite high number of poor presenting VA of light-perception in early PPV group. Streptococcal infection and retinal detachment were major poor prognostic factors for vision.
    MeSH term(s) Humans ; Vitrectomy ; Retinal Detachment/surgery ; Postoperative Complications/surgery ; Endophthalmitis/therapy ; Anti-Bacterial Agents ; Cataract ; Retrospective Studies ; Treatment Outcome
    Chemical Substances Anti-Bacterial Agents
    Language English
    Publishing date 2022-12-13
    Publishing country England
    Document type Journal Article
    ZDB-ID 91001-6
    ISSN 1476-5454 ; 0950-222X
    ISSN (online) 1476-5454
    ISSN 0950-222X
    DOI 10.1038/s41433-022-02347-1
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Academic advising in undergraduate education: A systematic review.

    Chan, Zenobia C Y / Chan, Ho Yan / Chow, Hang Chak Jason / Choy, Sze Nga / Ng, Ka Yan / Wong, Koon Yiu / Yu, Pui Kan

    Nurse education today

    2019  Volume 75, Page(s) 58–74

    Abstract: Objectives: The aim of this review is to describe academic advising schemes at the undergraduate level, examine the perspectives of advisors and advisees towards the schemes, and explore the implications of academic advising in undergraduate and nursing ...

    Abstract Objectives: The aim of this review is to describe academic advising schemes at the undergraduate level, examine the perspectives of advisors and advisees towards the schemes, and explore the implications of academic advising in undergraduate and nursing education.
    Design: A systematic review was conducted of the protocol of PRISMA-P.
    Data sources: Six electronic databases were searched for journal articles, namely, Academic Search Premier, CINAHL, ERIC, Medline, Teacher Reference Center, and Scopus.
    Review methods: A total of 6189 articles were examined, and 37 empirical studies were included in the final review. The Mixed Methods Appraisal Tool (MMAT) was used to assess the eligibility of studies for inclusion in the review.
    Results: The review involved summarizing and categorizing the components of existing academic advising schemes, analysing the perspectives of advisors and advisees, and identifying four aspects of the perspectives of advisees: their experiences, preferences, benefits gained from the scheme, and barriers to seeking help from advisors. Six issues relating to academic advising schemes were discussed: insufficient information about the schemes, the means of communication used in the process of advising, the issue of time management for both advisors and advisees, a lack of training for advisors, the evaluation of the outcomes of advising, and the implications for nursing education.
    Conclusions: Advisors and advisees held positive views of the scheme. Academic advising benefited students and advisors, even as some barriers were identified. It is suggested that sufficient training, better time management, and the utilization of different tools for communication are needed to increase the effectiveness of academic advising. Further studies should be conducted to investigate the effects of different elements of the scheme on the outcome of advising.
    MeSH term(s) Communication ; Education, Nursing, Baccalaureate/methods ; Education, Nursing, Baccalaureate/trends ; Humans ; Mentors/psychology ; Universities/organization & administration
    Language English
    Publishing date 2019-01-26
    Publishing country Scotland
    Document type Journal Article ; Systematic Review
    ZDB-ID 1062570-7
    ISSN 1532-2793 ; 0260-6917
    ISSN (online) 1532-2793
    ISSN 0260-6917
    DOI 10.1016/j.nedt.2019.01.009
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Return and risk-return ratio based momentum strategies

    Chia Rui Ming Daryl / Chan Ho Yan Sabrina / Lim Kai Jie Shawn

    Journal of finance and investment analysis Vol. 2, No. 1 , p. 1-13

    a fresh perspective

    2013  Volume 2, Issue 1, Page(s) 1–13

    Abstract: In this study, we contribute to existing literature on momentum strategies by assessing a modified version of risk-return ratio based security selection criterion in an untested market – the KOSPI 200 over June 2006 to June 2012. Besides conventional ... ...

    Author's details Chia Rui Ming Daryl, Lim Kai Jie Shawn, and Chan Ho Yan Sabrina
    Abstract In this study, we contribute to existing literature on momentum strategies by assessing a modified version of risk-return ratio based security selection criterion in an untested market – the KOSPI 200 over June 2006 to June 2012. Besides conventional risk-return ratios such as the Sharpe ratio, we also employ the use of risk-return ratio based ranking criterion first introduced in Biglova et al. (2004) when ranking securities to form portfolios for these strategies. These ratios take into account the non-normality and kurtosis that are ubiquitous in equity time series returns. In contrast to their approach however, we invert the ordinal ranking of negative risk-return ratios to be consistent with the interpretation of negative ratios presented in Sharpe (1994). Applying these methods, this study quantifies and compares the performance of returns based and risk-return ratio based momentum strategies while estimating the transaction costs involved in implementing such strategies. For return based momentum strategies, we show that most strategies involving a 3 or 6 month formation period exhibit statistically significant positive returns, while those with a 9 or 12 month formation period do not. In addition, all risk-return ratio based strategies failed to generate returns that are significantly greater than zero.
    Keywords momentum strategies ; risk-return ratio based selection criteria ; portfolio turnover
    Language English
    Size Online-Ressource
    Publisher Scienpress
    Publishing place London
    Document type Article ; Online
    Note IMD-Felder maschinell generiert
    ZDB-ID 2655150-0
    ISSN 2241-0996 ; 2241-0988
    ISSN (online) 2241-0996
    ISSN 2241-0988
    Database ECONomics Information System

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  7. Article: A cross-sectional study on compliance with topical glaucoma medication and its associated socioeconomic burden for a Chinese population.

    Lui, Man-Hin / Lam, Jason Chun Ho / Kwong, Yi Lee / Wong, Tak Siu / Cheung, Pak Long / Lai, Sherri Shun Yan / Yuen, Pak Lun / Lam, Wai Yiu / Chan, Ho Yan / Wong, Yiu Fai / Lai, Jimmy Shiu Ming / Shih, Kendrick Co

    International journal of ophthalmology

    2017  Volume 10, Issue 2, Page(s) 293–299

    Abstract: Aim: To estimate the overall drug compliance for local Chinese glaucoma patients on long-term topical treatment.: Methods: This was a retrospective cross-sectional study. Fifty-seven primary glaucoma patients from the subspecialty clinic of a ... ...

    Abstract Aim: To estimate the overall drug compliance for local Chinese glaucoma patients on long-term topical treatment.
    Methods: This was a retrospective cross-sectional study. Fifty-seven primary glaucoma patients from the subspecialty clinic of a publicly-funded tertiary care hospital in Hong Kong completed a questionnaire on compliance with topical glaucoma medication, attitude towards glaucoma and therapy and vision related quality of life. Noncompliance was defined as reporting missing more than or equal to 10% of the prescribed topical glaucoma medication during the 2wk immediately prior to the consultation. Relationships between noncompliance and demographics, attitude, disease and treatment status was studied. Cost was estimated with quality of life and direct medical cost involved with noncompliance. Multivariable logistic regression on noncompliance was performed on selected factors.
    Results: Compliance was calculated as 75% (95% CI: 64%-87%) among 57 subjects (mean age 69y, female 51%). No statistical significant relationship was established between noncompliance and any single factors or outcomes. Age (
    Conclusion: The compliance of Chinese glaucoma patients in Hong Kong is comparable to other parts in the world, and carries detrimental impacts on individual and societal levels. Age and forgetfulness are two possible independent predictors for noncompliance.
    Language English
    Publishing date 2017-02-18
    Publishing country China
    Document type Journal Article
    ZDB-ID 2663246-9
    ISSN 2227-4898 ; 2222-3959
    ISSN (online) 2227-4898
    ISSN 2222-3959
    DOI 10.18240/ijo.2017.02.18
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article: Han yang liang dui xiu li zhi wen luo de ying xiang

    Chan, Ho Yan (陳可欣)

    Abstract: As one of the major outcomes of eutrophication, ecological effects of hypoxia have received an increasing concern in the past few years. Information on effects of hypoxia on individual species, however, is scarce. The present study investigated adult ... ...

    Abstract As one of the major outcomes of eutrophication, ecological effects of hypoxia have received an increasing concern in the past few years. Information on effects of hypoxia on individual species, however, is scarce. The present study investigated adult physiology and behaviour, embryonic development, larval development and swimming behaviour of marine scavenging gastropods Nassarius festivus at reduced dissolved oxygen levels. N. festivus (shell length: 8 + 1 mm) were exposed to reduced oxygen levels (3.0 and 1.5 mg O2/l) and normoxia (6.0 mg O2/l) for 7 weeks. Food consumption, percentage of feeding individual, oxygen consumption rate, ammonia excretion rate, egg production, dimensions of egg capsules and embryos produced, mortality and shell growth were measured weekly. Scope for growth (SFG) was also calculated. Results showed that food consumption, percentage of individuals feeding, oxygen consumption rate, ammonia excretion rate, egg capsules production and SFG were significantly lowered at reduced dissolved oxygen levels. The size of egg capsules was similar at reduced dissolved oxygen levels. The mean number of eggs produced per capsule was 13.28, 12.46 and 12.88 for 6.0 mg O2/l, 3.0 mg O2/l and 1.5 mg O2/l, respectively. N. festivus exposed to 6.0 mg O2/l, 3.0 mg O2/l and 1.5 mg O2/l have mean shell growth rate 12%, 6% and 5%, respectively. No mortality was observed for adult N. festivus at 6.0 mg O2/l. Cumulative mortality at 3.0 mg O2/l and 1.5 mg O2/l was 7% and 15%, respectively. Stage 1 embryos were exposed to four dissolved oxygen levels (0.5, 1.5, 3.0 and 6.0 mg O2/l) and development was observed at 12-hour interval until the veliger larvae hatched. Once the veliger larvae hatched, their shell length, shell width and length of velum were measured. Significant delay in embryonic development was observed when dissolved oxygen concentration decreased. Embryos required 132, 156 and 252 hours to complete the whole embryonic development at 6.0 mg O2/l, 3.0 mg O2/l and 1.5 mg O2/l, respectively. No embryos hatched at 0.5 mg O2/l throughout the whole experiment (252 hours). Larvae hatched from egg capsules exposed to reduced dissolved oxygen concentrations (3.0 mg O2/l and 1.5 mg O2/l) had a smaller mean shell width and velum size when compared with those hatched at 6.0 mg O2/l. Mortality and swimming behaviour of larvae was recorded after exposure to six dissolved oxygen concentrations (0.5, 1.0, 2.0, 3.0, 4.0 and 6.0 mg O2/l) for 48 hours. Larvae of N. festivus exhibited median 48-h LC50 values at 1.65 mg O2/l. Under 0.5 mg O2/l, all larvae died during the first 24 hours. Swimming speed of larvae reduced significantly upon exposure to reduced dissolved oxygen levels. Larvae were reared in three different dissolved oxygen levels (3.5, 4.5 and 6.0 mg O2/l). Size of velar lobes, shell length and width of 30 larvae were measured at 4-day interval. Ingestion rates of 60 larvae were also measured. Larvae reared at 4.5 mg O2/l and 3.5 mg O2/l had significantly smaller shell length, shell width and velum in comparison with larvae reared at 6.0 mg O2/l. Ingestion rates of N. festivus larvae were similar during the first 8 days at 6.0 mg O2/l and 4.5 mg O2/l, whereas ingestion rates of larvae were significantly reduced at 3.5 mg O2/l. On day 12, larvae reared at 6.0 mg O2/l had higher ingestion rate than those at 4.5 mg O2/l. The percentage of larvae undergo spontaneous metamorphosis was reduced and metamorphosis was delayed under reduced dissolved oxygen level. At 6.0 mg O2/l, larvae of N. festivus started to metamorphose on day 8 with 100% success. At 4.5 mg O2/l, metamorphose started on day 11 with 49% of larvae competent to metamorphosis. At 3.5 mg O2/l, all larvae died before they underwent metamorphosis. Larvae reared at 4.5 mg O2/l tended to form juveniles with smaller shell length and width in comparison with those reared at 6.0 mg O2/l. Larvae reared under reduced dissolved oxygen concentration had significantly higher mortality. No mortality was observed for larvae reared at 6.0 mg O2/l. To summarize, adult N. festivus showed retardation in growth and reduction in food consumption under reduced dissolved oxygen levels. The larvae, on the other hand, showed high mortality, and reduction in swimming activities and growth under reduced dissolved oxygen levels. Since adult N. festivus play an important role in nutrient recycling on sandy shores whereas their planktonic larvae play an important trophic link between phytoplankton and higher trophic levels, hypoxic stress on this animal may lead to disruption of trophodynamics and nutrient recycling in marine coastal systems.
    Language en_us
    Document type Article
    Database AGRIS - International Information System for the Agricultural Sciences and Technology

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