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  1. Article ; Online: "Baby Spleen Sleeping in a Cradle": An Intrapancreatic Accessory Spleen.

    Cheuk, W / Liao, J / Chan, J K C

    International journal of surgical pathology

    2020  Volume 29, Issue 5, Page(s) 516–517

    MeSH term(s) Aged ; Choristoma/diagnostic imaging ; Choristoma/pathology ; Humans ; Male ; Pancreatic Diseases/diagnostic imaging ; Pancreatic Diseases/pathology ; Spleen ; Tomography, X-Ray Computed
    Language English
    Publishing date 2020-06-19
    Publishing country United States
    Document type Case Reports ; Journal Article
    ZDB-ID 1336393-1
    ISSN 1940-2465 ; 1066-8969
    ISSN (online) 1940-2465
    ISSN 1066-8969
    DOI 10.1177/1066896920935586
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Thyroid Adenoma of Probable Ultimobranchial Body Origin: A Case Report.

    Yuen, K K W / Chan, A N H / Chan, J K C / Cheuk, W

    International journal of surgical pathology

    2020  Volume 29, Issue 2, Page(s) 223–227

    Abstract: Solid cell nests are generally believed to represent remnants of the ultimobranchial body, which can be found in the normal thyroid gland, occasionally associated with other branchial pouch remnants such as salivary gland, cartilage, and adipose tissue. ... ...

    Abstract Solid cell nests are generally believed to represent remnants of the ultimobranchial body, which can be found in the normal thyroid gland, occasionally associated with other branchial pouch remnants such as salivary gland, cartilage, and adipose tissue. We describe the case of a 44-year-old man incidentally found to have a large tumor in the left lobe of the thyroid. The tumor was a circumscribed growth consisting of distinctly lobulated proliferation of solid to cystic epidermoid cell nests and thyroid follicles in a fibromatous stroma, which merged into abundant adipose tissue and focally myxoid matrix. The solid epidermoid cell nests resembled solid cell nests and exhibited a p63+, GATA3+, galectin-3+, TTF1-, PAX8-, thyroglobulin- phenotypes, while the follicles were p63-, GATA3-, galectin-3-, TTF1+, PAX8+, and thyroglobulin+.
    MeSH term(s) Adenoma/diagnosis ; Adenoma/pathology ; Adenoma/surgery ; Adult ; Animals ; Biomarkers, Tumor/analysis ; Humans ; Incidental Findings ; Male ; Thyroid Function Tests ; Thyroid Gland/diagnostic imaging ; Thyroid Gland/pathology ; Thyroid Gland/surgery ; Thyroid Neoplasms/diagnosis ; Thyroid Neoplasms/pathology ; Thyroid Neoplasms/surgery ; Thyroidectomy ; Tomography, X-Ray Computed ; Ultimobranchial Body/pathology
    Chemical Substances Biomarkers, Tumor
    Keywords covid19
    Language English
    Publishing date 2020-08-04
    Publishing country United States
    Document type Case Reports ; Journal Article
    ZDB-ID 1336393-1
    ISSN 1940-2465 ; 1066-8969
    ISSN (online) 1940-2465
    ISSN 1066-8969
    DOI 10.1177/1066896920946444
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article: Peanut allergy and oral immunotherapy.

    Lee, T H / Chan, J K C / Lau, P C / Luk, W P / Fung, L H

    Hong Kong medical journal = Xianggang yi xue za zhi

    2019  Volume 25, Issue 3, Page(s) 228–234

    Abstract: Peanut allergy is the commonest cause of food-induced anaphylaxis in the world, and it can be fatal. There have been many recent improvements to achieve safe methods of peanut desensitisation, one of which is to use a combination of anti-immunoglobulin E ...

    Abstract Peanut allergy is the commonest cause of food-induced anaphylaxis in the world, and it can be fatal. There have been many recent improvements to achieve safe methods of peanut desensitisation, one of which is to use a combination of anti-immunoglobulin E and oral immunotherapy. We have treated 27 patients with anti-immunoglobulin E and oral immunotherapy, and report on the outcomes and incidence of adverse reactions encountered during treatment. The dose of peanut protein tolerated increased from a median baseline of 5 to 2000 mg after desensitisation, which is substantially more than would be encountered through accidental ingestion. The incidence of adverse reactions during the escalation phase of oral immunotherapy was 1.8%, and that during the maintenance phase was 0.6%. Most adverse reactions were mild; three episodes were severe enough to warrant withdrawal from oral immunotherapy, but none required epinephrine injection. Preliminary data suggest that unresponsiveness is lost when daily ingestion of peanuts is stopped after the maintenance period.
    MeSH term(s) Administration, Oral ; Adolescent ; Allergens/administration & dosage ; Allergens/immunology ; Arachis/immunology ; Child ; Desensitization, Immunologic/adverse effects ; Desensitization, Immunologic/methods ; Epinephrine/therapeutic use ; Female ; Histamine H1 Antagonists/therapeutic use ; Humans ; Immunologic Factors/adverse effects ; Male ; Peanut Hypersensitivity/immunology ; Peanut Hypersensitivity/therapy
    Chemical Substances Allergens ; Histamine H1 Antagonists ; Immunologic Factors ; Epinephrine (YKH834O4BH)
    Language English
    Publishing date 2019-06-10
    Publishing country China
    Document type Journal Article
    ZDB-ID 1239255-8
    ISSN 1024-2708
    ISSN 1024-2708
    DOI 10.12809/hkmj187743
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article: Thyroid Adenoma of Probable Ultimobranchial Body Origin: A Case Report

    Yuen, K K W / Chan, A N H / Chan, J K C / Cheuk, W

    Int J Surg Pathol

    Abstract: Solid cell nests are generally believed to represent remnants of the ultimobranchial body, which can be found in the normal thyroid gland, occasionally associated with other branchial pouch remnants such as salivary gland, cartilage, and adipose tissue. ... ...

    Abstract Solid cell nests are generally believed to represent remnants of the ultimobranchial body, which can be found in the normal thyroid gland, occasionally associated with other branchial pouch remnants such as salivary gland, cartilage, and adipose tissue. We describe the case of a 44-year-old man incidentally found to have a large tumor in the left lobe of the thyroid. The tumor was a circumscribed growth consisting of distinctly lobulated proliferation of solid to cystic epidermoid cell nests and thyroid follicles in a fibromatous stroma, which merged into abundant adipose tissue and focally myxoid matrix. The solid epidermoid cell nests resembled solid cell nests and exhibited a p63+, GATA3+, galectin-3+, TTF1-, PAX8-, thyroglobulin- phenotypes, while the follicles were p63-, GATA3-, galectin-3-, TTF1+, PAX8+, and thyroglobulin+. RAS mutations were not found. This thyroid tumor may represent a hitherto undescribed "ultimobranchial body adenoma" in human.
    Keywords covid19
    Publisher WHO
    Document type Article
    Note WHO #Covidence: #694851
    Database COVID19

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  5. Article: Authors' reply to "Physical activity is also an allergy prevention measure"

    Chan, A W M / Chan, J K C / Tam, A Y C / Leung, T F / Lee, T H

    Hong Kong medical journal = Xianggang yi xue za zhi

    2016  Volume 22, Issue 5, Page(s) 514

    Language English
    Publishing date 2016-10
    Publishing country China
    Document type Journal Article ; Comment
    ZDB-ID 1239255-8
    ISSN 1024-2708
    ISSN 1024-2708
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article: Advances in salivary gland pathology.

    Cheuk, W / Chan, J K C

    Histopathology

    2007  Volume 51, Issue 1, Page(s) 1–20

    Abstract: This review summarizes the new findings on salivary gland pathology under the following categories: immunohistochemistry; molecular genetics; newly recognized tumour types; known tumour entities with new findings; and progression of salivary gland ... ...

    Abstract This review summarizes the new findings on salivary gland pathology under the following categories: immunohistochemistry; molecular genetics; newly recognized tumour types; known tumour entities with new findings; and progression of salivary gland tumours. In the application of immunohistochemistry, CD117 can aid in highlighting the luminal cell component of various salivary gland tumours, whereas p63 or maspin can aid in highlighting the abluminal cell component. A high Ki67 index remains the most useful marker to predict adverse outcome in salivary gland carcinoma. Specific chromosomal translocations are recognized in pleomorphic adenoma (with translocation involving PLGA1 or HMGA2 gene) and mucoepidermoid carcinoma (with MECT1-MAML2 gene fusion). Newly recognized entities include: sclerosing polycystic adenosis (with recent molecular evidence supporting its neoplastic nature), sclerosing mucoepidermoid carcinoma with eosinophilia, keratocystoma, adenoma with additional stromal component (lymphadenoma, lipoadenoma and adenofibroma), cribriform adenocarcinoma of the tongue and signet ring adenocarcinoma of minor salivary gland. Known tumour entities with new findings include: salivary duct carcinoma (with newly recognized mucinous, micropapillary and sarcomatoid variants), intraductal carcinoma (with controversies in terminology), mucoepidermoid carcinoma (with newly proposed grading parameters and oncocytic variant), epithelial-myoepithelial carcinoma (with newly recognized morphological variants), small cell carcinoma (with most cases being related to Merkel cell carcinoma), extranodal marginal zone B-cell lymphoma (with specific chromosomal translocation) and chronic sclerosing sialadenitis (being a component of IgG4-related sclerosing disease). Progression of salivary gland tumours can take the form of malignant transformation of a benign tumour, progression from low-grade to high-grade carcinoma, dedifferentiation, or stromal invasion of an in situ carcinoma.
    MeSH term(s) Biomarkers, Tumor/genetics ; Biomarkers, Tumor/metabolism ; Cell Transformation, Neoplastic/genetics ; Cell Transformation, Neoplastic/metabolism ; Cell Transformation, Neoplastic/pathology ; Disease Progression ; Gene Expression Regulation, Neoplastic ; Humans ; Immunohistochemistry/trends ; Salivary Gland Neoplasms/genetics ; Salivary Gland Neoplasms/metabolism ; Salivary Gland Neoplasms/pathology ; Salivary Glands/metabolism ; Salivary Glands/pathology
    Chemical Substances Biomarkers, Tumor
    Language English
    Publishing date 2007-07
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 131914-0
    ISSN 1365-2559 ; 0309-0167
    ISSN (online) 1365-2559
    ISSN 0309-0167
    DOI 10.1111/j.1365-2559.2007.02719.x
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Ocular PEComas are frequently melanotic and TFE3-translocated: report of two cases including the first description of PRCC-TFE3 fusion in PEComa.

    Gao, Y / Chen, G / Chow, C / Io, I / Wong, E W N / Tsui, W M S / Lam, W Y / To, K F / Chan, J K C / Cheuk, Wah

    Virchows Archiv : an international journal of pathology

    2020  Volume 478, Issue 5, Page(s) 1025–1031

    Abstract: Ocular perivascular epithelioid cell tumor (PEComa) is exceedingly rare. We reported two examples involving the choroid and subconjunctival tissue, respectively, in patients aged 17 and 20 years. Both tumors comprised packets and sheets of large ... ...

    Abstract Ocular perivascular epithelioid cell tumor (PEComa) is exceedingly rare. We reported two examples involving the choroid and subconjunctival tissue, respectively, in patients aged 17 and 20 years. Both tumors comprised packets and sheets of large polygonal cells with moderately pleomorphic nuclei and prominent nucleoli, traversed by delicate fibrovascular septa. Melanin pigmentation was present in one case. The tumors showed HMB45 and TFE3 immunoreactivity. TFE3 gene translocation was confirmed by FISH break-apart probes. RNA seq revealed PRCC-TFE3 and NONO-TFE3 fusions, with the former representing the first description of PRCC-TFE3 in PEComa. Critical reappraisal of the reported cases showed that ocular PEComa frequently affected young patents with melanin pigmentation, frequent TFE3 protein expression, and/or TFE3 gene translocation. No recurrence or metastasis was reported after complete excision despite the presence of cytologic atypia.
    MeSH term(s) Adolescent ; Basic Helix-Loop-Helix Leucine Zipper Transcription Factors/genetics ; Biomarkers, Tumor/analysis ; Biomarkers, Tumor/genetics ; Cell Cycle Proteins/genetics ; Choroid Neoplasms/chemistry ; Choroid Neoplasms/genetics ; Choroid Neoplasms/pathology ; Choroid Neoplasms/surgery ; Eye Neoplasms/chemistry ; Eye Neoplasms/genetics ; Eye Neoplasms/pathology ; Eye Neoplasms/surgery ; Female ; Gene Fusion ; Humans ; Immunohistochemistry ; In Situ Hybridization, Fluorescence ; Lacrimal Apparatus Diseases/genetics ; Lacrimal Apparatus Diseases/metabolism ; Lacrimal Apparatus Diseases/pathology ; Lacrimal Apparatus Diseases/surgery ; Male ; Melanins/analysis ; Neoplasm Proteins/genetics ; Perivascular Epithelioid Cell Neoplasms/chemistry ; Perivascular Epithelioid Cell Neoplasms/genetics ; Perivascular Epithelioid Cell Neoplasms/pathology ; Perivascular Epithelioid Cell Neoplasms/surgery ; RNA-Seq ; Young Adult
    Chemical Substances Basic Helix-Loop-Helix Leucine Zipper Transcription Factors ; Biomarkers, Tumor ; Cell Cycle Proteins ; Melanins ; Neoplasm Proteins ; PRCC protein, human ; TFE3 protein, human
    Language English
    Publishing date 2020-07-16
    Publishing country Germany
    Document type Case Reports ; Journal Article ; Review
    ZDB-ID 1184867-4
    ISSN 1432-2307 ; 0945-6317
    ISSN (online) 1432-2307
    ISSN 0945-6317
    DOI 10.1007/s00428-020-02890-w
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Anaplastic large cell Ki-1 lymphoma. Delineation of two morphological types. J. K. C. Chan, C. S. Ng, P. K. Hui, T. W. Leung, E. S. F. Lo, W. H. Lau, L. J. McGuire. Histopathology 1989; 15; 11-34.

    Chan, J K C

    Histopathology

    2002  Volume 41, Issue 3A, Page(s) 124–5, discussion 125–6

    MeSH term(s) B-Lymphocytes/metabolism ; B-Lymphocytes/pathology ; Diagnosis, Differential ; Humans ; Ki-1 Antigen/metabolism ; Lymphoma, Large-Cell, Anaplastic/diagnosis ; Lymphoma, Large-Cell, Anaplastic/pathology ; Protein-Tyrosine Kinases/metabolism ; Receptor Protein-Tyrosine Kinases
    Chemical Substances Ki-1 Antigen ; Protein-Tyrosine Kinases (EC 2.7.10.1) ; Receptor Protein-Tyrosine Kinases (EC 2.7.10.1) ; anaplastic lymphoma kinase (EC 2.7.10.1)
    Language English
    Publishing date 2002-09
    Publishing country England
    Document type Journal Article ; Comment
    ZDB-ID 131914-0
    ISSN 1365-2559 ; 0309-0167
    ISSN (online) 1365-2559
    ISSN 0309-0167
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article: Sinonasal haemangiopericytoma-like tumour: a sinonasal glomus tumour or a haemangiopericytoma?

    Tse, L L Y / Chan, J K C

    Histopathology

    2002  Volume 40, Issue 6, Page(s) 510–517

    Abstract: Aims: Sinonasal haemangiopericytoma-like tumour is controversial with regard to its nosologic nature. This study aims to investigate its relationship with glomus tumour and haemangiopericytoma.: Methods and results: Six cases of sinonasal ... ...

    Abstract Aims: Sinonasal haemangiopericytoma-like tumour is controversial with regard to its nosologic nature. This study aims to investigate its relationship with glomus tumour and haemangiopericytoma.
    Methods and results: Six cases of sinonasal haemangiopericytoma-like tumours identified in our files were reviewed for clinicopathological features, and compared with five cases each of soft tissue glomus tumour and meningeal haemangiopericytoma. Immunohistochemical studies for muscle-specific actin, smooth muscle actin, desmin and CD34 were performed. Sinonasal haemangiopericytoma-like tumour demonstrated a uniform histological appearance with bland-looking short, spindly cells forming sheets and short fascicles. The tumour cells were interspersed with slit-like, round and ectatic blood vessels. Actin immunoreactivity was demonstrated in all six cases, although occasionally patchy. The histological appearance and immunohistochemical phenotype of sinonasal haemangiopericytoma-like tumour were very similar to and focally indistinguishable from glomus tumour. Meningeal haemangiopericytoma, in contrast, was characterized by high tumour cellularity, random nuclear orientation, presence of staghorn vasculature and lack of immunohistochemical evidence of myogenic differentiation.
    Conclusions: We conclude that sinonasal haemangiopericytoma-like tumour is biologically close to or identical to glomus tumour, but is not related to haemangiopericytoma.
    MeSH term(s) Actins/analysis ; Aged ; Aged, 80 and over ; Diagnosis, Differential ; Female ; Glomus Tumor/metabolism ; Glomus Tumor/pathology ; Hemangiopericytoma/metabolism ; Hemangiopericytoma/pathology ; Humans ; Immunohistochemistry ; Male ; Middle Aged ; Muscle, Smooth/chemistry ; Paranasal Sinus Neoplasms/metabolism ; Paranasal Sinus Neoplasms/pathology
    Chemical Substances Actins
    Language English
    Publishing date 2002-08-16
    Publishing country England
    Document type Journal Article
    ZDB-ID 131914-0
    ISSN 1365-2559 ; 0309-0167
    ISSN (online) 1365-2559
    ISSN 0309-0167
    DOI 10.1046/j.1365-2559.2002.01396.x
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article: Can pulmonary sclerosing haemangioma be accurately diagnosed by intra-operative frozen section?

    Chan, A C L / Chan, J K C

    Histopathology

    2002  Volume 41, Issue 5, Page(s) 392–403

    Abstract: Aims: Pulmonary sclerosing haemangioma is a rare benign tumour with a characteristic variegated histological pattern. In this retrospective study we aimed to identify features that can aid in making a correct diagnosis and avoiding potential pitfalls at ...

    Abstract Aims: Pulmonary sclerosing haemangioma is a rare benign tumour with a characteristic variegated histological pattern. In this retrospective study we aimed to identify features that can aid in making a correct diagnosis and avoiding potential pitfalls at the time of intra-operative frozen section.
    Methods and results: Twenty cases of pulmonary sclerosing haemangioma with intra-operative frozen section were reviewed. The four major histological patterns (solid, sclerotic, papillary and haemorrhagic) were found in various combinations in the frozen sections. In 17 cases, three or more patterns were present. There could be focal areas mimicking epithelioid haemangioendothelioma or carcinoid tumour. Intra-operative imprint/scrape cytology served as a helpful adjunct in confirming the cytological blandness, although occasional atypical cells could be present. An intra-operative frozen section diagnosis of 'sclerosing haemangioma' or 'benign tumour' was given in 14 cases; the diagnosis was deferred in six cases. Retrospective analysis of the deferred cases showed that a definitive intra-operative diagnosis could have been made in three, because three or more major histological patterns were present. One case showed a pure papillary pattern at frozen section, mimicking the appearance of papillary adenocarcinoma (primary or secondary), bronchioloalveolar carcinoma, epithelioid mesothelioma or papillary adenoma; two tumours from a patient with multicentric disease showed widespread significant cytological atypia in the tumours raising a serious consideration of malignancy.
    Conclusion: A diagnosis of pulmonary sclerosing haemangioma can be made at intra-operative frozen sections in most cases based on the tumour circumscription and variegated histological patterns. When only a single histological pattern is identified or when there is significant cytological atypia, distinction from other tumours can be problematic, and the diagnosis is best deferred.
    MeSH term(s) Adult ; Aged ; Female ; Frozen Sections/methods ; Hemangioma/classification ; Hemangioma/diagnosis ; Humans ; Intraoperative Period ; Lung Neoplasms/classification ; Lung Neoplasms/diagnosis ; Middle Aged ; Retrospective Studies ; Sclerosis/pathology
    Language English
    Publishing date 2002-08-16
    Publishing country England
    Document type Journal Article
    ZDB-ID 131914-0
    ISSN 1365-2559 ; 0309-0167
    ISSN (online) 1365-2559
    ISSN 0309-0167
    DOI 10.1046/j.1365-2559.2002.01461.x
    Database MEDical Literature Analysis and Retrieval System OnLINE

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