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Article ; Online: Postoperative Delirium: The Search for Effective Interventions.

Campbell, Doug / Short, Timothy G / Chan, Matthew T V

2022 Volume 34, Issue 2, Page(s) 163–164

MeSH term(s)	Delirium/etiology ; Delirium/therapy ; Humans ; Postoperative Complications/therapy
Language	English
Publishing date	2022-01-22
Publishing country	United States
Document type	Journal Article
ZDB-ID	1018119-2
ISSN	1537-1921 ; 0898-4921
ISSN (online)	1537-1921
ISSN	0898-4921
DOI	10.1097/ANA.0000000000000834
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Zs.A 2656: Show issues

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Article ; Online: Prevention of perioperative stroke in patients undergoing non-cardiac surgery.

Marcucci, Maura / Chan, Matthew T V / Smith, Eric E / Absalom, Anthony R / Devereaux, P J

The Lancet. Neurology

2023 Volume 22, Issue 10, Page(s) 946–958

Abstract: About 300 million adults undergo non-cardiac surgery annually. Although, in this setting, the incidence of perioperative stroke is low, the absolute number of patients experiencing a stroke is substantial. Furthermore, most patients with this ... ...

Abstract	About 300 million adults undergo non-cardiac surgery annually. Although, in this setting, the incidence of perioperative stroke is low, the absolute number of patients experiencing a stroke is substantial. Furthermore, most patients with this complication will die or end up with severe disability. Covert brain infarctions are more frequent than overt strokes and are associated with postoperative delirium, cognitive decline, and cerebrovascular events at 1 year after surgery. Evidence shows that traditional stroke risk factors including older age, hypertension, and atrial fibrillation are also associated with perioperative stroke; previous stroke is the strongest risk factor for perioperative stroke. Increasing evidence also suggests the pathogenic role of perioperative events, such as hypotension, new atrial fibrillation, paradoxical embolism, and bleeding. Clinicians involved in perioperative care should be aware of this evidence on prevention strategies to improve patient outcomes after non-cardiac surgery.
MeSH term(s)	Adult ; Humans ; Atrial Fibrillation/complications ; Stroke/epidemiology ; Stroke/etiology ; Stroke/prevention & control ; Cognitive Dysfunction ; Hypertension ; Risk Factors
Language	English
Publishing date	2023-09-20
Publishing country	England
Document type	Journal Article ; Review ; Research Support, Non-U.S. Gov't
ZDB-ID	2081241-3
ISSN	1474-4465 ; 1474-4422
ISSN (online)	1474-4465
ISSN	1474-4422
DOI	10.1016/S1474-4422(23)00209-0
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Zs.A 5955: Show issues

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Article ; Online: In reply: Please stop using nitrous oxide in routine clinical practice (comment on: Use of nitrous oxide in contemporary anesthesia-an ongoing tug of war).

Chan, Chee Sam / Chan, Matthew T V

Canadian journal of anaesthesia = Journal canadien d'anesthesie

2021 Volume 69, Issue 2, Page(s) 273

MeSH term(s)	Anesthesia ; Anesthesiology ; Humans ; Nitrous Oxide
Chemical Substances	Nitrous Oxide (K50XQU1029)
Language	English
Publishing date	2021-11-08
Publishing country	United States
Document type	Letter ; Comment
ZDB-ID	91002-8
ISSN	1496-8975 ; 0832-610X
ISSN (online)	1496-8975
ISSN	0832-610X
DOI	10.1007/s12630-021-02137-5
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Zs.A 109: Show issues

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Article ; Online: Unrecognized Obstructive Sleep Apnea in Patients Undergoing Surgery-Reply.

Chan, Matthew T V / Chung, Frances

JAMA

2019 Volume 322, Issue 12, Page(s) 1211–1212

MeSH term(s)	Cardiovascular Diseases ; Humans ; Polysomnography ; Postoperative Period ; Sleep Apnea, Obstructive
Language	English
Publishing date	2019-09-24
Publishing country	United States
Document type	Letter ; Comment
ZDB-ID	2958-0
ISSN	1538-3598 ; 0254-9077 ; 0002-9955 ; 0098-7484
ISSN (online)	1538-3598
ISSN	0254-9077 ; 0002-9955 ; 0098-7484
DOI	10.1001/jama.2019.10994
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Article ; Online: Use of nitrous oxide in contemporary anesthesia-an ongoing tug of war.

Chan, Chee Sam / Chan, Matthew T V

Canadian journal of anaesthesia = Journal canadien d'anesthesie

2021 Volume 68, Issue 11, Page(s) 1597–1600

Title translation	Utilisation du protoxyde d’azote en anesthésie contemporaine — un bras de fer continu.
MeSH term(s)	Anesthesia ; Anesthesiology ; Humans ; Isoflurane ; Nitrous Oxide
Chemical Substances	Isoflurane (CYS9AKD70P) ; Nitrous Oxide (K50XQU1029)
Language	English
Publishing date	2021-08-26
Publishing country	United States
Document type	Editorial ; Comment
ZDB-ID	91002-8
ISSN	1496-8975 ; 0832-610X
ISSN (online)	1496-8975
ISSN	0832-610X
DOI	10.1007/s12630-021-02094-z
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Article ; Online: Vulnerability to Postoperative Complications in Obstructive Sleep Apnea: Importance of Phenotypes.

Altree, Thomas J / Chung, Frances / Chan, Matthew T V / Eckert, Danny J

Anesthesia and analgesia

2021 Volume 132, Issue 5, Page(s) 1328–1337

Abstract: Obstructive sleep apnea (OSA) is a common comorbidity in patients undergoing surgical procedures. Patients with OSA are at heightened risk of postoperative complications. Current treatments for OSA focus on alleviating upper airway collapse due to ... ...

Abstract	Obstructive sleep apnea (OSA) is a common comorbidity in patients undergoing surgical procedures. Patients with OSA are at heightened risk of postoperative complications. Current treatments for OSA focus on alleviating upper airway collapse due to impaired upper airway anatomy. Although impaired upper airway anatomy is the primary cause of OSA, the pathogenesis of OSA is highly variable from person to person. In many patients, nonanatomical traits play a critical role in the development of OSA. There are 4 key traits or "phenotypes" that contribute to OSA pathogenesis. In addition to (1) impaired upper airway anatomy, nonanatomical contributors include: (2) impaired upper airway dilator muscle responsiveness; (3) low respiratory arousal threshold (waking up too easily to minor airway narrowing); and (4) unstable control of breathing (high loop gain). Each of these phenotypes respond differently to postoperative factors, such as opioid medications. An understanding of these phenotypes and their highly varied interactions with postoperative risk factors is key to providing safer personalized care for postoperative patients with OSA. Accordingly, this review describes the 4 OSA phenotypes, highlights how the impact on OSA severity from postoperative risk factors, such as opioids and other sedatives, is influenced by OSA phenotypes, and outlines how this knowledge can be applied to provide individualized care to minimize postoperative risk in surgical patients with OSA.
MeSH term(s)	Anesthesia/adverse effects ; Humans ; Lung/physiopathology ; Phenotype ; Postoperative Complications/etiology ; Postoperative Complications/physiopathology ; Respiration ; Risk Assessment ; Risk Factors ; Severity of Illness Index ; Sleep ; Sleep Apnea, Obstructive/complications ; Sleep Apnea, Obstructive/diagnosis ; Sleep Apnea, Obstructive/physiopathology ; Surgical Procedures, Operative/adverse effects ; Treatment Outcome
Language	English
Publishing date	2021-04-20
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Review
ZDB-ID	80032-6
ISSN	1526-7598 ; 0003-2999
ISSN (online)	1526-7598
ISSN	0003-2999
DOI	10.1213/ANE.0000000000005390
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Uk I Zs.78: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular ab Jg. 2022: Lesesaal (EG)
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Article ; Online: Bioinformatic analyses suggest augmented interleukin-17 signaling as the mechanism of COVID-19-associated herpes zoster.

Yu, Xin / Li, Linfeng / Chan, Matthew T V / Wu, William Ka Kei

Environmental science and pollution research international

2021 Volume 28, Issue 46, Page(s) 65769–65775

Abstract: Herpes zoster results from latent varicella zoster virus reactivation in the dorsal root ganglia, causing blistering rash along the dermatomal distribution and post-herpetic neuralgia. Increasing studies indicated that there may be a correlation between ... ...

Abstract	Herpes zoster results from latent varicella zoster virus reactivation in the dorsal root ganglia, causing blistering rash along the dermatomal distribution and post-herpetic neuralgia. Increasing studies indicated that there may be a correlation between herpes zoster and COVID-19. Nevertheless, the detailed pathophysiological mechanism is still unclear. We used bioinformatic analyses to study the potential genetic crosstalk between herpes zoster and COVID-19. COVID-19 and herpes zoster were associated with a similar subset of genes involved in "cytokine-cytokine receptor interaction," "Jak-STAT signaling pathway," and "IL-17 signaling pathway," including TNF, IL10, ESR1, INFG, HLA-A, CRP, STAT3, IL6, IL7, and IL17A. Protein-protein interaction network assay showed that the combined gene set indicated a raised connectivity as compared to herpes zoster or COVID-19 alone, particularly the potentiated interactions with APOE, ARSA, CCR2, CCR5, CXCL13, EGFR, GAL, GP2, HLA-B, HLA-DRB1, IL5, TECTA, and THBS1, and these genes are related to "cytokine-cytokine receptor interaction". Augmented Th17 cell differentiation and the resulting enhanced IL-17 signaling were identified in both COVID-19 and herpes zoster. Our data suggested aberrant interleukin-17 signaling as one possible mechanism through which COVID-19 could raise the risk of herpes zoster.
MeSH term(s)	COVID-19/complications ; Computational Biology ; Herpes Zoster/complications ; Herpesvirus 3, Human ; Humans ; Interleukin-17/immunology ; Signal Transduction
Chemical Substances	Interleukin-17
Language	English
Publishing date	2021-07-28
Publishing country	Germany
Document type	Journal Article
ZDB-ID	1178791-0
ISSN	1614-7499 ; 0944-1344
ISSN (online)	1614-7499
ISSN	0944-1344
DOI	10.1007/s11356-021-15567-x
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Article ; Online: Compatibility of intravenous acetaminophen with morphine, fentanyl and ketamine in acute pediatric pain setting.

O'Loughlin, Edmond / Peng, Yan Ghee / Cheaib, Angela / Chan, Matthew T V / Williams, Robin

Paediatric anaesthesia

2022 Volume 32, Issue 7, Page(s) 862–869

Abstract: Background: Intravenous acetaminophen and opioid analgesics are routinely given concurrently to children after major surgery, where intravenous access can be limited. There is limited information about the compatibility of acetaminophen with opioid ... ...

Abstract	Background: Intravenous acetaminophen and opioid analgesics are routinely given concurrently to children after major surgery, where intravenous access can be limited. There is limited information about the compatibility of acetaminophen with opioid analgesics and ketamine in concentrations commonly used in pediatric setting. Aims: We aimed to determine the physical and chemical compatibility in mixtures of intravenous acetaminophen 10 mg/mL with morphine (0.025, 0.05, 0.1, 0.2, 1, and 2 mg/ml), fentanyl (0.5, 0.75, 1, 1.5, 2, and 5 mcg/ml) and ketamine (0.01, 0.1, 0.5, 1, 1.5, and 3 mg/ml). Methods: Acetaminophen was mixed with all 18 solutions and was examined at time 0, 15, 30, and 60 min. In Phase one of the study, we used a colorimetric method to assess preliminary feasibility and acetaminophen recovery. In Phase two study, we used high-performance liquid chromatography to evaluate the recovery of all components of the mixtures. Results: All solutions tested, for both acetaminophen and the three analgesics, had more than 90% of the drug recovery, up to 60 min after mixing. Conclusion: Our data demonstrated the stability of acetaminophen, in combination with fentanyl, morphine, and ketamine at clinical concentrations used in acute pediatric pain setting.
MeSH term(s)	Acetaminophen/therapeutic use ; Acute Pain ; Analgesics, Opioid/therapeutic use ; Child ; Double-Blind Method ; Fentanyl ; Humans ; Ketamine/therapeutic use ; Morphine/therapeutic use ; Pain Measurement ; Pain, Postoperative/drug therapy
Chemical Substances	Analgesics, Opioid ; Acetaminophen (362O9ITL9D) ; Ketamine (690G0D6V8H) ; Morphine (76I7G6D29C) ; Fentanyl (UF599785JZ)
Language	English
Publishing date	2022-04-24
Publishing country	France
Document type	Journal Article
ZDB-ID	1086049-6
ISSN	1460-9592 ; 1155-5645
ISSN (online)	1460-9592
ISSN	1155-5645
DOI	10.1111/pan.14455
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Zs.A 3306: Show issues

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Article ; Online: Preoperative oximetry-derived hypoxemia predicts postoperative cardiovascular events in surgical patients with unrecognized obstructive sleep apnea.

Chung, Frances / Waseem, Rida / Wang, Chew Yin / Seet, Edwin / Suen, Colin / Chan, Matthew T V

Journal of clinical anesthesia

2022 Volume 78, Page(s) 110653

Abstract: Study objective: Obstructive sleep apnea (OSA) is known to be associated with postoperative cardiovascular events in patients undergoing major non-cardiac surgery. The objective of the study is to determine whether preoperative oximetry-derived ... ...

Abstract	Study objective: Obstructive sleep apnea (OSA) is known to be associated with postoperative cardiovascular events in patients undergoing major non-cardiac surgery. The objective of the study is to determine whether preoperative oximetry-derived hypoxemia predicts postoperative cardiovascular events in surgical patients with unrecognized obstructive sleep apnea. Design and setting: The study was a planned post hoc analyses of a multicenter prospective cohort study. Patients: The inclusion criteria were patients ≥45 years old undergoing major non-cardiac surgery with cardiovascular risk factors. Interventions and measurements: All patients underwent pre-operative pulse oximetry (PULSOX-300i, Konica-Minolta Sensing, Inc). The severity of OSA was classified based on oxygen desaturation index (ODI) (mild: ≥5 to <15, moderate: ≥15 to <30, and severe OSA: ≥30 events/h). The 30 days cardiovascular events were a composite of myocardial injury, cardiac death, congestive heart failure, thromboembolism, atrial fibrillation, and stroke. Main results: For 1218 patients with mild, moderate, or severe OSA (mean age: 67.2 ± 9.3 years; body mass index: 27.0 ± 5.3 kg/m Conclusions: Preoperative ODI ≥30 events per hour and CT80 ≥ 10 min are associated with increased risk of postoperative cardiovascular events. Preoperative screening using oximetry helps in risk stratification for unrecognized sleep apnea. Clinical trial registration: ClinicalTrials.gov Identifier: NCT01494181.
MeSH term(s)	Aged ; Atrial Fibrillation/complications ; Heart Failure/complications ; Humans ; Hypoxia/diagnosis ; Hypoxia/epidemiology ; Hypoxia/etiology ; Middle Aged ; Oximetry ; Polysomnography ; Prospective Studies ; Sleep Apnea, Obstructive/complications ; Sleep Apnea, Obstructive/diagnosis
Language	English
Publishing date	2022-02-04
Publishing country	United States
Document type	Journal Article ; Multicenter Study
ZDB-ID	1011618-7
ISSN	1873-4529 ; 0952-8180
ISSN (online)	1873-4529
ISSN	0952-8180
DOI	10.1016/j.jclinane.2022.110653
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Zs.A 2622: Show issues

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Article ; Online: Lower gut abundance of

Liu, Yingzhi / Chan, Matthew T V / Chan, Francis K L / Wu, William K K / Ng, Siew C / Zhang, Lin

Frontiers in cellular and infection microbiology

2023 Volume 13, Page(s) 1249069

Abstract: Introduction: Emerging preclinical and clinical studies suggest that altered gut microbiome composition and functions are associated with coronavirus 2019 (COVID- 19) severity and its long-term complications. We hypothesize that COVID-19 outcome is ... ...

Abstract	Introduction: Emerging preclinical and clinical studies suggest that altered gut microbiome composition and functions are associated with coronavirus 2019 (COVID- 19) severity and its long-term complications. We hypothesize that COVID-19 outcome is associated with gut microbiome status in population-based settings. Methods: Gut metagenomic data of the adult population consisting of 2871 subjects from 16 countries were obtained from ExperimentHub through R, while the dynamic death data of COVID-19 patients between January 22, 2020 and December 8, 2020 in each country was acquired from Johns Hopkins Coronavirus Resource Center. An adjusted stable mortality rate (SMR) was used to represent these countries' mortality and correlated with the mean relative abundance (mRA) of healthy adult gut microbiome species. Results: After excluding bacterial species with low prevalence (prevalence <0.2 in the included countries), the β-diversity was significantly higher in the countries with high SMR when compared with those with median or low SMR (p <0.001). We then identified the mRA of two butyrate producers, Conclusion: Population-based microbiome signatures with the stable mortality rate of COVID-19 in different countries suggest that altered gut microbiome composition and functions are associated with mortality of COVID-19.
MeSH term(s)	Adult ; Humans ; Eubacterium ; COVID-19 ; Butyrates ; Gastrointestinal Microbiome ; Metagenome
Chemical Substances	Butyrates
Language	English
Publishing date	2023-09-06
Publishing country	Switzerland
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2619676-1
ISSN	2235-2988 ; 2235-2988
ISSN (online)	2235-2988
ISSN	2235-2988
DOI	10.3389/fcimb.2023.1249069
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