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  1. Article ; Online: Testing for Hypercoagulability in Patients With Unexplained Arterial Thromboembolism.

    Chan, Noel / Eikelboom, John

    JACC. Case reports

    2023  Volume 20, Page(s) 101944

    Language English
    Publishing date 2023-07-06
    Publishing country Netherlands
    Document type Editorial
    ISSN 2666-0849
    ISSN (online) 2666-0849
    DOI 10.1016/j.jaccas.2023.101944
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  2. Article ; Online: Recurrent Thrombosis and Bleeding in Patients with Cancer-Associated Venous Thromboembolism Receiving Anticoagulation: Are These Modifiable Risk Factors for Mortality?

    Xu, Ke / Chan, Noel C

    Thrombosis and haemostasis

    2023  Volume 123, Issue 5, Page(s) 487–489

    MeSH term(s) Humans ; Venous Thromboembolism/etiology ; Hemorrhage ; Anticoagulants/adverse effects ; Risk Factors ; Thrombosis/complications ; Neoplasms/complications ; Neoplasms/drug therapy ; Neoplasms/chemically induced ; Recurrence
    Chemical Substances Anticoagulants
    Language English
    Publishing date 2023-01-19
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 518294-3
    ISSN 2567-689X ; 0340-6245
    ISSN (online) 2567-689X
    ISSN 0340-6245
    DOI 10.1055/a-2015-8597
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    Uh III Zs.192: Show issues Location:
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    Zs.MO 433: Show issues

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  3. Article ; Online: Risk Factors for Venous Thromboembolism in Women of Childbearing Age.

    Xu, Ke / Chan, Noel C

    Thrombosis and haemostasis

    2023  Volume 123, Issue 11, Page(s) 1069–1071

    MeSH term(s) Humans ; Female ; Venous Thromboembolism/diagnosis ; Venous Thromboembolism/epidemiology ; Risk Factors
    Language English
    Publishing date 2023-07-07
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 518294-3
    ISSN 2567-689X ; 0340-6245
    ISSN (online) 2567-689X
    ISSN 0340-6245
    DOI 10.1055/a-2125-3290
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    Uh III Zs.192: Show issues Location:
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    Zs.MO 433: Show issues

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  4. Article ; Online: New Therapeutic Targets for the Prevention and Treatment of Venous Thromboembolism With a Focus on Factor XI Inhibitors.

    Chan, Noel C / Weitz, Jeffrey I

    Arteriosclerosis, thrombosis, and vascular biology

    2023  Volume 43, Issue 10, Page(s) 1755–1763

    Abstract: FXI (factor XI) and FXII (factor XII) have emerged as targets for new anticoagulants that have the potential to be both more efficacious and safer than the currently available direct oral anticoagulants for the prevention and treatment of venous ... ...

    Abstract FXI (factor XI) and FXII (factor XII) have emerged as targets for new anticoagulants that have the potential to be both more efficacious and safer than the currently available direct oral anticoagulants for the prevention and treatment of venous thromboembolism. In this review, we discuss the role of FXI and FXII in the pathogenesis of venous thromboembolism, explain why FXI is a better target, and explain why FXI inhibitors have potential advantages over currently available anticoagulants. Finally, we describe the FXI inhibitors under development and discuss their potential to address unmet needs in venous thromboembolism management.
    MeSH term(s) Humans ; Factor XI ; Blood Coagulation ; Thrombosis/drug therapy ; Venous Thromboembolism/drug therapy ; Venous Thromboembolism/prevention & control ; Anticoagulants/adverse effects ; Factor XII
    Chemical Substances Factor XI (9013-55-2) ; Anticoagulants ; Factor XII (9001-30-3)
    Language English
    Publishing date 2023-08-31
    Publishing country United States
    Document type Review ; Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 1221433-4
    ISSN 1524-4636 ; 1079-5642
    ISSN (online) 1524-4636
    ISSN 1079-5642
    DOI 10.1161/ATVBAHA.123.318781
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    Zs.A 1705: Show issues Location:
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  5. Article ; Online: Unresolved issues in the use of direct acting oral anticoagulants.

    Chan, Noel / Hirsh, Jack

    Expert review of cardiovascular therapy

    2023  Volume 21, Issue 12, Page(s) 913–921

    Abstract: Introduction: Currently approved direct oral anticoagulants (DOACs) target thrombin or coagulation factor Xa. Administered in fixed doses without routine laboratory monitoring, DOACs have simplified the approach to oral anticoagulation, when previously ... ...

    Abstract Introduction: Currently approved direct oral anticoagulants (DOACs) target thrombin or coagulation factor Xa. Administered in fixed doses without routine laboratory monitoring, DOACs have simplified the approach to oral anticoagulation, when previously the choice was limited to vitamin K antagonists (VKAs).
    Area covered: We discuss a) unresolved issues related to optimal use of DOACs and b) new developments including the potential for FXIa inhibitors to be effective and safer anticoagulants.
    Expert opinion: By simplifying oral anticoagulation, DOACs have facilitated the uptake of anticoagulation. The DOACs are approved for stroke prevention in atrial fibrillation and for the prevention and treatment of venous thromboembolism, and their indications are expanding to include the prevention of atherothrombosis. DOACs have now replaced vitamin K antagonists (VKAs) for most indications, but not all. DOACs are inferior to VKAs for patients with mechanical heart valves, left ventricular assist device, rheumatic atrial fibrillation, and those with antiphospholipid syndrome, and their safety and efficacy are uncertain in some populations (e.g. advanced renal and liver disease). Impediments to use include concerns for bleeding and cost. The newly developed FXIa and FXIIa inhibitors have the potential to be safer than current anticoagulants, but phase 3 trials are needed to confirm their clinical efficacy and safety.
    MeSH term(s) Humans ; Factor Xa Inhibitors/therapeutic use ; Atrial Fibrillation/complications ; Atrial Fibrillation/drug therapy ; Anticoagulants/adverse effects ; Hemorrhage/chemically induced ; Fibrinolytic Agents/therapeutic use ; Vitamin K ; Administration, Oral ; Stroke/etiology ; Stroke/prevention & control ; Stroke/drug therapy
    Chemical Substances Factor Xa Inhibitors ; Anticoagulants ; Fibrinolytic Agents ; Vitamin K (12001-79-5)
    Language English
    Publishing date 2023-12-13
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 2192343-7
    ISSN 1744-8344 ; 1477-9072
    ISSN (online) 1744-8344
    ISSN 1477-9072
    DOI 10.1080/14779072.2023.2271388
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  6. Article ; Online: Patterns and Persistence of Anticoagulant Use in the Treatment of Venous Thromboembolism: Insights from South Korea.

    Germini, Federico / Chan, Noel C

    Thrombosis and haemostasis

    2023  Volume 124, Issue 2, Page(s) 163–165

    MeSH term(s) Humans ; Venous Thromboembolism/drug therapy ; Anticoagulants/adverse effects ; Warfarin ; Republic of Korea/epidemiology
    Chemical Substances Anticoagulants ; Warfarin (5Q7ZVV76EI)
    Language English
    Publishing date 2023-07-18
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 518294-3
    ISSN 2567-689X ; 0340-6245
    ISSN (online) 2567-689X
    ISSN 0340-6245
    DOI 10.1055/a-2131-7066
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    Zs.MO 433: Show issues

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  7. Article ; Online: Human papilloma virus and atherosclerotic cardiovascular disease.

    Chan, Noel C / Lawson, James S / Hirsh, Jack

    European heart journal

    2024  Volume 45, Issue 12, Page(s) 1083–1085

    MeSH term(s) Humans ; Human Papillomavirus Viruses ; Cardiovascular Diseases ; Atherosclerosis
    Language English
    Publishing date 2024-02-06
    Publishing country England
    Document type Journal Article
    ZDB-ID 603098-1
    ISSN 1522-9645 ; 0195-668X
    ISSN (online) 1522-9645
    ISSN 0195-668X
    DOI 10.1093/eurheartj/ehad829
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    Zs.A 1563: Show issues Location:
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  8. Article ; Online: Ciraparantag as a potential universal anticoagulant reversal agent.

    Chan, Noel C / Weitz, Jeffrey I

    European heart journal

    2022  Volume 43, Issue 10, Page(s) 993–995

    MeSH term(s) Anticoagulants/therapeutic use ; Anticoagulation Reversal ; Arginine/analogs & derivatives ; Humans ; Piperazines
    Chemical Substances Anticoagulants ; Piperazines ; Arginine (94ZLA3W45F) ; PER977 (U2R67KV65Q)
    Language English
    Publishing date 2022-06-23
    Publishing country England
    Document type Editorial ; Research Support, Non-U.S. Gov't ; Comment
    ZDB-ID 603098-1
    ISSN 1522-9645 ; 0195-668X
    ISSN (online) 1522-9645
    ISSN 0195-668X
    DOI 10.1093/eurheartj/ehab706
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  9. Article ; Online: Thromboprophylaxis After Hip or Knee Arthroplasty.

    Chan, Noel C / Bhandari, Mohit

    JAMA

    2022  Volume 328, Issue 8, Page(s) 712–713

    MeSH term(s) Anticoagulants/therapeutic use ; Arthroplasty, Replacement, Hip/adverse effects ; Arthroplasty, Replacement, Knee/adverse effects ; Chemoprevention ; Humans ; Postoperative Complications/prevention & control ; Venous Thromboembolism/etiology ; Venous Thromboembolism/prevention & control
    Chemical Substances Anticoagulants
    Language English
    Publishing date 2022-08-23
    Publishing country United States
    Document type Journal Article ; Comment
    ZDB-ID 2958-0
    ISSN 1538-3598 ; 0254-9077 ; 0002-9955 ; 0098-7484
    ISSN (online) 1538-3598
    ISSN 0254-9077 ; 0002-9955 ; 0098-7484
    DOI 10.1001/jama.2022.11249
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  10. Article ; Online: Routine measurement of DOAC concentrations for prognostication and clinical management in acute ischemic stroke: Is it ready for prime time?

    Carlin, Stephanie / Chan, Noel C / Douketis, James D

    European journal of internal medicine

    2023  Volume 113, Page(s) 18–19

    MeSH term(s) Humans ; Ischemic Stroke ; Stroke/therapy ; Stroke/drug therapy ; Anticoagulants/therapeutic use ; Blood Coagulation Tests ; Administration, Oral ; Atrial Fibrillation/drug therapy
    Chemical Substances Anticoagulants
    Language English
    Publishing date 2023-04-29
    Publishing country Netherlands
    Document type Journal Article ; Comment
    ZDB-ID 1038679-8
    ISSN 1879-0828 ; 0953-6205
    ISSN (online) 1879-0828
    ISSN 0953-6205
    DOI 10.1016/j.ejim.2023.04.024
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